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The map label for this gene is ahcY [H]

Identifier: 157963215

GI number: 157963215

Start: 4155333

End: 4156553

Strand: Direct

Name: ahcY [H]

Synonym: Spea_3401

Alternate gene names: 157963215

Gene position: 4155333-4156553 (Clockwise)

Preceding gene: 157963213

Following gene: 157963216

Centisome position: 80.3

GC content: 46.03

Gene sequence:

>1221_bases
ATGACAACAATAACGACAAAACCTCAAATTGATTGTGAAATCGCAGATATCAGTCTCGCCCCATTAGGCAGAAAACGTAT
TGACTGGGCTCGCGCCCATATGCCGATTATGCGTAATATTATTGAACGCTTTGAAAAAGAGCAGCCATTCAAAGGCCTAA
CTATCGGGATTTGTTTACATGTAGAGGCAAAAACAGGAGTTTGGCTTGAGGCCTTAACCAAAGGTGGGGCAAGGGTGGCA
ATAACCGGCTCACCAGGCACAACGCAAGATGAAACCGTCGCAGCCATTGTTGAAGATTACGGTGTGCATGTTTACAGCCA
ACGCAATGAAAGCTTTGAAGATCATCTGCGGTATTGCCAAAAAGTGCTCGACCACCAGCCAAATATTATCTCTGATAATG
GCGCAGATCTACATGAATTGTTGTTTACCCTGCCACAAAACCAACACCTGATAGATCAGTTATTAGGAGCCACAGAGGAG
ACAACCACAGGGGCTAACCGCCTACGTGAAGACTTTAAATCAGATAAATTTGCCACCTTAATCATTAATGATACCCAAGC
AAAACGCATTATTGAAAACCGCTATGGGGTGGGCTCATCGGTCGTTGACGGCTTAATGCGTGCCACTAACGTGATGCTGC
ATGGCAAAAAAGTGGTGGTTATTGGCTATGGATATTGCGGCAGCGGCACAGCACAGAGACTTAGAGGCATGGGGGCCCAT
GTGACGGTGGTTGAGCCTAATCCATTAACCAGATTAGAAGCGCACATGGAAGGCTTTTATACCGCATCAATAGAAGATGC
ACTGCCTAATGCCGACATGGTGATCACCATTACCGGCCGCGACAATGTACTCGACAAGCAACACTTTGAGCTGATGGCTA
ACAATGTGATTATTGCTAATGCAGGCCACTTTCAGCGAGAAATTAATCTACCAGCATTGGCGGAAATGGCCGAGTCTGTT
GAGGCTATCCGCCCTCAAGTCAAAGGTTATAAGCTAAACGATAAGACGCTATTTGTATTGTCTGACGCAAATTTAGTCAA
CTTGGCAGCCGGAGATGGTAACCCTATTGAGATCATGGATCTCGGCTTAGCACTACAATCGTTAAGCCTTGAGCGTATTG
CTCTAGGCGTTAAGTCGTTATCCCCTATTCCTCAGCCCGTGCCCTATGATATTGAATTAGATGTTGCAGCACTCGCCTGC
CAGCACTGGATTAATCACTAA

Upstream 100 bases:

>100_bases
ATTCATGCTTTATTGGAAAGAATATTGTTCAATATGTGAAATTGTTAAAACATGCCGCTCAATCAATGATGAATAAACAC
TATTAAGTTGGATCTTCATC

Downstream 100 bases:

>100_bases
GCATTATACTTAGCAGGAAGCGCGTGTCTTCCTGCTTTGACCATAAAAACCTTTGCCGTATTCAAACCGTATTACCTGCG
CTGAACTATAATTATAGGTA

Product: adenosylhomocysteinase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MTTITTKPQIDCEIADISLAPLGRKRIDWARAHMPIMRNIIERFEKEQPFKGLTIGICLHVEAKTGVWLEALTKGGARVA
ITGSPGTTQDETVAAIVEDYGVHVYSQRNESFEDHLRYCQKVLDHQPNIISDNGADLHELLFTLPQNQHLIDQLLGATEE
TTTGANRLREDFKSDKFATLIINDTQAKRIIENRYGVGSSVVDGLMRATNVMLHGKKVVVIGYGYCGSGTAQRLRGMGAH
VTVVEPNPLTRLEAHMEGFYTASIEDALPNADMVITITGRDNVLDKQHFELMANNVIIANAGHFQREINLPALAEMAESV
EAIRPQVKGYKLNDKTLFVLSDANLVNLAAGDGNPIEIMDLGLALQSLSLERIALGVKSLSPIPQPVPYDIELDVAALAC
QHWINH

Sequences:

>Translated_406_residues
MTTITTKPQIDCEIADISLAPLGRKRIDWARAHMPIMRNIIERFEKEQPFKGLTIGICLHVEAKTGVWLEALTKGGARVA
ITGSPGTTQDETVAAIVEDYGVHVYSQRNESFEDHLRYCQKVLDHQPNIISDNGADLHELLFTLPQNQHLIDQLLGATEE
TTTGANRLREDFKSDKFATLIINDTQAKRIIENRYGVGSSVVDGLMRATNVMLHGKKVVVIGYGYCGSGTAQRLRGMGAH
VTVVEPNPLTRLEAHMEGFYTASIEDALPNADMVITITGRDNVLDKQHFELMANNVIIANAGHFQREINLPALAEMAESV
EAIRPQVKGYKLNDKTLFVLSDANLVNLAAGDGNPIEIMDLGLALQSLSLERIALGVKSLSPIPQPVPYDIELDVAALAC
QHWINH
>Mature_405_residues
TTITTKPQIDCEIADISLAPLGRKRIDWARAHMPIMRNIIERFEKEQPFKGLTIGICLHVEAKTGVWLEALTKGGARVAI
TGSPGTTQDETVAAIVEDYGVHVYSQRNESFEDHLRYCQKVLDHQPNIISDNGADLHELLFTLPQNQHLIDQLLGATEET
TTGANRLREDFKSDKFATLIINDTQAKRIIENRYGVGSSVVDGLMRATNVMLHGKKVVVIGYGYCGSGTAQRLRGMGAHV
TVVEPNPLTRLEAHMEGFYTASIEDALPNADMVITITGRDNVLDKQHFELMANNVIIANAGHFQREINLPALAEMAESVE
AIRPQVKGYKLNDKTLFVLSDANLVNLAAGDGNPIEIMDLGLALQSLSLERIALGVKSLSPIPQPVPYDIELDVAALACQ
HWINH

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=364, Percent_Identity=35.7142857142857, Blast_Score=211, Evalue=7e-55,
Organism=Homo sapiens, GI239937451, Length=343, Percent_Identity=34.9854227405248, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI298286489, Length=371, Percent_Identity=31.8059299191375, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI195539349, Length=371, Percent_Identity=31.8059299191375, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI195539337, Length=371, Percent_Identity=31.8059299191375, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI24308043, Length=371, Percent_Identity=31.8059299191375, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI21361647, Length=363, Percent_Identity=31.404958677686, Blast_Score=172, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17506425, Length=380, Percent_Identity=37.3684210526316, Blast_Score=219, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6320882, Length=378, Percent_Identity=35.4497354497354, Blast_Score=206, Evalue=5e-54,
Organism=Drosophila melanogaster, GI24642172, Length=382, Percent_Identity=34.5549738219895, Blast_Score=204, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24656245, Length=356, Percent_Identity=32.8651685393258, Blast_Score=182, Evalue=3e-46,
Organism=Drosophila melanogaster, GI45553385, Length=350, Percent_Identity=32.2857142857143, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI45553387, Length=350, Percent_Identity=32.2857142857143, Blast_Score=174, Evalue=8e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 44686; Mature: 44555

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTITTKPQIDCEIADISLAPLGRKRIDWARAHMPIMRNIIERFEKEQPFKGLTIGICLH
CCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
VEAKTGVWLEALTKGGARVAITGSPGTTQDETVAAIVEDYGVHVYSQRNESFEDHLRYCQ
EECCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHH
KVLDHQPNIISDNGADLHELLFTLPQNQHLIDQLLGATEETTTGANRLREDFKSDKFATL
HHHCCCCCEECCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEE
IINDTQAKRIIENRYGVGSSVVDGLMRATNVMLHGKKVVVIGYGYCGSGTAQRLRGMGAH
EEECHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCEEEEEEECCCCCCHHHHHHCCCCE
VTVVEPNPLTRLEAHMEGFYTASIEDALPNADMVITITGRDNVLDKQHFELMANNVIIAN
EEEECCCCCHHHHHHHCCEEEEEHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCEEEEE
AGHFQREINLPALAEMAESVEAIRPQVKGYKLNDKTLFVLSDANLVNLAAGDGNPIEIMD
CCCCCEECCCHHHHHHHHHHHHHCCCCCCEEECCCEEEEEECCCEEEEECCCCCCEEEEE
LGLALQSLSLERIALGVKSLSPIPQPVPYDIELDVAALACQHWINH
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHCC
>Mature Secondary Structure 
TTITTKPQIDCEIADISLAPLGRKRIDWARAHMPIMRNIIERFEKEQPFKGLTIGICLH
CCCCCCCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEE
VEAKTGVWLEALTKGGARVAITGSPGTTQDETVAAIVEDYGVHVYSQRNESFEDHLRYCQ
EECCCCHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHH
KVLDHQPNIISDNGADLHELLFTLPQNQHLIDQLLGATEETTTGANRLREDFKSDKFATL
HHHCCCCCEECCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEE
IINDTQAKRIIENRYGVGSSVVDGLMRATNVMLHGKKVVVIGYGYCGSGTAQRLRGMGAH
EEECHHHHHHHHHHCCCCHHHHHHHHHHHHHEEECCEEEEEEECCCCCCHHHHHHCCCCE
VTVVEPNPLTRLEAHMEGFYTASIEDALPNADMVITITGRDNVLDKQHFELMANNVIIAN
EEEECCCCCHHHHHHHCCEEEEEHHHCCCCCCEEEEECCCCCCCCHHHHHHHHCCEEEEE
AGHFQREINLPALAEMAESVEAIRPQVKGYKLNDKTLFVLSDANLVNLAAGDGNPIEIMD
CCCCCEECCCHHHHHHHHHHHHHCCCCCCEEECCCEEEEEECCCEEEEECCCCCCEEEEE
LGLALQSLSLERIALGVKSLSPIPQPVPYDIELDVAALACQHWINH
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]