Click here to switch to the map view.

The map label for this gene is lpxK

Identifier: 157961595

GI number: 157961595

Start: 2154011

End: 2155003

Strand: Direct

Name: lpxK

Synonym: Spea_1771

Alternate gene names: 157961595

Gene position: 2154011-2155003 (Clockwise)

Preceding gene: 157961594

Following gene: 157961596

Centisome position: 41.63

GC content: 48.74

Gene sequence:

>993_bases
ATGCAGTCTTGGGTTAATAAACTATGGTATCAGAGCCATCCGCTTAGATTTGCGCTATGGCCTCTGACCCTGCTATTTGG
TGCTGTCAGTTGGCTAAGACGGTTGCTCTTTAGCTTAGGGCTCAAAAAAGCGACTAAATTACCCGTTCCCGTTATTATCG
TGGGAAATATTACCGTTGGTGGCAGTGGTAAAACTCCCACTGTGATCTATCTTATCGAGTTACTCAGAAGTCACGGCTTT
AAGCCAGGCGTGATAAGCCGTGGTTACGGCGTCGAAATCGAGGGCGTAAGATCGGTATTGCCTGAAGACAAGCCTGCCAG
CGTAGGCGATGAGCCTGCGATGATAGTGTCGCGCACCGCAGTGCCCATGGTCGTTGGTGCTAAGCGAGTCGATGCGGCTA
AACATCTGTTGGCAGAATTTGATGTCGATATTATTATCAGTGACGATGGGCTGCAGCATTACCAATTGGCTCGAGATATC
GAGCTTATTATTCTTGATGGAGAGCGGCGGTTAGGCAATGGCATGTTACTACCAGCAGGACCGCTGCGCGAAGCGGCTTG
GCGGTTAAAAAGCGTCGATCAGGTTATCGTTAATGGAGGTATTGCCCAGAGCGGCGAGCAAGCGATGCTGCTTGAGCCTT
CGAAATGGCTACCGGTTTCACCTGTGCATAATGGCAGTTTGCCACCGAGTCAGTCACAGCCTTTAGTGGCTATGGCAGGT
ATTGGTAACCCACAGCGCTTCTTTGATACGCTACAAGCACTGGGCTATTGCGTCGAACAAGCGCAAGCATTTGACGATCA
TAGCGCTTATAGTGAAACAGCGCTTAATGAACTGGCAAATGGTCGTTTGTTGGCGATGACAGAAAAAGATGCGGTGAAAT
GTCGCGATTTTGCAAAAGATAACTGGTGGTCTCTCGCGGTAGATGCGAAGCTATCTCCCTCATTTGATAAACAACTACTG
GCCAAAATTGATAGGTTGGTAGCAGATAAGTAA

Upstream 100 bases:

>100_bases
GGTTGATCAAGGTAAGATTGTCGAGCGTGGCACCCATGAGTCGCTGCTTGCCAAAGGCGGCGTTTACGCTAACCTGTATC
AGATGCAGTTTGGTAGCTAG

Downstream 100 bases:

>100_bases
AGGCATTCGAAATGGCATTTGATAAAAAATTACTCGAAATCGTTGCGTGTCCAGTGTGTAAAGGCAAACTTGAATTCAAC
AAAGAAGCCCAACAGCTGAT

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase

Number of amino acids: Translated: 330; Mature: 330

Protein sequence:

>330_residues
MQSWVNKLWYQSHPLRFALWPLTLLFGAVSWLRRLLFSLGLKKATKLPVPVIIVGNITVGGSGKTPTVIYLIELLRSHGF
KPGVISRGYGVEIEGVRSVLPEDKPASVGDEPAMIVSRTAVPMVVGAKRVDAAKHLLAEFDVDIIISDDGLQHYQLARDI
ELIILDGERRLGNGMLLPAGPLREAAWRLKSVDQVIVNGGIAQSGEQAMLLEPSKWLPVSPVHNGSLPPSQSQPLVAMAG
IGNPQRFFDTLQALGYCVEQAQAFDDHSAYSETALNELANGRLLAMTEKDAVKCRDFAKDNWWSLAVDAKLSPSFDKQLL
AKIDRLVADK

Sequences:

>Translated_330_residues
MQSWVNKLWYQSHPLRFALWPLTLLFGAVSWLRRLLFSLGLKKATKLPVPVIIVGNITVGGSGKTPTVIYLIELLRSHGF
KPGVISRGYGVEIEGVRSVLPEDKPASVGDEPAMIVSRTAVPMVVGAKRVDAAKHLLAEFDVDIIISDDGLQHYQLARDI
ELIILDGERRLGNGMLLPAGPLREAAWRLKSVDQVIVNGGIAQSGEQAMLLEPSKWLPVSPVHNGSLPPSQSQPLVAMAG
IGNPQRFFDTLQALGYCVEQAQAFDDHSAYSETALNELANGRLLAMTEKDAVKCRDFAKDNWWSLAVDAKLSPSFDKQLL
AKIDRLVADK
>Mature_330_residues
MQSWVNKLWYQSHPLRFALWPLTLLFGAVSWLRRLLFSLGLKKATKLPVPVIIVGNITVGGSGKTPTVIYLIELLRSHGF
KPGVISRGYGVEIEGVRSVLPEDKPASVGDEPAMIVSRTAVPMVVGAKRVDAAKHLLAEFDVDIIISDDGLQHYQLARDI
ELIILDGERRLGNGMLLPAGPLREAAWRLKSVDQVIVNGGIAQSGEQAMLLEPSKWLPVSPVHNGSLPPSQSQPLVAMAG
IGNPQRFFDTLQALGYCVEQAQAFDDHSAYSETALNELANGRLLAMTEKDAVKCRDFAKDNWWSLAVDAKLSPSFDKQLL
AKIDRLVADK

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family

Homologues:

Organism=Escherichia coli, GI1787144, Length=327, Percent_Identity=48.0122324159021, Blast_Score=285, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LPXK_SHEPA (A8H3F7)

Other databases:

- EMBL:   CP000851
- RefSeq:   YP_001501629.1
- STRING:   A8H3F7
- GeneID:   5662166
- GenomeReviews:   CP000851_GR
- KEGG:   spl:Spea_1771
- NMPDR:   fig|398579.3.peg.1525
- eggNOG:   COG1663
- HOGENOM:   HBG663914
- OMA:   VILMDDG
- ProtClustDB:   PRK00652
- BioCyc:   SPEA398579:SPEA_1771-MONOMER
- HAMAP:   MF_00409
- InterPro:   IPR003758
- TIGRFAMs:   TIGR00682

Pfam domain/function: PF02606 LpxK

EC number: =2.7.1.130

Molecular weight: Translated: 36148; Mature: 36148

Theoretical pI: Translated: 7.66; Mature: 7.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSWVNKLWYQSHPLRFALWPLTLLFGAVSWLRRLLFSLGLKKATKLPVPVIIVGNITVG
CCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEEEEEEC
GSGKTPTVIYLIELLRSHGFKPGVISRGYGVEIEGVRSVLPEDKPASVGDEPAMIVSRTA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHCCCCCCCCCCCCCCEEEECCC
VPMVVGAKRVDAAKHLLAEFDVDIIISDDGLQHYQLARDIELIILDGERRLGNGMLLPAG
CCHHHCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCEEEEEECCCCCCCCCEECCCC
PLREAAWRLKSVDQVIVNGGIAQSGEQAMLLEPSKWLPVSPVHNGSLPPSQSQPLVAMAG
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEC
IGNPQRFFDTLQALGYCVEQAQAFDDHSAYSETALNELANGRLLAMTEKDAVKCRDFAKD
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCC
NWWSLAVDAKLSPSFDKQLLAKIDRLVADK
CCEEEEEECCCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MQSWVNKLWYQSHPLRFALWPLTLLFGAVSWLRRLLFSLGLKKATKLPVPVIIVGNITVG
CCHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCEEEEEEEEEC
GSGKTPTVIYLIELLRSHGFKPGVISRGYGVEIEGVRSVLPEDKPASVGDEPAMIVSRTA
CCCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHCCCCCCCCCCCCCCEEEECCC
VPMVVGAKRVDAAKHLLAEFDVDIIISDDGLQHYQLARDIELIILDGERRLGNGMLLPAG
CCHHHCHHHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCEEEEEECCCCCCCCCEECCCC
PLREAAWRLKSVDQVIVNGGIAQSGEQAMLLEPSKWLPVSPVHNGSLPPSQSQPLVAMAG
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEEC
IGNPQRFFDTLQALGYCVEQAQAFDDHSAYSETALNELANGRLLAMTEKDAVKCRDFAKD
CCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECCCHHHHHHHCCC
NWWSLAVDAKLSPSFDKQLLAKIDRLVADK
CCEEEEEECCCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA