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The map label for this gene is hflC [H]

Identifier: 157963053

GI number: 157963053

Start: 3968235

End: 3969122

Strand: Direct

Name: hflC [H]

Synonym: Spea_3236

Alternate gene names: 157963053

Gene position: 3968235-3969122 (Clockwise)

Preceding gene: 157963051

Following gene: 157963054

Centisome position: 76.69

GC content: 44.71

Gene sequence:

>888_bases
ATGCTACAAAAATCAAAACTTAGCCAATTTTTCAAATCGGCTTCAGTGGTAAAGCTACTACCGCTTGCACTCATAATCAT
CGCCATCTTTAACTCCTACTTCATCGTTATTGAAGGTCATGTCGGCGTAGTGAAACGCTTTGGCGAAGCCAAGGATCAAC
AAAATCCTGGTTTACACTTTAAGATCCCCTTTATTGAAACCGTCGAGATGATTGAAGTGCGTACCCGTAAGAATGCCGAG
AAAATGGCCTCTAGTACTAAAGAACAGATGCCAGTAACAATTGAGGTTTCGGTTAACTGGACAGTTAATAAAGAAGCCGC
GTTAGAGTTATTTAAACGTTACGGCGGCCTTACTCAATTTGAACAACGCATTCTGGACCCGCGTTTTCGCTCGGCAACCA
AAGACACTATCCCTCAATTTGAAGCAGAGCAGCTTATACAAGACCGAGCCAGTGCAATTCAGGGCATCGAGCGTCGCTTA
GCCGAAGAAATGGAAGGCTTCCCTGTTGTGGTCGATAACATTCAAATTGAAAACATTATTCTGCCGCAAAAATACATTAA
CTCGATTGAAATCAAGCAGACAGAAAAGAACCTTGCTGCCGCTGAGGAGCATAAGCTTGAGCGTCAACGCCTTGAAGCAT
TAAGAGCAGTAAACACCGCCGATGCACGAGCGAAAGGCATTCTTAAAGTGGCTGAGGCCGAAGCGCAATCCATACTGCTA
AAAGGTAAAGCTGAGGCACAGGCAATTGAAGCCAAAGCTAAGGCACTTAAGAACAATCCATTGATTGTTAAACTTACTGA
AGCACAAGCATGGGACGGCAGATTACCTATGACTATGATGGGCGAAGGCGCGATGCCCATTATGGATCTTCGCGACGCAA
GCAAGTAA

Upstream 100 bases:

>100_bases
AGTCACAAAAAACAAACAAACACAACCAAAAGCACACAATCATTTCATCGTGGTAACTTTACTGGTATCTTTGCTGCGCA
TATTTAGAAAGGACACTCCA

Downstream 100 bases:

>100_bases
CAACACAATATTCATCAACGTAAAACAATAAATGGAACCTAAGGGTTCCATTTATTGTATGAGCCCTGCAGATTTACTCG
ATCGACTTCAAGCAATTCAA

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 295; Mature: 295

Protein sequence:

>295_residues
MLQKSKLSQFFKSASVVKLLPLALIIIAIFNSYFIVIEGHVGVVKRFGEAKDQQNPGLHFKIPFIETVEMIEVRTRKNAE
KMASSTKEQMPVTIEVSVNWTVNKEAALELFKRYGGLTQFEQRILDPRFRSATKDTIPQFEAEQLIQDRASAIQGIERRL
AEEMEGFPVVVDNIQIENIILPQKYINSIEIKQTEKNLAAAEEHKLERQRLEALRAVNTADARAKGILKVAEAEAQSILL
KGKAEAQAIEAKAKALKNNPLIVKLTEAQAWDGRLPMTMMGEGAMPIMDLRDASK

Sequences:

>Translated_295_residues
MLQKSKLSQFFKSASVVKLLPLALIIIAIFNSYFIVIEGHVGVVKRFGEAKDQQNPGLHFKIPFIETVEMIEVRTRKNAE
KMASSTKEQMPVTIEVSVNWTVNKEAALELFKRYGGLTQFEQRILDPRFRSATKDTIPQFEAEQLIQDRASAIQGIERRL
AEEMEGFPVVVDNIQIENIILPQKYINSIEIKQTEKNLAAAEEHKLERQRLEALRAVNTADARAKGILKVAEAEAQSILL
KGKAEAQAIEAKAKALKNNPLIVKLTEAQAWDGRLPMTMMGEGAMPIMDLRDASK
>Mature_295_residues
MLQKSKLSQFFKSASVVKLLPLALIIIAIFNSYFIVIEGHVGVVKRFGEAKDQQNPGLHFKIPFIETVEMIEVRTRKNAE
KMASSTKEQMPVTIEVSVNWTVNKEAALELFKRYGGLTQFEQRILDPRFRSATKDTIPQFEAEQLIQDRASAIQGIERRL
AEEMEGFPVVVDNIQIENIILPQKYINSIEIKQTEKNLAAAEEHKLERQRLEALRAVNTADARAKGILKVAEAEAQSILL
KGKAEAQAIEAKAKALKNNPLIVKLTEAQAWDGRLPMTMMGEGAMPIMDLRDASK

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Homo sapiens, GI6005854, Length=257, Percent_Identity=24.5136186770428, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI221307584, Length=257, Percent_Identity=24.5136186770428, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1790617, Length=281, Percent_Identity=27.7580071174377, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI193205005, Length=241, Percent_Identity=24.0663900414938, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.- [C]

Molecular weight: Translated: 33140; Mature: 33140

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQKSKLSQFFKSASVVKLLPLALIIIAIFNSYFIVIEGHVGVVKRFGEAKDQQNPGLHF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHCCCCCCCCEE
KIPFIETVEMIEVRTRKNAEKMASSTKEQMPVTIEVSVNWTVNKEAALELFKRYGGLTQF
ECCHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEEEEEECHHHHHHHHHHHCCHHHH
EQRILDPRFRSATKDTIPQFEAEQLIQDRASAIQGIERRLAEEMEGFPVVVDNIQIENII
HHHHCCHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECEEEEEEE
LPQKYINSIEIKQTEKNLAAAEEHKLERQRLEALRAVNTADARAKGILKVAEAEAQSILL
CCHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
KGKAEAQAIEAKAKALKNNPLIVKLTEAQAWDGRLPMTMMGEGAMPIMDLRDASK
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCC
>Mature Secondary Structure
MLQKSKLSQFFKSASVVKLLPLALIIIAIFNSYFIVIEGHVGVVKRFGEAKDQQNPGLHF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHCCCCCCCCEE
KIPFIETVEMIEVRTRKNAEKMASSTKEQMPVTIEVSVNWTVNKEAALELFKRYGGLTQF
ECCHHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEEEEEEECHHHHHHHHHHHCCHHHH
EQRILDPRFRSATKDTIPQFEAEQLIQDRASAIQGIERRLAEEMEGFPVVVDNIQIENII
HHHHCCHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECEEEEEEE
LPQKYINSIEIKQTEKNLAAAEEHKLERQRLEALRAVNTADARAKGILKVAEAEAQSILL
CCHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
KGKAEAQAIEAKAKALKNNPLIVKLTEAQAWDGRLPMTMMGEGAMPIMDLRDASK
CCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCEEECCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]