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The map label for this gene is dxs [H]

Identifier: 157962809

GI number: 157962809

Start: 3662701

End: 3664566

Strand: Direct

Name: dxs [H]

Synonym: Spea_2991

Alternate gene names: 157962809

Gene position: 3662701-3664566 (Clockwise)

Preceding gene: 157962808

Following gene: 157962811

Centisome position: 70.78

GC content: 48.12

Gene sequence:

>1866_bases
ATGAGTTTTGATATTTCTCAATTTCCTGTGCTTGCACAGGCTAATACCCCAGATGAGCTAAGACAGCTCCCTCAAGCCGT
GTTGCCACAATTGGCAGATGAGCTTAGAGGTTTCCTATTGAAGTCTGTTGGTAAATCAAGCGGTCACTTCGCATCGGGTC
TTGGCACGGTGGAGCTCACCGTAGCACTTCATTATGTGTACAACACACCATTCGACAGACTGGTCTGGGACGTGGGTCAC
CAAGCCTACCCTCACAAGATCTTAACTGGACGCCGTGAAAGAATGCACACGATTCGCCAAAAAGGCGGCGTGCACCCTTT
CCCATGGCGTGAAGAAAGTGAATACGACACCTTTAGTGTTGGTCACTCAGGTACCTCTATCAGTGCCGCTCTTGCTATGG
CTGTCGCTGCAGAAAAAGAGCAAGCCGGTCGTAAAGTAGTTGCCGTAATTGGTGACGGCGCAATGACAGGTGGCATGGTG
TTTGAAGCCATGAACCACGCAGGTGACTTGCATAACGACATGCTAGTCGTGCTCAACGATAACGAGATGTCTATCTCAGA
GAACGTTGGCGCACTCAATAACCATCTTGCACAACTGATGTCAGGCCGCTTCTATACCACGATTCGTGAAAGCAGCAAGA
AAGTGCTTAAAGGCATGCCTGTTATCAAAGAGATGGCTAAGCGCACCGAAGAGCACCTGAAAGGCATGGTGGTTCCTGGC
ACTTTATTTGAAGAACTTGGCTTTAACTATATTGGCCCTATCGATGGTCATGACGTGGACGCTCTTGTTGAAACCATGCG
TAATATGCGCAACTTAAGTGGTCCACAAGTGCTGCATATCATGACGAAAAAAGGTCGTGGTTATGAGCCTGCAGAGAAAG
ATCCTATCGGCTGGCACGCGGTACCTAAGTTTGATCCGTCAACCTTTGAAAAGCCTGCGGCTAAACCATCAGACCCAACC
TTCTCTGAAGTGTTTGGTAAATGGTTATGTGATATTGCCGAAAAAGATGAAAAGGTATTAGGTATTACGCCGGCCATGCG
CGAAGGCTCAGGTATGGTTGAGTTTTCTCAGCGCTTTCCTAAGCAATATTTCGATGCAGCGATTGCCGAGCAACACGCGG
TCACCTTAGGTGCGGGTTTTGCCTGCGAAGGCTATAAGCCTGTTGTGGCAATCTACTCTACCTTCCTACAACGCGGCTAT
GATCAAATGATCCACGACGTGGCTCTACAGCGACTGCCTGTACTGTTTGCTATCGACCGCGGTGGTATTGTGGGTGCCGA
TGGCCCAACTCACCAGGGTGCATTCGATTTAAGCTTTATGCGCATAGTACCCAATATGGTGATCATGGCGCCATCTGATG
AAAACGAATGTCGCCAGATGCTATATACAGGTTATTGCTACAATGATGGCCCAACTGCCGTACGTTACCCTCGCGGGAGT
GCAACTGGTGCTAAACAAGTCGAAACCATGACGGCTATGCCAATTGGTAAAGGCTTGATTAAGCGTCAAGGTAAGAAGAT
TGCCATTCTTAACTTTGGTACCTTGCTAGCAAGCAGTTTAACTGCTGCTGAAGCATTGGACGCCACCGTTGCCGATATGC
GCTTTGTGAAGCCACTGGATGTTGAGCTGGTTAAACAGCTGGCAGAGAGTCACGATATGTTAGTCACTGTGGAAGAGAAC
GCCATCATGGGCGGCGCAGGTTCAGGCATACTTGAACTATTGCAAACTCTTAAGTTACCAAAGCCAGTATTACTAATTGG
TTTACCTGATGAGTTTATTAAGCATGGTGCCCCAGATGAGATCATCAGTGAACTAGGCTTAGATGCCACAGGTATTCAAA
AGCAGATCGAAGACTTTATCGCCTAA

Upstream 100 bases:

>100_bases
TCAGCGCTGGCCAAATTACCATACAATAGCCAGCTAATTGCAGAATTCGCCCGTTACATCATTGAGCGAAGAGTTTAATA
AAGAGACAAAGAATCTCGAT

Downstream 100 bases:

>100_bases
TCAATCAGCGAGAGTGTTTATTTCTTGAATCTGTAAGAGAATAGCTAAATAAAAAGGACTGCCATGGCAGTCCTTTTTTT
ATTGCCAGTACTCACTCAAT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 621; Mature: 620

Protein sequence:

>621_residues
MSFDISQFPVLAQANTPDELRQLPQAVLPQLADELRGFLLKSVGKSSGHFASGLGTVELTVALHYVYNTPFDRLVWDVGH
QAYPHKILTGRRERMHTIRQKGGVHPFPWREESEYDTFSVGHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMV
FEAMNHAGDLHNDMLVVLNDNEMSISENVGALNNHLAQLMSGRFYTTIRESSKKVLKGMPVIKEMAKRTEEHLKGMVVPG
TLFEELGFNYIGPIDGHDVDALVETMRNMRNLSGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPSTFEKPAAKPSDPT
FSEVFGKWLCDIAEKDEKVLGITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLGAGFACEGYKPVVAIYSTFLQRGY
DQMIHDVALQRLPVLFAIDRGGIVGADGPTHQGAFDLSFMRIVPNMVIMAPSDENECRQMLYTGYCYNDGPTAVRYPRGS
ATGAKQVETMTAMPIGKGLIKRQGKKIAILNFGTLLASSLTAAEALDATVADMRFVKPLDVELVKQLAESHDMLVTVEEN
AIMGGAGSGILELLQTLKLPKPVLLIGLPDEFIKHGAPDEIISELGLDATGIQKQIEDFIA

Sequences:

>Translated_621_residues
MSFDISQFPVLAQANTPDELRQLPQAVLPQLADELRGFLLKSVGKSSGHFASGLGTVELTVALHYVYNTPFDRLVWDVGH
QAYPHKILTGRRERMHTIRQKGGVHPFPWREESEYDTFSVGHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMV
FEAMNHAGDLHNDMLVVLNDNEMSISENVGALNNHLAQLMSGRFYTTIRESSKKVLKGMPVIKEMAKRTEEHLKGMVVPG
TLFEELGFNYIGPIDGHDVDALVETMRNMRNLSGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPSTFEKPAAKPSDPT
FSEVFGKWLCDIAEKDEKVLGITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLGAGFACEGYKPVVAIYSTFLQRGY
DQMIHDVALQRLPVLFAIDRGGIVGADGPTHQGAFDLSFMRIVPNMVIMAPSDENECRQMLYTGYCYNDGPTAVRYPRGS
ATGAKQVETMTAMPIGKGLIKRQGKKIAILNFGTLLASSLTAAEALDATVADMRFVKPLDVELVKQLAESHDMLVTVEEN
AIMGGAGSGILELLQTLKLPKPVLLIGLPDEFIKHGAPDEIISELGLDATGIQKQIEDFIA
>Mature_620_residues
SFDISQFPVLAQANTPDELRQLPQAVLPQLADELRGFLLKSVGKSSGHFASGLGTVELTVALHYVYNTPFDRLVWDVGHQ
AYPHKILTGRRERMHTIRQKGGVHPFPWREESEYDTFSVGHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMVF
EAMNHAGDLHNDMLVVLNDNEMSISENVGALNNHLAQLMSGRFYTTIRESSKKVLKGMPVIKEMAKRTEEHLKGMVVPGT
LFEELGFNYIGPIDGHDVDALVETMRNMRNLSGPQVLHIMTKKGRGYEPAEKDPIGWHAVPKFDPSTFEKPAAKPSDPTF
SEVFGKWLCDIAEKDEKVLGITPAMREGSGMVEFSQRFPKQYFDAAIAEQHAVTLGAGFACEGYKPVVAIYSTFLQRGYD
QMIHDVALQRLPVLFAIDRGGIVGADGPTHQGAFDLSFMRIVPNMVIMAPSDENECRQMLYTGYCYNDGPTAVRYPRGSA
TGAKQVETMTAMPIGKGLIKRQGKKIAILNFGTLLASSLTAAEALDATVADMRFVKPLDVELVKQLAESHDMLVTVEENA
IMGGAGSGILELLQTLKLPKPVLLIGLPDEFIKHGAPDEIISELGLDATGIQKQIEDFIA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=570, Percent_Identity=20.8771929824561, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4507521, Length=570, Percent_Identity=20.8771929824561, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI133778974, Length=623, Percent_Identity=23.4349919743178, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1786622, Length=621, Percent_Identity=69.5652173913043, Blast_Score=924, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=564, Percent_Identity=23.2269503546099, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI24666278, Length=564, Percent_Identity=23.4042553191489, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45551847, Length=671, Percent_Identity=22.354694485842, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI45550715, Length=671, Percent_Identity=22.354694485842, Blast_Score=97, Evalue=3e-20,
Organism=Drosophila melanogaster, GI24645119, Length=572, Percent_Identity=22.3776223776224, Blast_Score=97, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR011766
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67857; Mature: 67726

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDISQFPVLAQANTPDELRQLPQAVLPQLADELRGFLLKSVGKSSGHFASGLGTVELT
CCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCEEEE
VALHYVYNTPFDRLVWDVGHQAYPHKILTGRRERMHTIRQKGGVHPFPWREESEYDTFSV
EEEEHHHCCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEC
GHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMVFEAMNHAGDLHNDMLVVLND
CCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLMSGRFYTTIRESSKKVLKGMPVIKEMAKRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPIDGHDVDALVETMRNMRNLSGPQVLHIMTKKGRGYEPAEKDPIGWHA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPSTFEKPAAKPSDPTFSEVFGKWLCDIAEKDEKVLGITPAMREGSGMVEFSQRFP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCHHCCCCCHHHHHHCC
KQYFDAAIAEQHAVTLGAGFACEGYKPVVAIYSTFLQRGYDQMIHDVALQRLPVLFAIDR
HHHHHHHHHHHHEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
GGIVGADGPTHQGAFDLSFMRIVPNMVIMAPSDENECRQMLYTGYCYNDGPTAVRYPRGS
CCEECCCCCCCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHCEEECCCCCEEECCCCC
ATGAKQVETMTAMPIGKGLIKRQGKKIAILNFGTLLASSLTAAEALDATVADMRFVKPLD
CCCHHHHHHHHHCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VELVKQLAESHDMLVTVEENAIMGGAGSGILELLQTLKLPKPVLLIGLPDEFIKHGAPDE
HHHHHHHHCCCCEEEEEECCEEECCCCHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCHH
IISELGLDATGIQKQIEDFIA
HHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SFDISQFPVLAQANTPDELRQLPQAVLPQLADELRGFLLKSVGKSSGHFASGLGTVELT
CCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCEEEE
VALHYVYNTPFDRLVWDVGHQAYPHKILTGRRERMHTIRQKGGVHPFPWREESEYDTFSV
EEEEHHHCCCHHHHHHHHCCCCCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCCCCCEEEC
GHSGTSISAALAMAVAAEKEQAGRKVVAVIGDGAMTGGMVFEAMNHAGDLHNDMLVVLND
CCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCCEEEEECC
NEMSISENVGALNNHLAQLMSGRFYTTIRESSKKVLKGMPVIKEMAKRTEEHLKGMVVPG
CCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCEECCC
TLFEELGFNYIGPIDGHDVDALVETMRNMRNLSGPQVLHIMTKKGRGYEPAEKDPIGWHA
HHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCC
VPKFDPSTFEKPAAKPSDPTFSEVFGKWLCDIAEKDEKVLGITPAMREGSGMVEFSQRFP
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCHHCCCCCHHHHHHCC
KQYFDAAIAEQHAVTLGAGFACEGYKPVVAIYSTFLQRGYDQMIHDVALQRLPVLFAIDR
HHHHHHHHHHHHEEEECCCEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECC
GGIVGADGPTHQGAFDLSFMRIVPNMVIMAPSDENECRQMLYTGYCYNDGPTAVRYPRGS
CCEECCCCCCCCCCHHHHHHHHHCCEEEECCCCHHHHHHHHHHCEEECCCCCEEECCCCC
ATGAKQVETMTAMPIGKGLIKRQGKKIAILNFGTLLASSLTAAEALDATVADMRFVKPLD
CCCHHHHHHHHHCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
VELVKQLAESHDMLVTVEENAIMGGAGSGILELLQTLKLPKPVLLIGLPDEFIKHGAPDE
HHHHHHHHCCCCEEEEEECCEEECCCCHHHHHHHHHHCCCCCEEEEECCHHHHHCCCCHH
IISELGLDATGIQKQIEDFIA
HHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA