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The map label for this gene is tyrA [H]

Identifier: 157960882

GI number: 157960882

Start: 1276112

End: 1277266

Strand: Direct

Name: tyrA [H]

Synonym: Spea_1054

Alternate gene names: 157960882

Gene position: 1276112-1277266 (Clockwise)

Preceding gene: 157960881

Following gene: 157960883

Centisome position: 24.66

GC content: 46.06

Gene sequence:

>1155_bases
ATGGAAGAAACACAGATGAATGAGAAGACTACCGCAGAGCTTGAAAATCTAAGAGGTTTGATTGACGGTGTCGATCAGCA
GTTACTGCACCTGTTACGCAAACGATTAGACTTGGTGGCCCAAGTTGGCGCGGTGAAGCATGGTGCTGGTCTACCGATTT
ATGCGCCGCAGCGTGAAGCCAATATGCTAGCAAAAAGACGCGAAGAAGCTAAGGCGATGAATGTGGCGCCACAGTTGATT
GAAGATATCCTGCGTCGCCTTATGCGAGAGTCCTACCTTAATGAAAAAGATGTTGGCTTTAAGCAAATTAAAGCTGATCT
TGGACATGTGGTGATTGTTGGTGGAGAGGGCAAACTTGGCGGCTTGTTTTCGCAAATGCTAACGTTATCGGGTTATGAGG
TTAAATCTCTCGATAAAGATGATTGGGCCAATAGCCAGGCTATTTTCGATGGTGCAGGTCTTGTGATTGTAACTGTGCCT
ATCAACATCACCTGTGATCTCATTGCAGACAAGCTGACGAACTTACCTGAAAATTGCATCTTGGCAGATCTCACATCCAT
TAAAGGCGCGCCAGTTGACGCAATGCTCGCGGCGCATTCAGGCCCAGTGCTTGGGTTACATCCTATGTTTGGCCCTGATG
TAGGTAGTTTAGCTAAACAAGTTGTGGTGGTGTGTCATGGGCGTAATCCTGAGGCTTATCAATGGTTGATTGAACAGATT
GAAATCTGGGGTGCACGCATTGTTGAAGCCGAGCCGAGTAAACATGATAAAGCGATGCAGCTGGTACAGGCGATGCGACA
TTTCTCTTCCTTTGTTTACGGGTTAAACCTTTATAAAGAAGAAGCGGATATCGAGTCTTTACTGCAGTTTAGCTCACCGA
TTTACCGCTTAGAGCTGGCGATGGTGGGACGCTTGTTTGCCCAAAGCCCAGAGCTTTACGCCGATATTATTTTTGCTCAA
GAAGAAAGCTTAGTAGCGATTGGTGATTACTTAGATAACTACTCTCAGGCGCTATCTATTTTAAAATCGGGTAATCGCGA
TGCCTTTGTGGCTCAATTTGCAGAGGTATCTAGCTGGTTTGGTGATTTTGCGCCGCAATTCCAAAGAGAGAGTAGGGCGA
TGCTGCAATCAGTCAACGATATGAAAACGGGCTAA

Upstream 100 bases:

>100_bases
TCGACTGGAAAACCACAGAAGCGTTATTACGAACGGGAGCCGATGAGTTAGCCTCGGTATTACCGACAAGATTTGATATG
CTAAAAGTTGCAAACGGCTG

Downstream 100 bases:

>100_bases
TTGAAAGCCAATTTTAAGACTGTACCTAACAGCTGACTCTCATGAGTTAACTGATCTGACAAAAGGCGCTTAGGCGCCTT
TTTTGTGTTTGGCCTATTTA

Product: bifunctional chorismate mutase/prephenate dehydrogenase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydrogenase; PDH [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MEETQMNEKTTAELENLRGLIDGVDQQLLHLLRKRLDLVAQVGAVKHGAGLPIYAPQREANMLAKRREEAKAMNVAPQLI
EDILRRLMRESYLNEKDVGFKQIKADLGHVVIVGGEGKLGGLFSQMLTLSGYEVKSLDKDDWANSQAIFDGAGLVIVTVP
INITCDLIADKLTNLPENCILADLTSIKGAPVDAMLAAHSGPVLGLHPMFGPDVGSLAKQVVVVCHGRNPEAYQWLIEQI
EIWGARIVEAEPSKHDKAMQLVQAMRHFSSFVYGLNLYKEEADIESLLQFSSPIYRLELAMVGRLFAQSPELYADIIFAQ
EESLVAIGDYLDNYSQALSILKSGNRDAFVAQFAEVSSWFGDFAPQFQRESRAMLQSVNDMKTG

Sequences:

>Translated_384_residues
MEETQMNEKTTAELENLRGLIDGVDQQLLHLLRKRLDLVAQVGAVKHGAGLPIYAPQREANMLAKRREEAKAMNVAPQLI
EDILRRLMRESYLNEKDVGFKQIKADLGHVVIVGGEGKLGGLFSQMLTLSGYEVKSLDKDDWANSQAIFDGAGLVIVTVP
INITCDLIADKLTNLPENCILADLTSIKGAPVDAMLAAHSGPVLGLHPMFGPDVGSLAKQVVVVCHGRNPEAYQWLIEQI
EIWGARIVEAEPSKHDKAMQLVQAMRHFSSFVYGLNLYKEEADIESLLQFSSPIYRLELAMVGRLFAQSPELYADIIFAQ
EESLVAIGDYLDNYSQALSILKSGNRDAFVAQFAEVSSWFGDFAPQFQRESRAMLQSVNDMKTG
>Mature_384_residues
MEETQMNEKTTAELENLRGLIDGVDQQLLHLLRKRLDLVAQVGAVKHGAGLPIYAPQREANMLAKRREEAKAMNVAPQLI
EDILRRLMRESYLNEKDVGFKQIKADLGHVVIVGGEGKLGGLFSQMLTLSGYEVKSLDKDDWANSQAIFDGAGLVIVTVP
INITCDLIADKLTNLPENCILADLTSIKGAPVDAMLAAHSGPVLGLHPMFGPDVGSLAKQVVVVCHGRNPEAYQWLIEQI
EIWGARIVEAEPSKHDKAMQLVQAMRHFSSFVYGLNLYKEEADIESLLQFSSPIYRLELAMVGRLFAQSPELYADIIFAQ
EESLVAIGDYLDNYSQALSILKSGNRDAFVAQFAEVSSWFGDFAPQFQRESRAMLQSVNDMKTG

Specific function: Tyrosine biosynthesis [C]

COG id: COG0287

COG function: function code E; Prephenate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate/arogenate dehydrogenase domain [H]

Homologues:

Organism=Escherichia coli, GI1788952, Length=372, Percent_Identity=57.258064516129, Blast_Score=438, Evalue=1e-124,

Paralogues:

None

Copy number: 500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR008244
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR011277
- InterPro:   IPR016040
- InterPro:   IPR003099 [H]

Pfam domain/function: PF01817 CM_2; PF02153 PDH [H]

EC number: =5.4.99.5; =1.3.1.12 [H]

Molecular weight: Translated: 42491; Mature: 42491

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEETQMNEKTTAELENLRGLIDGVDQQLLHLLRKRLDLVAQVGAVKHGAGLPIYAPQREA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
NMLAKRREEAKAMNVAPQLIEDILRRLMRESYLNEKDVGFKQIKADLGHVVIVGGEGKLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEECCCCCHH
GLFSQMLTLSGYEVKSLDKDDWANSQAIFDGAGLVIVTVPINITCDLIADKLTNLPENCI
HHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCEEHHHHHHHHHCCCCHHH
LADLTSIKGAPVDAMLAAHSGPVLGLHPMFGPDVGSLAKQVVVVCHGRNPEAYQWLIEQI
HHHHHHCCCCCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHEEEEECCCCHHHHHHHHHH
EIWGARIVEAEPSKHDKAMQLVQAMRHFSSFVYGLNLYKEEADIESLLQFSSPIYRLELA
HHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
MVGRLFAQSPELYADIIFAQEESLVAIGDYLDNYSQALSILKSGNRDAFVAQFAEVSSWF
HHHHHHHCCCHHHHHHHEECCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GDFAPQFQRESRAMLQSVNDMKTG
HHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEETQMNEKTTAELENLRGLIDGVDQQLLHLLRKRLDLVAQVGAVKHGAGLPIYAPQREA
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHH
NMLAKRREEAKAMNVAPQLIEDILRRLMRESYLNEKDVGFKQIKADLGHVVIVGGEGKLG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEECCCCCHH
GLFSQMLTLSGYEVKSLDKDDWANSQAIFDGAGLVIVTVPINITCDLIADKLTNLPENCI
HHHHHHHHHCCCCCCCCCCCCCCCCCEEECCCCEEEEEECCCEEHHHHHHHHHCCCCHHH
LADLTSIKGAPVDAMLAAHSGPVLGLHPMFGPDVGSLAKQVVVVCHGRNPEAYQWLIEQI
HHHHHHCCCCCHHHHHHHCCCCEEEECCCCCCCHHHHHHHHEEEEECCCCHHHHHHHHHH
EIWGARIVEAEPSKHDKAMQLVQAMRHFSSFVYGLNLYKEEADIESLLQFSSPIYRLELA
HHHCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
MVGRLFAQSPELYADIIFAQEESLVAIGDYLDNYSQALSILKSGNRDAFVAQFAEVSSWF
HHHHHHHCCCHHHHHHHEECCCCEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
GDFAPQFQRESRAMLQSVNDMKTG
HHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]