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The map label for this gene is mrdA [H]

Identifier: 158317022

GI number: 158317022

Start: 6333670

End: 6335964

Strand: Reverse

Name: mrdA [H]

Synonym: Franean1_5266

Alternate gene names: 158317022

Gene position: 6335964-6333670 (Counterclockwise)

Preceding gene: 158317023

Following gene: 158317021

Centisome position: 70.54

GC content: 72.46

Gene sequence:

>2295_bases
GTGACCGACCGGATGCGCATCCGGCTGCTGATCCTGCGGGTCCTCGTGCTCTCCCTGCTGGTGACGCTCGGCGCCCGGCT
GTGGGTGCTGCAGATCCTCGACGGCGAGCGCTACCGCCAGGTCGCGGAGACCAACCGCGTCCGTGAGGTGGTCACCCCCG
CCACCCGGGGCATGATCGTCGACGACGAGGGTCAGCCCCTGGTGCGCAACCGCACCTCGCTGGTCATCTCGGTCAACCGG
TCGACCATCGACCGCCAGGCGGACAAGGGCAAGGCCGTGCTCGACCGGCTGGCCACCGTCATCGGGGCACCGCTGGCCGA
GCTCGAGCAGCGGGTCCGCTTCTGCTCGGCCACGGTGCGGGCGCCGTGCTGGAACGGCTCGCCCTACCAGCCGGTCCCGG
TGGCCAAGGACGTCACCCCGGCGCAGGCACTCGCGGTGATCGAACACCCGGACCGCTTCCCCGGCGTGTCCGCGGATCTA
CAGGCCGTCCGCGAGTACCCGAACGGCGGGCTCGCCGCGCACGAGCTCGGCTACCTCGCCCCCGTCTCGCAGGACCAGCT
CGACAAGCAGGGCGACGAGAAGGGCTACCACCTCAACAGCCTGATCGGCGTCTCCGGCCTGGAGTACACCTACGACGACG
CGCTACGCGGCGCGGACGGGGTGGAACGCCTCGAGGTCGACCGGTTCGGCCGGGTCGCGGGCACCGCGTCGACGACCCCG
CCGGTCAGCGGCGACCACCTCGTGCTCAACCTCGATCTCGACGTCCAGCGCGCCGCCGAGGAGGCGCTGGCCAGGACGCT
CGACTCGCTCGGCGGGGGAGCCCGGTCCGCCTCCGCGGTCGTGCTGGACGTGCGCACCGGCGGCGTCGTCGCGCTGGCCA
GCCTGCCGTCCTACGACCCGTCGGTGTTCGTCGGCGGCGTGTCCCAGAACGACTACGCCGCGCTGTCCGACCCCGCCAAC
GGGACGCCGCTGCTCTCCCGCGCCTTCCAGGGCTCGGCGGCGGCCGGGTCGACGTTCAAGGTGGTCTCGACCGCCGTCGC
CATGCAGAACATGGGCGCGACCGGCGACCAGACCTACGACTGCGCCCCGACCCTGCAGGTAGGCGACCAGATCTTCCACA
ACTTCGACGGCTCGTCCGCCGGCCCGATCACGCTGCACCAGGCGCTGGTCATCTCCTGCGACGTCATCTTCGACAAGTTC
GCCTACGACGCCTGGGTCGCGGACGGCGGCCTGCGTAACGGCCGTGGTCCCTACCCGGAGCCGAAGGAGTACTTCATCCA
CATGGCCGAGGCCATGGGCTTCGGCCGGCGTACCGGCATCGACCTGCCGGGCGAGACCGCCGGGTCCGTCGTCGACCGGG
AGGGCGCGAAGAAGATCTGGGAGGAGCTCAAGGACTCCTACTGCCGGCGCGCGCAGAACGGCTACCCGGAGGAACCCGAC
CCCACGAAGGCCGAGCGCTTCCGGAAATACGCGGCCGAGGCCTGCGTCGACGGATACCTGTACAACGCCGGTGCGGCCGT
CCAGTTCGCCATCGGGCAGGGGCAGTACCTCTCGGCCAGCCCGTTGCAGCTCGCCACCGCCTACGCGGCCATCGCGAACG
GCGGGACGATCTACCAGCCCACCCTCGCCAGGGCCACGATCTCGCCGGACGGCACGGAAGTGAAGCCGATCGCGCCGAAA
GTCGTCGGGAAGCTGCCCGTCTCGCCGGAGATCCTCGCCTACATCCGGGGCGGCCTGAGCGGGGTGACGACCGAGGGCGG
CGGCACGGCGACCGGGGTGTTCGCCGACTGGCCCAGCGACATGGTCCCGGTGGCCGGCAAGACCGGAACCGCCGAGGTCG
AGGGCAAGGGCGACACCTCGTGGTTCGCCTCGTTCGCCCCGGCGAACGACCCTCAGTTCGCGGTCGTCGTGAGCATCCCG
GAGTCGGGAACCGGCGCCGAGTACGCCGCGCCCGTGGCCAAGGAGATCTACCAGGCGCTCTACGGCGTGGGACGTCCCGG
GGCGCTGCCCGGCGGCAAGCCACCGGCCGAGCTGCCCAAGCTGAGTCGTGACGGCACGTTCTCCGCGGCCTCCGGCGCCC
CCGCGGCCCCGCCCGGCGCGGCCGGTACGACGGCCCCGGGCGCGGTGCTGCCAGGAACGGTGCCAACGGGCACGGTGCCG
GCCACGCTCACGGGAACGGGGCCGACGGGGGTCGTGCTGGCCGGAACGGCGCCGCCGGGGACGACAGCGGTATCCGGCAC
ACCAGGGGCCGGTGAGCAGGAGGCACGGGCACGGGGCCCGACCGGCCCTGGCTGA

Upstream 100 bases:

>100_bases
GCGCGATCGCCGCCGGGCTCTACGCCCTGCTCGTCACGCCGTTCCTGTTCCCGCTCGCGGCGGCGGCCTCCCGCCGCCTG
CACGGGGATCGGAGGCGGGT

Downstream 100 bases:

>100_bases
CGACAAGACCCGGCGACGAGAACAGCAGGCGGCGAGCGGCCGTCCACAGGCAGCAGGGGAGGGGAATGATGACGCAGGAC
CCGGGTCCTACCGCGCTGCG

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 764; Mature: 763

Protein sequence:

>764_residues
MTDRMRIRLLILRVLVLSLLVTLGARLWVLQILDGERYRQVAETNRVREVVTPATRGMIVDDEGQPLVRNRTSLVISVNR
STIDRQADKGKAVLDRLATVIGAPLAELEQRVRFCSATVRAPCWNGSPYQPVPVAKDVTPAQALAVIEHPDRFPGVSADL
QAVREYPNGGLAAHELGYLAPVSQDQLDKQGDEKGYHLNSLIGVSGLEYTYDDALRGADGVERLEVDRFGRVAGTASTTP
PVSGDHLVLNLDLDVQRAAEEALARTLDSLGGGARSASAVVLDVRTGGVVALASLPSYDPSVFVGGVSQNDYAALSDPAN
GTPLLSRAFQGSAAAGSTFKVVSTAVAMQNMGATGDQTYDCAPTLQVGDQIFHNFDGSSAGPITLHQALVISCDVIFDKF
AYDAWVADGGLRNGRGPYPEPKEYFIHMAEAMGFGRRTGIDLPGETAGSVVDREGAKKIWEELKDSYCRRAQNGYPEEPD
PTKAERFRKYAAEACVDGYLYNAGAAVQFAIGQGQYLSASPLQLATAYAAIANGGTIYQPTLARATISPDGTEVKPIAPK
VVGKLPVSPEILAYIRGGLSGVTTEGGGTATGVFADWPSDMVPVAGKTGTAEVEGKGDTSWFASFAPANDPQFAVVVSIP
ESGTGAEYAAPVAKEIYQALYGVGRPGALPGGKPPAELPKLSRDGTFSAASGAPAAPPGAAGTTAPGAVLPGTVPTGTVP
ATLTGTGPTGVVLAGTAPPGTTAVSGTPGAGEQEARARGPTGPG

Sequences:

>Translated_764_residues
MTDRMRIRLLILRVLVLSLLVTLGARLWVLQILDGERYRQVAETNRVREVVTPATRGMIVDDEGQPLVRNRTSLVISVNR
STIDRQADKGKAVLDRLATVIGAPLAELEQRVRFCSATVRAPCWNGSPYQPVPVAKDVTPAQALAVIEHPDRFPGVSADL
QAVREYPNGGLAAHELGYLAPVSQDQLDKQGDEKGYHLNSLIGVSGLEYTYDDALRGADGVERLEVDRFGRVAGTASTTP
PVSGDHLVLNLDLDVQRAAEEALARTLDSLGGGARSASAVVLDVRTGGVVALASLPSYDPSVFVGGVSQNDYAALSDPAN
GTPLLSRAFQGSAAAGSTFKVVSTAVAMQNMGATGDQTYDCAPTLQVGDQIFHNFDGSSAGPITLHQALVISCDVIFDKF
AYDAWVADGGLRNGRGPYPEPKEYFIHMAEAMGFGRRTGIDLPGETAGSVVDREGAKKIWEELKDSYCRRAQNGYPEEPD
PTKAERFRKYAAEACVDGYLYNAGAAVQFAIGQGQYLSASPLQLATAYAAIANGGTIYQPTLARATISPDGTEVKPIAPK
VVGKLPVSPEILAYIRGGLSGVTTEGGGTATGVFADWPSDMVPVAGKTGTAEVEGKGDTSWFASFAPANDPQFAVVVSIP
ESGTGAEYAAPVAKEIYQALYGVGRPGALPGGKPPAELPKLSRDGTFSAASGAPAAPPGAAGTTAPGAVLPGTVPTGTVP
ATLTGTGPTGVVLAGTAPPGTTAVSGTPGAGEQEARARGPTGPG
>Mature_763_residues
TDRMRIRLLILRVLVLSLLVTLGARLWVLQILDGERYRQVAETNRVREVVTPATRGMIVDDEGQPLVRNRTSLVISVNRS
TIDRQADKGKAVLDRLATVIGAPLAELEQRVRFCSATVRAPCWNGSPYQPVPVAKDVTPAQALAVIEHPDRFPGVSADLQ
AVREYPNGGLAAHELGYLAPVSQDQLDKQGDEKGYHLNSLIGVSGLEYTYDDALRGADGVERLEVDRFGRVAGTASTTPP
VSGDHLVLNLDLDVQRAAEEALARTLDSLGGGARSASAVVLDVRTGGVVALASLPSYDPSVFVGGVSQNDYAALSDPANG
TPLLSRAFQGSAAAGSTFKVVSTAVAMQNMGATGDQTYDCAPTLQVGDQIFHNFDGSSAGPITLHQALVISCDVIFDKFA
YDAWVADGGLRNGRGPYPEPKEYFIHMAEAMGFGRRTGIDLPGETAGSVVDREGAKKIWEELKDSYCRRAQNGYPEEPDP
TKAERFRKYAAEACVDGYLYNAGAAVQFAIGQGQYLSASPLQLATAYAAIANGGTIYQPTLARATISPDGTEVKPIAPKV
VGKLPVSPEILAYIRGGLSGVTTEGGGTATGVFADWPSDMVPVAGKTGTAEVEGKGDTSWFASFAPANDPQFAVVVSIPE
SGTGAEYAAPVAKEIYQALYGVGRPGALPGGKPPAELPKLSRDGTFSAASGAPAAPPGAAGTTAPGAVLPGTVPTGTVPA
TLTGTGPTGVVLAGTAPPGTTAVSGTPGAGEQEARARGPTGPG

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=664, Percent_Identity=29.9698795180723, Blast_Score=212, Evalue=6e-56,
Organism=Escherichia coli, GI1786272, Length=666, Percent_Identity=24.024024024024, Blast_Score=111, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 79365; Mature: 79234

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: PS00589 PTS_HPR_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDRMRIRLLILRVLVLSLLVTLGARLWVLQILDGERYRQVAETNRVREVVTPATRGMIV
CCCHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCHHHHHHHHHHHHHHHHCHHHCCEEE
DDEGQPLVRNRTSLVISVNRSTIDRQADKGKAVLDRLATVIGAPLAELEQRVRFCSATVR
CCCCCCCCCCCCEEEEEECCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
APCWNGSPYQPVPVAKDVTPAQALAVIEHPDRFPGVSADLQAVREYPNGGLAAHELGYLA
CCCCCCCCCCCCCCCCCCCHHHHEEEEECCCCCCCCCHHHHHHHHCCCCCEEHHHCCCCC
PVSQDQLDKQGDEKGYHLNSLIGVSGLEYTYDDALRGADGVERLEVDRFGRVAGTASTTP
CCCHHHHHCCCCCCCCCHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC
PVSGDHLVLNLDLDVQRAAEEALARTLDSLGGGARSASAVVLDVRTGGVVALASLPSYDP
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCC
SVFVGGVSQNDYAALSDPANGTPLLSRAFQGSAAAGSTFKVVSTAVAMQNMGATGDQTYD
CEEECCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
CAPTLQVGDQIFHNFDGSSAGPITLHQALVISCDVIFDKFAYDAWVADGGLRNGRGPYPE
CCCCHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PKEYFIHMAEAMGFGRRTGIDLPGETAGSVVDREGAKKIWEELKDSYCRRAQNGYPEEPD
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PTKAERFRKYAAEACVDGYLYNAGAAVQFAIGQGQYLSASPLQLATAYAAIANGGTIYQP
CHHHHHHHHHHHHHHHCCEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEECC
TLARATISPDGTEVKPIAPKVVGKLPVSPEILAYIRGGLSGVTTEGGGTATGVFADWPSD
CCEEEEECCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCEEECCCCEEEEEEECCCCC
MVPVAGKTGTAEVEGKGDTSWFASFAPANDPQFAVVVSIPESGTGAEYAAPVAKEIYQAL
CCCCCCCCCCEEECCCCCCCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
YGVGRPGALPGGKPPAELPKLSRDGTFSAASGAPAAPPGAAGTTAPGAVLPGTVPTGTVP
HCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ATLTGTGPTGVVLAGTAPPGTTAVSGTPGAGEQEARARGPTGPG
EEEECCCCCCEEEECCCCCCCCEECCCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
TDRMRIRLLILRVLVLSLLVTLGARLWVLQILDGERYRQVAETNRVREVVTPATRGMIV
CCHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHCCHHHHHHHHHHHHHHHHCHHHCCEEE
DDEGQPLVRNRTSLVISVNRSTIDRQADKGKAVLDRLATVIGAPLAELEQRVRFCSATVR
CCCCCCCCCCCCEEEEEECCHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
APCWNGSPYQPVPVAKDVTPAQALAVIEHPDRFPGVSADLQAVREYPNGGLAAHELGYLA
CCCCCCCCCCCCCCCCCCCHHHHEEEEECCCCCCCCCHHHHHHHHCCCCCEEHHHCCCCC
PVSQDQLDKQGDEKGYHLNSLIGVSGLEYTYDDALRGADGVERLEVDRFGRVAGTASTTP
CCCHHHHHCCCCCCCCCHHHHHCCCCCCCCHHHHHCCCCCHHHHHHHHHHHHCCCCCCCC
PVSGDHLVLNLDLDVQRAAEEALARTLDSLGGGARSASAVVLDVRTGGVVALASLPSYDP
CCCCCEEEEEECCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEECCCCCCC
SVFVGGVSQNDYAALSDPANGTPLLSRAFQGSAAAGSTFKVVSTAVAMQNMGATGDQTYD
CEEECCCCCCCCEEECCCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCC
CAPTLQVGDQIFHNFDGSSAGPITLHQALVISCDVIFDKFAYDAWVADGGLRNGRGPYPE
CCCCHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
PKEYFIHMAEAMGFGRRTGIDLPGETAGSVVDREGAKKIWEELKDSYCRRAQNGYPEEPD
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PTKAERFRKYAAEACVDGYLYNAGAAVQFAIGQGQYLSASPLQLATAYAAIANGGTIYQP
CHHHHHHHHHHHHHHHCCEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEECC
TLARATISPDGTEVKPIAPKVVGKLPVSPEILAYIRGGLSGVTTEGGGTATGVFADWPSD
CCEEEEECCCCCCCCCCCHHHHCCCCCCHHHHHHHHCCCCCEEECCCCEEEEEEECCCCC
MVPVAGKTGTAEVEGKGDTSWFASFAPANDPQFAVVVSIPESGTGAEYAAPVAKEIYQAL
CCCCCCCCCCEEECCCCCCCCEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
YGVGRPGALPGGKPPAELPKLSRDGTFSAASGAPAAPPGAAGTTAPGAVLPGTVPTGTVP
HCCCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
ATLTGTGPTGVVLAGTAPPGTTAVSGTPGAGEQEARARGPTGPG
EEEECCCCCCEEEECCCCCCCCEECCCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]