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The map label for this gene is sufS [H]

Identifier: 157960595

GI number: 157960595

Start: 951760

End: 952971

Strand: Reverse

Name: sufS [H]

Synonym: Spea_0767

Alternate gene names: 157960595

Gene position: 952971-951760 (Counterclockwise)

Preceding gene: 157960596

Following gene: 157960594

Centisome position: 18.42

GC content: 50.25

Gene sequence:

>1212_bases
ATGGATCTCTCAACGCTGCGATCACTGTTCCCAACTCTGGCTCAATCTAACGATGGTTACCCTCTGTGTTATCTAGATAC
GGCGGCTACCAGTCAGAAGCCTCAGCAGGTGATCGATGCCATGAATCACTATTATCACCATGATAATGCCAATGTGCATC
GCGCAGCCCATCAGCTATCGGCACGTGCCACCAGCCAGTATGAAGCGGTGCGTGACAAGCTGTGTAAATTCATTAATGCC
AATCGACGTGAAGAGATCATCTTTACCCATGGCACCACAGAATCTATCAACACAGTTGCTAACGGTTTAACGGCTCAAAT
AAAGCAAGGCAGCCTTATTCTTATCGATAGCGCCGCCCATCACGCCAATATTGTGCCTTGGCAACAACTTGCTAAGCGCA
CTGGCGCAATTATCAAGCCTATTCCGCTGACAGCCGATTGCCGCCTCGATACCGCAGCTTTCGATGTTTTACTCAGTGAA
AAGCCAGCTGTCGTCGCCCTAAGTCATGTATCCAACGCTCTGGGCACTGTCAACCCAGTCAAAGACTTGGTCAGCAAAGC
CAATCAGGTCGGCGCGATCACCTTGGTCGATGGCGCTCAAGCCATAGCTCATATGGGTGTCGATGTACAAGCTATCGGTT
GTGACTTCTATGTATTCTCAGGCCACAAGATGTACGGCCCAACAGGCATAGGCGTCTTATATGGGCGCTTCGATATTCTG
GACAGATTAAGCCCTCTCATCACCGGCGGCGAGATGATAAAAAGCGTCAGCTTTGAGGTTACAGAGTTTAACGTATTACC
CAACCGCCTAGAAGCTGGCACCCCGCCGATAGCAGAAGTGATTGGCCTAGGCGCGGCTATCGACTTCATCGAGGCCTTAC
CGAGCGAGCAGATCCACGCCAAAGAGCAAGAGCTACTCAATTACCTGCAAGACGAGTTAAAGAACATGGGAGATGTGGTA
CTTTACGGCGCCCACACCGATAACCTTGGCGCAGTCGCTTTTAATCTGGCCGATGAGCATCATCAAGATGTGGGTATTTT
ACTCGACCAACAAGGCATTGCCGTGCGCTGCGGCCACCACTGCGCCATGCCACTGATGCAAAGCCTTGGACTAAAAGGCT
GCTGCCGAGCATCAATTGGCGTTTATACTAATAAGGACGATATCGACAACTTTATTGCGGCTATGGAGTCGGTGAAAGAG
TTGTTGTTATAA

Upstream 100 bases:

>100_bases
CCCTTAAAGCGATATTTTTAACTGTCTAACTTGCTTTAGGGGCTCAGATCTTACAAGATCTGAGCGCCTTTTCTTTTTAT
CGATAATCTTGGATCAATTA

Downstream 100 bases:

>100_bases
AAGAAGGGGCTAGGTCCTAGGAAAAGCAGGTTCTAGGTTAAAAGCAAAGACGGAACAGGCTGAGACGGTAACAGCCGAGC
AAAGCCGGAAGAGCAGAACC

Product: SufS subfamily cysteine desulfurase

Products: NA

Alternate protein names: Selenocysteine beta-lyase; SCL; Selenocysteine lyase; Selenocysteine reductase [H]

Number of amino acids: Translated: 403; Mature: 403

Protein sequence:

>403_residues
MDLSTLRSLFPTLAQSNDGYPLCYLDTAATSQKPQQVIDAMNHYYHHDNANVHRAAHQLSARATSQYEAVRDKLCKFINA
NRREEIIFTHGTTESINTVANGLTAQIKQGSLILIDSAAHHANIVPWQQLAKRTGAIIKPIPLTADCRLDTAAFDVLLSE
KPAVVALSHVSNALGTVNPVKDLVSKANQVGAITLVDGAQAIAHMGVDVQAIGCDFYVFSGHKMYGPTGIGVLYGRFDIL
DRLSPLITGGEMIKSVSFEVTEFNVLPNRLEAGTPPIAEVIGLGAAIDFIEALPSEQIHAKEQELLNYLQDELKNMGDVV
LYGAHTDNLGAVAFNLADEHHQDVGILLDQQGIAVRCGHHCAMPLMQSLGLKGCCRASIGVYTNKDDIDNFIAAMESVKE
LLL

Sequences:

>Translated_403_residues
MDLSTLRSLFPTLAQSNDGYPLCYLDTAATSQKPQQVIDAMNHYYHHDNANVHRAAHQLSARATSQYEAVRDKLCKFINA
NRREEIIFTHGTTESINTVANGLTAQIKQGSLILIDSAAHHANIVPWQQLAKRTGAIIKPIPLTADCRLDTAAFDVLLSE
KPAVVALSHVSNALGTVNPVKDLVSKANQVGAITLVDGAQAIAHMGVDVQAIGCDFYVFSGHKMYGPTGIGVLYGRFDIL
DRLSPLITGGEMIKSVSFEVTEFNVLPNRLEAGTPPIAEVIGLGAAIDFIEALPSEQIHAKEQELLNYLQDELKNMGDVV
LYGAHTDNLGAVAFNLADEHHQDVGILLDQQGIAVRCGHHCAMPLMQSLGLKGCCRASIGVYTNKDDIDNFIAAMESVKE
LLL
>Mature_403_residues
MDLSTLRSLFPTLAQSNDGYPLCYLDTAATSQKPQQVIDAMNHYYHHDNANVHRAAHQLSARATSQYEAVRDKLCKFINA
NRREEIIFTHGTTESINTVANGLTAQIKQGSLILIDSAAHHANIVPWQQLAKRTGAIIKPIPLTADCRLDTAAFDVLLSE
KPAVVALSHVSNALGTVNPVKDLVSKANQVGAITLVDGAQAIAHMGVDVQAIGCDFYVFSGHKMYGPTGIGVLYGRFDIL
DRLSPLITGGEMIKSVSFEVTEFNVLPNRLEAGTPPIAEVIGLGAAIDFIEALPSEQIHAKEQELLNYLQDELKNMGDVV
LYGAHTDNLGAVAFNLADEHHQDVGILLDQQGIAVRCGHHCAMPLMQSLGLKGCCRASIGVYTNKDDIDNFIAAMESVKE
LLL

Specific function: Cysteine desulfurases mobilize the sulfur from L- cysteine to yield L-alanine, an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Component of the suf operon, which is activated and required under speci

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=391, Percent_Identity=24.2966751918159, Blast_Score=108, Evalue=8e-24,
Organism=Homo sapiens, GI156713448, Length=325, Percent_Identity=26.4615384615385, Blast_Score=72, Evalue=8e-13,
Organism=Escherichia coli, GI1787970, Length=399, Percent_Identity=47.6190476190476, Blast_Score=380, Evalue=1e-107,
Organism=Escherichia coli, GI1789175, Length=401, Percent_Identity=38.1546134663342, Blast_Score=291, Evalue=8e-80,
Organism=Escherichia coli, GI48994898, Length=387, Percent_Identity=25.3229974160207, Blast_Score=110, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI25143064, Length=342, Percent_Identity=25.4385964912281, Blast_Score=102, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6319831, Length=407, Percent_Identity=25.3071253071253, Blast_Score=106, Evalue=5e-24,
Organism=Drosophila melanogaster, GI20129463, Length=403, Percent_Identity=24.8138957816377, Blast_Score=114, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7; =4.4.1.16 [H]

Molecular weight: Translated: 43629; Mature: 43629

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS00595 AA_TRANSFER_CLASS_5

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSTLRSLFPTLAQSNDGYPLCYLDTAATSQKPQQVIDAMNHYYHHDNANVHRAAHQLS
CCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHH
ARATSQYEAVRDKLCKFINANRREEIIFTHGTTESINTVANGLTAQIKQGSLILIDSAAH
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCEEECCCCEEEEECCCC
HANIVPWQQLAKRTGAIIKPIPLTADCRLDTAAFDVLLSEKPAVVALSHVSNALGTVNPV
CCCCCCHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHCCCHHH
KDLVSKANQVGAITLVDGAQAIAHMGVDVQAIGCDFYVFSGHKMYGPTGIGVLYGRFDIL
HHHHHHHHHCCEEEEECHHHHHHHCCCCEEEEEEEEEEEECCEEECCCCHHHHHHHHHHH
DRLSPLITGGEMIKSVSFEVTEFNVLPNRLEAGTPPIAEVIGLGAAIDFIEALPSEQIHA
HHHHHHHCCHHHHHHHCEEEEEEECCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
KEQELLNYLQDELKNMGDVVLYGAHTDNLGAVAFNLADEHHQDVGILLDQQGIAVRCGHH
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCHHCCCCCEEEEECCCCEEECCCH
CAMPLMQSLGLKGCCRASIGVYTNKDDIDNFIAAMESVKELLL
HHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC
>Mature Secondary Structure
MDLSTLRSLFPTLAQSNDGYPLCYLDTAATSQKPQQVIDAMNHYYHHDNANVHRAAHQLS
CCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHEECCCCHHHHHHHHHH
ARATSQYEAVRDKLCKFINANRREEIIFTHGTTESINTVANGLTAQIKQGSLILIDSAAH
HHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHCCCCEEECCCCEEEEECCCC
HANIVPWQQLAKRTGAIIKPIPLTADCRLDTAAFDVLLSEKPAVVALSHVSNALGTVNPV
CCCCCCHHHHHHHCCCEEECCCCCCCCCCCHHHHHHHHCCCCCEEEHHHHHHHHCCCHHH
KDLVSKANQVGAITLVDGAQAIAHMGVDVQAIGCDFYVFSGHKMYGPTGIGVLYGRFDIL
HHHHHHHHHCCEEEEECHHHHHHHCCCCEEEEEEEEEEEECCEEECCCCHHHHHHHHHHH
DRLSPLITGGEMIKSVSFEVTEFNVLPNRLEAGTPPIAEVIGLGAAIDFIEALPSEQIHA
HHHHHHHCCHHHHHHHCEEEEEEECCCCHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHH
KEQELLNYLQDELKNMGDVVLYGAHTDNLGAVAFNLADEHHQDVGILLDQQGIAVRCGHH
HHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEEECCHHCCCCCEEEEECCCCEEECCCH
CAMPLMQSLGLKGCCRASIGVYTNKDDIDNFIAAMESVKELLL
HHHHHHHHCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA