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The map label for this gene is glyA [H]

Identifier: 157960988

GI number: 157960988

Start: 1405628

End: 1406884

Strand: Direct

Name: glyA [H]

Synonym: Spea_1160

Alternate gene names: 157960988

Gene position: 1405628-1406884 (Clockwise)

Preceding gene: 157960979

Following gene: 157960989

Centisome position: 27.16

GC content: 46.62

Gene sequence:

>1257_bases
ATGCTGAAAAAAGATATGAATATCGCGGATTATGATCCACAACTATTTGCAGCAATTGAAGATGAAACGCGCCGTCAAGA
AGAGCACATCGAACTTATTGCTTCAGAAAACTACTGTAGTCCTCGCGTAATCGAAGCACAAGGTACTCAGCTTACTAACA
AGTATGCTGAAGGCTACCCAGGTAAGCGTTACTATGGTGGTTGTGAGCATGTAGATATTGTTGAAGAGTTAGCAATTTCT
CGTGCTAAAGAACTATTTGGCGCGACTTATGCCAACGTTCAGCCACACTCAGGCTCTCAAGCTAACGCAGCCGTATTTAT
GGCACTACTTCAAGGCGGCGACACGGTTCTAGGTATGAGCCTAGCACACGGTGGTCACCTAACTCACGGCTCTCACGTGA
GCTTTTCAGGCAAACTATACAACGCAGTTCAGTATGGTATCGACGAAACAACAGGCCAGATTGACTACGCCGAAGTTGAG
CGTCTAGCCGTTGAGCACAAGCCAAAGATGATCATCGCAGGTTTCAGTGCCTACTCAGGTATCATCGACTGGGGTAAGTT
CCGCGAAATCGCTGACAAAGTTGGCGCATACCTATTCGTTGATATGGCGCACGTTGCAGGTCTTGTTGCTGCAGGTATCT
ATCCAAACCCAATGCCACACGCGCACGTTGTAACAACAACGACTCATAAGACGCTAGCTGGTCCACGTGGCGGTTTGATC
CTTTCATCAATCAATGATGAAGATATCTACAAGAAGCTAAACTCTGCAGTATTTCCAGGCGGCCAAGGCGGTCCTTTGAT
GCACGTTATTGCTGCTAAAGCAGTTGCATTTAAAGAAGCCCTAGACCCAGAGTTCACGACTTATCAAGAGCAAGTAGTTG
TTAACGCAAAGGCAATGGCTCGTACGTTTATCGAACGTGGCTATAATGTAGTTTCTGGTGGTACTGATAACCACCTATTC
TTGCTTGATTTGATCAGTAAAGACATCACAGGTAAAGATGCTGACGCGGCCCTAGGCAACGCTAACATCACAGTGAACAA
GAACTCAGTACCGAACGATCCACGTTCACCATTTGTGACTTCAGGTCTACGTATCGGTTCTCCTGCAATCACGCGTCGTG
GTTTTGGTGAGGAAGAGAGCGTGCAGTTAACTCACTGGATGTGTGATGTACTGGATGATATTTCAGATCTAGCCGTTAGC
GAGCGCGTTAAAGGACAGGTTCTGGAATTGTGCGCTAAGTTCCCTGTTTACGGTTAA

Upstream 100 bases:

>100_bases
AAATGCAAGTAATTTCATGTTGTAAATGCTGGGATTGTGATCGAATGCGCTGTAGAATACCGCGCAACCCTATTACAAGA
CTTTACAGCTGGAGTGAGTA

Downstream 100 bases:

>100_bases
CCTTAAGCGTTAAATAAGTTAGACTCCAATGGCCGCATCTATGCGGCCATTTTTGTATGTAAAGAACATACTTTCTGAGT
TTTTAAGTCGTACCAATCAC

Product: serine hydroxymethyltransferase

Products: NA

Alternate protein names: SHMT; Serine methylase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MLKKDMNIADYDPQLFAAIEDETRRQEEHIELIASENYCSPRVIEAQGTQLTNKYAEGYPGKRYYGGCEHVDIVEELAIS
RAKELFGATYANVQPHSGSQANAAVFMALLQGGDTVLGMSLAHGGHLTHGSHVSFSGKLYNAVQYGIDETTGQIDYAEVE
RLAVEHKPKMIIAGFSAYSGIIDWGKFREIADKVGAYLFVDMAHVAGLVAAGIYPNPMPHAHVVTTTTHKTLAGPRGGLI
LSSINDEDIYKKLNSAVFPGGQGGPLMHVIAAKAVAFKEALDPEFTTYQEQVVVNAKAMARTFIERGYNVVSGGTDNHLF
LLDLISKDITGKDADAALGNANITVNKNSVPNDPRSPFVTSGLRIGSPAITRRGFGEEESVQLTHWMCDVLDDISDLAVS
ERVKGQVLELCAKFPVYG

Sequences:

>Translated_418_residues
MLKKDMNIADYDPQLFAAIEDETRRQEEHIELIASENYCSPRVIEAQGTQLTNKYAEGYPGKRYYGGCEHVDIVEELAIS
RAKELFGATYANVQPHSGSQANAAVFMALLQGGDTVLGMSLAHGGHLTHGSHVSFSGKLYNAVQYGIDETTGQIDYAEVE
RLAVEHKPKMIIAGFSAYSGIIDWGKFREIADKVGAYLFVDMAHVAGLVAAGIYPNPMPHAHVVTTTTHKTLAGPRGGLI
LSSINDEDIYKKLNSAVFPGGQGGPLMHVIAAKAVAFKEALDPEFTTYQEQVVVNAKAMARTFIERGYNVVSGGTDNHLF
LLDLISKDITGKDADAALGNANITVNKNSVPNDPRSPFVTSGLRIGSPAITRRGFGEEESVQLTHWMCDVLDDISDLAVS
ERVKGQVLELCAKFPVYG
>Mature_418_residues
MLKKDMNIADYDPQLFAAIEDETRRQEEHIELIASENYCSPRVIEAQGTQLTNKYAEGYPGKRYYGGCEHVDIVEELAIS
RAKELFGATYANVQPHSGSQANAAVFMALLQGGDTVLGMSLAHGGHLTHGSHVSFSGKLYNAVQYGIDETTGQIDYAEVE
RLAVEHKPKMIIAGFSAYSGIIDWGKFREIADKVGAYLFVDMAHVAGLVAAGIYPNPMPHAHVVTTTTHKTLAGPRGGLI
LSSINDEDIYKKLNSAVFPGGQGGPLMHVIAAKAVAFKEALDPEFTTYQEQVVVNAKAMARTFIERGYNVVSGGTDNHLF
LLDLISKDITGKDADAALGNANITVNKNSVPNDPRSPFVTSGLRIGSPAITRRGFGEEESVQLTHWMCDVLDDISDLAVS
ERVKGQVLELCAKFPVYG

Specific function: Interconversion of serine and glycine [H]

COG id: COG0112

COG function: function code E; Glycine/serine hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SHMT family [H]

Homologues:

Organism=Homo sapiens, GI19923315, Length=394, Percent_Identity=47.7157360406091, Blast_Score=349, Evalue=2e-96,
Organism=Homo sapiens, GI261862352, Length=394, Percent_Identity=47.7157360406091, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI261862350, Length=394, Percent_Identity=47.7157360406091, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI261862348, Length=394, Percent_Identity=47.7157360406091, Blast_Score=349, Evalue=3e-96,
Organism=Homo sapiens, GI261862346, Length=394, Percent_Identity=46.9543147208122, Blast_Score=334, Evalue=1e-91,
Organism=Homo sapiens, GI22547186, Length=401, Percent_Identity=44.8877805486284, Blast_Score=313, Evalue=2e-85,
Organism=Homo sapiens, GI22547189, Length=389, Percent_Identity=42.9305912596401, Blast_Score=284, Evalue=1e-76,
Organism=Escherichia coli, GI1788902, Length=417, Percent_Identity=77.6978417266187, Blast_Score=667, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25144732, Length=393, Percent_Identity=46.3104325699746, Blast_Score=340, Evalue=1e-93,
Organism=Caenorhabditis elegans, GI25144729, Length=393, Percent_Identity=46.3104325699746, Blast_Score=339, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6319739, Length=401, Percent_Identity=45.3865336658354, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6323087, Length=402, Percent_Identity=45.273631840796, Blast_Score=343, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24640005, Length=400, Percent_Identity=45.5, Blast_Score=347, Evalue=1e-95,
Organism=Drosophila melanogaster, GI221329721, Length=400, Percent_Identity=45.5, Blast_Score=346, Evalue=2e-95,

Paralogues:

None

Copy number: 3180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 12,000 Molecules/Cell In: Glucose minimal

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR001085
- InterPro:   IPR019798 [H]

Pfam domain/function: PF00464 SHMT [H]

EC number: =2.1.2.1 [H]

Molecular weight: Translated: 45293; Mature: 45293

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: PS00096 SHMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKKDMNIADYDPQLFAAIEDETRRQEEHIELIASENYCSPRVIEAQGTQLTNKYAEGYP
CCCCCCCCCCCCCHHEEEHHHHHHHHHHHHEEEECCCCCCCEEEECCCCHHHHHHHCCCC
GKRYYGGCEHVDIVEELAISRAKELFGATYANVQPHSGSQANAAVFMALLQGGDTVLGMS
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEE
LAHGGHLTHGSHVSFSGKLYNAVQYGIDETTGQIDYAEVERLAVEHKPKMIIAGFSAYSG
ECCCCCCCCCCCEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHH
IIDWGKFREIADKVGAYLFVDMAHVAGLVAAGIYPNPMPHAHVVTTTTHKTLAGPRGGLI
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHCCCCCCEE
LSSINDEDIYKKLNSAVFPGGQGGPLMHVIAAKAVAFKEALDPEFTTYQEQVVVNAKAMA
EECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHEEHHHHHH
RTFIERGYNVVSGGTDNHLFLLDLISKDITGKDADAALGNANITVNKNSVPNDPRSPFVT
HHHHHCCCEEECCCCCCCEEEEEEHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHH
SGLRIGSPAITRRGFGEEESVQLTHWMCDVLDDISDLAVSERVKGQVLELCAKFPVYG
CCEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MLKKDMNIADYDPQLFAAIEDETRRQEEHIELIASENYCSPRVIEAQGTQLTNKYAEGYP
CCCCCCCCCCCCCHHEEEHHHHHHHHHHHHEEEECCCCCCCEEEECCCCHHHHHHHCCCC
GKRYYGGCEHVDIVEELAISRAKELFGATYANVQPHSGSQANAAVFMALLQGGDTVLGMS
CCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCEEEEEE
LAHGGHLTHGSHVSFSGKLYNAVQYGIDETTGQIDYAEVERLAVEHKPKMIIAGFSAYSG
ECCCCCCCCCCCEEECCHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCCEEEEECHHHHH
IIDWGKFREIADKVGAYLFVDMAHVAGLVAAGIYPNPMPHAHVVTTTTHKTLAGPRGGLI
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCHHHCCCCCCEE
LSSINDEDIYKKLNSAVFPGGQGGPLMHVIAAKAVAFKEALDPEFTTYQEQVVVNAKAMA
EECCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHEEHHHHHH
RTFIERGYNVVSGGTDNHLFLLDLISKDITGKDADAALGNANITVNKNSVPNDPRSPFVT
HHHHHCCCEEECCCCCCCEEEEEEHHCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCHHH
SGLRIGSPAITRRGFGEEESVQLTHWMCDVLDDISDLAVSERVKGQVLELCAKFPVYG
CCEECCCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA