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The map label for this gene is dmsA [H]

Identifier: 157963672

GI number: 157963672

Start: 4693023

End: 4695473

Strand: Direct

Name: dmsA [H]

Synonym: Spea_3861

Alternate gene names: 157963672

Gene position: 4693023-4695473 (Clockwise)

Preceding gene: 157963671

Following gene: 157963673

Centisome position: 90.69

GC content: 50.06

Gene sequence:

>2451_bases
ATGGAACGTCGTACGTTTCTTAAATTCACCGCGGCGGCAGCGGCTGTAGCGACTGTTACAGGTTGTGACAGTAGCAGTGC
CAGCGATCCTCTGCCGACTCCGAGCGAGCCAGTGCTTCCTCCAGTTGGAGAAGGTGTGACATGGGGCTCATGTGCCACGA
ACTGCTGGCAAGCATGTCCATTAAAAGTACACAGTAAAGATGGCGTGATCACGCGCATTGAAACTGAAGGCAAAGCTACG
GACGATTGGGATAGTTTCGAGCATGAAATTCGCCCTTGCCCTCGCGGCCGCTCAATGCGTCAGAAGGTTTACAACCACGA
TCGTCTTAAGTACCCAATGAAACGCGTAGGACGTCGAGGTTCTGATGAATTCGTGCGTATTAGCTGGCAAGAAGCTGTCT
CTAGCGTCGCCGCAGCGATGCAAAAGACCTACGCTGAATACGGTAAGAACGCCATTTTCATGCCTCTGGGCGGCGGTTCT
CACGATCTAAATACTGGTGTGACTCAATCCAGTGTTCGTCTACTAAATATGGCTGGCGGATGCCTTTTCTTCCATAACGA
TTACTCTGCATCTCAGTACCGTGAAGGCTCTGCTGGTATGTACGGATACCTAGCATCTAACGATGGTGATACCGTCGGTT
TTTGGAATACGGGCTCTAGCCTGCGTAGCCTAGAAAATAGCGATCTGATGGTCTGCTTCGGCTATAACCCAATGGAAGCC
CGTTTGGGTGGCGCAGGTTCTGGTTATGAATATTTGAATGTTAAGAAGAAAAATAACTTCAAGACATACTATATCGACCC
ACGGTTTACCGATACAGCCGTAACCGCTACCGATGAGTGGGTGCCTATCCGCCCAGGTACTGACGCAGCATTATGTGAAG
CATTAGCACATGTATTGATAGCAGATGGCTACGCGGATATCCCATTCCTTGAGCAGTACACTTTTGGCTACGATAAATAC
CAAGATTACATCTTAGGTGTTACCGACGGCATCGCTAAGACGCCAGAGCGCGCCGAAAGTATCTGTGGTATCCCGGCAGA
GAAGATCCGTGAAATAGCTCAAGCAATTGGAGCCGCGTCAGCGCCATTCGTGACACAGGGTTTCGGTCCACAACGTCAAG
GTAATGGTGAGAACAACGCACGTGCTGTGATGATGCTGCCGTTACTCGTCGGTAAGATTAGTGGCGCGGGGACTAACCAC
GGCGGCACCCCTGGTAACGATGGTTTATCCCATTACGCCATGATGCCGGCTGATTCGCTCAAAGATCTTATGAACATGAA
GATCATGGACGTTACGATCCCAGCAGCATCACATCTAGACGCCATCGAGTTCGGCACAGAAATGAAGCCGAGCACCCATG
ATGTGCGTTATTCAGATAAGAGTCTGATGGATGCAGATACTCCGCTAGAAACTAACGTACGTTTCTTATGGTTAGCCTCA
TCCAATATGTTGGCTAACCAAAACGGTGATATCAACCGAGCTGACCGCCTACTTAACGACGAGAGCCTAGTGGACTTTGT
TGTTGTAGTTGAACAGCATATGACGGCCTCAGCAAAGTATGCCGACATCATCCTACCGGAAGTAAGCTGGCTTGAGATGT
ATGACGTCATCCAAAGCTACAACAAGATGGACTGTGGTTCATTGATGTACGCCTACGGGATCACCCCTGCTGTGGACCCT
ATGTTCGAATGTAAGCCTGCCTATGACATCTGCCATATGATCGCCAACGAGCTAGGCATAGGCAGTAAATTCACCAATGG
TGGCATGACCTACTTAGATCAGGTGCGTAAGGTCTTTACCGAGTTCAAGAAAAGCAATCCATGGATCCAAGGTGACACCT
TCGAAGAGTTTGTTAGCTTTGGTCCTCAGCGCCAACCCGCTGGTGAGCACCCCAACGTAGGTAAGATCCGCGACTTCGTC
GCCAACCCTGAACAAAACCCTCTAGGTACACCTAGCGGCAAGGTCGAGATCTACTCTCAATATTTCGAGAGTAAGCAGAG
CCAAGCTGAAGGCACCGACGAGATCAACCCACTGCCCGTCTACTTTGCCTGTGACGAGTCATATGAAGATGCTACTGCTG
CAGAATACCCGCTGCAGTGCATTAACTATCACGGTAAACATAGCGCTCACAGTATCCATGCCAGTACACCTTGGCTCAAT
GAAGTACTCGAGCATCACCTATGGCTAAACCCAATAGATGCAGGTGCTGCAGGCCTTATCAATGGCCAAAAGGTCATTGT
TGAGAGCCGCAGAGGCAAGCTCGAAATTACCGCTCGCGTCACTCCTAGAATCGTCCCTGGTGTTGTGGCAATGCCTCAAG
GCCAATGGCGTCGTATGAAAGGGGATATCGATGTGGGTGGCTGCGCAAATACCCTGACCGACAGTAAGCCTAGTCCGGTT
GCTAAGTCATTCCGTTCTAATACTAACCGAGTCAGAGTTTACTCGGCATAG

Upstream 100 bases:

>100_bases
CAACCGATTGAGAGCATCAACTCCATTGCTGACCTCAATCAGAATTACACCGACCACAAGATCGGTGTATTTTTCACAAT
CAAGCTTTGAGGTAATCATT

Downstream 100 bases:

>100_bases
GAGAGAAAATATGCAATTAGGATTCTATGTTGATACAGCAATCTGTTCAGGCTGCAAGGCCTGTATGGTCTCCTGTAAAG
ATAAGAATGACCTGAATGTA

Product: anaerobic dimethyl sulfoxide reductase subunit A

Products: Reduced form of N-Oxide compounds [C]

Alternate protein names: DMSO reductase [H]

Number of amino acids: Translated: 816; Mature: 816

Protein sequence:

>816_residues
MERRTFLKFTAAAAAVATVTGCDSSSASDPLPTPSEPVLPPVGEGVTWGSCATNCWQACPLKVHSKDGVITRIETEGKAT
DDWDSFEHEIRPCPRGRSMRQKVYNHDRLKYPMKRVGRRGSDEFVRISWQEAVSSVAAAMQKTYAEYGKNAIFMPLGGGS
HDLNTGVTQSSVRLLNMAGGCLFFHNDYSASQYREGSAGMYGYLASNDGDTVGFWNTGSSLRSLENSDLMVCFGYNPMEA
RLGGAGSGYEYLNVKKKNNFKTYYIDPRFTDTAVTATDEWVPIRPGTDAALCEALAHVLIADGYADIPFLEQYTFGYDKY
QDYILGVTDGIAKTPERAESICGIPAEKIREIAQAIGAASAPFVTQGFGPQRQGNGENNARAVMMLPLLVGKISGAGTNH
GGTPGNDGLSHYAMMPADSLKDLMNMKIMDVTIPAASHLDAIEFGTEMKPSTHDVRYSDKSLMDADTPLETNVRFLWLAS
SNMLANQNGDINRADRLLNDESLVDFVVVVEQHMTASAKYADIILPEVSWLEMYDVIQSYNKMDCGSLMYAYGITPAVDP
MFECKPAYDICHMIANELGIGSKFTNGGMTYLDQVRKVFTEFKKSNPWIQGDTFEEFVSFGPQRQPAGEHPNVGKIRDFV
ANPEQNPLGTPSGKVEIYSQYFESKQSQAEGTDEINPLPVYFACDESYEDATAAEYPLQCINYHGKHSAHSIHASTPWLN
EVLEHHLWLNPIDAGAAGLINGQKVIVESRRGKLEITARVTPRIVPGVVAMPQGQWRRMKGDIDVGGCANTLTDSKPSPV
AKSFRSNTNRVRVYSA

Sequences:

>Translated_816_residues
MERRTFLKFTAAAAAVATVTGCDSSSASDPLPTPSEPVLPPVGEGVTWGSCATNCWQACPLKVHSKDGVITRIETEGKAT
DDWDSFEHEIRPCPRGRSMRQKVYNHDRLKYPMKRVGRRGSDEFVRISWQEAVSSVAAAMQKTYAEYGKNAIFMPLGGGS
HDLNTGVTQSSVRLLNMAGGCLFFHNDYSASQYREGSAGMYGYLASNDGDTVGFWNTGSSLRSLENSDLMVCFGYNPMEA
RLGGAGSGYEYLNVKKKNNFKTYYIDPRFTDTAVTATDEWVPIRPGTDAALCEALAHVLIADGYADIPFLEQYTFGYDKY
QDYILGVTDGIAKTPERAESICGIPAEKIREIAQAIGAASAPFVTQGFGPQRQGNGENNARAVMMLPLLVGKISGAGTNH
GGTPGNDGLSHYAMMPADSLKDLMNMKIMDVTIPAASHLDAIEFGTEMKPSTHDVRYSDKSLMDADTPLETNVRFLWLAS
SNMLANQNGDINRADRLLNDESLVDFVVVVEQHMTASAKYADIILPEVSWLEMYDVIQSYNKMDCGSLMYAYGITPAVDP
MFECKPAYDICHMIANELGIGSKFTNGGMTYLDQVRKVFTEFKKSNPWIQGDTFEEFVSFGPQRQPAGEHPNVGKIRDFV
ANPEQNPLGTPSGKVEIYSQYFESKQSQAEGTDEINPLPVYFACDESYEDATAAEYPLQCINYHGKHSAHSIHASTPWLN
EVLEHHLWLNPIDAGAAGLINGQKVIVESRRGKLEITARVTPRIVPGVVAMPQGQWRRMKGDIDVGGCANTLTDSKPSPV
AKSFRSNTNRVRVYSA
>Mature_816_residues
MERRTFLKFTAAAAAVATVTGCDSSSASDPLPTPSEPVLPPVGEGVTWGSCATNCWQACPLKVHSKDGVITRIETEGKAT
DDWDSFEHEIRPCPRGRSMRQKVYNHDRLKYPMKRVGRRGSDEFVRISWQEAVSSVAAAMQKTYAEYGKNAIFMPLGGGS
HDLNTGVTQSSVRLLNMAGGCLFFHNDYSASQYREGSAGMYGYLASNDGDTVGFWNTGSSLRSLENSDLMVCFGYNPMEA
RLGGAGSGYEYLNVKKKNNFKTYYIDPRFTDTAVTATDEWVPIRPGTDAALCEALAHVLIADGYADIPFLEQYTFGYDKY
QDYILGVTDGIAKTPERAESICGIPAEKIREIAQAIGAASAPFVTQGFGPQRQGNGENNARAVMMLPLLVGKISGAGTNH
GGTPGNDGLSHYAMMPADSLKDLMNMKIMDVTIPAASHLDAIEFGTEMKPSTHDVRYSDKSLMDADTPLETNVRFLWLAS
SNMLANQNGDINRADRLLNDESLVDFVVVVEQHMTASAKYADIILPEVSWLEMYDVIQSYNKMDCGSLMYAYGITPAVDP
MFECKPAYDICHMIANELGIGSKFTNGGMTYLDQVRKVFTEFKKSNPWIQGDTFEEFVSFGPQRQPAGEHPNVGKIRDFV
ANPEQNPLGTPSGKVEIYSQYFESKQSQAEGTDEINPLPVYFACDESYEDATAAEYPLQCINYHGKHSAHSIHASTPWLN
EVLEHHLWLNPIDAGAAGLINGQKVIVESRRGKLEITARVTPRIVPGVVAMPQGQWRRMKGDIDVGGCANTLTDSKPSPV
AKSFRSNTNRVRVYSA

Specific function: Terminal reductase during anaerobic growth on various sulfoxide and N-oxide compounds. Allows E.coli to grow anaerobically on Me(2)SO as respiratory oxidant [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081797, Length=846, Percent_Identity=38.5342789598109, Blast_Score=538, Evalue=1e-154,
Organism=Escherichia coli, GI1787870, Length=842, Percent_Identity=37.4109263657957, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI171474008, Length=835, Percent_Identity=36.4071856287425, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI145693196, Length=738, Percent_Identity=28.1842818428184, Blast_Score=206, Evalue=7e-54,
Organism=Escherichia coli, GI87081994, Length=842, Percent_Identity=27.0783847980998, Blast_Score=203, Evalue=4e-53,
Organism=Escherichia coli, GI1787231, Length=780, Percent_Identity=25.3846153846154, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI3868721, Length=721, Percent_Identity=24.2718446601942, Blast_Score=138, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011888
- InterPro:   IPR009010
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: 1.8.99.- [C]

Molecular weight: Translated: 89592; Mature: 89592

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERRTFLKFTAAAAAVATVTGCDSSSASDPLPTPSEPVLPPVGEGVTWGSCATNCWQACP
CCCCCEEHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
LKVHSKDGVITRIETEGKATDDWDSFEHEIRPCPRGRSMRQKVYNHDRLKYPMKRVGRRG
EEEECCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHCCHHHCCHHHHHCCCC
SDEFVRISWQEAVSSVAAAMQKTYAEYGKNAIFMPLGGGSHDLNTGVTQSSVRLLNMAGG
CCCEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHEEECCC
CLFFHNDYSASQYREGSAGMYGYLASNDGDTVGFWNTGSSLRSLENSDLMVCFGYNPMEA
EEEEECCCCHHHHCCCCCCEEEEEECCCCCEEEEECCCHHHHHCCCCCEEEEECCCCHHH
RLGGAGSGYEYLNVKKKNNFKTYYIDPRFTDTAVTATDEWVPIRPGTDAALCEALAHVLI
HCCCCCCCCEEEEEEECCCEEEEEECCCCCCCEEECCCCEEECCCCCCHHHHHHHHHHHH
ADGYADIPFLEQYTFGYDKYQDYILGVTDGIAKTPERAESICGIPAEKIREIAQAIGAAS
HCCCCCCCHHHHHHCCHHHHHCEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCC
APFVTQGFGPQRQGNGENNARAVMMLPLLVGKISGAGTNHGGTPGNDGLSHYAMMPADSL
CCCEECCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCHHHH
KDLMNMKIMDVTIPAASHLDAIEFGTEMKPSTHDVRYSDKSLMDADTPLETNVRFLWLAS
HHHHCCEEEEEECCCHHCCHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCCCEEEEEEEC
SNMLANQNGDINRADRLLNDESLVDFVVVVEQHMTASAKYADIILPEVSWLEMYDVIQSY
CCEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHC
NKMDCGSLMYAYGITPAVDPMFECKPAYDICHMIANELGIGSKFTNGGMTYLDQVRKVFT
CCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
EFKKSNPWIQGDTFEEFVSFGPQRQPAGEHPNVGKIRDFVANPEQNPLGTPSGKVEIYSQ
HHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHH
YFESKQSQAEGTDEINPLPVYFACDESYEDATAAEYPLQCINYHGKHSAHSIHASTPWLN
HHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHCCHHHHCCCCCCCCCEEECCCCHHH
EVLEHHLWLNPIDAGAAGLINGQKVIVESRRGKLEITARVTPRIVPGVVAMPQGQWRRMK
HHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEECCCCCHHHHC
GDIDVGGCANTLTDSKPSPVAKSFRSNTNRVRVYSA
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEC
>Mature Secondary Structure
MERRTFLKFTAAAAAVATVTGCDSSSASDPLPTPSEPVLPPVGEGVTWGSCATNCWQACP
CCCCCEEHHHHHHHHHHHEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCC
LKVHSKDGVITRIETEGKATDDWDSFEHEIRPCPRGRSMRQKVYNHDRLKYPMKRVGRRG
EEEECCCCEEEEEECCCCCCCCHHHHHHHCCCCCCCHHHHHHHHCCHHHCCHHHHHCCCC
SDEFVRISWQEAVSSVAAAMQKTYAEYGKNAIFMPLGGGSHDLNTGVTQSSVRLLNMAGG
CCCEEEEEHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCHHHHHHEEECCC
CLFFHNDYSASQYREGSAGMYGYLASNDGDTVGFWNTGSSLRSLENSDLMVCFGYNPMEA
EEEEECCCCHHHHCCCCCCEEEEEECCCCCEEEEECCCHHHHHCCCCCEEEEECCCCHHH
RLGGAGSGYEYLNVKKKNNFKTYYIDPRFTDTAVTATDEWVPIRPGTDAALCEALAHVLI
HCCCCCCCCEEEEEEECCCEEEEEECCCCCCCEEECCCCEEECCCCCCHHHHHHHHHHHH
ADGYADIPFLEQYTFGYDKYQDYILGVTDGIAKTPERAESICGIPAEKIREIAQAIGAAS
HCCCCCCCHHHHHHCCHHHHHCEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCC
APFVTQGFGPQRQGNGENNARAVMMLPLLVGKISGAGTNHGGTPGNDGLSHYAMMPADSL
CCCEECCCCCCCCCCCCCCCEEEEEHHHHHHHCCCCCCCCCCCCCCCCCCCEEECCHHHH
KDLMNMKIMDVTIPAASHLDAIEFGTEMKPSTHDVRYSDKSLMDADTPLETNVRFLWLAS
HHHHCCEEEEEECCCHHCCHHHHCCCCCCCCCCCCCCCCCHHCCCCCCCCCCEEEEEEEC
SNMLANQNGDINRADRLLNDESLVDFVVVVEQHMTASAKYADIILPEVSWLEMYDVIQSY
CCEEECCCCCCHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCEEECCCCHHHHHHHHHHHC
NKMDCGSLMYAYGITPAVDPMFECKPAYDICHMIANELGIGSKFTNGGMTYLDQVRKVFT
CCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHH
EFKKSNPWIQGDTFEEFVSFGPQRQPAGEHPNVGKIRDFVANPEQNPLGTPSGKVEIYSQ
HHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHH
YFESKQSQAEGTDEINPLPVYFACDESYEDATAAEYPLQCINYHGKHSAHSIHASTPWLN
HHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHCCHHHHCCCCCCCCCEEECCCCHHH
EVLEHHLWLNPIDAGAAGLINGQKVIVESRRGKLEITARVTPRIVPGVVAMPQGQWRRMK
HHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEEEEECCCCCCCEEECCCCCHHHHC
GDIDVGGCANTLTDSKPSPVAKSFRSNTNRVRVYSA
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: May Bind 4Fe-4S Cluster. [C]

Metal ions: Fe; Mo [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: N-Oxide; Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

Specific reaction: Reduces Various N-Oxide And Sulfoxide Compounds Including Trimethylamine N-Oxide. [C]

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3062312; 8905232; 9278503; 2170332; 8125918; 10801884 [H]