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The map label for this gene is aer [H]

Identifier: 157961684

GI number: 157961684

Start: 2264244

End: 2265818

Strand: Direct

Name: aer [H]

Synonym: Spea_1860

Alternate gene names: 157961684

Gene position: 2264244-2265818 (Clockwise)

Preceding gene: 157961683

Following gene: 157961686

Centisome position: 43.76

GC content: 47.56

Gene sequence:

>1575_bases
ATGCGAAACAACCAACCCGTGACTCAAACGGAAAAGACTCTAACCGATAATTGTATTTTACTGTCGACCACCAATCTTGA
CGGTAATATTAAGTATGCCAATGAGAGCTTTACCAAGGTTAGTGGCTACAGTTTTGATGAGTTACAAGGTCAACCTCACA
ACATGGTGCGGCACCCTGATATGCCAGAGGCTGCCTTTCAGTCACTTTGGGAGCGTATTAAACAAGGGAAACCTTGGGTT
GGTATTGTTAAGAATCGCACCAAGTCAGGCGATCACTACTGGGTTAATGCATATATAGCCCCTGTGTATGAAAATGGCAA
AATCCACGAGTATCAGTCGGTACGCCGTAAGGCTACACCGGAGCAAATCCTGCGCGCAGAAGCGATTTACCAGCAGGTAA
AAGCGGGAAAGCAACCTAAGGCGCTACGCAACCCGCTACTAGGTTTTGGGGCAAAGTTGTATGCTTGGCTGCTGTCGATG
TTAGTGATGGCGGTTATTTTAGCGAGTTATTCACCGATAGCTGCAGTGATACTACTTAGCCTAGTTGGCGCGATTGGCTT
GCACCGTATCTTGAAGCCATTCAACCAATTAGTGACACAAGCTAAAAATACTGTCGATGATCCTCTCGCTAAAGGTGTAT
TTACCGGCCGGCAAGATGAATTAGGCACAATAAGCTTTGCGCTGCAGTTCTTACTTACAGAAACTGGCGGCGTGATAGGC
CGAATGGCGGATTCAGCAGGCTCAATCGAGTCCCTTAGCGCGAGTTTAAACGATACCATTCACAATACCCGACAACGTGC
CGACAGCCAGAGTATGCAAACCAGCCAAGCGGCCACCGCGATGGAAGAGATGAGCGCTAGCTTTGCTGAAGTGAATAATA
ATATTCACAGCGCGGCGAGAGAGATGTCGGTGAGTAACCTTTCTGCAGAAAAGGGTCATCAACTGCTTGAACGGGTGATT
GAGTCCATTACACAACTCAAAGATGAGGTGGGTAACTTTGCTTCAGTCGTCGCGTCAATCGAACAAGATAGCCAAGATAT
CAATAAGGTATTGGAGGTGATCCGTGGCATTGCAGAGCAAACAAATCTGTTAGCACTTAACGCTGCGATTGAAGCGGCGA
GGGCGGGAGAGTCGGGTCGAGGCTTTGCAGTGGTTGCCGATGAAGTGCGTCAACTTTCTAGCCGTACCAGTGAATCTACC
TCTCATATCGAAGCCATTGTTGCTAAGTTCCGCGAAAGTACCGTTATGGCAGCTAAGACCATGGAGGCCGGTCAACGCAG
TGCTGAGCAATCGGTAGACTTGGCAAAACAGGTTGATGAGTCATTTGAGGCACTACGTCACTCGATTATTAAGATGAATA
CTATGAGTGATGAAAATGCTTGTGCTATGACACAGCAAACGACTGTCGCCAACGATATCAGCCACTCAATTCAAGTGATC
AGTGAGCTCGCAATTGAGAGTCTTGAACAGACACAAGATGCGGCAGAGCGTGGTCAGCAAGTGTCTCGCCTATCGACTAA
AACCCATAGTTTATCTAAGCAGTTCTGGGAGCAGAGCGTACAGAGAAAGATTTGA

Upstream 100 bases:

>100_bases
GATTTTAGCCTAACTGCATTTTCGTGATAGTAATCAATACTTTCTTTGTTAATATCTGTAAGAATGACGTACGTTATTTT
ACGCGATAAGACTGATAACA

Downstream 100 bases:

>100_bases
TTTAAAGAAGATTTATTAAAGAAGGTTCTAGGGAAGGCAAAGAAAGGTTCTAGGACCTAGGAAAAGCTGAGACGGTACAA
GCAAAGACGGAAAAGCGGTG

Product: Pas/Pac sensor containing methyl-accepting chemotaxis sensory transducer

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MRNNQPVTQTEKTLTDNCILLSTTNLDGNIKYANESFTKVSGYSFDELQGQPHNMVRHPDMPEAAFQSLWERIKQGKPWV
GIVKNRTKSGDHYWVNAYIAPVYENGKIHEYQSVRRKATPEQILRAEAIYQQVKAGKQPKALRNPLLGFGAKLYAWLLSM
LVMAVILASYSPIAAVILLSLVGAIGLHRILKPFNQLVTQAKNTVDDPLAKGVFTGRQDELGTISFALQFLLTETGGVIG
RMADSAGSIESLSASLNDTIHNTRQRADSQSMQTSQAATAMEEMSASFAEVNNNIHSAAREMSVSNLSAEKGHQLLERVI
ESITQLKDEVGNFASVVASIEQDSQDINKVLEVIRGIAEQTNLLALNAAIEAARAGESGRGFAVVADEVRQLSSRTSEST
SHIEAIVAKFRESTVMAAKTMEAGQRSAEQSVDLAKQVDESFEALRHSIIKMNTMSDENACAMTQQTTVANDISHSIQVI
SELAIESLEQTQDAAERGQQVSRLSTKTHSLSKQFWEQSVQRKI

Sequences:

>Translated_524_residues
MRNNQPVTQTEKTLTDNCILLSTTNLDGNIKYANESFTKVSGYSFDELQGQPHNMVRHPDMPEAAFQSLWERIKQGKPWV
GIVKNRTKSGDHYWVNAYIAPVYENGKIHEYQSVRRKATPEQILRAEAIYQQVKAGKQPKALRNPLLGFGAKLYAWLLSM
LVMAVILASYSPIAAVILLSLVGAIGLHRILKPFNQLVTQAKNTVDDPLAKGVFTGRQDELGTISFALQFLLTETGGVIG
RMADSAGSIESLSASLNDTIHNTRQRADSQSMQTSQAATAMEEMSASFAEVNNNIHSAAREMSVSNLSAEKGHQLLERVI
ESITQLKDEVGNFASVVASIEQDSQDINKVLEVIRGIAEQTNLLALNAAIEAARAGESGRGFAVVADEVRQLSSRTSEST
SHIEAIVAKFRESTVMAAKTMEAGQRSAEQSVDLAKQVDESFEALRHSIIKMNTMSDENACAMTQQTTVANDISHSIQVI
SELAIESLEQTQDAAERGQQVSRLSTKTHSLSKQFWEQSVQRKI
>Mature_524_residues
MRNNQPVTQTEKTLTDNCILLSTTNLDGNIKYANESFTKVSGYSFDELQGQPHNMVRHPDMPEAAFQSLWERIKQGKPWV
GIVKNRTKSGDHYWVNAYIAPVYENGKIHEYQSVRRKATPEQILRAEAIYQQVKAGKQPKALRNPLLGFGAKLYAWLLSM
LVMAVILASYSPIAAVILLSLVGAIGLHRILKPFNQLVTQAKNTVDDPLAKGVFTGRQDELGTISFALQFLLTETGGVIG
RMADSAGSIESLSASLNDTIHNTRQRADSQSMQTSQAATAMEEMSASFAEVNNNIHSAAREMSVSNLSAEKGHQLLERVI
ESITQLKDEVGNFASVVASIEQDSQDINKVLEVIRGIAEQTNLLALNAAIEAARAGESGRGFAVVADEVRQLSSRTSEST
SHIEAIVAKFRESTVMAAKTMEAGQRSAEQSVDLAKQVDESFEALRHSIIKMNTMSDENACAMTQQTTVANDISHSIQVI
SELAIESLEQTQDAAERGQQVSRLSTKTHSLSKQFWEQSVQRKI

Specific function: Signal transducer for aerotaxis. The aerotactic response is the accumulation of cells around air bubbles. The nature of the sensory stimulus detected by this protein is the proton motive force or cellular redox state. It uses a FAD prosthetic group as a r

COG id: COG0840

COG function: function code NT; Methyl-accepting chemotaxis protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1789453, Length=474, Percent_Identity=34.3881856540084, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI2367378, Length=255, Percent_Identity=29.8039215686275, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1787690, Length=234, Percent_Identity=29.0598290598291, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788195, Length=199, Percent_Identity=34.1708542713568, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1788194, Length=142, Percent_Identity=36.6197183098592, Blast_Score=86, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004090
- InterPro:   IPR004089
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR013655 [H]

Pfam domain/function: PF00672 HAMP; PF00015 MCPsignal; PF08447 PAS_3 [H]

EC number: NA

Molecular weight: Translated: 57581; Mature: 57581

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS50112 PAS ; PS50111 CHEMOTAXIS_TRANSDUC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNNQPVTQTEKTLTDNCILLSTTNLDGNIKYANESFTKVSGYSFDELQGQPHNMVRHPD
CCCCCCCCHHHHHHCCCEEEEEECCCCCCEEECCCCHHHCCCCCHHHHCCCCCCCCCCCC
MPEAAFQSLWERIKQGKPWVGIVKNRTKSGDHYWVNAYIAPVYENGKIHEYQSVRRKATP
CCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHCCH
EQILRAEAIYQQVKAGKQPKALRNPLLGFGAKLYAWLLSMLVMAVILASYSPIAAVILLS
HHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LVGAIGLHRILKPFNQLVTQAKNTVDDPLAKGVFTGRQDELGTISFALQFLLTETGGVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHH
RMADSAGSIESLSASLNDTIHNTRQRADSQSMQTSQAATAMEEMSASFAEVNNNIHSAAR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMSVSNLSAEKGHQLLERVIESITQLKDEVGNFASVVASIEQDSQDINKVLEVIRGIAEQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNLLALNAAIEAARAGESGRGFAVVADEVRQLSSRTSESTSHIEAIVAKFRESTVMAAKT
CCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
MEAGQRSAEQSVDLAKQVDESFEALRHSIIKMNTMSDENACAMTQQTTVANDISHSIQVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SELAIESLEQTQDAAERGQQVSRLSTKTHSLSKQFWEQSVQRKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRNNQPVTQTEKTLTDNCILLSTTNLDGNIKYANESFTKVSGYSFDELQGQPHNMVRHPD
CCCCCCCCHHHHHHCCCEEEEEECCCCCCEEECCCCHHHCCCCCHHHHCCCCCCCCCCCC
MPEAAFQSLWERIKQGKPWVGIVKNRTKSGDHYWVNAYIAPVYENGKIHEYQSVRRKATP
CCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCEEEEEEEEEEECCCCCHHHHHHHHHCCH
EQILRAEAIYQQVKAGKQPKALRNPLLGFGAKLYAWLLSMLVMAVILASYSPIAAVILLS
HHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LVGAIGLHRILKPFNQLVTQAKNTVDDPLAKGVFTGRQDELGTISFALQFLLTETGGVIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHH
RMADSAGSIESLSASLNDTIHNTRQRADSQSMQTSQAATAMEEMSASFAEVNNNIHSAAR
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EMSVSNLSAEKGHQLLERVIESITQLKDEVGNFASVVASIEQDSQDINKVLEVIRGIAEQ
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNLLALNAAIEAARAGESGRGFAVVADEVRQLSSRTSESTSHIEAIVAKFRESTVMAAKT
CCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
MEAGQRSAEQSVDLAKQVDESFEALRHSIIKMNTMSDENACAMTQQTTVANDISHSIQVI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHH
SELAIESLEQTQDAAERGQQVSRLSTKTHSLSKQFWEQSVQRKI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9190831; 9380671 [H]