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The map label for this gene is dacC [H]

Identifier: 158423796

GI number: 158423796

Start: 2488701

End: 2489981

Strand: Direct

Name: dacC [H]

Synonym: AZC_2172

Alternate gene names: 158423796

Gene position: 2488701-2489981 (Clockwise)

Preceding gene: 158423795

Following gene: 158423797

Centisome position: 46.35

GC content: 67.53

Gene sequence:

>1281_bases
ATGACGTTCGAAATGTGTCACGAGCAGCCCCGGTCGGGGCGCTCCGCAGGAATGAAGCGCCGCCGGCCTCTCGGTCTGGC
GGCGTTTTTGTCGGCGGGCGCTGGCGCGCTGCTGACGGTGGTGGCTGCGCTGCTGCCGCTTCAGGCGGCCCGCGCCCAAA
CGGCGTTCCAGACAGCGGTGCCCGAGGCGACGCTGGTGGATTTCGCTTCCGGCACGATCCTGTTCGAGAAGAATGCGCAG
GGGCGCGTGGCGCCCGGCGGCATCGTCAAGATCATGACGGCGGCGGTGATCTTCGATCAGATCCGCGCCGGCAAGATCAC
CCTCGATACGCCCTTCTATGTGAGCGAGAACGCTTGGCGGCGCGGCGGCGGCCCGTCGGGCGGCGCGGCCATGTTCGTGC
CGGTGAAGAGCCAGGTGCGCGTGGGCGACCTGTTGCAGGGCGCGCTCGTGGTCTCGGGCAATGACGCGGCCATCGCTCTG
GCGGAAGGCCTCTCTGGCACCGAGAGCGAGTTCGCCCAGCGCATGAATGCGAAGGCGGCGGAACTCGGCATGTCCGGTTC
GCAGTTCCGCAATGCCACGGGCTTTGCCGATCCCGACCAGTTCACCAATGCCCGCGACATGGCGGTGTTGGCGCGCTCGA
TCATCCGCAACGATCCCGAACTCTACAAGATCTTCGCCGTCCCCGACATCGAGTGGAGCAAGATCAAGCAGCGCAACCGC
AACACACTGCTGAATGCCGGCATCGGCGCCGACGGCCTGCACATGTCCTGGGTCAAGGATGCCGGCTATCACCTCGTCGG
TTCGGCGGTGCAGGGTAACCAGCGGCTGATCGTCGTGGTGATGGGCGCCAAGACCGAGAAGGAGCGGCTGGAAGAGGCCC
GCCGTCTGCTCGAATGGGGATTCCATTCCTTCCAGTACAAACTGCTGTTCGCCGGCGACACCGAAGTCGGGCGCGCCAGC
ATCTGGGGCGGGGCGGTAGGCTCCGTGCCGCTCGTCACCGGTTCGGAACTCTCGCTGCTGCTGCCGCGCAACAGCCAGGA
GAAGCTGGTGGCCCGTGTCAGCTACAAGGGCCCGCTGCGGGCGCCGGTGGCCAAGGGCACGGAGGTGGGGCGCCTCGAAC
TGACGCGCGGCCAGCTCAAGGTGCTGGACGTACCGGTCTATACGGCCGCCGATGTGCCCGTGGGCACACTGTGGCAGCGG
GCGCTCGACGGCGGCTGGACCGTCGCGGGCGACGCGGCGCGGGACCTCACCACGCAGGTCATGGCGAAGTTCCGCAAATG
A

Upstream 100 bases:

>100_bases
CGACCGGCTGGAACGTTGGCCCTGCGCCGGTTTCCGGCCTCAGCTATTCCGGCGTGACGTCGTCGCGCTGATCCGTAACG
GGTGCTCCGGGGGGGCGTCC

Downstream 100 bases:

>100_bases
GTTCCGCCCGCGGGCGCTTCATCACGCTGGAAGGCGGAGAAGGCACCGGAAAGTCCACACAGGCCCGCCGTCTCGCCGCT
GCCCTCCAGAAGGGCGGCCT

Product: D-alanyl-D-alanine carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTFEMCHEQPRSGRSAGMKRRRPLGLAAFLSAGAGALLTVVAALLPLQAARAQTAFQTAVPEATLVDFASGTILFEKNAQ
GRVAPGGIVKIMTAAVIFDQIRAGKITLDTPFYVSENAWRRGGGPSGGAAMFVPVKSQVRVGDLLQGALVVSGNDAAIAL
AEGLSGTESEFAQRMNAKAAELGMSGSQFRNATGFADPDQFTNARDMAVLARSIIRNDPELYKIFAVPDIEWSKIKQRNR
NTLLNAGIGADGLHMSWVKDAGYHLVGSAVQGNQRLIVVVMGAKTEKERLEEARRLLEWGFHSFQYKLLFAGDTEVGRAS
IWGGAVGSVPLVTGSELSLLLPRNSQEKLVARVSYKGPLRAPVAKGTEVGRLELTRGQLKVLDVPVYTAADVPVGTLWQR
ALDGGWTVAGDAARDLTTQVMAKFRK

Sequences:

>Translated_426_residues
MTFEMCHEQPRSGRSAGMKRRRPLGLAAFLSAGAGALLTVVAALLPLQAARAQTAFQTAVPEATLVDFASGTILFEKNAQ
GRVAPGGIVKIMTAAVIFDQIRAGKITLDTPFYVSENAWRRGGGPSGGAAMFVPVKSQVRVGDLLQGALVVSGNDAAIAL
AEGLSGTESEFAQRMNAKAAELGMSGSQFRNATGFADPDQFTNARDMAVLARSIIRNDPELYKIFAVPDIEWSKIKQRNR
NTLLNAGIGADGLHMSWVKDAGYHLVGSAVQGNQRLIVVVMGAKTEKERLEEARRLLEWGFHSFQYKLLFAGDTEVGRAS
IWGGAVGSVPLVTGSELSLLLPRNSQEKLVARVSYKGPLRAPVAKGTEVGRLELTRGQLKVLDVPVYTAADVPVGTLWQR
ALDGGWTVAGDAARDLTTQVMAKFRK
>Mature_425_residues
TFEMCHEQPRSGRSAGMKRRRPLGLAAFLSAGAGALLTVVAALLPLQAARAQTAFQTAVPEATLVDFASGTILFEKNAQG
RVAPGGIVKIMTAAVIFDQIRAGKITLDTPFYVSENAWRRGGGPSGGAAMFVPVKSQVRVGDLLQGALVVSGNDAAIALA
EGLSGTESEFAQRMNAKAAELGMSGSQFRNATGFADPDQFTNARDMAVLARSIIRNDPELYKIFAVPDIEWSKIKQRNRN
TLLNAGIGADGLHMSWVKDAGYHLVGSAVQGNQRLIVVVMGAKTEKERLEEARRLLEWGFHSFQYKLLFAGDTEVGRASI
WGGAVGSVPLVTGSELSLLLPRNSQEKLVARVSYKGPLRAPVAKGTEVGRLELTRGQLKVLDVPVYTAADVPVGTLWQRA
LDGGWTVAGDAARDLTTQVMAKFRK

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=343, Percent_Identity=36.4431486880466, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI87082022, Length=342, Percent_Identity=34.7953216374269, Blast_Score=200, Evalue=2e-52,
Organism=Escherichia coli, GI1786851, Length=350, Percent_Identity=31.1428571428571, Blast_Score=178, Evalue=6e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 45591; Mature: 45460

Theoretical pI: Translated: 10.35; Mature: 10.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFEMCHEQPRSGRSAGMKRRRPLGLAAFLSAGAGALLTVVAALLPLQAARAQTAFQTAV
CCHHHHHCCCCCCHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PEATLVDFASGTILFEKNAQGRVAPGGIVKIMTAAVIFDQIRAGKITLDTPFYVSENAWR
CCHHEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCEEECCCCHH
RGGGPSGGAAMFVPVKSQVRVGDLLQGALVVSGNDAAIALAEGLSGTESEFAQRMNAKAA
CCCCCCCCEEEEEECCCCCCHHHHCCCEEEEECCCCEEEEECCCCCCHHHHHHHHCCHHH
ELGMSGSQFRNATGFADPDQFTNARDMAVLARSIIRNDPELYKIFAVPDIEWSKIKQRNR
HHCCCCHHHCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCCC
NTLLNAGIGADGLHMSWVKDAGYHLVGSAVQGNQRLIVVVMGAKTEKERLEEARRLLEWG
CEEEECCCCCCCCEEHHHHCCCCEEEEHEECCCCEEEEEEECCCCHHHHHHHHHHHHHHC
FHSFQYKLLFAGDTEVGRASIWGGAVGSVPLVTGSELSLLLPRNSQEKLVARVSYKGPLR
CCCEEEEEEEECCCCCCCEEECCCCCCCCEEEECCCEEEEECCCCHHHEEEEECCCCCCC
APVAKGTEVGRLELTRGQLKVLDVPVYTAADVPVGTLWQRALDGGWTVAGDAARDLTTQV
CCCCCCCCCCEEEEECCCEEEEEECEEEECCCCHHHHHHHHHCCCCEEECCHHHHHHHHH
MAKFRK
HHHHCC
>Mature Secondary Structure 
TFEMCHEQPRSGRSAGMKRRRPLGLAAFLSAGAGALLTVVAALLPLQAARAQTAFQTAV
CHHHHHCCCCCCHHCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
PEATLVDFASGTILFEKNAQGRVAPGGIVKIMTAAVIFDQIRAGKITLDTPFYVSENAWR
CCHHEEECCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECCCEEECCCCHH
RGGGPSGGAAMFVPVKSQVRVGDLLQGALVVSGNDAAIALAEGLSGTESEFAQRMNAKAA
CCCCCCCCEEEEEECCCCCCHHHHCCCEEEEECCCCEEEEECCCCCCHHHHHHHHCCHHH
ELGMSGSQFRNATGFADPDQFTNARDMAVLARSIIRNDPELYKIFAVPDIEWSKIKQRNR
HHCCCCHHHCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCCC
NTLLNAGIGADGLHMSWVKDAGYHLVGSAVQGNQRLIVVVMGAKTEKERLEEARRLLEWG
CEEEECCCCCCCCEEHHHHCCCCEEEEHEECCCCEEEEEEECCCCHHHHHHHHHHHHHHC
FHSFQYKLLFAGDTEVGRASIWGGAVGSVPLVTGSELSLLLPRNSQEKLVARVSYKGPLR
CCCEEEEEEEECCCCCCCEEECCCCCCCCEEEECCCEEEEECCCCHHHEEEEECCCCCCC
APVAKGTEVGRLELTRGQLKVLDVPVYTAADVPVGTLWQRALDGGWTVAGDAARDLTTQV
CCCCCCCCCCEEEEECCCEEEEEECEEEECCCCHHHHHHHHHCCCCEEECCHHHHHHHHH
MAKFRK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]