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The map label for this gene is acsA [H]

Identifier: 157962379

GI number: 157962379

Start: 3113995

End: 3115947

Strand: Direct

Name: acsA [H]

Synonym: Spea_2558

Alternate gene names: 157962379

Gene position: 3113995-3115947 (Clockwise)

Preceding gene: 157962377

Following gene: 157962380

Centisome position: 60.18

GC content: 48.13

Gene sequence:

>1953_bases
ATGAGCACGCAGTCTCTCTATAAAGTACCAAGTGAAATCGCTGCAAACGCACTTGTAAACGATGAACAATATAAAAAAAT
GTATCAGGAGTCGATTGTAAACCCTGAAGGTTTCTGGAGAGAACACGGTAACCGTATCGACTGGATCAAACCTTTTACTA
AGGTAAAGAAAACCTCATTCGATGACCACAATCTATTTATCAAGTGGTTCTATGACGGCACGCTCAATGCCTCTGCTAAC
TGTTTAGACAGGCACCTTGAAAACAATGCCGATAAATTAGCAATTATCTGGGAAGGTGATGACGCTAAAGATCAGCGCAC
TCTAACTTACGGCCAGCTTCACGCCGAAGTTTGTAAATTCGCTAATGCACTTCGTAGCCAGGGTGTACGTCGAGGCGATG
TTGTGACTGTTTACATGCCTATGGTGCCAGAGGCCGCAGTCGCCATGCTTGCATGTGCCCGAATTGGTGCAATTCATTCG
GTTGTATTTGGTGGCTTCTCACCGGACTCTATTGCTTCTCGCGTTATCGATGGCAACTCAAAAGTCGTCATCACTGCCGA
TGAAGGCGTTCGTGCCGGCCGTATCATTCCTCTAAAAGCCAATATTGATGAAGCCCTTTCTCACCCTGATGTCAATTGCG
TCGAAAAAGTGATCGTGATGAAACGCACAGGCGGTGATATTAACTGGGTAGAAGGTCGTGATATCTGGTGGGGATCTTTA
ATGGAGACCGCATCTGAGCATTGCATTCCTGAAGAGATGGGTGCCGAAGATCCGCTATTCTTACTCTATACCTCGGGCTC
CACCGGTAATCCTAAAGGTGTGCTGCACACTACAGGTGGTTACATGGTTTATGCGGCCATGACTCACGAGTACGTATTCG
ACTATAAAGAAAATGAAGTCTATTGGTGTACGGCTGATGTTGGCTGGATCACAGGCCACTCTTATATGGTCTACGGACCA
CTCGCCAATGGCGCGACAGTGCTTATTCACGAAGGTGTACCAAACTATCCAACCCCTGCACGCTTAGGTGAGATGGTTGA
CCGTCATAAAGTAAACATTCTATATACGGCTCCAACCCTTATTCGCGCACTCATGGCTGAAGGCAAAGAACAATTCGAAG
GGTTTGACGGTAGTTCGTTACGTATTATGGGATCTGTCGGTGAGCCGATTAACCCAGAGGCTTGGCGCTGGTATAACGAT
GTTATTGGCCATGAAAAATGCCCAATCGTAGATACTTGGTGGCAGACTGAAACTGGCGGCATCTTGATCAGCCCGCTACC
AGGTGCCACAGATACCAAACCTGGATCCGCGACTCGCCCATTCTTTGGCGTACAGCCGGCTCTTGTCGATAATATAGGTA
ATATCGTCGAAGGAGCTAACGAAGGTAACTTAGTTATCTTAGACTCTTGGCCTGGACAGATGCGTACGGTATTCGGCGAC
CACGACAGATTCGTACTCACCTACTTTAAAACCTTCAGAGGCATGTACTTTACAGGTGATGGCGCTAGGCGTGATGAAGA
TGGTTACTACTGGATCACCGGCCGTGTGGATGATGTGATTAATGTGTCGGGGCACCGCTTAGGTACTGCAGAAGTAGAAA
GCGCATTGGTCGCCCATGAACTCGTTGCCGAAGCCGCTGTAGTAGGTTACCCCCATGACATTAAGGGCCAAGGTATTTAC
GCCTATGTCACCTTAACTAAAGGCTCGGTTGAAACAGAGGAGCTTCGTCAAGAACTGAGACAGTGGGTTCGTAAAGAGAT
TGGCGCACTGGCAACGCCAGATCTTATCCAATGGGCTGGCGGCTTACCTAAGACACGTTCAGGTAAGATCATGCGTCGCT
TCCTGCGTAAGATTGCCGCAAACGAGGTCACTAACCTAGGTGACTCATCGACTCTCGCAGATCCAGCGGTAATCGATACC
TTGATTGAGACTCGCCTTAATCGCAGCGAATAG

Upstream 100 bases:

>100_bases
AAAAAATAAGGATATTTAATTACTAGACCAAGGTCTAATAGAGAAATAACCCCTTCCCAATCCATACTCAGCTTACGCAT
TATTAGATAAGGGAAGCCAA

Downstream 100 bases:

>100_bases
TTAATTTTCATCAAGTAAAATATCTATTGTTTGACCTCCCCTAGCCCCTCTATGAGGGGCTTTTTTTGTCCCATTTTTCC
ATCAATATATACAAAAACAA

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MSTQSLYKVPSEIAANALVNDEQYKKMYQESIVNPEGFWREHGNRIDWIKPFTKVKKTSFDDHNLFIKWFYDGTLNASAN
CLDRHLENNADKLAIIWEGDDAKDQRTLTYGQLHAEVCKFANALRSQGVRRGDVVTVYMPMVPEAAVAMLACARIGAIHS
VVFGGFSPDSIASRVIDGNSKVVITADEGVRAGRIIPLKANIDEALSHPDVNCVEKVIVMKRTGGDINWVEGRDIWWGSL
METASEHCIPEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYAAMTHEYVFDYKENEVYWCTADVGWITGHSYMVYGP
LANGATVLIHEGVPNYPTPARLGEMVDRHKVNILYTAPTLIRALMAEGKEQFEGFDGSSLRIMGSVGEPINPEAWRWYND
VIGHEKCPIVDTWWQTETGGILISPLPGATDTKPGSATRPFFGVQPALVDNIGNIVEGANEGNLVILDSWPGQMRTVFGD
HDRFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHELVAEAAVVGYPHDIKGQGIY
AYVTLTKGSVETEELRQELRQWVRKEIGALATPDLIQWAGGLPKTRSGKIMRRFLRKIAANEVTNLGDSSTLADPAVIDT
LIETRLNRSE

Sequences:

>Translated_650_residues
MSTQSLYKVPSEIAANALVNDEQYKKMYQESIVNPEGFWREHGNRIDWIKPFTKVKKTSFDDHNLFIKWFYDGTLNASAN
CLDRHLENNADKLAIIWEGDDAKDQRTLTYGQLHAEVCKFANALRSQGVRRGDVVTVYMPMVPEAAVAMLACARIGAIHS
VVFGGFSPDSIASRVIDGNSKVVITADEGVRAGRIIPLKANIDEALSHPDVNCVEKVIVMKRTGGDINWVEGRDIWWGSL
METASEHCIPEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYAAMTHEYVFDYKENEVYWCTADVGWITGHSYMVYGP
LANGATVLIHEGVPNYPTPARLGEMVDRHKVNILYTAPTLIRALMAEGKEQFEGFDGSSLRIMGSVGEPINPEAWRWYND
VIGHEKCPIVDTWWQTETGGILISPLPGATDTKPGSATRPFFGVQPALVDNIGNIVEGANEGNLVILDSWPGQMRTVFGD
HDRFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHELVAEAAVVGYPHDIKGQGIY
AYVTLTKGSVETEELRQELRQWVRKEIGALATPDLIQWAGGLPKTRSGKIMRRFLRKIAANEVTNLGDSSTLADPAVIDT
LIETRLNRSE
>Mature_649_residues
STQSLYKVPSEIAANALVNDEQYKKMYQESIVNPEGFWREHGNRIDWIKPFTKVKKTSFDDHNLFIKWFYDGTLNASANC
LDRHLENNADKLAIIWEGDDAKDQRTLTYGQLHAEVCKFANALRSQGVRRGDVVTVYMPMVPEAAVAMLACARIGAIHSV
VFGGFSPDSIASRVIDGNSKVVITADEGVRAGRIIPLKANIDEALSHPDVNCVEKVIVMKRTGGDINWVEGRDIWWGSLM
ETASEHCIPEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYAAMTHEYVFDYKENEVYWCTADVGWITGHSYMVYGPL
ANGATVLIHEGVPNYPTPARLGEMVDRHKVNILYTAPTLIRALMAEGKEQFEGFDGSSLRIMGSVGEPINPEAWRWYNDV
IGHEKCPIVDTWWQTETGGILISPLPGATDTKPGSATRPFFGVQPALVDNIGNIVEGANEGNLVILDSWPGQMRTVFGDH
DRFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHELVAEAAVVGYPHDIKGQGIYA
YVTLTKGSVETEELRQELRQWVRKEIGALATPDLIQWAGGLPKTRSGKIMRRFLRKIAANEVTNLGDSSTLADPAVIDTL
IETRLNRSE

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=670, Percent_Identity=51.7910447761194, Blast_Score=680, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=683, Percent_Identity=50.805270863836, Blast_Score=676, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=624, Percent_Identity=48.2371794871795, Blast_Score=617, Evalue=1e-176,
Organism=Homo sapiens, GI13375727, Length=631, Percent_Identity=36.1331220285262, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI42544132, Length=533, Percent_Identity=29.6435272045028, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI122937307, Length=550, Percent_Identity=28.3636363636364, Blast_Score=196, Evalue=8e-50,
Organism=Homo sapiens, GI38505220, Length=515, Percent_Identity=29.7087378640777, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI115511026, Length=512, Percent_Identity=29.4921875, Blast_Score=180, Evalue=4e-45,
Organism=Homo sapiens, GI31982927, Length=653, Percent_Identity=25.5742725880551, Blast_Score=178, Evalue=1e-44,
Organism=Homo sapiens, GI58082049, Length=513, Percent_Identity=27.2904483430799, Blast_Score=166, Evalue=8e-41,
Organism=Homo sapiens, GI157311624, Length=494, Percent_Identity=26.9230769230769, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI157311622, Length=494, Percent_Identity=26.9230769230769, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI195947378, Length=408, Percent_Identity=25, Blast_Score=102, Evalue=8e-22,
Organism=Homo sapiens, GI187761345, Length=409, Percent_Identity=26.4058679706601, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI187761343, Length=409, Percent_Identity=26.4058679706601, Blast_Score=101, Evalue=2e-21,
Organism=Homo sapiens, GI42544134, Length=351, Percent_Identity=26.2108262108262, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI156151445, Length=585, Percent_Identity=21.5384615384615, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790505, Length=645, Percent_Identity=68.8372093023256, Blast_Score=959, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=630, Percent_Identity=38.5714285714286, Blast_Score=417, Evalue=1e-118,
Organism=Escherichia coli, GI1788107, Length=592, Percent_Identity=23.6486486486486, Blast_Score=102, Evalue=5e-23,
Organism=Escherichia coli, GI221142682, Length=528, Percent_Identity=21.5909090909091, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI145693145, Length=380, Percent_Identity=24.4736842105263, Blast_Score=81, Evalue=3e-16,
Organism=Escherichia coli, GI1786810, Length=559, Percent_Identity=20.9302325581395, Blast_Score=74, Evalue=4e-14,
Organism=Escherichia coli, GI1789201, Length=368, Percent_Identity=23.0978260869565, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71982997, Length=663, Percent_Identity=50.6787330316742, Blast_Score=634, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71983001, Length=661, Percent_Identity=50.8320726172466, Blast_Score=634, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17569507, Length=619, Percent_Identity=22.7786752827141, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17558820, Length=519, Percent_Identity=23.8921001926782, Blast_Score=103, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI32563687, Length=541, Percent_Identity=22.181146025878, Blast_Score=98, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17560308, Length=566, Percent_Identity=24.0282685512367, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538037, Length=137, Percent_Identity=32.1167883211679, Blast_Score=77, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17560140, Length=376, Percent_Identity=22.3404255319149, Blast_Score=74, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17557194, Length=127, Percent_Identity=33.8582677165354, Blast_Score=73, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6323182, Length=643, Percent_Identity=48.9891135303266, Blast_Score=625, Evalue=1e-180,
Organism=Saccharomyces cerevisiae, GI6319264, Length=645, Percent_Identity=46.3565891472868, Blast_Score=568, Evalue=1e-163,
Organism=Saccharomyces cerevisiae, GI6319699, Length=377, Percent_Identity=22.5464190981432, Blast_Score=89, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24667955, Length=664, Percent_Identity=52.1084337349398, Blast_Score=672, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=55.6939501779359, Blast_Score=622, Evalue=1e-178,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=56.1538461538462, Blast_Score=580, Evalue=1e-165,
Organism=Drosophila melanogaster, GI21355225, Length=646, Percent_Identity=34.3653250773994, Blast_Score=367, Evalue=1e-101,
Organism=Drosophila melanogaster, GI24581924, Length=545, Percent_Identity=21.651376146789, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI18859661, Length=121, Percent_Identity=33.8842975206612, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21358303, Length=561, Percent_Identity=20.855614973262, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 72107; Mature: 71976

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTQSLYKVPSEIAANALVNDEQYKKMYQESIVNPEGFWREHGNRIDWIKPFTKVKKTSF
CCCCHHHHCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHCCC
DDHNLFIKWFYDGTLNASANCLDRHLENNADKLAIIWEGDDAKDQRTLTYGQLHAEVCKF
CCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHH
ANALRSQGVRRGDVVTVYMPMVPEAAVAMLACARIGAIHSVVFGGFSPDSIASRVIDGNS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
KVVITADEGVRAGRIIPLKANIDEALSHPDVNCVEKVIVMKRTGGDINWVEGRDIWWGSL
EEEEECCCCCCCCEEEEEECCHHHHHCCCCHHHHHHHHEEEECCCCEEEECCCCCCHHHH
METASEHCIPEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYAAMTHEYVFDYKENEV
HHHHHHCCCHHHHCCCCCEEEEEECCCCCCCCEEEECCCCEEEEEEEEEEEEEEECCCEE
YWCTADVGWITGHSYMVYGPLANGATVLIHEGVPNYPTPARLGEMVDRHKVNILYTAPTL
EEEECCCCEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAEGKEQFEGFDGSSLRIMGSVGEPINPEAWRWYNDVIGHEKCPIVDTWWQTETGG
HHHHHHCCHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCC
ILISPLPGATDTKPGSATRPFFGVQPALVDNIGNIVEGANEGNLVILDSWPGQMRTVFGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEHEECC
HDRFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHE
CCCCCEEEHHHHCCEEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHH
LVAEAAVVGYPHDIKGQGIYAYVTLTKGSVETEELRQELRQWVRKEIGALATPDLIQWAG
HHHHHHHCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCC
GLPKTRSGKIMRRFLRKIAANEVTNLGDSSTLADPAVIDTLIETRLNRSE
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STQSLYKVPSEIAANALVNDEQYKKMYQESIVNPEGFWREHGNRIDWIKPFTKVKKTSF
CCCHHHHCHHHHHHHHHCCHHHHHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHCCC
DDHNLFIKWFYDGTLNASANCLDRHLENNADKLAIIWEGDDAKDQRTLTYGQLHAEVCKF
CCCCEEEEEEECCCCCCCHHHHHHHHCCCCCEEEEEECCCCCCCCCEEHHHHHHHHHHHH
ANALRSQGVRRGDVVTVYMPMVPEAAVAMLACARIGAIHSVVFGGFSPDSIASRVIDGNS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCC
KVVITADEGVRAGRIIPLKANIDEALSHPDVNCVEKVIVMKRTGGDINWVEGRDIWWGSL
EEEEECCCCCCCCEEEEEECCHHHHHCCCCHHHHHHHHEEEECCCCEEEECCCCCCHHHH
METASEHCIPEEMGAEDPLFLLYTSGSTGNPKGVLHTTGGYMVYAAMTHEYVFDYKENEV
HHHHHHCCCHHHHCCCCCEEEEEECCCCCCCCEEEECCCCEEEEEEEEEEEEEEECCCEE
YWCTADVGWITGHSYMVYGPLANGATVLIHEGVPNYPTPARLGEMVDRHKVNILYTAPTL
EEEECCCCEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHCEEEEEECHHH
IRALMAEGKEQFEGFDGSSLRIMGSVGEPINPEAWRWYNDVIGHEKCPIVDTWWQTETGG
HHHHHHCCHHHHCCCCCCCEEEEECCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCC
ILISPLPGATDTKPGSATRPFFGVQPALVDNIGNIVEGANEGNLVILDSWPGQMRTVFGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCEEHEECC
HDRFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVAHE
CCCCCEEEHHHHCCEEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHH
LVAEAAVVGYPHDIKGQGIYAYVTLTKGSVETEELRQELRQWVRKEIGALATPDLIQWAG
HHHHHHHCCCCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHCC
GLPKTRSGKIMRRFLRKIAANEVTNLGDSSTLADPAVIDTLIETRLNRSE
CCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA