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The map label for this gene is yuxL [H]

Identifier: 157825720

GI number: 157825720

Start: 588753

End: 590789

Strand: Reverse

Name: yuxL [H]

Synonym: A1C_03230

Alternate gene names: 157825720

Gene position: 590789-588753 (Counterclockwise)

Preceding gene: 157825721

Following gene: 157825719

Centisome position: 47.99

GC content: 33.97

Gene sequence:

>2037_bases
ATGAGTAAAATTTGCTATATTATAGGCACTATATTAATAATAAGTGTCGGTATTTTTATGTTTCAAAAGCAAACAATAAC
GGATAACAATCAAATAATCCCAAGAAAAGTTTTATTCGGTAACCCTGATAAAGCAAGGGTTTCTCTAACCCACGACGGTA
AATATATTCTGTATGTTGCACCGCAAGATGGTGTCTTAAATATTTGGCTAGCACCATCAGATGATATTAGTAAAGCAGAA
GCCATCACCAATGATAAAGGACGTGGTATTTGGTCTTATACTAAAGCTTATAATAATAAAAATATTTTATATACACAAGA
TTTTAACGGTGATGAAAATGACCGAATTTATAGCTATAACATAGAGACCAAAGAGACAAAATTACTTACTCCTGAAAGAG
GCGTTAAAGCCGGTATAGCTGGAGTGAGCTATAAAAAGCCAAATGAGATATTAATATATTTAAATGAGCGTAATCCTGAA
TATTTTGATATTTATAAATTAAATCTAGATACTTTAGAAAAAGAACTCATTTATAAAAATGATAGATTTACTGATTATGT
AACTGATGAAAATTTAAATTTAAGATTCGGTAATTTACTAGATAAAGATGGAGCCGTTGAATATTATGAATTAAAAGACG
GAGCATCTAAATTATATACTAAAATCTCAATGGAGGATTCTTTCAATACTTCTATACTAGGTTTTGATGCTAGCGGCGAA
ATTCTTTATATGCTTGATGGGCGTAACCGCAATACTTCAGCACTTAAGGCGATAACACTCGCTACAGATAACGAAGTAAT
ATTAGCTGAAGATCCAAAAGCCGATATCGGTTTGTTTACTATGCATCCTACCAAACACACTCCGCAAGCAGTATCCATAG
ACTATGATAGAGTTTCATATAAAATATTAGATAAAGAGATTGAAGATGATATGAAATATCTGCAGACTCTTGATCGTGGT
GATTTAATTATCAATAGTAGGACGTTAGACGACAAAACTTGGATCGTTGCTTATATGGCTGATAATGCACCGGTGAAATA
TTATAAATATGATAGGGCAAATAAAAAAGCCGAATTTTTATTTACTAATCGCAAAGAACTTGAGCAATATAGCCTTGCTA
AGATGATACCGGTAATTATCAAGTCACGTGACGGGCTTGATTTAGTTAGCTATATCACTTTTCCCAATGATGTAAAGCTT
GATGAAAATAATATTCCTGATAAAAAAGTACCGCTAATAATTAATGTTCATGGCGGACCGTGGGCTCGTGATAGCTGGGG
ATACAATCCTGAGCATCAATGGCTTGCAAATCGTGGTTACGCAGTTTTAAGTATAAATTACCGTGGTTCTACCGGTTTTG
GGAAACATTTCTTAAACGCCGGTAATTTAGAATATGCCGGTAAAATGCACACCGATTTAATTGACGGTGTTAACTGGGCT
ATTAAAAATAATATAGTTGATTTTGACAAAGTTTGTATTATGGGCGGAAGTTATGGAGGTTATGCAACGCTTGTAGGTCT
TACCATGACCCCTGACATATTTGCTTGCGGTGTTGATGTTGTAGGTATGTCTAATTTATTAACTCATGTGCAATCTAAAG
CTCCTTATATTACACCATTGTTAAGTATATATAAAACACGTATAGGACCTTGGGATACTGAAGAAGAACAAGAGTTTTTA
AGAAAAAGATCACCGATTAATTTTGTTGATAATATCAAAAAGCCTTTATTTATAGCACAAGGTGCTCACGATGTGAGGGT
CGTACAGGCAGAATCAGAACAGATTGTAAACAGCATGAAAGCAAAGAATATATCGGTAGTTTATGCACTTTACAAAGATG
AAGGACATGGCTTTGCAAAACCAGGTAACAGAATCTCATATTACGCTCTTGCCGAACAGTTTTTAGCTAAGATTTTAAAA
GGAAGAGCAGAAGCAATAGGAGATGACTTAAAGAATGCTAATCTCATTCTGAATGATAAAGCAAAAATTAGTGGCGAGGA
AGCGGAAAAGATTATAGATAAAGCAATTGGGCATTGA

Upstream 100 bases:

>100_bases
GAGAGAGTATAGTTTTTGTCGTCCCGTGCCCATTATGTTATTCCCGCCTACGCTGAAATGACATAAAAAGAACATCAATT
TAAATAACAAACCATTAGTA

Downstream 100 bases:

>100_bases
TATCCTTGCGTCATTGCGAGCAGTCATAATCGAGCCATACATTAGTTAGGAATAACATTAGGTTCAGAATAATTTATTAG
CGTATTAATAATGCTACTTA

Product: acylamino-acid-releasing protein

Products: Hydrolyzed protein [C]

Alternate protein names: NA

Number of amino acids: Translated: 678; Mature: 677

Protein sequence:

>678_residues
MSKICYIIGTILIISVGIFMFQKQTITDNNQIIPRKVLFGNPDKARVSLTHDGKYILYVAPQDGVLNIWLAPSDDISKAE
AITNDKGRGIWSYTKAYNNKNILYTQDFNGDENDRIYSYNIETKETKLLTPERGVKAGIAGVSYKKPNEILIYLNERNPE
YFDIYKLNLDTLEKELIYKNDRFTDYVTDENLNLRFGNLLDKDGAVEYYELKDGASKLYTKISMEDSFNTSILGFDASGE
ILYMLDGRNRNTSALKAITLATDNEVILAEDPKADIGLFTMHPTKHTPQAVSIDYDRVSYKILDKEIEDDMKYLQTLDRG
DLIINSRTLDDKTWIVAYMADNAPVKYYKYDRANKKAEFLFTNRKELEQYSLAKMIPVIIKSRDGLDLVSYITFPNDVKL
DENNIPDKKVPLIINVHGGPWARDSWGYNPEHQWLANRGYAVLSINYRGSTGFGKHFLNAGNLEYAGKMHTDLIDGVNWA
IKNNIVDFDKVCIMGGSYGGYATLVGLTMTPDIFACGVDVVGMSNLLTHVQSKAPYITPLLSIYKTRIGPWDTEEEQEFL
RKRSPINFVDNIKKPLFIAQGAHDVRVVQAESEQIVNSMKAKNISVVYALYKDEGHGFAKPGNRISYYALAEQFLAKILK
GRAEAIGDDLKNANLILNDKAKISGEEAEKIIDKAIGH

Sequences:

>Translated_678_residues
MSKICYIIGTILIISVGIFMFQKQTITDNNQIIPRKVLFGNPDKARVSLTHDGKYILYVAPQDGVLNIWLAPSDDISKAE
AITNDKGRGIWSYTKAYNNKNILYTQDFNGDENDRIYSYNIETKETKLLTPERGVKAGIAGVSYKKPNEILIYLNERNPE
YFDIYKLNLDTLEKELIYKNDRFTDYVTDENLNLRFGNLLDKDGAVEYYELKDGASKLYTKISMEDSFNTSILGFDASGE
ILYMLDGRNRNTSALKAITLATDNEVILAEDPKADIGLFTMHPTKHTPQAVSIDYDRVSYKILDKEIEDDMKYLQTLDRG
DLIINSRTLDDKTWIVAYMADNAPVKYYKYDRANKKAEFLFTNRKELEQYSLAKMIPVIIKSRDGLDLVSYITFPNDVKL
DENNIPDKKVPLIINVHGGPWARDSWGYNPEHQWLANRGYAVLSINYRGSTGFGKHFLNAGNLEYAGKMHTDLIDGVNWA
IKNNIVDFDKVCIMGGSYGGYATLVGLTMTPDIFACGVDVVGMSNLLTHVQSKAPYITPLLSIYKTRIGPWDTEEEQEFL
RKRSPINFVDNIKKPLFIAQGAHDVRVVQAESEQIVNSMKAKNISVVYALYKDEGHGFAKPGNRISYYALAEQFLAKILK
GRAEAIGDDLKNANLILNDKAKISGEEAEKIIDKAIGH
>Mature_677_residues
SKICYIIGTILIISVGIFMFQKQTITDNNQIIPRKVLFGNPDKARVSLTHDGKYILYVAPQDGVLNIWLAPSDDISKAEA
ITNDKGRGIWSYTKAYNNKNILYTQDFNGDENDRIYSYNIETKETKLLTPERGVKAGIAGVSYKKPNEILIYLNERNPEY
FDIYKLNLDTLEKELIYKNDRFTDYVTDENLNLRFGNLLDKDGAVEYYELKDGASKLYTKISMEDSFNTSILGFDASGEI
LYMLDGRNRNTSALKAITLATDNEVILAEDPKADIGLFTMHPTKHTPQAVSIDYDRVSYKILDKEIEDDMKYLQTLDRGD
LIINSRTLDDKTWIVAYMADNAPVKYYKYDRANKKAEFLFTNRKELEQYSLAKMIPVIIKSRDGLDLVSYITFPNDVKLD
ENNIPDKKVPLIINVHGGPWARDSWGYNPEHQWLANRGYAVLSINYRGSTGFGKHFLNAGNLEYAGKMHTDLIDGVNWAI
KNNIVDFDKVCIMGGSYGGYATLVGLTMTPDIFACGVDVVGMSNLLTHVQSKAPYITPLLSIYKTRIGPWDTEEEQEFLR
KRSPINFVDNIKKPLFIAQGAHDVRVVQAESEQIVNSMKAKNISVVYALYKDEGHGFAKPGNRISYYALAEQFLAKILKG
RAEAIGDDLKNANLILNDKAKISGEEAEKIIDKAIGH

Specific function: Cleaves Peptide Bonds On The C-Terminal Side Of Lysyl And Argininyl Residues. [C]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI23510451, Length=244, Percent_Identity=27.8688524590164, Blast_Score=84, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI25144537, Length=659, Percent_Identity=36.1153262518968, Blast_Score=398, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI25144543, Length=537, Percent_Identity=35.9404096834264, Blast_Score=322, Evalue=5e-88,
Organism=Caenorhabditis elegans, GI25144540, Length=447, Percent_Identity=38.255033557047, Blast_Score=312, Evalue=4e-85,
Organism=Caenorhabditis elegans, GI17552908, Length=282, Percent_Identity=28.0141843971631, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25149159, Length=247, Percent_Identity=29.9595141700405, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011042
- InterPro:   IPR011659
- InterPro:   IPR001375 [H]

Pfam domain/function: PF07676 PD40; PF00326 Peptidase_S9 [H]

EC number: 3.4.21.83 [C]

Molecular weight: Translated: 76688; Mature: 76557

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKICYIIGTILIISVGIFMFQKQTITDNNQIIPRKVLFGNPDKARVSLTHDGKYILYVA
CCHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEECCCCCEEEEEEECCEEEEEEC
PQDGVLNIWLAPSDDISKAEAITNDKGRGIWSYTKAYNNKNILYTQDFNGDENDRIYSYN
CCCCEEEEEECCCCCCCHHHHHCCCCCCCEEEEHHHCCCCCEEEEECCCCCCCCEEEEEE
IETKETKLLTPERGVKAGIAGVSYKKPNEILIYLNERNPEYFDIYKLNLDTLEKELIYKN
CCCCCEEEECCCCCCHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEECHHHHHHHHHCCC
DRFTDYVTDENLNLRFGNLLDKDGAVEYYELKDGASKLYTKISMEDSFNTSILGFDASGE
CCCEEEECCCCCCEEECCCCCCCCCEEEEEECCCCHHHEEEEEECCCCCCEEEEECCCCC
ILYMLDGRNRNTSALKAITLATDNEVILAEDPKADIGLFTMHPTKHTPQAVSIDYDRVSY
EEEEEECCCCCCCCEEEEEEECCCCEEEECCCCCCEEEEEECCCCCCCCEEEEEHHHEEE
KILDKEIEDDMKYLQTLDRGDLIINSRTLDDKTWIVAYMADNAPVKYYKYDRANKKAEFL
EEHHHHHHHHHHHHHHCCCCCEEEECEECCCCEEEEEEEECCCCEEEEEECCCCCCEEEE
FTNRKELEQYSLAKMIPVIIKSRDGLDLVSYITFPNDVKLDENNIPDKKVPLIINVHGGP
ECCHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCCCEEECCCCCCCCCCCEEEEECCCC
WARDSWGYNPEHQWLANRGYAVLSINYRGSTGFGKHFLNAGNLEYAGKMHTDLIDGVNWA
CCCCCCCCCCCHHHHHCCCEEEEEEEECCCCCCHHHHCCCCCEEECCCHHHHHHHCCCEE
IKNNIVDFDKVCIMGGSYGGYATLVGLTMTPDIFACGVDVVGMSNLLTHVQSKAPYITPL
EECCCCCCCCEEEECCCCCCEEEEEEEEECCCCEECCCCHHHHHHHHHHHHHCCCHHHHH
LSIYKTRIGPWDTEEEQEFLRKRSPINFVDNIKKPLFIAQGAHDVRVVQAESEQIVNSMK
HHHHHHCCCCCCCHHHHHHHHHCCCCCHHHCCCCCEEEECCCCCEEEEECCHHHHHHHHH
AKNISVVYALYKDEGHGFAKPGNRISYYALAEQFLAKILKGRAEAIGDDLKNANLILNDK
CCCEEEEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCHHHHHCCCCCCCEEEEECC
AKISGEEAEKIIDKAIGH
CCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
SKICYIIGTILIISVGIFMFQKQTITDNNQIIPRKVLFGNPDKARVSLTHDGKYILYVA
CHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCEEEEECCCCCEEEEEEECCEEEEEEC
PQDGVLNIWLAPSDDISKAEAITNDKGRGIWSYTKAYNNKNILYTQDFNGDENDRIYSYN
CCCCEEEEEECCCCCCCHHHHHCCCCCCCEEEEHHHCCCCCEEEEECCCCCCCCEEEEEE
IETKETKLLTPERGVKAGIAGVSYKKPNEILIYLNERNPEYFDIYKLNLDTLEKELIYKN
CCCCCEEEECCCCCCHHCCCCCCCCCCCEEEEEEECCCCCEEEEEEECHHHHHHHHHCCC
DRFTDYVTDENLNLRFGNLLDKDGAVEYYELKDGASKLYTKISMEDSFNTSILGFDASGE
CCCEEEECCCCCCEEECCCCCCCCCEEEEEECCCCHHHEEEEEECCCCCCEEEEECCCCC
ILYMLDGRNRNTSALKAITLATDNEVILAEDPKADIGLFTMHPTKHTPQAVSIDYDRVSY
EEEEEECCCCCCCCEEEEEEECCCCEEEECCCCCCEEEEEECCCCCCCCEEEEEHHHEEE
KILDKEIEDDMKYLQTLDRGDLIINSRTLDDKTWIVAYMADNAPVKYYKYDRANKKAEFL
EEHHHHHHHHHHHHHHCCCCCEEEECEECCCCEEEEEEEECCCCEEEEEECCCCCCEEEE
FTNRKELEQYSLAKMIPVIIKSRDGLDLVSYITFPNDVKLDENNIPDKKVPLIINVHGGP
ECCHHHHHHHHHHHHHHHEEECCCCCEEEEEEECCCCEEECCCCCCCCCCCEEEEECCCC
WARDSWGYNPEHQWLANRGYAVLSINYRGSTGFGKHFLNAGNLEYAGKMHTDLIDGVNWA
CCCCCCCCCCCHHHHHCCCEEEEEEEECCCCCCHHHHCCCCCEEECCCHHHHHHHCCCEE
IKNNIVDFDKVCIMGGSYGGYATLVGLTMTPDIFACGVDVVGMSNLLTHVQSKAPYITPL
EECCCCCCCCEEEECCCCCCEEEEEEEEECCCCEECCCCHHHHHHHHHHHHHCCCHHHHH
LSIYKTRIGPWDTEEEQEFLRKRSPINFVDNIKKPLFIAQGAHDVRVVQAESEQIVNSMK
HHHHHHCCCCCCCHHHHHHHHHCCCCCHHHCCCCCEEEECCCCCEEEEECCHHHHHHHHH
AKNISVVYALYKDEGHGFAKPGNRISYYALAEQFLAKILKGRAEAIGDDLKNANLILNDK
CCCEEEEEEEEECCCCCCCCCCCCEEHHHHHHHHHHHHHHCHHHHHCCCCCCCEEEEECC
AKISGEEAEKIIDKAIGH
CCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+ [C]

Kcat value (1/min): 11820 [C]

Specific activity: NA

Km value (mM): 0.92 {benzoyl-Lys} 0.6 {N-benzoyl-Arg} 0.23 {tosyl-Arg} 0.5 {benzoyl-Arg} 0.48 {benzoyl-Arg} 0.25 {benzoyl-Arg} 0.33 {N-benzyloxycarbonyl-Lys} 0.31 {N-benzyloxycarbonyl-Lys} 80 {acetyl-tyrosine} 0.47 {tosyl-Lys-methyl} [C]

Substrates: Protein; H2O [C]

Specific reaction: Protein + H2O = hydrolyzed protein [C]

General reaction: Peptide bond hydrolysis [C]

Inhibitor: Antipain; Aromaticamidines; Benzamidine; Co2+; DFP; Fe2+; Hg2+; L-Arginine; Leupeptin sulfhydryl agents, trypsin inhibitors, 1, 10-phenanthroline; p-Aminobenzamidine; Tosyl -Leuchloromethyl ketone; Zn2+ [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377; 3098560 [H]