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The map label for this gene is maeB [C]

Identifier: 157825636

GI number: 157825636

Start: 501203

End: 503506

Strand: Direct

Name: maeB [C]

Synonym: A1C_02765

Alternate gene names: 157825636

Gene position: 501203-503506 (Clockwise)

Preceding gene: 157825635

Following gene: 157825637

Centisome position: 40.71

GC content: 35.55

Gene sequence:

>2304_bases
ATGGATGAAATGAATAGAATAAATTATGCTGAGGCCCTTGAATATCATGAAAAAGATAAGCCTGGTAAAATTGCTATTAC
TGCTACAAAGTCTTTAGTTACTCAGCAAGATTTATCGCTTGCTTATTCGCCAGGTGTTGCAGCTCCTTGCCTTGAAATTG
CTAAAAATTTAGAGGATGTATATAAATATACCGCTCGTGGTAATTTAGTTGCCGTAATCTCTAACGGTACTGCAGTACTT
GGGCTTGGTAATTTAGGAGCGGCTGCTTCAAAACCGGTAATGGAAGGTAAAGCCGTACTATTCAAAAAATTTGCCGATAT
TGATGCAATTGACTTGGAAGTGAATACGGAAGACCCTGAAGAATTTATTAATGCTGTAAAATATCTTAGTTATAGCTTCG
GCGGTATTAACCTCGAAGATATTAAAGCTCCTGAATGTTTTATTATAGAAGAAAAATTAAAATCTTTAATGGATATACCA
GTCTTTCATGACGATCAGCATGGAACGGCGATTATTACCGCTGCAGGGCTAATAAATGCAGCATATCTTACTAATCGCAA
GCTTGAAGATCTAAAAATAGTAGTAAATGGAGCAGGGGCCGCTGCTATTGCTTGCATTGATTTATTAATTGCTCTTGGAG
CCGATAAATCAAAGATTATTTTATGTGATACTAAAGGTGTGGTGTACAAAGGACGCCTAGAAGGTATGAATAAATGGAAA
GAGCTATATGCAAGCGATACCAAGTTTAGAACTTTAGCGGAAAGCTTAAATAATGCGGATGTATTTATAGGGTTATCGGT
AAAAGGGGTGGTAACTAAAGAGATGGTGAAAAGGATGGCAAATAATCCGATTATTTTTGCTATGGCTAACCCTGATCCTG
AAATTACTCCTGAAGATATAAAGTTTGTACGAGATGATGCAATTATAGCAACAGGGCGATCTGATTATAATAATCAGATT
AATAATGTTATGGGATTTCCTTATATTTTTAGAGGAGCATTAGACGTAAGAGCCACGACCATTAATATGGAAATGAAAAT
AGCTGCAGCAAAAGCTATTGCAGATTTAGCACGTAGACCTGTACCGGAAGAGGTATCTAAAGCTTACTCAGGGCGTAAGA
TGGTTTTTTGTAAGGAATATATTATTCCCGTACCGTTTGATCCTCGTTTAATTACCGTAGTAGCAGCGGCAGTTGCTGTT
GCTGCAATAGAAAGCGGTGTTGCTAAGGTTAAAGATTTGAGTATAGGTAAATATAGGAAAGAATTGGGTAGTAGATTAAA
CCCTACTGCTAACTATATGAATTTCTTAGCTGAAAAAATTCATAATGCACCGCTTAAGCGGATTGTTTTTGCTGAAGGTG
AAGAAGAAGAAGTCATTTCTGCCGCCCTTATGATGCGAGACGAGAAATATGGTCATCCGATTATAATCGGTCGTGTTGAG
CGGATTGAGGCTACGTTAAAAAAGATAGGTCAATATGTTAGCTTAGACGGAATTCAAATAATGAATGCATCTTTAACTGA
TAGTTTAGAGAAATATATTGATTATTTATATAAAAGACTTCAGAGAAAAGGCTATTTATATCGTGATTGTGCTAAACTTG
TTGAAACAGATAAGGATATTTTTGCTGCTTGTATTGTAGCGTGCGGTGACGGTGATGCTCTTTTAACCGGTGTTACTAAA
AGCTATATAGATAGTTTAGAGAATATCATGAAAGTAATTTCGCCAAAACATAATCGTAGAATCCTTGGCTATTCAATTAT
GATTGCTAAAGACAATAATATTATTATTTCTGATAATTGTATTACTGCATATCCAAACAGCTTAGAGCTTGCTCAAATCG
CAACACAAACTGCAGAAATTGCTAAAAATATGGGTATTACCCCAAGAGTTGCATTTCTTTCTTGTTCCAGCTTCGGTAAT
GCTTCTAAGGCAACAACAGCTCGTATTTGTGAAGCAGTAAATATACTAGATAATTTTAGTAAAGACAAAAAAGAGCTGAG
CGGCATGAAAGTAGATTTTGAATATGATGGAGAAATGTCGGTTAAGGTAGCTTTAGACGGTGATTTACGTAAATTATATA
AATTTTGTAGATTATCAGGATCTGCAAATATATTAATTATGCCTGGTTTAAATTCAGCGTCTATTTCTACTGAATTATTA
CAAGAATTTTCATCCAATAGCTTCATAGGTCCTATAACAAACGGTTTTGAAAAACCCGTTCAAATACTTCAAGCTACAGC
CACAGCTAATGAAATACTAAAAATAGCAACTTTTGCTTGCGTTGAGGCTATAAAAGAGGTTTAG

Upstream 100 bases:

>100_bases
CTTGATCTCGGTATCTCAGGACGTAGCCTGTGTGATACAAGACTATGTGATCAAGTGACGGGGTGACACAAGAAAAACAA
ACAAAACAGGAATTTCTAAA

Downstream 100 bases:

>100_bases
GAGGCTATCTATAAATAAATTTTAACCGATAATTTAATTTTTTTTGCTGCGAATGATAAGTTTTTTTTGCAATACGAGTA
ATTATTCTTGCAAAAATCTT

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 767; Mature: 767

Protein sequence:

>767_residues
MDEMNRINYAEALEYHEKDKPGKIAITATKSLVTQQDLSLAYSPGVAAPCLEIAKNLEDVYKYTARGNLVAVISNGTAVL
GLGNLGAAASKPVMEGKAVLFKKFADIDAIDLEVNTEDPEEFINAVKYLSYSFGGINLEDIKAPECFIIEEKLKSLMDIP
VFHDDQHGTAIITAAGLINAAYLTNRKLEDLKIVVNGAGAAAIACIDLLIALGADKSKIILCDTKGVVYKGRLEGMNKWK
ELYASDTKFRTLAESLNNADVFIGLSVKGVVTKEMVKRMANNPIIFAMANPDPEITPEDIKFVRDDAIIATGRSDYNNQI
NNVMGFPYIFRGALDVRATTINMEMKIAAAKAIADLARRPVPEEVSKAYSGRKMVFCKEYIIPVPFDPRLITVVAAAVAV
AAIESGVAKVKDLSIGKYRKELGSRLNPTANYMNFLAEKIHNAPLKRIVFAEGEEEEVISAALMMRDEKYGHPIIIGRVE
RIEATLKKIGQYVSLDGIQIMNASLTDSLEKYIDYLYKRLQRKGYLYRDCAKLVETDKDIFAACIVACGDGDALLTGVTK
SYIDSLENIMKVISPKHNRRILGYSIMIAKDNNIIISDNCITAYPNSLELAQIATQTAEIAKNMGITPRVAFLSCSSFGN
ASKATTARICEAVNILDNFSKDKKELSGMKVDFEYDGEMSVKVALDGDLRKLYKFCRLSGSANILIMPGLNSASISTELL
QEFSSNSFIGPITNGFEKPVQILQATATANEILKIATFACVEAIKEV

Sequences:

>Translated_767_residues
MDEMNRINYAEALEYHEKDKPGKIAITATKSLVTQQDLSLAYSPGVAAPCLEIAKNLEDVYKYTARGNLVAVISNGTAVL
GLGNLGAAASKPVMEGKAVLFKKFADIDAIDLEVNTEDPEEFINAVKYLSYSFGGINLEDIKAPECFIIEEKLKSLMDIP
VFHDDQHGTAIITAAGLINAAYLTNRKLEDLKIVVNGAGAAAIACIDLLIALGADKSKIILCDTKGVVYKGRLEGMNKWK
ELYASDTKFRTLAESLNNADVFIGLSVKGVVTKEMVKRMANNPIIFAMANPDPEITPEDIKFVRDDAIIATGRSDYNNQI
NNVMGFPYIFRGALDVRATTINMEMKIAAAKAIADLARRPVPEEVSKAYSGRKMVFCKEYIIPVPFDPRLITVVAAAVAV
AAIESGVAKVKDLSIGKYRKELGSRLNPTANYMNFLAEKIHNAPLKRIVFAEGEEEEVISAALMMRDEKYGHPIIIGRVE
RIEATLKKIGQYVSLDGIQIMNASLTDSLEKYIDYLYKRLQRKGYLYRDCAKLVETDKDIFAACIVACGDGDALLTGVTK
SYIDSLENIMKVISPKHNRRILGYSIMIAKDNNIIISDNCITAYPNSLELAQIATQTAEIAKNMGITPRVAFLSCSSFGN
ASKATTARICEAVNILDNFSKDKKELSGMKVDFEYDGEMSVKVALDGDLRKLYKFCRLSGSANILIMPGLNSASISTELL
QEFSSNSFIGPITNGFEKPVQILQATATANEILKIATFACVEAIKEV
>Mature_767_residues
MDEMNRINYAEALEYHEKDKPGKIAITATKSLVTQQDLSLAYSPGVAAPCLEIAKNLEDVYKYTARGNLVAVISNGTAVL
GLGNLGAAASKPVMEGKAVLFKKFADIDAIDLEVNTEDPEEFINAVKYLSYSFGGINLEDIKAPECFIIEEKLKSLMDIP
VFHDDQHGTAIITAAGLINAAYLTNRKLEDLKIVVNGAGAAAIACIDLLIALGADKSKIILCDTKGVVYKGRLEGMNKWK
ELYASDTKFRTLAESLNNADVFIGLSVKGVVTKEMVKRMANNPIIFAMANPDPEITPEDIKFVRDDAIIATGRSDYNNQI
NNVMGFPYIFRGALDVRATTINMEMKIAAAKAIADLARRPVPEEVSKAYSGRKMVFCKEYIIPVPFDPRLITVVAAAVAV
AAIESGVAKVKDLSIGKYRKELGSRLNPTANYMNFLAEKIHNAPLKRIVFAEGEEEEVISAALMMRDEKYGHPIIIGRVE
RIEATLKKIGQYVSLDGIQIMNASLTDSLEKYIDYLYKRLQRKGYLYRDCAKLVETDKDIFAACIVACGDGDALLTGVTK
SYIDSLENIMKVISPKHNRRILGYSIMIAKDNNIIISDNCITAYPNSLELAQIATQTAEIAKNMGITPRVAFLSCSSFGN
ASKATTARICEAVNILDNFSKDKKELSGMKVDFEYDGEMSVKVALDGDLRKLYKFCRLSGSANILIMPGLNSASISTELL
QEFSSNSFIGPITNGFEKPVQILQATATANEILKIATFACVEAIKEV

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=351, Percent_Identity=28.2051282051282, Blast_Score=79, Evalue=2e-14,
Organism=Homo sapiens, GI62420882, Length=347, Percent_Identity=28.8184438040346, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI62420880, Length=347, Percent_Identity=28.8184438040346, Blast_Score=77, Evalue=6e-14,
Organism=Homo sapiens, GI239049447, Length=347, Percent_Identity=28.8184438040346, Blast_Score=77, Evalue=6e-14,
Organism=Escherichia coli, GI1788806, Length=756, Percent_Identity=44.973544973545, Blast_Score=618, Evalue=1e-178,
Organism=Escherichia coli, GI1788800, Length=325, Percent_Identity=23.3846153846154, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1788635, Length=352, Percent_Identity=23.2954545454545, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI87081919, Length=408, Percent_Identity=24.0196078431373, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17537199, Length=471, Percent_Identity=24.203821656051, Blast_Score=66, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322823, Length=267, Percent_Identity=31.4606741573034, Blast_Score=99, Evalue=3e-21,
Organism=Drosophila melanogaster, GI24646388, Length=412, Percent_Identity=27.1844660194175, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24646386, Length=412, Percent_Identity=27.1844660194175, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281362672, Length=359, Percent_Identity=28.9693593314763, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI281362674, Length=361, Percent_Identity=29.0858725761773, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI21356279, Length=359, Percent_Identity=28.9693593314763, Blast_Score=84, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 83964; Mature: 83964

Theoretical pI: Translated: 5.90; Mature: 5.90

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEMNRINYAEALEYHEKDKPGKIAITATKSLVTQQDLSLAYSPGVAAPCLEIAKNLEDV
CCCCHHCCHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHH
YKYTARGNLVAVISNGTAVLGLGNLGAAASKPVMEGKAVLFKKFADIDAIDLEVNTEDPE
HHHHCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHH
EFINAVKYLSYSFGGINLEDIKAPECFIIEEKLKSLMDIPVFHDDQHGTAIITAAGLINA
HHHHHHHHHHHCCCCCCHHHCCCCCEEEEHHHHHHHHCCCCEECCCCCCEEEEHHHHHHH
AYLTNRKLEDLKIVVNGAGAAAIACIDLLIALGADKSKIILCDTKGVVYKGRLEGMNKWK
HHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECHHHHHHHHH
ELYASDTKFRTLAESLNNADVFIGLSVKGVVTKEMVKRMANNPIIFAMANPDPEITPEDI
HHHCCCHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHH
KFVRDDAIIATGRSDYNNQINNVMGFPYIFRGALDVRATTINMEMKIAAAKAIADLARRP
HHEECCEEEEECCCCHHHHHHHCCCCCHHHHCCEEEEEEEEEEEEEHHHHHHHHHHHHCC
VPEEVSKAYSGRKMVFCKEYIIPVPFDPRLITVVAAAVAVAAIESGVAKVKDLSIGKYRK
CCHHHHHHHCCCEEEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ELGSRLNPTANYMNFLAEKIHNAPLKRIVFAEGEEEEVISAALMMRDEKYGHPIIIGRVE
HHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEHHH
RIEATLKKIGQYVSLDGIQIMNASLTDSLEKYIDYLYKRLQRKGYLYRDCAKLVETDKDI
HHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
FAACIVACGDGDALLTGVTKSYIDSLENIMKVISPKHNRRILGYSIMIAKDNNIIISDNC
HHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCEEEECCC
ITAYPNSLELAQIATQTAEIAKNMGITPRVAFLSCSSFGNASKATTARICEAVNILDNFS
EEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
KDKKELSGMKVDFEYDGEMSVKVALDGDLRKLYKFCRLSGSANILIMPGLNSASISTELL
HHHHHHCCCEEEEEECCCEEEEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHH
QEFSSNSFIGPITNGFEKPVQILQATATANEILKIATFACVEAIKEV
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDEMNRINYAEALEYHEKDKPGKIAITATKSLVTQQDLSLAYSPGVAAPCLEIAKNLEDV
CCCCHHCCHHHHHHHHCCCCCCEEEEEEHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHH
YKYTARGNLVAVISNGTAVLGLGNLGAAASKPVMEGKAVLFKKFADIDAIDLEVNTEDPE
HHHHCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEECCCCHH
EFINAVKYLSYSFGGINLEDIKAPECFIIEEKLKSLMDIPVFHDDQHGTAIITAAGLINA
HHHHHHHHHHHCCCCCCHHHCCCCCEEEEHHHHHHHHCCCCEECCCCCCEEEEHHHHHHH
AYLTNRKLEDLKIVVNGAGAAAIACIDLLIALGADKSKIILCDTKGVVYKGRLEGMNKWK
HHHHCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCEEEECHHHHHHHHH
ELYASDTKFRTLAESLNNADVFIGLSVKGVVTKEMVKRMANNPIIFAMANPDPEITPEDI
HHHCCCHHHHHHHHHCCCCEEEEEEEECHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHH
KFVRDDAIIATGRSDYNNQINNVMGFPYIFRGALDVRATTINMEMKIAAAKAIADLARRP
HHEECCEEEEECCCCHHHHHHHCCCCCHHHHCCEEEEEEEEEEEEEHHHHHHHHHHHHCC
VPEEVSKAYSGRKMVFCKEYIIPVPFDPRLITVVAAAVAVAAIESGVAKVKDLSIGKYRK
CCHHHHHHHCCCEEEEEECCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
ELGSRLNPTANYMNFLAEKIHNAPLKRIVFAEGEEEEVISAALMMRDEKYGHPIIIGRVE
HHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCEEEEHHH
RIEATLKKIGQYVSLDGIQIMNASLTDSLEKYIDYLYKRLQRKGYLYRDCAKLVETDKDI
HHHHHHHHHHHHCCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
FAACIVACGDGDALLTGVTKSYIDSLENIMKVISPKHNRRILGYSIMIAKDNNIIISDNC
HHHHHHEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEEEEEECCCEEEECCC
ITAYPNSLELAQIATQTAEIAKNMGITPRVAFLSCSSFGNASKATTARICEAVNILDNFS
EEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHCC
KDKKELSGMKVDFEYDGEMSVKVALDGDLRKLYKFCRLSGSANILIMPGLNSASISTELL
HHHHHHCCCEEEEEECCCEEEEEEECCCHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHH
QEFSSNSFIGPITNGFEKPVQILQATATANEILKIATFACVEAIKEV
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]