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The map label for this gene is panE [H]

Identifier: 157962933

GI number: 157962933

Start: 3817738

End: 3818769

Strand: Direct

Name: panE [H]

Synonym: Spea_3116

Alternate gene names: 157962933

Gene position: 3817738-3818769 (Clockwise)

Preceding gene: 157962932

Following gene: 157962934

Centisome position: 73.78

GC content: 47.29

Gene sequence:

>1032_bases
ATGTCCTCTAATTCGTCGCTCCAACTCAGTACTGAACAGCTAGATCCTAACCAGCCAAGTAATAAGCAACTAGGTAGTAA
GCAACTAAATGGTAAACAGTTAAGCGCTAGCCAAATTGCTATTTTAGGCGCAGGTGCTATTGGCCAGCTCATCTACCACC
AGCTAGCTAACGCCAAGCAACAACCCCATGTTGGCTTAAGCTTTATCGGTAGAAAAATACAATCTAAAGTTGTCCCCTTT
AGATTTACCAGACTCGATGGTCAAGTCGTTACAAGTAACGCCAAAGTGATCGGTCTAGAGGATTATGCCAAGGAGCTCGC
CAATACCGCGCTTTTGATCGTCAGTGTTAAGGCGCATCAAGTCAAACCAGCGCTTGCTGCTGTTCTGCCTCATCTTCCCG
GTAACACGCATATCTTGTTACTACATAATGGGATGGGACCTCATTTAGAGGTGCAGCCATATCTTGCTGGTCGTGGGCTG
AGTCTTGGTACCACTTCACAAGGGGCACTGAGGTTAGACAAATATCATGTGAAACAGACGGGATCGGGCCTGACGCAACT
TGGACCATTTATCGCGCCACAGCTTGATGACAATATCCGAGAGCGATTACTCAGCAGTATTGACCAAAGCACTTGGTACG
CCGATATCTTGCCGCTTCTTTGGCAAAAACTGGCCATCAATGTGGCAATAAACCCGTTAACCGCCATCCATGATTGCCCT
AATGGTGAGCTTGCTAAGCCTCAATACCGTAATGCCATAAACAATGCCGTTAGCGAACTGATTAAAGTTGCCGCCGCCGA
TGGCCTCACTCTGGACAAAGCGCTTTTAATTGAACGTGTTTATCAGGTCATAGAGCTAACGGCGCAGAACTTCTCTTCCA
TGCATCAGGATGTTTATCATCAAAGGCAAACGGAGATAGACGCCATTAATGGTTTTGTGCTCAAGCGAGCCATGGTTCAC
CATATCCCTGCCCCCGTAAATCAATCGCTCGCCCAGCAGATAACGCAACTAGAAGCCAAATACACGCGCTAG

Upstream 100 bases:

>100_bases
CGATATGGTGGGGATCTCCCTATTTTATTTTACTCATTGGCTTTATTGTCGCTACTTTAAAACCGCTAAGCTCACCGATC
CTGATCTGCAGTAACTTCAC

Downstream 100 bases:

>100_bases
CCTTGGGGGGAAGAGTCTTGTTTCCCCATCGACTAACGCTTGTGTTTATTATTAATAAGTTAAGCATTTCGTAAAGTACA
AACTTGAAGCAAGTTCTTTA

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MSSNSSLQLSTEQLDPNQPSNKQLGSKQLNGKQLSASQIAILGAGAIGQLIYHQLANAKQQPHVGLSFIGRKIQSKVVPF
RFTRLDGQVVTSNAKVIGLEDYAKELANTALLIVSVKAHQVKPALAAVLPHLPGNTHILLLHNGMGPHLEVQPYLAGRGL
SLGTTSQGALRLDKYHVKQTGSGLTQLGPFIAPQLDDNIRERLLSSIDQSTWYADILPLLWQKLAINVAINPLTAIHDCP
NGELAKPQYRNAINNAVSELIKVAAADGLTLDKALLIERVYQVIELTAQNFSSMHQDVYHQRQTEIDAINGFVLKRAMVH
HIPAPVNQSLAQQITQLEAKYTR

Sequences:

>Translated_343_residues
MSSNSSLQLSTEQLDPNQPSNKQLGSKQLNGKQLSASQIAILGAGAIGQLIYHQLANAKQQPHVGLSFIGRKIQSKVVPF
RFTRLDGQVVTSNAKVIGLEDYAKELANTALLIVSVKAHQVKPALAAVLPHLPGNTHILLLHNGMGPHLEVQPYLAGRGL
SLGTTSQGALRLDKYHVKQTGSGLTQLGPFIAPQLDDNIRERLLSSIDQSTWYADILPLLWQKLAINVAINPLTAIHDCP
NGELAKPQYRNAINNAVSELIKVAAADGLTLDKALLIERVYQVIELTAQNFSSMHQDVYHQRQTEIDAINGFVLKRAMVH
HIPAPVNQSLAQQITQLEAKYTR
>Mature_342_residues
SSNSSLQLSTEQLDPNQPSNKQLGSKQLNGKQLSASQIAILGAGAIGQLIYHQLANAKQQPHVGLSFIGRKIQSKVVPFR
FTRLDGQVVTSNAKVIGLEDYAKELANTALLIVSVKAHQVKPALAAVLPHLPGNTHILLLHNGMGPHLEVQPYLAGRGLS
LGTTSQGALRLDKYHVKQTGSGLTQLGPFIAPQLDDNIRERLLSSIDQSTWYADILPLLWQKLAINVAINPLTAIHDCPN
GELAKPQYRNAINNAVSELIKVAAADGLTLDKALLIERVYQVIELTAQNFSSMHQDVYHQRQTEIDAINGFVLKRAMVHH
IPAPVNQSLAQQITQLEAKYTR

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=310, Percent_Identity=35.8064516129032, Blast_Score=152, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 37451; Mature: 37319

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSNSSLQLSTEQLDPNQPSNKQLGSKQLNGKQLSASQIAILGAGAIGQLIYHQLANAKQ
CCCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCC
QPHVGLSFIGRKIQSKVVPFRFTRLDGQVVTSNAKVIGLEDYAKELANTALLIVSVKAHQ
CCCCCHHHHHHHHHHCCCCEEEEECCCEEEECCCEEEEHHHHHHHHHCCEEEEEEECHHH
VKPALAAVLPHLPGNTHILLLHNGMGPHLEVQPYLAGRGLSLGTTSQGALRLDKYHVKQT
HHHHHHHHHCCCCCCCEEEEEECCCCCCEEECCEECCCCCCCCCCCCCCEEHHHHHHHHC
GSGLTQLGPFIAPQLDDNIRERLLSSIDQSTWYADILPLLWQKLAINVAINPLTAIHDCP
CCCHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHCCC
NGELAKPQYRNAINNAVSELIKVAAADGLTLDKALLIERVYQVIELTAQNFSSMHQDVYH
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRQTEIDAINGFVLKRAMVHHIPAPVNQSLAQQITQLEAKYTR
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SSNSSLQLSTEQLDPNQPSNKQLGSKQLNGKQLSASQIAILGAGAIGQLIYHQLANAKQ
CCCCCEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHCCCC
QPHVGLSFIGRKIQSKVVPFRFTRLDGQVVTSNAKVIGLEDYAKELANTALLIVSVKAHQ
CCCCCHHHHHHHHHHCCCCEEEEECCCEEEECCCEEEEHHHHHHHHHCCEEEEEEECHHH
VKPALAAVLPHLPGNTHILLLHNGMGPHLEVQPYLAGRGLSLGTTSQGALRLDKYHVKQT
HHHHHHHHHCCCCCCCEEEEEECCCCCCEEECCEECCCCCCCCCCCCCCEEHHHHHHHHC
GSGLTQLGPFIAPQLDDNIRERLLSSIDQSTWYADILPLLWQKLAINVAINPLTAIHDCP
CCCHHHHCCHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCHHHHHCCC
NGELAKPQYRNAINNAVSELIKVAAADGLTLDKALLIERVYQVIELTAQNFSSMHQDVYH
CCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QRQTEIDAINGFVLKRAMVHHIPAPVNQSLAQQITQLEAKYTR
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]