| Definition | Rickettsia akari str. Hartford, complete genome. |
|---|---|
| Accession | NC_009881 |
| Length | 1,231,060 |
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The map label for this gene is nrdA [H]
Identifier: 157825768
GI number: 157825768
Start: 626481
End: 628304
Strand: Direct
Name: nrdA [H]
Synonym: A1C_03480
Alternate gene names: 157825768
Gene position: 626481-628304 (Clockwise)
Preceding gene: 157825762
Following gene: 157825769
Centisome position: 50.89
GC content: 35.25
Gene sequence:
>1824_bases ATGAACACGCTTAAAAAAAATAAATTTCAAATAACTATAAACAACAACCATAATAATTTACTTAATCCTTTCGGTAAAGC TATTCTGCGAGATCGATATCTTATGAAAGGTGAGGATTTTCAAGATTTATTTGCACGAGTTTCCAGTTATTATGCCGAAA ATAAGCAGCATGCTCAGAAGCTATATGAATATATGAGTAAAATGTGGTTTATGCCGGCAACACCAATCTTAAGTAACGGC GGAACGGATAGAGGGCTTCCTATTTCATGCTTCTTGAATGAGACCGATGACAGCTTAGACGATATAGTAAATCTATGGAC GGAAAATGTTTGGCTTGCTGCACGCGGCGGTGGGATTGGAAGTTATTGGGGTAATGTTCGTTCTATTAATGAAGGGATTC GTGATAAAGGTCATTCATCCGGTATTATACCGTTTATTAAAGTAATGGATTCTATGACTCTCGCTATTTCGCAAGGTTCT ATTAGACGAGGTTCATCGGCTGTATATTTGCCTATTAATCATCCTGAAATCGAAGAATTTATTGATATAAGACGTCCGAC AGGTGGGGATGTTAACCGTAAAGCTCTTAATATTCATCATGGTATAGCGATTACCGATGAATTTATGAAAGCAGTTGAAA ACAATACGGACTTTGACCTTATTAGTCCTGCTACCAAAAAAGTCGTAAATAAAATTAGAGCAAGAGACTTATGGGTTAAG TTATTAACTACTAGAATAGAAACGGGTGAGCCTTACTTGTTATTTATCGATAGTGTTAATAAATCTATCCCTGAGCATCA TAAAAAATTAGGGCTTCAAGTTAAAATGTCCAATCTTTGTAGCGAAATTACATTGCCGACTGGAATTGATCATTTAGGAA AGTCAAGAACGGCCGTTTGCTGCCTTGCTTCTTTAAATTTAGAGTATTATGAAGAATGGAAAGATGATAAAGAATTTATC TATTCTATTATGTTGTTCCTTGATAATGTTTTAGAAGACTTTATCAATAAAGCACCAAATACGATGGCAAGAGCTAAATA TTCGGCTTTGCGTGAGCGAAGCGTTGGACTTGGCGTAATGGGCTTCCACTCATTTTTGCAAATAAAAAAAGTACCGATAG AATCGGTGATGGCAAAAGTTTGGAATAAAAAAATATTTGAATATATATCTGCTGAAGCTGATAAAGCCTCAATAGAAATC GGTAAAGAAAAAGGAGCATGTCCTGATGCTCTAGATGCAGGAAGTAATGAACGATTTAGCAATAAAACCGCAATAGCACC CACAGCCTCAATTTCAGTAATAGCAGGTAATGCATCACCAGGAATAGAGCCGTTTGCTGCTAATAGCTTTGTACAAAAGA CTTTAACCGGTTCTTTTAATGTGCGTAACAAACATTTAGAAAAGTTATTAGAAGAGAAAGGATTTAATAATGACCAAGTT TGGTCTTCGATTGCAACACATGAAGGATCAGTGCAACATTTAACATTTTTATCCGAAGCAGAAAAACAGGTTTTTAAAAC CGCTTACGAAATTGATCAAAATTGGTTAATTGAACTAGCAAGCGATCGTACTCCTTACATTACGCAAGCACAATCTTTAA ACATCTTTGTACCAGGTAATGTTAGTAAGAAATATTTAAATAATATTCATTTTAAAGCATGGAAGAAAGGAGTAAAAAGT TTATATTATTGTAGATCGACATCAATACAGCGAGCCGATAAAGTGTCGCATGACATATTAAAAGCCGATTTTAAAGATTT AGAGAAACAAAACGATAAGCTAACAGAAGCCGGTAATTACGAAGAATGCTTGTCTTGCCAGTAA
Upstream 100 bases:
>100_bases TCTCGTGTCTACTTAAGTGAAGATTATATACACTAAATATGGTGTCATTTTTTCAAAATAAGCATTATGAATAACGCCTA CAGCCCCATTAGTACCTATA
Downstream 100 bases:
>100_bases TAGTGGTTAATGTTGTTTCTAGTTAAAAGCTCATGGGATTAACTTAAGAATCGATGCCATTCCTGCGCAAGCATGAATCC AGTAAAACATAAAAAACTTA
Product: ribonucleotide-diphosphate reductase subunit alpha
Products: NA
Alternate protein names: Ribonucleotide reductase [H]
Number of amino acids: Translated: 607; Mature: 607
Protein sequence:
>607_residues MNTLKKNKFQITINNNHNNLLNPFGKAILRDRYLMKGEDFQDLFARVSSYYAENKQHAQKLYEYMSKMWFMPATPILSNG GTDRGLPISCFLNETDDSLDDIVNLWTENVWLAARGGGIGSYWGNVRSINEGIRDKGHSSGIIPFIKVMDSMTLAISQGS IRRGSSAVYLPINHPEIEEFIDIRRPTGGDVNRKALNIHHGIAITDEFMKAVENNTDFDLISPATKKVVNKIRARDLWVK LLTTRIETGEPYLLFIDSVNKSIPEHHKKLGLQVKMSNLCSEITLPTGIDHLGKSRTAVCCLASLNLEYYEEWKDDKEFI YSIMLFLDNVLEDFINKAPNTMARAKYSALRERSVGLGVMGFHSFLQIKKVPIESVMAKVWNKKIFEYISAEADKASIEI GKEKGACPDALDAGSNERFSNKTAIAPTASISVIAGNASPGIEPFAANSFVQKTLTGSFNVRNKHLEKLLEEKGFNNDQV WSSIATHEGSVQHLTFLSEAEKQVFKTAYEIDQNWLIELASDRTPYITQAQSLNIFVPGNVSKKYLNNIHFKAWKKGVKS LYYCRSTSIQRADKVSHDILKADFKDLEKQNDKLTEAGNYEECLSCQ
Sequences:
>Translated_607_residues MNTLKKNKFQITINNNHNNLLNPFGKAILRDRYLMKGEDFQDLFARVSSYYAENKQHAQKLYEYMSKMWFMPATPILSNG GTDRGLPISCFLNETDDSLDDIVNLWTENVWLAARGGGIGSYWGNVRSINEGIRDKGHSSGIIPFIKVMDSMTLAISQGS IRRGSSAVYLPINHPEIEEFIDIRRPTGGDVNRKALNIHHGIAITDEFMKAVENNTDFDLISPATKKVVNKIRARDLWVK LLTTRIETGEPYLLFIDSVNKSIPEHHKKLGLQVKMSNLCSEITLPTGIDHLGKSRTAVCCLASLNLEYYEEWKDDKEFI YSIMLFLDNVLEDFINKAPNTMARAKYSALRERSVGLGVMGFHSFLQIKKVPIESVMAKVWNKKIFEYISAEADKASIEI GKEKGACPDALDAGSNERFSNKTAIAPTASISVIAGNASPGIEPFAANSFVQKTLTGSFNVRNKHLEKLLEEKGFNNDQV WSSIATHEGSVQHLTFLSEAEKQVFKTAYEIDQNWLIELASDRTPYITQAQSLNIFVPGNVSKKYLNNIHFKAWKKGVKS LYYCRSTSIQRADKVSHDILKADFKDLEKQNDKLTEAGNYEECLSCQ >Mature_607_residues MNTLKKNKFQITINNNHNNLLNPFGKAILRDRYLMKGEDFQDLFARVSSYYAENKQHAQKLYEYMSKMWFMPATPILSNG GTDRGLPISCFLNETDDSLDDIVNLWTENVWLAARGGGIGSYWGNVRSINEGIRDKGHSSGIIPFIKVMDSMTLAISQGS IRRGSSAVYLPINHPEIEEFIDIRRPTGGDVNRKALNIHHGIAITDEFMKAVENNTDFDLISPATKKVVNKIRARDLWVK LLTTRIETGEPYLLFIDSVNKSIPEHHKKLGLQVKMSNLCSEITLPTGIDHLGKSRTAVCCLASLNLEYYEEWKDDKEFI YSIMLFLDNVLEDFINKAPNTMARAKYSALRERSVGLGVMGFHSFLQIKKVPIESVMAKVWNKKIFEYISAEADKASIEI GKEKGACPDALDAGSNERFSNKTAIAPTASISVIAGNASPGIEPFAANSFVQKTLTGSFNVRNKHLEKLLEEKGFNNDQV WSSIATHEGSVQHLTFLSEAEKQVFKTAYEIDQNWLIELASDRTPYITQAQSLNIFVPGNVSKKYLNNIHFKAWKKGVKS LYYCRSTSIQRADKVSHDILKADFKDLEKQNDKLTEAGNYEECLSCQ
Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]
COG id: COG0209
COG function: function code F; Ribonucleotide reductase, alpha subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 3 ATP-cone domains [H]
Homologues:
Organism=Homo sapiens, GI4506749, Length=614, Percent_Identity=31.2703583061889, Blast_Score=254, Evalue=1e-67, Organism=Escherichia coli, GI1789030, Length=593, Percent_Identity=25.6323777403035, Blast_Score=158, Evalue=1e-39, Organism=Escherichia coli, GI2367133, Length=573, Percent_Identity=25.130890052356, Blast_Score=119, Evalue=6e-28, Organism=Caenorhabditis elegans, GI17555242, Length=650, Percent_Identity=30.1538461538462, Blast_Score=241, Evalue=1e-63, Organism=Saccharomyces cerevisiae, GI6320914, Length=646, Percent_Identity=29.1021671826625, Blast_Score=234, Evalue=4e-62, Organism=Saccharomyces cerevisiae, GI6322123, Length=630, Percent_Identity=29.5238095238095, Blast_Score=233, Evalue=6e-62, Organism=Drosophila melanogaster, GI17352481, Length=638, Percent_Identity=29.7805642633229, Blast_Score=232, Evalue=7e-61,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR005144 - InterPro: IPR013346 - InterPro: IPR013509 - InterPro: IPR000788 - InterPro: IPR008926 [H]
Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]
EC number: =1.17.4.1 [H]
Molecular weight: Translated: 68443; Mature: 68443
Theoretical pI: Translated: 8.02; Mature: 8.02
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 3.5 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 2.1 %Met (Mature Protein) 3.5 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNTLKKNKFQITINNNHNNLLNPFGKAILRDRYLMKGEDFQDLFARVSSYYAENKQHAQK CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHH LYEYMSKMWFMPATPILSNGGTDRGLPISCFLNETDDSLDDIVNLWTENVWLAARGGGIG HHHHHHHHCCCCCCCHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCH SYWGNVRSINEGIRDKGHSSGIIPFIKVMDSMTLAISQGSIRRGSSAVYLPINHPEIEEF HHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCEEEEECCCCCHHHH IDIRRPTGGDVNRKALNIHHGIAITDEFMKAVENNTDFDLISPATKKVVNKIRARDLWVK HHCCCCCCCCCCCCEEEEECCEEEHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHH LLTTRIETGEPYLLFIDSVNKSIPEHHKKLGLQVKMSNLCSEITLPTGIDHLGKSRTAVC HHHHHHCCCCCEEEEEECCCCCCHHHHHHHCCEEEHHHHHHHCCCCCCHHHHCCCCHHEE CLASLNLEYYEEWKDDKEFIYSIMLFLDNVLEDFINKAPNTMARAKYSALRERSVGLGVM HHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHH GFHSFLQIKKVPIESVMAKVWNKKIFEYISAEADKASIEIGKEKGACPDALDAGSNERFS HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHCCCCCCCCC NKTAIAPTASISVIAGNASPGIEPFAANSFVQKTLTGSFNVRNKHLEKLLEEKGFNNDQV CCCEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHH WSSIATHEGSVQHLTFLSEAEKQVFKTAYEIDQNWLIELASDRTPYITQAQSLNIFVPGN HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCEECCCEEEEEECCC VSKKYLNNIHFKAWKKGVKSLYYCRSTSIQRADKVSHDILKADFKDLEKQNDKLTEAGNY CCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCH EECLSCQ HHHCCCC >Mature Secondary Structure MNTLKKNKFQITINNNHNNLLNPFGKAILRDRYLMKGEDFQDLFARVSSYYAENKQHAQK CCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHH LYEYMSKMWFMPATPILSNGGTDRGLPISCFLNETDDSLDDIVNLWTENVWLAARGGGIG HHHHHHHHCCCCCCCHHCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCEEEEECCCCCH SYWGNVRSINEGIRDKGHSSGIIPFIKVMDSMTLAISQGSIRRGSSAVYLPINHPEIEEF HHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHEEEECCCCCCCCCEEEEECCCCCHHHH IDIRRPTGGDVNRKALNIHHGIAITDEFMKAVENNTDFDLISPATKKVVNKIRARDLWVK HHCCCCCCCCCCCCEEEEECCEEEHHHHHHHHCCCCCCCEECHHHHHHHHHHHHHHHHHH LLTTRIETGEPYLLFIDSVNKSIPEHHKKLGLQVKMSNLCSEITLPTGIDHLGKSRTAVC HHHHHHCCCCCEEEEEECCCCCCHHHHHHHCCEEEHHHHHHHCCCCCCHHHHCCCCHHEE CLASLNLEYYEEWKDDKEFIYSIMLFLDNVLEDFINKAPNTMARAKYSALRERSVGLGVM HHHHCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCHH GFHSFLQIKKVPIESVMAKVWNKKIFEYISAEADKASIEIGKEKGACPDALDAGSNERFS HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCHHCCCCCCCCC NKTAIAPTASISVIAGNASPGIEPFAANSFVQKTLTGSFNVRNKHLEKLLEEKGFNNDQV CCCEECCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHH WSSIATHEGSVQHLTFLSEAEKQVFKTAYEIDQNWLIELASDRTPYITQAQSLNIFVPGN HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHEECCCCCCCEECCCEEEEEECCC VSKKYLNNIHFKAWKKGVKSLYYCRSTSIQRADKVSHDILKADFKDLEKQNDKLTEAGNY CCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCCH EECLSCQ HHHCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 10192388; 10684935; 10871362 [H]