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The map label for this gene is tsaA [H]

Identifier: 157825578

GI number: 157825578

Start: 447151

End: 447753

Strand: Reverse

Name: tsaA [H]

Synonym: A1C_02455

Alternate gene names: 157825578

Gene position: 447753-447151 (Counterclockwise)

Preceding gene: 157825579

Following gene: 157825577

Centisome position: 36.37

GC content: 35.99

Gene sequence:

>603_bases
ATGTCAGTATTTGTCGGCAAAACTGCTCCGGATTTTACAGCTAAAGCTATTATGCCTAATAATAATATAGACGAAAAGTT
TAAACTTAGCGATTATGCTGCAGGGGATAATATAGTGTTATTTTTTTATCCCCTAGATTTTACTTTTGTTTGTCCATCGG
AAATTATAGCATTTCACAATAAGCTTGGCGAATTTACCGAAAGACGTACTAAAGTAGTAGCGGTTAGCGTTGATTCCCAT
TTTAGCCATTTAGCTTGGAAAAATACTCCGCATAATAAAGGCGGACTTGGACAAGTACAATTTCCAATGGTTTCCGATAT
AAAAAAGGATATTTCTTCAAAATATAACGTACTTAATGAAGACTGTTTTGCTTTGCGTGGAACTTTTTTAATTGATAAGG
ATTTCATAGTGCGTCACATGCTAGTTAACGACTTACCTATCGGTCGTGATATTAATTATACATTAAAAGTAATCGATGCT
TTAACTCATCATCAAAAACACGGTGAAGTTTGTCCTGCCGGCTGGCATAAAGGTGAGGAAGCAATTACCCCGTCACATGA
AGGTATAGCACATTATTTAAGCTCACATGCTGAGAAGCTGTAG

Upstream 100 bases:

>100_bases
AAAGAAAATAGATAAGTAACAATTTATAAAGATTTATTATTGTAATAATAATGAGTTTTATATATCATATCAGATTATTA
ATTAATAAAAGGTTATGAAT

Downstream 100 bases:

>100_bases
ATGATGTCATTCAGCGTGTATCGGTTTTTTCGTCATTACAAGAAGTATTATGCAGTAATTCGACGAAGCAATCCAGTAAA
AAATTCTGATTTACAGAATT

Product: thioredoxin peroxidase 1

Products: NA

Alternate protein names: 26 kDa antigen; Thioredoxin reductase [H]

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MSVFVGKTAPDFTAKAIMPNNNIDEKFKLSDYAAGDNIVLFFYPLDFTFVCPSEIIAFHNKLGEFTERRTKVVAVSVDSH
FSHLAWKNTPHNKGGLGQVQFPMVSDIKKDISSKYNVLNEDCFALRGTFLIDKDFIVRHMLVNDLPIGRDINYTLKVIDA
LTHHQKHGEVCPAGWHKGEEAITPSHEGIAHYLSSHAEKL

Sequences:

>Translated_200_residues
MSVFVGKTAPDFTAKAIMPNNNIDEKFKLSDYAAGDNIVLFFYPLDFTFVCPSEIIAFHNKLGEFTERRTKVVAVSVDSH
FSHLAWKNTPHNKGGLGQVQFPMVSDIKKDISSKYNVLNEDCFALRGTFLIDKDFIVRHMLVNDLPIGRDINYTLKVIDA
LTHHQKHGEVCPAGWHKGEEAITPSHEGIAHYLSSHAEKL
>Mature_199_residues
SVFVGKTAPDFTAKAIMPNNNIDEKFKLSDYAAGDNIVLFFYPLDFTFVCPSEIIAFHNKLGEFTERRTKVVAVSVDSHF
SHLAWKNTPHNKGGLGQVQFPMVSDIKKDISSKYNVLNEDCFALRGTFLIDKDFIVRHMLVNDLPIGRDINYTLKVIDAL
THHQKHGEVCPAGWHKGEEAITPSHEGIAHYLSSHAEKL

Specific function: Directly Reduces Organic Hydroperoxides In Its Reduced Dithiol Form. [C]

COG id: COG0450

COG function: function code O; Peroxiredoxin

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI4505591, Length=193, Percent_Identity=48.1865284974093, Blast_Score=194, Evalue=3e-50,
Organism=Homo sapiens, GI32455266, Length=193, Percent_Identity=48.1865284974093, Blast_Score=194, Evalue=3e-50,
Organism=Homo sapiens, GI32455264, Length=193, Percent_Identity=48.1865284974093, Blast_Score=194, Evalue=3e-50,
Organism=Homo sapiens, GI32189392, Length=193, Percent_Identity=47.1502590673575, Blast_Score=192, Evalue=2e-49,
Organism=Homo sapiens, GI5453549, Length=190, Percent_Identity=48.4210526315789, Blast_Score=186, Evalue=8e-48,
Organism=Homo sapiens, GI5802974, Length=190, Percent_Identity=47.8947368421053, Blast_Score=179, Evalue=1e-45,
Organism=Homo sapiens, GI32483377, Length=186, Percent_Identity=48.3870967741936, Blast_Score=179, Evalue=2e-45,
Organism=Homo sapiens, GI33188454, Length=82, Percent_Identity=56.0975609756098, Blast_Score=93, Evalue=2e-19,
Organism=Escherichia coli, GI1786822, Length=149, Percent_Identity=36.241610738255, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193204376, Length=194, Percent_Identity=47.4226804123711, Blast_Score=186, Evalue=7e-48,
Organism=Caenorhabditis elegans, GI32565831, Length=194, Percent_Identity=47.4226804123711, Blast_Score=186, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17554494, Length=181, Percent_Identity=48.0662983425414, Blast_Score=172, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI25153706, Length=189, Percent_Identity=23.8095238095238, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323613, Length=196, Percent_Identity=38.7755102040816, Blast_Score=151, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6320661, Length=196, Percent_Identity=38.265306122449, Blast_Score=143, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319407, Length=189, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656348, Length=193, Percent_Identity=46.6321243523316, Blast_Score=189, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17864676, Length=193, Percent_Identity=46.6321243523316, Blast_Score=189, Evalue=7e-49,
Organism=Drosophila melanogaster, GI17738015, Length=199, Percent_Identity=46.2311557788945, Blast_Score=185, Evalue=2e-47,
Organism=Drosophila melanogaster, GI17157991, Length=192, Percent_Identity=42.1875, Blast_Score=170, Evalue=5e-43,
Organism=Drosophila melanogaster, GI24641739, Length=192, Percent_Identity=42.1875, Blast_Score=170, Evalue=5e-43,
Organism=Drosophila melanogaster, GI21357347, Length=190, Percent_Identity=37.3684210526316, Blast_Score=151, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24581278, Length=181, Percent_Identity=27.6243093922652, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17975518, Length=190, Percent_Identity=28.9473684210526, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24652436, Length=194, Percent_Identity=29.8969072164948, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24652434, Length=190, Percent_Identity=28.9473684210526, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: 300 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2250 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 6040 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1580 Molecules/Cell In: Stationary-Phase

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000866
- InterPro:   IPR019479
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF10417 1-cysPrx_C; PF00578 AhpC-TSA [H]

EC number: =1.11.1.15 [H]

Molecular weight: Translated: 22499; Mature: 22368

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVFVGKTAPDFTAKAIMPNNNIDEKFKLSDYAAGDNIVLFFYPLDFTFVCPSEIIAFHN
CEEECCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCEEEEEECCCEEEECHHHHHHHHH
KLGEFTERRTKVVAVSVDSHFSHLAWKNTPHNKGGLGQVQFPMVSDIKKDISSKYNVLNE
HHHHHHHHCEEEEEEEECCCHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCC
DCFALRGTFLIDKDFIVRHMLVNDLPIGRDINYTLKVIDALTHHQKHGEVCPAGWHKGEE
CHHHHHCEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AITPSHEGIAHYLSSHAEKL
CCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SVFVGKTAPDFTAKAIMPNNNIDEKFKLSDYAAGDNIVLFFYPLDFTFVCPSEIIAFHN
EEECCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCEEEEEECCCEEEECHHHHHHHHH
KLGEFTERRTKVVAVSVDSHFSHLAWKNTPHNKGGLGQVQFPMVSDIKKDISSKYNVLNE
HHHHHHHHCEEEEEEEECCCHHHHHCCCCCCCCCCCCEEECHHHHHHHHHHHHHHHHCCC
DCFALRGTFLIDKDFIVRHMLVNDLPIGRDINYTLKVIDALTHHQKHGEVCPAGWHKGEE
CHHHHHCEEEECHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
AITPSHEGIAHYLSSHAEKL
CCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682; 1987145 [H]