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The map label for this gene is purC1 [H]

Identifier: 158423852

GI number: 158423852

Start: 2548440

End: 2549234

Strand: Direct

Name: purC1 [H]

Synonym: AZC_2228

Alternate gene names: 158423852

Gene position: 2548440-2549234 (Clockwise)

Preceding gene: 158423848

Following gene: 158423853

Centisome position: 47.46

GC content: 60.5

Gene sequence:

>795_bases
ATGGACTTCCTCAACCCACGGTACACCCCCATGAGCCGTCGCCGTCGCATTTACGAAGGCAAGGCCAAGGTCCTTTATGA
AGGCCCTGAGCCCGGCACTCTCATCCAGCACTTCAAGGATGATGCCACCGCCTTCAACGCCAAGAAGCATGATGTCATCG
ACGGCAAGGGCGTCCTCAACAACCGCATATCGGAATATATCTTCCAGCGGTTGAATGAGATCGGCGTGCCGACTCACTTC
ATCCGCCGCCTGAACATGCGCGAGCAGCTGATCCGCGAAGTGGAAATCATTCCGCTGGAGATCGTCGTGCGCAACGTGGC
GGCCGGCTCGCTCTCGACCCGCCTCGGCATCGAGGAGGGCACCGCGCTGCCCCGCTCGATCATCGAGTTCTATTACAAGA
ACGATGCCCTCAACGACCCGATGGTCTCCGAGGAGCACGTGACGGCGTTCGGCTGGGCCACCACCCAGGAAATCGACGAC
ATCATCGCGCTGGCGATCCGCGTCAACGACTTCCTCACCGGCCTCTTTCTCGGCGTCGGCATCCGTCTTGTGGATTTCAA
GATGGAATGCGGCCGCCTGTGGGAAAACGACATGATGCGGATCGTGGTCGCTGACGAGATCAGCCCCGATTCCTGCCGTC
TGTGGGACATCAAGTCCAACGACAAGCTGGACAAGGACCGCTTCCGTCGCGATCTCGGCGGTCTGGTGGAGGCCTATTCC
GAAGTGGCGCGCCGCCTCGGCATCCTCACCGACAACGAGCCGAATCAGACCAAGGGTCCGGCCCTCGTGAAGTGA

Upstream 100 bases:

>100_bases
CGGCTGATGGGCTAGTGTCGCCCTGGGTGTTCCTGTACTGCAAACCAGTCGCAGTTGCGCCCCGCCGAGGAGCGTCACCC
GAACGGAGCCTTGGCACATT

Downstream 100 bases:

>100_bases
GGCGGCTTGAGCCGCGCTGGAGCAGATGCTAGGGGCGGGGGCCGAGAGGCCCCCGCTTTCCGTTCGCCGGTGCCTTGTGC
ACGCGTTTGGACTGCGATCC

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase A [H]

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MDFLNPRYTPMSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHDVIDGKGVLNNRISEYIFQRLNEIGVPTHF
IRRLNMREQLIREVEIIPLEIVVRNVAAGSLSTRLGIEEGTALPRSIIEFYYKNDALNDPMVSEEHVTAFGWATTQEIDD
IIALAIRVNDFLTGLFLGVGIRLVDFKMECGRLWENDMMRIVVADEISPDSCRLWDIKSNDKLDKDRFRRDLGGLVEAYS
EVARRLGILTDNEPNQTKGPALVK

Sequences:

>Translated_264_residues
MDFLNPRYTPMSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHDVIDGKGVLNNRISEYIFQRLNEIGVPTHF
IRRLNMREQLIREVEIIPLEIVVRNVAAGSLSTRLGIEEGTALPRSIIEFYYKNDALNDPMVSEEHVTAFGWATTQEIDD
IIALAIRVNDFLTGLFLGVGIRLVDFKMECGRLWENDMMRIVVADEISPDSCRLWDIKSNDKLDKDRFRRDLGGLVEAYS
EVARRLGILTDNEPNQTKGPALVK
>Mature_264_residues
MDFLNPRYTPMSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHDVIDGKGVLNNRISEYIFQRLNEIGVPTHF
IRRLNMREQLIREVEIIPLEIVVRNVAAGSLSTRLGIEEGTALPRSIIEFYYKNDALNDPMVSEEHVTAFGWATTQEIDD
IIALAIRVNDFLTGLFLGVGIRLVDFKMECGRLWENDMMRIVVADEISPDSCRLWDIKSNDKLDKDRFRRDLGGLVEAYS
EVARRLGILTDNEPNQTKGPALVK

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=226, Percent_Identity=34.5132743362832, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI5453539, Length=226, Percent_Identity=34.5132743362832, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI119220559, Length=233, Percent_Identity=33.0472103004292, Blast_Score=103, Evalue=2e-22,
Organism=Escherichia coli, GI1788820, Length=241, Percent_Identity=43.1535269709544, Blast_Score=211, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17531275, Length=225, Percent_Identity=31.1111111111111, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI18860083, Length=224, Percent_Identity=32.5892857142857, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24583917, Length=207, Percent_Identity=25.6038647342995, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 30210; Mature: 30210

Theoretical pI: Translated: 5.80; Mature: 5.80

Prosite motif: PS01057 SAICAR_SYNTHETASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFLNPRYTPMSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHDVIDGKGVLN
CCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHH
NRISEYIFQRLNEIGVPTHFIRRLNMREQLIREVEIIPLEIVVRNVAAGSLSTRLGIEEG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
TALPRSIIEFYYKNDALNDPMVSEEHVTAFGWATTQEIDDIIALAIRVNDFLTGLFLGVG
CCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IRLVDFKMECGRLWENDMMRIVVADEISPDSCRLWDIKSNDKLDKDRFRRDLGGLVEAYS
HHEEEEEHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
EVARRLGILTDNEPNQTKGPALVK
HHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDFLNPRYTPMSRRRRIYEGKAKVLYEGPEPGTLIQHFKDDATAFNAKKHDVIDGKGVLN
CCCCCCCCCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCCHHH
NRISEYIFQRLNEIGVPTHFIRRLNMREQLIREVEIIPLEIVVRNVAAGSLSTRLGIEEG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCC
TALPRSIIEFYYKNDALNDPMVSEEHVTAFGWATTQEIDDIIALAIRVNDFLTGLFLGVG
CCHHHHHHHHHHHCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
IRLVDFKMECGRLWENDMMRIVVADEISPDSCRLWDIKSNDKLDKDRFRRDLGGLVEAYS
HHEEEEEHHHHHHCCCCCEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHH
EVARRLGILTDNEPNQTKGPALVK
HHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]