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The map label for this gene is cobB [H]

Identifier: 157961621

GI number: 157961621

Start: 2193748

End: 2194473

Strand: Direct

Name: cobB [H]

Synonym: Spea_1797

Alternate gene names: 157961621

Gene position: 2193748-2194473 (Clockwise)

Preceding gene: 157961619

Following gene: 157961622

Centisome position: 42.39

GC content: 46.28

Gene sequence:

>726_bases
ATGTACCAGCAGATTGTAATTTTGACCGGGGCAGGGATCTCAGCAGAATCTGGGTTACGTACCTTTAGAGATCAAGACGG
CCTGTGGGAGGAGCATAAAATTGAAGAGGTGGCGACACCAGAAGGGTATGCTAATAACCCTTTATTGGTCGAGCGCTTCT
ATAACGATCGTTGGCAGCAGTTTCATAATGGTTCAATTGAACCCAATGCGGGCCATACTGCACTGGCGAAGCTTGAGCAA
GAATTTGATGGGAAGCTCTTGGTTGTCACTCAGAACATTGATGACTTACATGAAAGAGCGGGCTCTAGGCGCCTGTTGCA
CATGCATGGTGAGTTATCAAAAGGCCGTTGCCCACGTTCACAGCAAACATTTCTTCTGCGAGAAGCTTTTGGACCTAAGC
ATACTTGTACATGTTGTATCCCAGCACAAAGATTAAGGCCTCACGTTGTATGGTTTGGAGAAATGCCTTTCGGTTTAGAT
AGAATTCAGCATGCGCTGGATACTTGCGATCTGTTCATTGCCATAGGCACATCTGGTACCGTCAATCCTGCAGCAGGCTT
TGTCGATACTGCAAATCATCACGGGGCTCAAACGGTTGAGGTTAATTTGATGCCAGCGGATCGGCACAGTCAGTTCCAAT
ACCATTTAGAGGGAAGGGCGAGTGAAGTCGTGCCAAAACTGGTAGATGATATTCTTAACGGAAAAATCGTCAATAACATA
GGATAA

Upstream 100 bases:

>100_bases
TACATTTTGTATTGTTATTGGCCATTTATACTAACGCCTAATGTCATGTGAGCCCACAAGCAGGCAAAATCATTATAAAG
ACAAATAAAAAGGACAGTAG

Downstream 100 bases:

>100_bases
TGGCTGGGGAGTCGTTGCGAGGAATAAGGACACAGCTTACTAATAACGAGTCAGATTTAGGGGATTAAACAGATGAAACA
CCAGTCAAATTATAATGGTA

Product: NAD-dependent deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog [H]

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MYQQIVILTGAGISAESGLRTFRDQDGLWEEHKIEEVATPEGYANNPLLVERFYNDRWQQFHNGSIEPNAGHTALAKLEQ
EFDGKLLVVTQNIDDLHERAGSRRLLHMHGELSKGRCPRSQQTFLLREAFGPKHTCTCCIPAQRLRPHVVWFGEMPFGLD
RIQHALDTCDLFIAIGTSGTVNPAAGFVDTANHHGAQTVEVNLMPADRHSQFQYHLEGRASEVVPKLVDDILNGKIVNNI
G

Sequences:

>Translated_241_residues
MYQQIVILTGAGISAESGLRTFRDQDGLWEEHKIEEVATPEGYANNPLLVERFYNDRWQQFHNGSIEPNAGHTALAKLEQ
EFDGKLLVVTQNIDDLHERAGSRRLLHMHGELSKGRCPRSQQTFLLREAFGPKHTCTCCIPAQRLRPHVVWFGEMPFGLD
RIQHALDTCDLFIAIGTSGTVNPAAGFVDTANHHGAQTVEVNLMPADRHSQFQYHLEGRASEVVPKLVDDILNGKIVNNI
G
>Mature_241_residues
MYQQIVILTGAGISAESGLRTFRDQDGLWEEHKIEEVATPEGYANNPLLVERFYNDRWQQFHNGSIEPNAGHTALAKLEQ
EFDGKLLVVTQNIDDLHERAGSRRLLHMHGELSKGRCPRSQQTFLLREAFGPKHTCTCCIPAQRLRPHVVWFGEMPFGLD
RIQHALDTCDLFIAIGTSGTVNPAAGFVDTANHHGAQTVEVNLMPADRHSQFQYHLEGRASEVVPKLVDDILNGKIVNNI
G

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=233, Percent_Identity=38.1974248927039, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI6912664, Length=251, Percent_Identity=36.6533864541833, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI13787215, Length=239, Percent_Identity=37.2384937238494, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI7657575, Length=242, Percent_Identity=27.6859504132231, Blast_Score=79, Evalue=3e-15,
Organism=Escherichia coli, GI308199517, Length=238, Percent_Identity=54.2016806722689, Blast_Score=261, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17541892, Length=197, Percent_Identity=30.4568527918782, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI28571445, Length=117, Percent_Identity=35.8974358974359, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 26971; Mature: 26971

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQQIVILTGAGISAESGLRTFRDQDGLWEEHKIEEVATPEGYANNPLLVERFYNDRWQQ
CCCEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEEEHHHHHHHHH
FHNGSIEPNAGHTALAKLEQEFDGKLLVVTQNIDDLHERAGSRRLLHMHGELSKGRCPRS
HCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCEEEEECCCCCCCCCCCC
QQTFLLREAFGPKHTCTCCIPAQRLRPHVVWFGEMPFGLDRIQHALDTCDLFIAIGTSGT
HHHHHHHHHCCCCCEEEEECCHHHCCCEEEEEECCCCCHHHHHHHHHHCEEEEEECCCCC
VNPAAGFVDTANHHGAQTVEVNLMPADRHSQFQYHLEGRASEVVPKLVDDILNGKIVNNI
CCCCCCCEECCCCCCCEEEEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCEEECCC
G
C
>Mature Secondary Structure
MYQQIVILTGAGISAESGLRTFRDQDGLWEEHKIEEVATPEGYANNPLLVERFYNDRWQQ
CCCEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHCCCCCCCCCCEEEEHHHHHHHHH
FHNGSIEPNAGHTALAKLEQEFDGKLLVVTQNIDDLHERAGSRRLLHMHGELSKGRCPRS
HCCCCCCCCCCHHHHHHHHHHHCCEEEEEECCHHHHHHCCCCCEEEEECCCCCCCCCCCC
QQTFLLREAFGPKHTCTCCIPAQRLRPHVVWFGEMPFGLDRIQHALDTCDLFIAIGTSGT
HHHHHHHHHCCCCCEEEEECCHHHCCCEEEEEECCCCCHHHHHHHHHHCEEEEEECCCCC
VNPAAGFVDTANHHGAQTVEVNLMPADRHSQFQYHLEGRASEVVPKLVDDILNGKIVNNI
CCCCCCCEECCCCCCCEEEEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHCCEEECCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]