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The map label for this gene is lysR [H]

Identifier: 158423552

GI number: 158423552

Start: 2230233

End: 2231177

Strand: Direct

Name: lysR [H]

Synonym: AZC_1928

Alternate gene names: 158423552

Gene position: 2230233-2231177 (Clockwise)

Preceding gene: 158423546

Following gene: 158423553

Centisome position: 41.53

GC content: 65.29

Gene sequence:

>945_bases
TTGATAGGCATTCCATACGGATCTGATATGGCACGACGGCGCATGGGGCTGCAGCATATCGAGGCGTTTCGCGCGGTGAT
CCAGACCGGATCCATGACCGAGGCGGCGCGCCGGATGCACACCTCCCAACCGCAGATCAGTCGCCTGGTGGCTCAACTGG
AGCAGATCGCCCAGTTTGCGCTGTTCGACCGGAGCGGGAGCCGCGTCTTTCCAACCGCCGAGGGCACGCGCTTCTTTCAG
GAGGTGGAGAAGGCCTTCACGGGCCTGACCACCTTGGAGGCGGCCGCGCAAGGCATCCGTTCGTTCCGGGCCGATCGCCT
GCGGGTCACGGCGATGCCGCGGCTTGCCAGCGGGCTTCTCACCCGCATCGCCGCCAACTTCATGATGGACTATCCCGAAG
CTATGGTTTCCATCCGCTCGGGAACCGCGACCACCGTCCATGAATGGGTTTCGTCAGGATTGTGCGACGTCGGGCTGGCG
ATGCTCTATCAGGAGACATCGGGTGTCGAAGTGGAGCCGCTCTTCACCGGCCAGTGCGTCGCCGTACTGCCGACGGGCCA
CCCGCTTGCCGCGCGTGATGTCCTGACGCCGGCGGATCTGGCCGAACAGCCCTTCATCGCCTCGCCCAGCGGCGGGCAAT
TGGCCGAGCGGATCGATCAGGTCTTCAATGCGGCCAACGCGCGCCGCCGCATCGTCGCGGAGACGGATCTCGGCGCCTCC
GTCTGCACGTTGGTGGGCGCGGGCCTCGGGGTCAGTGTCATCAATCCGCTCGCCGCGCATGAGGAGCGGGAAAACGCGGG
CTTGCTGATCCGTCCCTTCCAGCCGGCGATCGCGACCACCGTCGCGCTCATCTACCCGCCCTATGTCGCCCGCAGCCGGT
TGGTCAGCGTGTTCAGCGATTATGCGCGCAGGCGGGTTCAGCAAGAGTTGACCTTGATGGCTTAA

Upstream 100 bases:

>100_bases
GCAAGCGCTTTCATAAGTGTCCCCACTGGCATGGCGGTGTTACCGCTCGTTCTTCATGGCAAGGAATATGACAAGCCTCC
ATCATGAGGCATAATTCTAA

Downstream 100 bases:

>100_bases
GGGCAGCCGTCGGGCAGGGAGACGCCCTTCGGTAAAGGCGAGCACCCCCAGAACATTTGCATAAGCCGCTTATCTTACTG
GCGGAGTTCGCTGCGACCGA

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MIGIPYGSDMARRRMGLQHIEAFRAVIQTGSMTEAARRMHTSQPQISRLVAQLEQIAQFALFDRSGSRVFPTAEGTRFFQ
EVEKAFTGLTTLEAAAQGIRSFRADRLRVTAMPRLASGLLTRIAANFMMDYPEAMVSIRSGTATTVHEWVSSGLCDVGLA
MLYQETSGVEVEPLFTGQCVAVLPTGHPLAARDVLTPADLAEQPFIASPSGGQLAERIDQVFNAANARRRIVAETDLGAS
VCTLVGAGLGVSVINPLAAHEERENAGLLIRPFQPAIATTVALIYPPYVARSRLVSVFSDYARRRVQQELTLMA

Sequences:

>Translated_314_residues
MIGIPYGSDMARRRMGLQHIEAFRAVIQTGSMTEAARRMHTSQPQISRLVAQLEQIAQFALFDRSGSRVFPTAEGTRFFQ
EVEKAFTGLTTLEAAAQGIRSFRADRLRVTAMPRLASGLLTRIAANFMMDYPEAMVSIRSGTATTVHEWVSSGLCDVGLA
MLYQETSGVEVEPLFTGQCVAVLPTGHPLAARDVLTPADLAEQPFIASPSGGQLAERIDQVFNAANARRRIVAETDLGAS
VCTLVGAGLGVSVINPLAAHEERENAGLLIRPFQPAIATTVALIYPPYVARSRLVSVFSDYARRRVQQELTLMA
>Mature_314_residues
MIGIPYGSDMARRRMGLQHIEAFRAVIQTGSMTEAARRMHTSQPQISRLVAQLEQIAQFALFDRSGSRVFPTAEGTRFFQ
EVEKAFTGLTTLEAAAQGIRSFRADRLRVTAMPRLASGLLTRIAANFMMDYPEAMVSIRSGTATTVHEWVSSGLCDVGLA
MLYQETSGVEVEPLFTGQCVAVLPTGHPLAARDVLTPADLAEQPFIASPSGGQLAERIDQVFNAANARRRIVAETDLGAS
VCTLVGAGLGVSVINPLAAHEERENAGLLIRPFQPAIATTVALIYPPYVARSRLVSVFSDYARRRVQQELTLMA

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=287, Percent_Identity=37.2822299651568, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI1788887, Length=244, Percent_Identity=31.1475409836066, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI157672245, Length=228, Percent_Identity=26.3157894736842, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI87081904, Length=201, Percent_Identity=25.8706467661692, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1790262, Length=193, Percent_Identity=26.4248704663212, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1787530, Length=250, Percent_Identity=25.2, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1787879, Length=245, Percent_Identity=27.3469387755102, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788481, Length=241, Percent_Identity=24.896265560166, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790399, Length=275, Percent_Identity=22.5454545454545, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI145693105, Length=270, Percent_Identity=22.5925925925926, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34095; Mature: 34095

Theoretical pI: Translated: 8.08; Mature: 8.08

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGIPYGSDMARRRMGLQHIEAFRAVIQTGSMTEAARRMHTSQPQISRLVAQLEQIAQFA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LFDRSGSRVFPTAEGTRFFQEVEKAFTGLTTLEAAAQGIRSFRADRLRVTAMPRLASGLL
HHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHH
TRIAANFMMDYPEAMVSIRSGTATTVHEWVSSGLCDVGLAMLYQETSGVEVEPLFTGQCV
HHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEECEEECCCEE
AVLPTGHPLAARDVLTPADLAEQPFIASPSGGQLAERIDQVFNAANARRRIVAETDLGAS
EEECCCCCCHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCHH
VCTLVGAGLGVSVINPLAAHEERENAGLLIRPFQPAIATTVALIYPPYVARSRLVSVFSD
HHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHH
YARRRVQQELTLMA
HHHHHHHHHHHHCC
>Mature Secondary Structure
MIGIPYGSDMARRRMGLQHIEAFRAVIQTGSMTEAARRMHTSQPQISRLVAQLEQIAQFA
CCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LFDRSGSRVFPTAEGTRFFQEVEKAFTGLTTLEAAAQGIRSFRADRLRVTAMPRLASGLL
HHCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHHHHHH
TRIAANFMMDYPEAMVSIRSGTATTVHEWVSSGLCDVGLAMLYQETSGVEVEPLFTGQCV
HHHHHHHHHHCHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEECEEECCCEE
AVLPTGHPLAARDVLTPADLAEQPFIASPSGGQLAERIDQVFNAANARRRIVAETDLGAS
EEECCCCCCHHHHCCCCHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEEECCCCHH
VCTLVGAGLGVSVINPLAAHEERENAGLLIRPFQPAIATTVALIYPPYVARSRLVSVFSD
HHHHHHCCCCHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHH
YARRRVQQELTLMA
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]