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The map label for this gene is mco [H]

Identifier: 159046473

GI number: 159046473

Start: 2470

End: 3774

Strand: Direct

Name: mco [H]

Synonym: Dshi_3934

Alternate gene names: 159046473

Gene position: 2470-3774 (Clockwise)

Preceding gene: 159046472

Following gene: 159046474

Centisome position: 1.96

GC content: 59.31

Gene sequence:

>1305_bases
GTGACGGAATTGTCTTTGAGCCGGAGGTCTTTCCTTGGCGGGATGACCGTTGCGCTGGCTGGTACCCGCTTGCCAGCAGC
GACACACGAGTTGATCCTCGCGCCCCAATCGATCAAGGCGCACCTTGCTGGGTACGACGTGTCGATGTTGGGCTTCAACG
GTGGTCTGCCGGGCCCAGAAGTCAGAATGCGACAAGGACAAACCGCCCGCATTACCCTCGATAACCGATTGGAGGAGGGC
GCTCTCGTTCACTGGCATGGGTTGCGGGTTCCAAATCGGATGGATGGTGTCAACGTCCTCACTCAGGATGTGGTCATTCC
GGGCGACTCGTATCGTTATCAATTCGGCGTCCCGGATGCCGGCACGTATTGGTATCACTCGCATTACCTGTCTTACGATC
AGGTCAGCCGCGGTCTTTTCGGCGCCTTCATCGTCGAGGAGCAAAATGCGCCGGCTGTCGACCATGACATCGTTGTTCAG
TTCTTCGATGTCTTGCTGGATCAGTCCGGGCAGTACGACGAAGCGTTCAACCCGGCCCACTTCGCAACCGAGGGCCGTAT
CGGCAATACGGTCACGGCACTTGTTTTCAATGGAACCGGCAAGACTGTGAAACGAGGCGACCGTCTGCGACTGCGTCTCA
TAAATCCCTCTATCGACAGGGTGTACCGTGTCGGCCTGGATGGTTTGATAGGCAAGATCGTTGCACTGGATGGCATGCCT
CTGGCGCATCCTCGGACGCTCGAACCGATCCTTCTCGCTCCGGGGCAAAGATGCGATGTGATTGGTGATGCGACCGGGCC
TATTAGATTCGACGACAGCTTTGGAGAACAGACGTTGAGCCTTGGCGAAATCGCTGTTTCCGGTTCCCGTGAGCCCGCGA
AAGCGCCCATCACCGCATTGCCCGCCAACCGAATGCCCGCCCCGAAAGACCCCGGCCAAACCGCGGAGCTGGTGCTCCAG
GGAGGTGCGGGAAGCGCGTCCCACAACGGCACAGGGACATGGGCGCTCAATGACGTATCCGGCCTGCCTCGAAGGCCTTT
CCTATCCGCCGCGCAGGGGACGACCGCGCGCATTTCGATCCGCAACGAAACCGGGTTCCCACACGTCATGCATCTGCATG
GCCACCATTTCTGGGAACTCGATGCGGCGGGTGAAGCCGGTCCATACCGGGACTCGACCTATCTGGATACCGGCGAGACG
CGGGATATTCTCGTCGTCCTGGACAATCCGGGATCGTGGATGCTGCATTGCCACATGTTGAGCCACCAAGCCGACGGTAT
GGCAACGTGGATCAGAGTCGGCTGA

Upstream 100 bases:

>100_bases
AAGTGACAACGGCGTGAGGAGTGTTCTGTCGCCTTGAAGTTCCTCTTCCGGAAATGGCACAAGTGCGGCAGTTGGCGAAA
GCCAGTCTATCATTCATGAG

Downstream 100 bases:

>100_bases
GGGTCGAGACGGATACATACCGTTACAAATCTCTGAATGATAACAGGCCTTTCGCCGTCTACGTAACCTGACAAGCGAGA
AACAGGTCCATCGACTGCCA

Product: multicopper oxidase type 3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MTELSLSRRSFLGGMTVALAGTRLPAATHELILAPQSIKAHLAGYDVSMLGFNGGLPGPEVRMRQGQTARITLDNRLEEG
ALVHWHGLRVPNRMDGVNVLTQDVVIPGDSYRYQFGVPDAGTYWYHSHYLSYDQVSRGLFGAFIVEEQNAPAVDHDIVVQ
FFDVLLDQSGQYDEAFNPAHFATEGRIGNTVTALVFNGTGKTVKRGDRLRLRLINPSIDRVYRVGLDGLIGKIVALDGMP
LAHPRTLEPILLAPGQRCDVIGDATGPIRFDDSFGEQTLSLGEIAVSGSREPAKAPITALPANRMPAPKDPGQTAELVLQ
GGAGSASHNGTGTWALNDVSGLPRRPFLSAAQGTTARISIRNETGFPHVMHLHGHHFWELDAAGEAGPYRDSTYLDTGET
RDILVVLDNPGSWMLHCHMLSHQADGMATWIRVG

Sequences:

>Translated_434_residues
MTELSLSRRSFLGGMTVALAGTRLPAATHELILAPQSIKAHLAGYDVSMLGFNGGLPGPEVRMRQGQTARITLDNRLEEG
ALVHWHGLRVPNRMDGVNVLTQDVVIPGDSYRYQFGVPDAGTYWYHSHYLSYDQVSRGLFGAFIVEEQNAPAVDHDIVVQ
FFDVLLDQSGQYDEAFNPAHFATEGRIGNTVTALVFNGTGKTVKRGDRLRLRLINPSIDRVYRVGLDGLIGKIVALDGMP
LAHPRTLEPILLAPGQRCDVIGDATGPIRFDDSFGEQTLSLGEIAVSGSREPAKAPITALPANRMPAPKDPGQTAELVLQ
GGAGSASHNGTGTWALNDVSGLPRRPFLSAAQGTTARISIRNETGFPHVMHLHGHHFWELDAAGEAGPYRDSTYLDTGET
RDILVVLDNPGSWMLHCHMLSHQADGMATWIRVG
>Mature_433_residues
TELSLSRRSFLGGMTVALAGTRLPAATHELILAPQSIKAHLAGYDVSMLGFNGGLPGPEVRMRQGQTARITLDNRLEEGA
LVHWHGLRVPNRMDGVNVLTQDVVIPGDSYRYQFGVPDAGTYWYHSHYLSYDQVSRGLFGAFIVEEQNAPAVDHDIVVQF
FDVLLDQSGQYDEAFNPAHFATEGRIGNTVTALVFNGTGKTVKRGDRLRLRLINPSIDRVYRVGLDGLIGKIVALDGMPL
AHPRTLEPILLAPGQRCDVIGDATGPIRFDDSFGEQTLSLGEIAVSGSREPAKAPITALPANRMPAPKDPGQTAELVLQG
GAGSASHNGTGTWALNDVSGLPRRPFLSAAQGTTARISIRNETGFPHVMHLHGHHFWELDAAGEAGPYRDSTYLDTGETR
DILVVLDNPGSWMLHCHMLSHQADGMATWIRVG

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=464, Percent_Identity=24.5689655172414, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1789394, Length=489, Percent_Identity=25.3578732106339, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6321067, Length=273, Percent_Identity=27.4725274725275, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6323703, Length=454, Percent_Identity=23.7885462555066, Blast_Score=74, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24650186, Length=180, Percent_Identity=30, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 47060; Mature: 46929

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTELSLSRRSFLGGMTVALAGTRLPAATHELILAPQSIKAHLAGYDVSMLGFNGGLPGPE
CCCCCCCHHHHHCCEEEEEECCCCCCCCCEEEECCHHHHHHHCCCEEEEEEECCCCCCCH
VRMRQGQTARITLDNRLEEGALVHWHGLRVPNRMDGVNVLTQDVVIPGDSYRYQFGVPDA
HHCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEECCCCC
GTYWYHSHYLSYDQVSRGLFGAFIVEEQNAPAVDHDIVVQFFDVLLDQSGQYDEAFNPAH
CCEEEEEEECCHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
FATEGRIGNTVTALVFNGTGKTVKRGDRLRLRLINPSIDRVYRVGLDGLIGKIVALDGMP
EEECCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCHHHHHHHCHHHHHHHHEEECCCC
LAHPRTLEPILLAPGQRCDVIGDATGPIRFDDSFGEQTLSLGEIAVSGSREPAKAPITAL
CCCCCCCCCEEECCCCCCEEEECCCCCEEECCCCCCHHEEECEEEECCCCCCCCCCEEEC
PANRMPAPKDPGQTAELVLQGGAGSASHNGTGTWALNDVSGLPRRPFLSAAQGTTARISI
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEE
RNETGFPHVMHLHGHHFWELDAAGEAGPYRDSTYLDTGETRDILVVLDNPGSWMLHCHML
ECCCCCCEEEEECCCEEEEEECCCCCCCCCCCCEECCCCCCEEEEEEECCCCEEEEEEEE
SHQADGMATWIRVG
CCCCCCEEEEEEEC
>Mature Secondary Structure 
TELSLSRRSFLGGMTVALAGTRLPAATHELILAPQSIKAHLAGYDVSMLGFNGGLPGPE
CCCCCCHHHHHCCEEEEEECCCCCCCCCEEEECCHHHHHHHCCCEEEEEEECCCCCCCH
VRMRQGQTARITLDNRLEEGALVHWHGLRVPNRMDGVNVLTQDVVIPGDSYRYQFGVPDA
HHCCCCCEEEEEECCCCCCCCEEEEECCCCCCCCCCCEEEEEEEEECCCCEEEEECCCCC
GTYWYHSHYLSYDQVSRGLFGAFIVEEQNAPAVDHDIVVQFFDVLLDQSGQYDEAFNPAH
CCEEEEEEECCHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
FATEGRIGNTVTALVFNGTGKTVKRGDRLRLRLINPSIDRVYRVGLDGLIGKIVALDGMP
EEECCCCCCEEEEEEECCCCCCCCCCCEEEEEEECCCHHHHHHHCHHHHHHHHEEECCCC
LAHPRTLEPILLAPGQRCDVIGDATGPIRFDDSFGEQTLSLGEIAVSGSREPAKAPITAL
CCCCCCCCCEEECCCCCCEEEECCCCCEEECCCCCCHHEEECEEEECCCCCCCCCCEEEC
PANRMPAPKDPGQTAELVLQGGAGSASHNGTGTWALNDVSGLPRRPFLSAAQGTTARISI
CCCCCCCCCCCCCCEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCEEEEEE
RNETGFPHVMHLHGHHFWELDAAGEAGPYRDSTYLDTGETRDILVVLDNPGSWMLHCHML
ECCCCCCEEEEECCCEEEEEECCCCCCCCCCCCEECCCCCCEEEEEEECCCCEEEEEEEE
SHQADGMATWIRVG
CCCCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12950922 [H]