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The map label for this gene is ispA [H]

Identifier: 157962808

GI number: 157962808

Start: 3661797

End: 3662678

Strand: Direct

Name: ispA [H]

Synonym: Spea_2990

Alternate gene names: 157962808

Gene position: 3661797-3662678 (Clockwise)

Preceding gene: 157962807

Following gene: 157962809

Centisome position: 70.77

GC content: 47.28

Gene sequence:

>882_bases
TTGTTACTAGAGTCACTAAAGCTGTACCAAGAGCGTATCAACCAACAACTCGAGTTACGTATCGACTCACTTGCCGATAT
CGATCCGCAATTAAAAGCGGCGATGAAGCATGGTGCCTTAATTGGCGGAAAACGCATTAGGCCCTTTCTGGTTTATGCCA
TTGGCGACATGTTAGGCGTTAAGTTATCCACTTTAGACTCTTGTGCAGCAGCTATTGAGTGTGTACATGCTTACTCACTG
ATCCATGATGACTTACCCGCCATGGATGACGATGCACTGCGCCGCGGCCAACCTACAGTTCATATTGCATTCGATGAAGC
AACTGCCATATTAGCGGGTGATGCATTACAGGCTCTCGCCTTTGAAATCATCAGTGAGCCCATCGAAAACATCACTCCAT
CACAGAATTTGGCTATGGTTAGAGCGTTAGCGAACGCCTCTGGGTATAGTGGCATGTGTGGTGGTCAGGCAATGGATTTA
AGTGCCACCGATAAGCAGATCGAACTCGCCACCTTAATACAGCTACACAAACTAAAAACTGGTGCGCTTATTCGTTGTGC
GGTGGAGTTTGCCATCATAGCCGCAAAAATCGAGGGACAAGAGCGTCAGGCTTTACTCGATTTCGCCGACGCTATTGGCC
TCGCTTTTCAGGTGCAAGACGATGTGCTCGATATTATCGCTAGCACCGAAGAGCTTGGAAAGCCGCAAGGTTCAGATACA
GATTCAAACAAAAGCACCTATCCAAAGTTGCTTGGATTAGAGGGCGCTCAAGAAACTGCCAGCAGTTTGATTGAGGACGC
ACTATCAGCGCTGGCCAAATTACCATACAATAGCCAGCTAATTGCAGAATTCGCCCGTTACATCATTGAGCGAAGAGTTT
AA

Upstream 100 bases:

>100_bases
CAGCCAAAGCAAGTTAGAAAATGCTCAACAGAAAGTGGCCATACTAATGCAAGAAGAGGGTGTAGACTCTCTTAAACCTT
ATGATATTGAGGGTGAGTAA

Downstream 100 bases:

>100_bases
TAAAGAGACAAAGAATCTCGATATGAGTTTTGATATTTCTCAATTTCCTGTGCTTGCACAGGCTAATACCCCAGATGAGC
TAAGACAGCTCCCTCAAGCC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: FPP synthase; (2E,6E)-farnesyl diphosphate synthase; Geranyltranstransferase [H]

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MLLESLKLYQERINQQLELRIDSLADIDPQLKAAMKHGALIGGKRIRPFLVYAIGDMLGVKLSTLDSCAAAIECVHAYSL
IHDDLPAMDDDALRRGQPTVHIAFDEATAILAGDALQALAFEIISEPIENITPSQNLAMVRALANASGYSGMCGGQAMDL
SATDKQIELATLIQLHKLKTGALIRCAVEFAIIAAKIEGQERQALLDFADAIGLAFQVQDDVLDIIASTEELGKPQGSDT
DSNKSTYPKLLGLEGAQETASSLIEDALSALAKLPYNSQLIAEFARYIIERRV

Sequences:

>Translated_293_residues
MLLESLKLYQERINQQLELRIDSLADIDPQLKAAMKHGALIGGKRIRPFLVYAIGDMLGVKLSTLDSCAAAIECVHAYSL
IHDDLPAMDDDALRRGQPTVHIAFDEATAILAGDALQALAFEIISEPIENITPSQNLAMVRALANASGYSGMCGGQAMDL
SATDKQIELATLIQLHKLKTGALIRCAVEFAIIAAKIEGQERQALLDFADAIGLAFQVQDDVLDIIASTEELGKPQGSDT
DSNKSTYPKLLGLEGAQETASSLIEDALSALAKLPYNSQLIAEFARYIIERRV
>Mature_293_residues
MLLESLKLYQERINQQLELRIDSLADIDPQLKAAMKHGALIGGKRIRPFLVYAIGDMLGVKLSTLDSCAAAIECVHAYSL
IHDDLPAMDDDALRRGQPTVHIAFDEATAILAGDALQALAFEIISEPIENITPSQNLAMVRALANASGYSGMCGGQAMDL
SATDKQIELATLIQLHKLKTGALIRCAVEFAIIAAKIEGQERQALLDFADAIGLAFQVQDDVLDIIASTEELGKPQGSDT
DSNKSTYPKLLGLEGAQETASSLIEDALSALAKLPYNSQLIAEFARYIIERRV

Specific function: Unknown

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786623, Length=286, Percent_Identity=52.0979020979021, Blast_Score=256, Evalue=1e-69,
Organism=Escherichia coli, GI1789578, Length=228, Percent_Identity=29.3859649122807, Blast_Score=96, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24651612, Length=228, Percent_Identity=27.1929824561404, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.10 [H]

Molecular weight: Translated: 31636; Mature: 31636

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLESLKLYQERINQQLELRIDSLADIDPQLKAAMKHGALIGGKRIRPFLVYAIGDMLGV
CCHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHH
KLSTLDSCAAAIECVHAYSLIHDDLPAMDDDALRRGQPTVHIAFDEATAILAGDALQALA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHH
FEIISEPIENITPSQNLAMVRALANASGYSGMCGGQAMDLSATDKQIELATLIQLHKLKT
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCC
GALIRCAVEFAIIAAKIEGQERQALLDFADAIGLAFQVQDDVLDIIASTEELGKPQGSDT
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHCCCCCCCC
DSNKSTYPKLLGLEGAQETASSLIEDALSALAKLPYNSQLIAEFARYIIERRV
CCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MLLESLKLYQERINQQLELRIDSLADIDPQLKAAMKHGALIGGKRIRPFLVYAIGDMLGV
CCHHHHHHHHHHHCHHHHHHHHHHHCCCHHHHHHHHHCCEECCCCCHHHHHHHHHHHHHH
KLSTLDSCAAAIECVHAYSLIHDDLPAMDDDALRRGQPTVHIAFDEATAILAGDALQALA
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCCCEEEEEECCCHHHHHHHHHHHHH
FEIISEPIENITPSQNLAMVRALANASGYSGMCGGQAMDLSATDKQIELATLIQLHKLKT
HHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCCCCEECCCCCCCHHHHHHHHHHHHHCC
GALIRCAVEFAIIAAKIEGQERQALLDFADAIGLAFQVQDDVLDIIASTEELGKPQGSDT
CHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEHHHHHHHHHHHHHHCCCCCCCC
DSNKSTYPKLLGLEGAQETASSLIEDALSALAKLPYNSQLIAEFARYIIERRV
CCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]