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The map label for this gene is pdhA [H]

Identifier: 158423365

GI number: 158423365

Start: 1991777

End: 1992790

Strand: Direct

Name: pdhA [H]

Synonym: AZC_1741

Alternate gene names: 158423365

Gene position: 1991777-1992790 (Clockwise)

Preceding gene: 158423364

Following gene: 158423366

Centisome position: 37.09

GC content: 65.29

Gene sequence:

>1014_bases
ATGGCAGCGAGAAAACCTTCCGCCCGGGCAGAGGCGGCTCCGGCCGGCGTACCGACCTTCACCAAAGAGCAGGAATTGCT
CGCCTATCGCGAGATGCTGCTGATCCGGCGTTTCGAGGAGAAGGCCGGCCAGATGTACGGCATGGGCCTCATCGGCGGCT
TCTGCCACCTCTACATCGGCCAGGAAGCGGTCGTCGTCGGCATGCAGATGGCGATGAAGCAGGGCGACCAGGTGATCACC
GGTTACCGGGATCACGGCCACATGCTGGCCACCGGGATGGAGTCGCGCGGCGTCATGGCCGAGCTGACCGGCCGCAAGGG
CGGCTACTCCAAGGGCAAGGGCGGCTCGATGCACATGTTCAGCATCGAGAAACAGTTCTTCGGCGGCCACGGCATCGTGG
GCGCGCAGGTGTCGCTGGGCACCGGCCTCGGCTTCGCGAACCACTATCGCGAGAACGGCTCCGTCTCGGTCACCTATTTC
GGTGACGGCGCGGCCAACCAGGGCCAGGTCTACGAGAGCTTCAACATGGCCGAGCTCTGGAAGCTCCCGGTCGTGTACGT
GATCGAGAACAACAAGTACGCCATGGGCACCGCGGTGAGCCGCGCCTCCGCCCAGACGGACTTCTCCAAGCGCGGCCAGT
CCTTCAACATCCCCGGCGAGCAGGTGGATGGCATGGACGTGCGCGCCGTCAAGGCCGCCGGCGAGCGCGCCCTTGAGTTC
GCCCGCTCCGGCAAGGGCCCCTACATCCTCGAGATGCAGACCTACCGCTATCGCGGCCACTCCATGTCCGATCCGGCCAA
GTACCGGTCGAAGGAGGAGGTGCAGAAGATGCGGACCGAGCACGATCCCATCGAGCAGGTGCGCAACCGCCTGCTGGAGG
CCGGCCTCGTCACCGAGGACGAACTGAAGAAGGTGGATGCGGAGATCCGCGACATCGTCAACGATGCCGCCGATTTCGCC
ACCCACGATCCGGAACCCGATCCGTCCGAGCTGTACACGGACATCGTGCGCTGA

Upstream 100 bases:

>100_bases
TTGCAACGTGTTGCGGTGCAGCAAAGCACTTTTTCCGCTTTGGACTGTCCCTGAGGTGCGCTAGAGGAGAGGCCGGCTCT
AGCGTTTCCTGAGGAAGTCG

Downstream 100 bases:

>100_bases
CGAGCTGCCCGTGGCGGTCGTGGCCCTCATCGTCCTCTTTCTTGCGCTGGCGAGTGCCGTCGCCAGCTGGGGCGTTGCCG
TGACCGAGGGATTGAAGGCG

Product: pyruvate dehydrogenase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MAARKPSARAEAAPAGVPTFTKEQELLAYREMLLIRRFEEKAGQMYGMGLIGGFCHLYIGQEAVVVGMQMAMKQGDQVIT
GYRDHGHMLATGMESRGVMAELTGRKGGYSKGKGGSMHMFSIEKQFFGGHGIVGAQVSLGTGLGFANHYRENGSVSVTYF
GDGAANQGQVYESFNMAELWKLPVVYVIENNKYAMGTAVSRASAQTDFSKRGQSFNIPGEQVDGMDVRAVKAAGERALEF
ARSGKGPYILEMQTYRYRGHSMSDPAKYRSKEEVQKMRTEHDPIEQVRNRLLEAGLVTEDELKKVDAEIRDIVNDAADFA
THDPEPDPSELYTDIVR

Sequences:

>Translated_337_residues
MAARKPSARAEAAPAGVPTFTKEQELLAYREMLLIRRFEEKAGQMYGMGLIGGFCHLYIGQEAVVVGMQMAMKQGDQVIT
GYRDHGHMLATGMESRGVMAELTGRKGGYSKGKGGSMHMFSIEKQFFGGHGIVGAQVSLGTGLGFANHYRENGSVSVTYF
GDGAANQGQVYESFNMAELWKLPVVYVIENNKYAMGTAVSRASAQTDFSKRGQSFNIPGEQVDGMDVRAVKAAGERALEF
ARSGKGPYILEMQTYRYRGHSMSDPAKYRSKEEVQKMRTEHDPIEQVRNRLLEAGLVTEDELKKVDAEIRDIVNDAADFA
THDPEPDPSELYTDIVR
>Mature_336_residues
AARKPSARAEAAPAGVPTFTKEQELLAYREMLLIRRFEEKAGQMYGMGLIGGFCHLYIGQEAVVVGMQMAMKQGDQVITG
YRDHGHMLATGMESRGVMAELTGRKGGYSKGKGGSMHMFSIEKQFFGGHGIVGAQVSLGTGLGFANHYRENGSVSVTYFG
DGAANQGQVYESFNMAELWKLPVVYVIENNKYAMGTAVSRASAQTDFSKRGQSFNIPGEQVDGMDVRAVKAAGERALEFA
RSGKGPYILEMQTYRYRGHSMSDPAKYRSKEEVQKMRTEHDPIEQVRNRLLEAGLVTEDELKKVDAEIRDIVNDAADFAT
HDPEPDPSELYTDIVR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4885543, Length=322, Percent_Identity=51.5527950310559, Blast_Score=343, Evalue=9e-95,
Organism=Homo sapiens, GI291084742, Length=324, Percent_Identity=51.2345679012346, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI4505685, Length=324, Percent_Identity=51.2345679012346, Blast_Score=324, Evalue=7e-89,
Organism=Homo sapiens, GI291084744, Length=331, Percent_Identity=50.1510574018127, Blast_Score=317, Evalue=8e-87,
Organism=Homo sapiens, GI291084757, Length=324, Percent_Identity=46.6049382716049, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI11386135, Length=323, Percent_Identity=29.1021671826625, Blast_Score=135, Evalue=5e-32,
Organism=Homo sapiens, GI258645172, Length=323, Percent_Identity=29.4117647058824, Blast_Score=133, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI32564172, Length=323, Percent_Identity=51.3931888544892, Blast_Score=330, Evalue=8e-91,
Organism=Caenorhabditis elegans, GI17536047, Length=323, Percent_Identity=51.3931888544892, Blast_Score=329, Evalue=1e-90,
Organism=Caenorhabditis elegans, GI86563355, Length=298, Percent_Identity=27.8523489932886, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI86563357, Length=298, Percent_Identity=27.8523489932886, Blast_Score=119, Evalue=3e-27,
Organism=Saccharomyces cerevisiae, GI6321026, Length=318, Percent_Identity=49.0566037735849, Blast_Score=315, Evalue=1e-86,
Organism=Drosophila melanogaster, GI24639740, Length=328, Percent_Identity=50, Blast_Score=335, Evalue=4e-92,
Organism=Drosophila melanogaster, GI24639744, Length=328, Percent_Identity=50, Blast_Score=334, Evalue=4e-92,
Organism=Drosophila melanogaster, GI28571106, Length=328, Percent_Identity=50, Blast_Score=334, Evalue=4e-92,
Organism=Drosophila melanogaster, GI24639746, Length=305, Percent_Identity=51.1475409836066, Blast_Score=321, Evalue=5e-88,
Organism=Drosophila melanogaster, GI24639748, Length=326, Percent_Identity=51.2269938650307, Blast_Score=313, Evalue=8e-86,
Organism=Drosophila melanogaster, GI21355903, Length=318, Percent_Identity=25.1572327044025, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017597 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 37164; Mature: 37032

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
5.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAARKPSARAEAAPAGVPTFTKEQELLAYREMLLIRRFEEKAGQMYGMGLIGGFCHLYIG
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHCC
QEAVVVGMQMAMKQGDQVITGYRDHGHMLATGMESRGVMAELTGRKGGYSKGKGGSMHMF
CHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCEEEE
SIEKQFFGGHGIVGAQVSLGTGLGFANHYRENGSVSVTYFGDGAANQGQVYESFNMAELW
EEHHHHCCCCCEEEEEEECCCCCCHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCHHHHH
KLPVVYVIENNKYAMGTAVSRASAQTDFSKRGQSFNIPGEQVDGMDVRAVKAAGERALEF
CCCEEEEEECCCEEEHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ARSGKGPYILEMQTYRYRGHSMSDPAKYRSKEEVQKMRTEHDPIEQVRNRLLEAGLVTED
HHCCCCCEEEEEEEEEECCCCCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCHH
ELKKVDAEIRDIVNDAADFATHDPEPDPSELYTDIVR
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
AARKPSARAEAAPAGVPTFTKEQELLAYREMLLIRRFEEKAGQMYGMGLIGGFCHLYIG
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECHHHHHHHHHHHCC
QEAVVVGMQMAMKQGDQVITGYRDHGHMLATGMESRGVMAELTGRKGGYSKGKGGSMHMF
CHHHHHHHHHHHHCCCEEEEEECCCCCEEEECCCCCCCEEEECCCCCCCCCCCCCCEEEE
SIEKQFFGGHGIVGAQVSLGTGLGFANHYRENGSVSVTYFGDGAANQGQVYESFNMAELW
EEHHHHCCCCCEEEEEEECCCCCCHHHHHCCCCCEEEEEECCCCCCCCCHHHCCCHHHHH
KLPVVYVIENNKYAMGTAVSRASAQTDFSKRGQSFNIPGEQVDGMDVRAVKAAGERALEF
CCCEEEEEECCCEEEHHHHHHHHHHCHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
ARSGKGPYILEMQTYRYRGHSMSDPAKYRSKEEVQKMRTEHDPIEQVRNRLLEAGLVTED
HHCCCCCEEEEEEEEEECCCCCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCHH
ELKKVDAEIRDIVNDAADFATHDPEPDPSELYTDIVR
HHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10796014; 11481430 [H]