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The map label for this gene is serS

Identifier: 158423363

GI number: 158423363

Start: 1989556

End: 1990893

Strand: Direct

Name: serS

Synonym: AZC_1739

Alternate gene names: 158423363

Gene position: 1989556-1990893 (Clockwise)

Preceding gene: 158423362

Following gene: 158423364

Centisome position: 37.05

GC content: 66.37

Gene sequence:

>1338_bases
ATGCATGACATCAAGTGGATTCGCGAGGAGCCCGAGGCTCTGGTGCGCGCGCTCGTGCGCCGTCAGGTGGCGAAGGACGA
GGCGGTCGCCCTGCGCGACAAGCTCCTTTCCCTCGACACCGCCCGCCGCGAGACGCTGACCAAGCTGGAAGGCCTGCTCG
CCCGCCGCAACGCCGCCTCCAAGGAGATCGGCCAGGCCAAGGCCGCCAAGGACGAGGCCCGCGCGGCCGCTCTGATGGAC
GAGGTGGCGAAGCTGAAGGTGGACGTGCCGGAACTGGAGCAGTCCGCCAAGGCCATCGAGGGGGAACTGGACGGCCTGCT
CGCCGCCATTCCCAACGTGCCGCTTGAAAGCGTGCCGGAGGGCAAGGACGAGCACGACAATGTCGAGCTGAAGGTCGTCG
GCACCAAGCGCAACTATGCCTTCACGCCGAAGCAGCATTTCGAGCTGGGCGAGGCGCTCGGCCTCATGGACTTCGAGACC
GCCTCGAAGCTCTCGGGCGCCCGTTTCGTGGTGAACAAGGGGCCGCTCGCCCGTCTGGAGCGCGCGCTCGGCCAGTTCTT
CCTCGACATGCATGTGGAGCAACACGGCTACACGGAAGTGAACCCGCCGCTGCTGGTGCGCGACGAGACCATGTATGGCA
CGGCGCAACTGCCGAAGTTCTTTGACGACCAGTTCGCCGTTTACGCCGGCTCCACCCAACGGGCGATCGGGGATGAAACC
GATGCCGAGCGCTACTGGCTCATCCCCACGGCCGAAGTGCCCCTGACCAATCTGGTGCGAGACTCGATCCTCTCCGAGGA
CGAACTGCCGCTGCGCTTCACCGCCAATACGCCTTGCTTCCGCGCCGAGGCGGGATCGGCGGGGCGTGACACACGCGGCA
TGATCCGCCAGCACCAGTTCACCAAGGTGGAGATGGTCTCCATCACCACGCCGGAGACCTCGGAGGAGGAGCATCACCGC
ATGCTCGCCTGCGCCGAGGCGGTGTTGCAGAAGCTCGATTTGCATTATCGCGTGGTGACGCTGTGCACCGGCGACATGGG
CTTTGCCTCGCGCAAGACCTTCGACATCGAGGTCTGGCTGCCCGGCCAGAACGCCTATCGCGAGATTTCGTCCTGCTCCG
TCTGCGGCGACTTCCAGGCCCGGCGCATGAATGCCCGCTACCGTCCCGCCGAGGGCAAGGGGCCGCGCTTCGTTCATACG
CTGAACGGCTCCGGCGTCGCCGTCGGCCGCGCGCTGGTGGCGGTGCTGGAGACCTATCAGCAGGAGGACGGCTCCATCGT
CGTCCCCGACGTGCTCCAGTCCTACATGGGCGGCGTGACGGTCATCGCGAAGGCGTGA

Upstream 100 bases:

>100_bases
CGGGCGCCGCCGGCGCGGCGGGGCGGCGTGGATGCCCGGCACTGGGCCGGCATGACGGCGAGGGGCGCCCGGCCATCCGG
TCTGCGGCGGAGCCGATTTC

Downstream 100 bases:

>100_bases
TCCGAAGGGCGTTGCTGTTGTGCAGCGACTGCGAGGCCAACTCCCCTTGCGGGGGAGGGCTGGGGAGGGGGGTAATGCCC
TCTCCACCTGAGCGTCCCAT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MHDIKWIREEPEALVRALVRRQVAKDEAVALRDKLLSLDTARRETLTKLEGLLARRNAASKEIGQAKAAKDEARAAALMD
EVAKLKVDVPELEQSAKAIEGELDGLLAAIPNVPLESVPEGKDEHDNVELKVVGTKRNYAFTPKQHFELGEALGLMDFET
ASKLSGARFVVNKGPLARLERALGQFFLDMHVEQHGYTEVNPPLLVRDETMYGTAQLPKFFDDQFAVYAGSTQRAIGDET
DAERYWLIPTAEVPLTNLVRDSILSEDELPLRFTANTPCFRAEAGSAGRDTRGMIRQHQFTKVEMVSITTPETSEEEHHR
MLACAEAVLQKLDLHYRVVTLCTGDMGFASRKTFDIEVWLPGQNAYREISSCSVCGDFQARRMNARYRPAEGKGPRFVHT
LNGSGVAVGRALVAVLETYQQEDGSIVVPDVLQSYMGGVTVIAKA

Sequences:

>Translated_445_residues
MHDIKWIREEPEALVRALVRRQVAKDEAVALRDKLLSLDTARRETLTKLEGLLARRNAASKEIGQAKAAKDEARAAALMD
EVAKLKVDVPELEQSAKAIEGELDGLLAAIPNVPLESVPEGKDEHDNVELKVVGTKRNYAFTPKQHFELGEALGLMDFET
ASKLSGARFVVNKGPLARLERALGQFFLDMHVEQHGYTEVNPPLLVRDETMYGTAQLPKFFDDQFAVYAGSTQRAIGDET
DAERYWLIPTAEVPLTNLVRDSILSEDELPLRFTANTPCFRAEAGSAGRDTRGMIRQHQFTKVEMVSITTPETSEEEHHR
MLACAEAVLQKLDLHYRVVTLCTGDMGFASRKTFDIEVWLPGQNAYREISSCSVCGDFQARRMNARYRPAEGKGPRFVHT
LNGSGVAVGRALVAVLETYQQEDGSIVVPDVLQSYMGGVTVIAKA
>Mature_445_residues
MHDIKWIREEPEALVRALVRRQVAKDEAVALRDKLLSLDTARRETLTKLEGLLARRNAASKEIGQAKAAKDEARAAALMD
EVAKLKVDVPELEQSAKAIEGELDGLLAAIPNVPLESVPEGKDEHDNVELKVVGTKRNYAFTPKQHFELGEALGLMDFET
ASKLSGARFVVNKGPLARLERALGQFFLDMHVEQHGYTEVNPPLLVRDETMYGTAQLPKFFDDQFAVYAGSTQRAIGDET
DAERYWLIPTAEVPLTNLVRDSILSEDELPLRFTANTPCFRAEAGSAGRDTRGMIRQHQFTKVEMVSITTPETSEEEHHR
MLACAEAVLQKLDLHYRVVTLCTGDMGFASRKTFDIEVWLPGQNAYREISSCSVCGDFQARRMNARYRPAEGKGPRFVHT
LNGSGVAVGRALVAVLETYQQEDGSIVVPDVLQSYMGGVTVIAKA

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=453, Percent_Identity=32.0088300220751, Blast_Score=202, Evalue=6e-52,
Organism=Homo sapiens, GI8923421, Length=416, Percent_Identity=32.4519230769231, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI225579074, Length=330, Percent_Identity=34.8484848484849, Blast_Score=189, Evalue=5e-48,
Organism=Escherichia coli, GI1787120, Length=443, Percent_Identity=52.3702031602709, Blast_Score=434, Evalue=1e-123,
Organism=Caenorhabditis elegans, GI17539260, Length=439, Percent_Identity=34.3963553530752, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17542084, Length=330, Percent_Identity=29.3939393939394, Blast_Score=148, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=438, Percent_Identity=30.8219178082192, Blast_Score=190, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6321799, Length=408, Percent_Identity=27.9411764705882, Blast_Score=177, Evalue=4e-45,
Organism=Drosophila melanogaster, GI24581334, Length=451, Percent_Identity=31.7073170731707, Blast_Score=195, Evalue=5e-50,
Organism=Drosophila melanogaster, GI17737985, Length=305, Percent_Identity=34.4262295081967, Blast_Score=160, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_AZOC5 (A8I4J4)

Other databases:

- EMBL:   AP009384
- RefSeq:   YP_001524655.1
- ProteinModelPortal:   A8I4J4
- SMR:   A8I4J4
- GeneID:   5691171
- GenomeReviews:   AP009384_GR
- KEGG:   azc:AZC_1739
- HOGENOM:   HBG629391
- OMA:   ENGYTEV
- ProtClustDB:   PRK05431
- BioCyc:   ACAU438753:AZC_1739-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 49326; Mature: 49326

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 304-304 BINDING 404-404

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDIKWIREEPEALVRALVRRQVAKDEAVALRDKLLSLDTARRETLTKLEGLLARRNAAS
CCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
KEIGQAKAAKDEARAAALMDEVAKLKVDVPELEQSAKAIEGELDGLLAAIPNVPLESVPE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GKDEHDNVELKVVGTKRNYAFTPKQHFELGEALGLMDFETASKLSGARFVVNKGPLARLE
CCCCCCCEEEEEEEECCCCEECCHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCHHHHH
RALGQFFLDMHVEQHGYTEVNPPLLVRDETMYGTAQLPKFFDDQFAVYAGSTQRAIGDET
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHCCHHHCCCEEEEECCCCCCCCCCC
DAERYWLIPTAEVPLTNLVRDSILSEDELPLRFTANTPCFRAEAGSAGRDTRGMIRQHQF
CCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCCHHHHHHHHCC
TKVEMVSITTPETSEEEHHRMLACAEAVLQKLDLHYRVVTLCTGDMGFASRKTFDIEVWL
CEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEE
PGQNAYREISSCSVCGDFQARRMNARYRPAEGKGPRFVHTLNGSGVAVGRALVAVLETYQ
CCCHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
QEDGSIVVPDVLQSYMGGVTVIAKA
HCCCCEECHHHHHHHCCCEEEEEEC
>Mature Secondary Structure
MHDIKWIREEPEALVRALVRRQVAKDEAVALRDKLLSLDTARRETLTKLEGLLARRNAAS
CCCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
KEIGQAKAAKDEARAAALMDEVAKLKVDVPELEQSAKAIEGELDGLLAAIPNVPLESVPE
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
GKDEHDNVELKVVGTKRNYAFTPKQHFELGEALGLMDFETASKLSGARFVVNKGPLARLE
CCCCCCCEEEEEEEECCCCEECCHHHHHHHHHHCCCCHHHHHHCCCCEEEECCCCHHHHH
RALGQFFLDMHVEQHGYTEVNPPLLVRDETMYGTAQLPKFFDDQFAVYAGSTQRAIGDET
HHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCCHHCCHHHCCCEEEEECCCCCCCCCCC
DAERYWLIPTAEVPLTNLVRDSILSEDELPLRFTANTPCFRAEAGSAGRDTRGMIRQHQF
CCCEEEEEECCCCCHHHHHHHHHCCCCCCCEEEECCCCCEECCCCCCCCCHHHHHHHHCC
TKVEMVSITTPETSEEEHHRMLACAEAVLQKLDLHYRVVTLCTGDMGFASRKTFDIEVWL
CEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEE
PGQNAYREISSCSVCGDFQARRMNARYRPAEGKGPRFVHTLNGSGVAVGRALVAVLETYQ
CCCHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHH
QEDGSIVVPDVLQSYMGGVTVIAKA
HCCCCEECHHHHHHHCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA