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The map label for this gene is mdh [H]

Identifier: 158423414

GI number: 158423414

Start: 2048755

End: 2049885

Strand: Direct

Name: mdh [H]

Synonym: AZC_1790

Alternate gene names: 158423414

Gene position: 2048755-2049885 (Clockwise)

Preceding gene: 158423410

Following gene: 158423415

Centisome position: 38.15

GC content: 70.73

Gene sequence:

>1131_bases
GTGCCGCGCATCGCACGCGGGAGGTCCGGCACCATGGCTGAGCCGCGCTCCCCCATCCCGGTCTATGCCGCCCGCTATCG
CGAGGCGGACCTGTCCGCCTTCTGCGAGGCCGCGTTGCGCGCTGCCGGTGCCGATGCGCCGACCGTCGATGCGGCGACGC
GCGCCATGATGCACGCCTCCCGCCTGGGCGTGGACAGCCACGGCGTGCGGCTGCTCAACCATTATGTCTCGGCGCTGGAG
GGCGGGCGCGTCGCCCGCGCGCCGCATCTCACCTATGTGCGCGAGACGGGTGCGGTGGCGACGCTGGATGCCGGTGCCGC
CCATGGGGCCCTTGCCGCCTATACGGCAATGGACCGGGCCATGGATCTCGCGAGCGGCTTCGGCATCGGAGCGGTGGCCA
TCCGCAATTCCTCTCATTTCGGGCCGGCGGGGGCCTTTGCCCTGGCAGCGGCAGAGCGGGGGTTCGTCGGGCTCGCCTTC
TGCAATTCCGACAGTTTCGTGCGTCTTCATGAGGGCGCCGAGCGCTTCCACGGCACCAATCCCATCGCCGCCGCCGCGCC
CGTGCGCGGTGCCCGGCCGTGGCTGTTCGACATGGCGACCAGCTCCGTGCCGTTCAACCGCGTGCTGCTCTACCGCAGCC
TCGACATTCCGTTGCCGCGCGACGCCGCCTCGGACGCTGAGGGGGTGGATACGCAGGATGCGAATGCGGTGGACATGCTG
GCGCCGCTTGGAGGAGCGTTCGGCTTCAAGGGCGCCGGGCTCGCAGGCCTCGTGGAGATATTCAGCGCGCTGCTTTCCGG
CGCGCTTCTCAGCTTCGACATCGCGCCCATGGTCGGGCCGGACATGGCGACGCCGCGCAATATCGGAGCCTTCGTGCTGG
CGGTGCGCCCCAGCGCCTTCCTGGAGCCGGAGGTCTATGAGGAGGGCATGGCGCGCTATCTGCGCACGCTGCGCCGCTCC
CGCCCCACCGCCGGCGGCGAGGTGCTGGCTCCCGGCGACCGTGAATGGCGCGAGGCGGACAATCGGGCGCGCATGGGCAT
TCCCGTGGACCCGGCGACGGCGGAGGCCTTCGCCCAACTCTCCCTGCGCTATGGCCTTTATCTGCCCGAGACGCAGTCCA
CCGCGTACTGA

Upstream 100 bases:

>100_bases
AGCGGGTCCGCCCCATGAGGCCTGCGACGGCTTGGGAGAAGAGCCATGGTAGCACTCGCGGCCAGCGCCCTGAGGGCGCG
TCCGGGCACGGCTTTATGCC

Downstream 100 bases:

>100_bases
ACGGCCGATCACAGACGGGATGTGACGTCGCCCGCCTTGCGGCGCCGGCGCGCCGGGCGTTCAATGCCGTCGTCAGGCAT
GGGGAACGTGGTGACGGCGG

Product: malate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MPRIARGRSGTMAEPRSPIPVYAARYREADLSAFCEAALRAAGADAPTVDAATRAMMHASRLGVDSHGVRLLNHYVSALE
GGRVARAPHLTYVRETGAVATLDAGAAHGALAAYTAMDRAMDLASGFGIGAVAIRNSSHFGPAGAFALAAAERGFVGLAF
CNSDSFVRLHEGAERFHGTNPIAAAAPVRGARPWLFDMATSSVPFNRVLLYRSLDIPLPRDAASDAEGVDTQDANAVDML
APLGGAFGFKGAGLAGLVEIFSALLSGALLSFDIAPMVGPDMATPRNIGAFVLAVRPSAFLEPEVYEEGMARYLRTLRRS
RPTAGGEVLAPGDREWREADNRARMGIPVDPATAEAFAQLSLRYGLYLPETQSTAY

Sequences:

>Translated_376_residues
MPRIARGRSGTMAEPRSPIPVYAARYREADLSAFCEAALRAAGADAPTVDAATRAMMHASRLGVDSHGVRLLNHYVSALE
GGRVARAPHLTYVRETGAVATLDAGAAHGALAAYTAMDRAMDLASGFGIGAVAIRNSSHFGPAGAFALAAAERGFVGLAF
CNSDSFVRLHEGAERFHGTNPIAAAAPVRGARPWLFDMATSSVPFNRVLLYRSLDIPLPRDAASDAEGVDTQDANAVDML
APLGGAFGFKGAGLAGLVEIFSALLSGALLSFDIAPMVGPDMATPRNIGAFVLAVRPSAFLEPEVYEEGMARYLRTLRRS
RPTAGGEVLAPGDREWREADNRARMGIPVDPATAEAFAQLSLRYGLYLPETQSTAY
>Mature_375_residues
PRIARGRSGTMAEPRSPIPVYAARYREADLSAFCEAALRAAGADAPTVDAATRAMMHASRLGVDSHGVRLLNHYVSALEG
GRVARAPHLTYVRETGAVATLDAGAAHGALAAYTAMDRAMDLASGFGIGAVAIRNSSHFGPAGAFALAAAERGFVGLAFC
NSDSFVRLHEGAERFHGTNPIAAAAPVRGARPWLFDMATSSVPFNRVLLYRSLDIPLPRDAASDAEGVDTQDANAVDMLA
PLGGAFGFKGAGLAGLVEIFSALLSGALLSFDIAPMVGPDMATPRNIGAFVLAVRPSAFLEPEVYEEGMARYLRTLRRSR
PTAGGEVLAPGDREWREADNRARMGIPVDPATAEAFAQLSLRYGLYLPETQSTAY

Specific function: Involved In The Anaerobic Utilization Of Allantoin. [C]

COG id: COG2055

COG function: function code C; Malate/L-lactate dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LDH2/MDH2 oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI1786727, Length=321, Percent_Identity=31.4641744548287, Blast_Score=138, Evalue=5e-34,
Organism=Escherichia coli, GI1787020, Length=358, Percent_Identity=29.0502793296089, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790000, Length=239, Percent_Identity=30.1255230125523, Blast_Score=108, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17507179, Length=333, Percent_Identity=28.2282282282282, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17536633, Length=349, Percent_Identity=26.9340974212034, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI45553211, Length=277, Percent_Identity=32.4909747292419, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24667912, Length=277, Percent_Identity=32.4909747292419, Blast_Score=125, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24667908, Length=277, Percent_Identity=32.4909747292419, Blast_Score=124, Evalue=7e-29,
Organism=Drosophila melanogaster, GI24667904, Length=277, Percent_Identity=32.4909747292419, Blast_Score=124, Evalue=9e-29,
Organism=Drosophila melanogaster, GI24648360, Length=288, Percent_Identity=29.8611111111111, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24658010, Length=307, Percent_Identity=26.3843648208469, Blast_Score=75, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003767 [H]

Pfam domain/function: PF02615 Ldh_2 [H]

EC number: =1.1.1.37 [H]

Molecular weight: Translated: 39620; Mature: 39489

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRIARGRSGTMAEPRSPIPVYAARYREADLSAFCEAALRAAGADAPTVDAATRAMMHAS
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
RLGVDSHGVRLLNHYVSALEGGRVARAPHLTYVRETGAVATLDAGAAHGALAAYTAMDRA
HCCCCHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHH
MDLASGFGIGAVAIRNSSHFGPAGAFALAAAERGFVGLAFCNSDSFVRLHEGAERFHGTN
HHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEHHHHHHHCCCC
PIAAAAPVRGARPWLFDMATSSVPFNRVLLYRSLDIPLPRDAASDAEGVDTQDANAVDML
CCCCCCCCCCCCCEEEEHHCCCCCHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHH
APLGGAFGFKGAGLAGLVEIFSALLSGALLSFDIAPMVGPDMATPRNIGAFVLAVRPSAF
HHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHH
LEPEVYEEGMARYLRTLRRSRPTAGGEVLAPGDREWREADNRARMGIPVDPATAEAFAQL
CCHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHCCCCCCCCCCCCHHHHHHHHH
SLRYGLYLPETQSTAY
HHHHCEECCCCCCCCC
>Mature Secondary Structure 
PRIARGRSGTMAEPRSPIPVYAARYREADLSAFCEAALRAAGADAPTVDAATRAMMHAS
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
RLGVDSHGVRLLNHYVSALEGGRVARAPHLTYVRETGAVATLDAGAAHGALAAYTAMDRA
HCCCCHHHHHHHHHHHHHHCCCCEECCCCEEEEECCCCEEEECCCCCCHHHHHHHHHHHH
MDLASGFGIGAVAIRNSSHFGPAGAFALAAAERGFVGLAFCNSDSFVRLHEGAERFHGTN
HHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEEEEEECCCCEEEEHHHHHHHCCCC
PIAAAAPVRGARPWLFDMATSSVPFNRVLLYRSLDIPLPRDAASDAEGVDTQDANAVDML
CCCCCCCCCCCCCEEEEHHCCCCCHHHEEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHH
APLGGAFGFKGAGLAGLVEIFSALLSGALLSFDIAPMVGPDMATPRNIGAFVLAVRPSAF
HHCCCCCCCCCCCHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHH
LEPEVYEEGMARYLRTLRRSRPTAGGEVLAPGDREWREADNRARMGIPVDPATAEAFAQL
CCHHHHHHHHHHHHHHHHHCCCCCCCCEECCCCHHHHHHCCCCCCCCCCCCHHHHHHHHH
SLRYGLYLPETQSTAY
HHHHCEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]