Click here to switch to the map view.

The map label for this gene is adiC [H]

Identifier: 157962027

GI number: 157962027

Start: 2675433

End: 2676791

Strand: Direct

Name: adiC [H]

Synonym: Spea_2206

Alternate gene names: 157962027

Gene position: 2675433-2676791 (Clockwise)

Preceding gene: 157962026

Following gene: 157962035

Centisome position: 51.7

GC content: 43.64

Gene sequence:

>1359_bases
ATGACACAAAACATCTCTTCACATTCCCAAGGCCATAGAGTCATGGGGTTTTGGCGCGTTTGGGCGCTTGCCGTAGGATG
TGCTATTGGTTCGGGGATCTTTATGATGCCGACCTTGTTAGCCCCTTATGGCATGTTAGGATTGAGTAGCTGGCTAGTCG
CTGGCGCTGGTACGGTGCTGATTGCACTGACATTTGCAAGGTTAGCAACCAGAATACCTAAAACCGGTGGTTTGTATATT
TACGCTGACTCAGGTTTAGGGGCTATGGCCGGATTCATTGTCGGCTGGTGCTATTGGATCTCCTGTTTAACTGCCGTAGC
AAGTGTTGCCATTGCATTTATCAGTTATCTCTCCGCTTATGTGCCAATGCTGGCAGAACACAATCAAGTCGGGTTGGTCG
CATGTTTAGGTTTAATTTGGCTTATTATCGGCTTGAATATTCGGTCGATTAAGGGCAGTAGTATATTCCAAGTGATCACG
ACGATTTTAAAGATCGTGCCCTTGTTACTACTGGCAGTATTAGGCTTAATCAATATGCAGCCGGAAATGCTACCCGAGTA
CAATCCGACTGAGTTATCACCGATTGCGGCAATATCCGCTGCCACTATGTTGGTTATGTGGTCATTTTTAGGGATTGAAT
CAGCCACCGTTCCTGCGGGTAATGTGATCAAACCTGAAAAGACCATTCCAAGAGCGATTATAGCCTCTGTACTGACTATC
TTAGTCTTGTATATCTTGGTGAGTTTAGCGGTGAATCTAACTGTACCGACGAGCGAACTTAAGGATTCAACTGCGCCATT
TAAGCTAGCAGCTGAGCGGTTAATGGGTCCTGTTGGCGCGTTAGTGGTAACTCTTGGTGCTTTATTGTCGACGCTAGGAT
CCTTAAATGCGAATACCTTAATGTGTGGACAGATGCCGATGGCCATCGCAAAAAATGGCTTATTTCCGAAGCGATTTAAA
CATTTATCTAAAAATGGTACACCAACATTTGGTTTATTTGTGTCGGGCGGAATTGTCTCTGTGTTATTGATAATGAATTA
CACCAAAGGTTTAATCGGTGCGTTTACTTTTTTAGTGATGATGGCGACGTTAGCAACCTTGATGGCTTATACCTTATGTG
CCATTGCTGAGTTTTACTTTTTAAAACAGGATAAACCATCGGCAGCACGAAACCGCGCCATCGTTCTAGGGATCGGCACC
TTTGTGTATAGTTTATTTTGTATTTTGGGAGCAGGGCAGGAAATTGTCTTTTACTCTTTCTTCCTGATTTTATTAGGTTT
GCCTATATACGCCTTACAAAGAAAACCAGAGAAAAGAAAAACAAAGACGAGCATGAATGAAGAGTTGTTCACTGACTAG

Upstream 100 bases:

>100_bases
GTGAGCAGATGCGTTTGGTCACTCACTTAAATATTAATGATGATGACCTAAAAGCCATTATTGAGTTATTTCAACAAGCG
GCTTAACGCTAGGGCACCTG

Downstream 100 bases:

>100_bases
TTGAACCTAAGCGGTACTGACATCAACATTTTTATATTACTGGCCAATGCTATGTTCAAGGCGCTACATCAATTTTGTAG
CGCCGTTTGGCGGATTTAAG

Product: amino acid permease-associated protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MTQNISSHSQGHRVMGFWRVWALAVGCAIGSGIFMMPTLLAPYGMLGLSSWLVAGAGTVLIALTFARLATRIPKTGGLYI
YADSGLGAMAGFIVGWCYWISCLTAVASVAIAFISYLSAYVPMLAEHNQVGLVACLGLIWLIIGLNIRSIKGSSIFQVIT
TILKIVPLLLLAVLGLINMQPEMLPEYNPTELSPIAAISAATMLVMWSFLGIESATVPAGNVIKPEKTIPRAIIASVLTI
LVLYILVSLAVNLTVPTSELKDSTAPFKLAAERLMGPVGALVVTLGALLSTLGSLNANTLMCGQMPMAIAKNGLFPKRFK
HLSKNGTPTFGLFVSGGIVSVLLIMNYTKGLIGAFTFLVMMATLATLMAYTLCAIAEFYFLKQDKPSAARNRAIVLGIGT
FVYSLFCILGAGQEIVFYSFFLILLGLPIYALQRKPEKRKTKTSMNEELFTD

Sequences:

>Translated_452_residues
MTQNISSHSQGHRVMGFWRVWALAVGCAIGSGIFMMPTLLAPYGMLGLSSWLVAGAGTVLIALTFARLATRIPKTGGLYI
YADSGLGAMAGFIVGWCYWISCLTAVASVAIAFISYLSAYVPMLAEHNQVGLVACLGLIWLIIGLNIRSIKGSSIFQVIT
TILKIVPLLLLAVLGLINMQPEMLPEYNPTELSPIAAISAATMLVMWSFLGIESATVPAGNVIKPEKTIPRAIIASVLTI
LVLYILVSLAVNLTVPTSELKDSTAPFKLAAERLMGPVGALVVTLGALLSTLGSLNANTLMCGQMPMAIAKNGLFPKRFK
HLSKNGTPTFGLFVSGGIVSVLLIMNYTKGLIGAFTFLVMMATLATLMAYTLCAIAEFYFLKQDKPSAARNRAIVLGIGT
FVYSLFCILGAGQEIVFYSFFLILLGLPIYALQRKPEKRKTKTSMNEELFTD
>Mature_451_residues
TQNISSHSQGHRVMGFWRVWALAVGCAIGSGIFMMPTLLAPYGMLGLSSWLVAGAGTVLIALTFARLATRIPKTGGLYIY
ADSGLGAMAGFIVGWCYWISCLTAVASVAIAFISYLSAYVPMLAEHNQVGLVACLGLIWLIIGLNIRSIKGSSIFQVITT
ILKIVPLLLLAVLGLINMQPEMLPEYNPTELSPIAAISAATMLVMWSFLGIESATVPAGNVIKPEKTIPRAIIASVLTIL
VLYILVSLAVNLTVPTSELKDSTAPFKLAAERLMGPVGALVVTLGALLSTLGSLNANTLMCGQMPMAIAKNGLFPKRFKH
LSKNGTPTFGLFVSGGIVSVLLIMNYTKGLIGAFTFLVMMATLATLMAYTLCAIAEFYFLKQDKPSAARNRAIVLGIGTF
VYSLFCILGAGQEIVFYSFFLILLGLPIYALQRKPEKRKTKTSMNEELFTD

Specific function: Major component of the acid-resistance (AR) system allowing enteric pathogens to survive the acidic environment in the stomach. Exchanges extracellular arginine for its intracellular decarboxylation product agmatine (Agm) thereby expelling intracellular p

COG id: COG0531

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI258645169, Length=396, Percent_Identity=24.4949494949495, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI258614005, Length=397, Percent_Identity=24.9370277078086, Blast_Score=83, Evalue=5e-16,
Organism=Homo sapiens, GI258614003, Length=397, Percent_Identity=24.9370277078086, Blast_Score=82, Evalue=7e-16,
Organism=Homo sapiens, GI33286428, Length=312, Percent_Identity=28.525641025641, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI115648063, Length=354, Percent_Identity=27.1186440677966, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI115648022, Length=354, Percent_Identity=27.1186440677966, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI187423910, Length=347, Percent_Identity=26.2247838616715, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI7657591, Length=347, Percent_Identity=26.2247838616715, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI7657683, Length=416, Percent_Identity=25.9615384615385, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI186910308, Length=352, Percent_Identity=26.7045454545455, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI186910306, Length=352, Percent_Identity=26.7045454545455, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI186910304, Length=352, Percent_Identity=26.7045454545455, Blast_Score=79, Evalue=9e-15,
Organism=Homo sapiens, GI9790235, Length=327, Percent_Identity=24.4648318042813, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI181337167, Length=396, Percent_Identity=25.2525252525253, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI71999149, Length=330, Percent_Identity=22.4242424242424, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI2367353, Length=449, Percent_Identity=28.7305122494432, Blast_Score=191, Evalue=1e-49,
Organism=Escherichia coli, GI1786908, Length=418, Percent_Identity=29.1866028708134, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI1790575, Length=441, Percent_Identity=26.3038548752834, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI87082250, Length=455, Percent_Identity=26.8131868131868, Blast_Score=120, Evalue=2e-28,
Organism=Escherichia coli, GI1787890, Length=443, Percent_Identity=24.8306997742664, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1790653, Length=389, Percent_Identity=25.1928020565553, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1786602, Length=338, Percent_Identity=22.4852071005917, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789017, Length=443, Percent_Identity=25.0564334085779, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081708, Length=362, Percent_Identity=25.6906077348066, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786789, Length=366, Percent_Identity=25.4098360655738, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788480, Length=380, Percent_Identity=23.4210526315789, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1786694, Length=350, Percent_Identity=27.1428571428571, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786302, Length=397, Percent_Identity=23.6775818639798, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87081915, Length=413, Percent_Identity=23.0024213075061, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI48994972, Length=404, Percent_Identity=22.029702970297, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI87081869, Length=335, Percent_Identity=25.0746268656716, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17540018, Length=383, Percent_Identity=27.154046997389, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI32566699, Length=400, Percent_Identity=25.75, Blast_Score=83, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17531343, Length=409, Percent_Identity=23.4718826405868, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17532491, Length=387, Percent_Identity=21.9638242894057, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17568033, Length=324, Percent_Identity=25.6172839506173, Blast_Score=69, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71993915, Length=369, Percent_Identity=24.1192411924119, Blast_Score=65, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324061, Length=405, Percent_Identity=23.2098765432099, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320772, Length=391, Percent_Identity=25.0639386189258, Blast_Score=83, Evalue=1e-16,
Organism=Saccharomyces cerevisiae, GI6324059, Length=370, Percent_Identity=24.5945945945946, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24668806, Length=468, Percent_Identity=23.7179487179487, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI21356285, Length=468, Percent_Identity=23.7179487179487, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI24668802, Length=468, Percent_Identity=23.7179487179487, Blast_Score=105, Evalue=6e-23,
Organism=Drosophila melanogaster, GI45550968, Length=383, Percent_Identity=28.7206266318538, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI19921172, Length=383, Percent_Identity=28.7206266318538, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI281366235, Length=400, Percent_Identity=25, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI116007820, Length=400, Percent_Identity=25, Blast_Score=90, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24667468, Length=384, Percent_Identity=24.21875, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI116007818, Length=410, Percent_Identity=26.3414634146341, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI85725152, Length=410, Percent_Identity=26.3414634146341, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI221512776, Length=397, Percent_Identity=24.1813602015113, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24666159, Length=397, Percent_Identity=24.1813602015113, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24641995, Length=368, Percent_Identity=25, Blast_Score=79, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24641993, Length=368, Percent_Identity=25, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI21357367, Length=345, Percent_Identity=25.7971014492754, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI221331183, Length=469, Percent_Identity=24.0938166311301, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17647653, Length=469, Percent_Identity=24.0938166311301, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664379, Length=469, Percent_Identity=24.0938166311301, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24651635, Length=322, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24651633, Length=322, Percent_Identity=26.0869565217391, Blast_Score=71, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 48487; Mature: 48356

Theoretical pI: Translated: 9.72; Mature: 9.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNISSHSQGHRVMGFWRVWALAVGCAIGSGIFMMPTLLAPYGMLGLSSWLVAGAGTVL
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
IALTFARLATRIPKTGGLYIYADSGLGAMAGFIVGWCYWISCLTAVASVAIAFISYLSAY
HHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPMLAEHNQVGLVACLGLIWLIIGLNIRSIKGSSIFQVITTILKIVPLLLLAVLGLINMQ
HHHHHCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PEMLPEYNPTELSPIAAISAATMLVMWSFLGIESATVPAGNVIKPEKTIPRAIIASVLTI
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LVLYILVSLAVNLTVPTSELKDSTAPFKLAAERLMGPVGALVVTLGALLSTLGSLNANTL
HHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
MCGQMPMAIAKNGLFPKRFKHLSKNGTPTFGLFVSGGIVSVLLIMNYTKGLIGAFTFLVM
EECCCCHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MATLATLMAYTLCAIAEFYFLKQDKPSAARNRAIVLGIGTFVYSLFCILGAGQEIVFYSF
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEEEHHHHHHHHHHHHCCCCHHHHHHH
FLILLGLPIYALQRKPEKRKTKTSMNEELFTD
HHHHHCCHHHHHHCCCHHHHHHHHCCHHHCCC
>Mature Secondary Structure 
TQNISSHSQGHRVMGFWRVWALAVGCAIGSGIFMMPTLLAPYGMLGLSSWLVAGAGTVL
CCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHH
IALTFARLATRIPKTGGLYIYADSGLGAMAGFIVGWCYWISCLTAVASVAIAFISYLSAY
HHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPMLAEHNQVGLVACLGLIWLIIGLNIRSIKGSSIFQVITTILKIVPLLLLAVLGLINMQ
HHHHHCCCCHHHHHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PEMLPEYNPTELSPIAAISAATMLVMWSFLGIESATVPAGNVIKPEKTIPRAIIASVLTI
HHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHH
LVLYILVSLAVNLTVPTSELKDSTAPFKLAAERLMGPVGALVVTLGALLSTLGSLNANTL
HHHHHHHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
MCGQMPMAIAKNGLFPKRFKHLSKNGTPTFGLFVSGGIVSVLLIMNYTKGLIGAFTFLVM
EECCCCHHHHHCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MATLATLMAYTLCAIAEFYFLKQDKPSAARNRAIVLGIGTFVYSLFCILGAGQEIVFYSF
HHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCEEEEEHHHHHHHHHHHHCCCCHHHHHHH
FLILLGLPIYALQRKPEKRKTKTSMNEELFTD
HHHHHCCHHHHHHCCCHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]