Click here to switch to the map view.

The map label for this gene is dctA [H]

Identifier: 157825362

GI number: 157825362

Start: 238225

End: 239424

Strand: Reverse

Name: dctA [H]

Synonym: A1C_01280

Alternate gene names: 157825362

Gene position: 239424-238225 (Counterclockwise)

Preceding gene: 157825363

Following gene: 157825361

Centisome position: 19.45

GC content: 35.0

Gene sequence:

>1200_bases
ATGAAATTATGGCAAAAAGTTACCTTAGGGTTAAGCTTAGGTATTATATTTGGTATATACTTACCACAATATGTTAGTTA
TATTAAACCTATCGGTGACATTTTCTTACGTTTGATAAAAATGATCATTACCCCTTTAATTTTCTTTAGTTTGGTTTCAG
GTATCACTAGTATGAATGATACTTCTGCCCTGGGTAGAGTAGGAATGAAAGCGGTAGCTGCTTTTTTAGGTACTACTTTT
TTTGCTACGGTTTTTGGACTCACTGTTGCCTTAGTATTAAAGCCGGGAGTAGGCATACATATAGATTTTACCTATTCAGG
AATGACAAATAGAACTGCATTTAATATAGTTGATTTTTTTGTCAATATCGTCCCTGAGAATGCGGTTGGTGCTTTTGCAA
ACGGTGATGTCTTGCAAGTTGTATTTTTTGCTATTTTTGTTGGGATTACCTTAAACAAAATGAAATCTATCGGTGGGCCT
GTGACTGATTTAATTCATGTAATGTCAAAATTAATATTAAAAATGATATCGTTTGTTATTCAATTATCCCCTTACGGTGC
TTTTGCTTTAACTGGCTGGATTGTAGGGATGCAGGGAATTGAAGTCATGATTAGTTTATCAAAACTTGTTGTAGCGGTAG
TTGTGGCAATGACATTCCAATATTTAGTTTTTGGTTTACTTATATATGTATTTTGTCGTGTTTCACCTATACCGTTTTAT
AAGAAAAGTTTTGAGTATCAGATACTTGCTTTTTCTACTTCAAGTAGCAAAGCTACTCTTGCAACTACTATGCAAGTTTG
TCGTGCAAAGCTTGGAATTTCAGAGTCTAGTACTTCGTTCGTACTTCCGATAGGGGCATCAATTAATATGGACGGTTTTG
CTATAAATTTATCTCTTACTACTATATTCTTTGCTCAAATGATGGGAGTAACGCTTGCTCCTCACGACTATTTAGTAATT
ATTCTCACCTCAACACTTGGATCTATCGGCGGTGCAGGTATTCCAGGTGCCTCTTTGATAATGCTTCCAATGGTGCTTTC
TTCCGTTCACTTACCTATAGAGGGAGTCGCAATTATTGCCGGTATTGATCGAATACTTGATATGCTACGTACTACTATCA
ATATTACCGGCGATGCAACAATTACTATGATTATAGATAACAGCGAAAATACTTTAGATAAGGAAGTATATTTATCTTAA

Upstream 100 bases:

>100_bases
TGCCACAAATAATAAAAATAAGTATTGCGTATGGCTTTCAAAAGTACTTAGAGTGGATTGATCAAAATAGTAAATAAATT
TAAAATTAAGTAAGTAAATT

Downstream 100 bases:

>100_bases
TGAGGTCGGATATTCTTGACTATAGGCATCGTTGCATGGATACTAAAGGCCATCATTGCGAGGAAAAACTATAAGTTTCG
TCCACAATCTCAGGAGTTTC

Product: proton/sodium-glutamate symport protein

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 399; Mature: 399

Protein sequence:

>399_residues
MKLWQKVTLGLSLGIIFGIYLPQYVSYIKPIGDIFLRLIKMIITPLIFFSLVSGITSMNDTSALGRVGMKAVAAFLGTTF
FATVFGLTVALVLKPGVGIHIDFTYSGMTNRTAFNIVDFFVNIVPENAVGAFANGDVLQVVFFAIFVGITLNKMKSIGGP
VTDLIHVMSKLILKMISFVIQLSPYGAFALTGWIVGMQGIEVMISLSKLVVAVVVAMTFQYLVFGLLIYVFCRVSPIPFY
KKSFEYQILAFSTSSSKATLATTMQVCRAKLGISESSTSFVLPIGASINMDGFAINLSLTTIFFAQMMGVTLAPHDYLVI
ILTSTLGSIGGAGIPGASLIMLPMVLSSVHLPIEGVAIIAGIDRILDMLRTTINITGDATITMIIDNSENTLDKEVYLS

Sequences:

>Translated_399_residues
MKLWQKVTLGLSLGIIFGIYLPQYVSYIKPIGDIFLRLIKMIITPLIFFSLVSGITSMNDTSALGRVGMKAVAAFLGTTF
FATVFGLTVALVLKPGVGIHIDFTYSGMTNRTAFNIVDFFVNIVPENAVGAFANGDVLQVVFFAIFVGITLNKMKSIGGP
VTDLIHVMSKLILKMISFVIQLSPYGAFALTGWIVGMQGIEVMISLSKLVVAVVVAMTFQYLVFGLLIYVFCRVSPIPFY
KKSFEYQILAFSTSSSKATLATTMQVCRAKLGISESSTSFVLPIGASINMDGFAINLSLTTIFFAQMMGVTLAPHDYLVI
ILTSTLGSIGGAGIPGASLIMLPMVLSSVHLPIEGVAIIAGIDRILDMLRTTINITGDATITMIIDNSENTLDKEVYLS
>Mature_399_residues
MKLWQKVTLGLSLGIIFGIYLPQYVSYIKPIGDIFLRLIKMIITPLIFFSLVSGITSMNDTSALGRVGMKAVAAFLGTTF
FATVFGLTVALVLKPGVGIHIDFTYSGMTNRTAFNIVDFFVNIVPENAVGAFANGDVLQVVFFAIFVGITLNKMKSIGGP
VTDLIHVMSKLILKMISFVIQLSPYGAFALTGWIVGMQGIEVMISLSKLVVAVVVAMTFQYLVFGLLIYVFCRVSPIPFY
KKSFEYQILAFSTSSSKATLATTMQVCRAKLGISESSTSFVLPIGASINMDGFAINLSLTTIFFAQMMGVTLAPHDYLVI
ILTSTLGSIGGAGIPGASLIMLPMVLSSVHLPIEGVAIIAGIDRILDMLRTTINITGDATITMIIDNSENTLDKEVYLS

Specific function: Responsible for the transport of dicarboxylates such as succinate, fumarate, and malate from the periplasm across the membrane [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI40254478, Length=437, Percent_Identity=30.4347826086957, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI169790839, Length=430, Percent_Identity=29.7674418604651, Blast_Score=155, Evalue=6e-38,
Organism=Homo sapiens, GI21314632, Length=398, Percent_Identity=30.6532663316583, Blast_Score=155, Evalue=7e-38,
Organism=Homo sapiens, GI66773030, Length=444, Percent_Identity=27.7027027027027, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI5032093, Length=403, Percent_Identity=29.7766749379653, Blast_Score=136, Evalue=3e-32,
Organism=Homo sapiens, GI4827012, Length=286, Percent_Identity=33.2167832167832, Blast_Score=133, Evalue=4e-31,
Organism=Homo sapiens, GI194239697, Length=282, Percent_Identity=32.2695035460993, Blast_Score=128, Evalue=8e-30,
Organism=Homo sapiens, GI223468564, Length=255, Percent_Identity=29.4117647058824, Blast_Score=119, Evalue=4e-27,
Organism=Homo sapiens, GI223468566, Length=263, Percent_Identity=29.6577946768061, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI262359914, Length=391, Percent_Identity=27.6214833759591, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI301601644, Length=143, Percent_Identity=32.1678321678322, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1790514, Length=415, Percent_Identity=33.7349397590361, Blast_Score=211, Evalue=8e-56,
Organism=Escherichia coli, GI1789947, Length=404, Percent_Identity=30.9405940594059, Blast_Score=199, Evalue=2e-52,
Organism=Escherichia coli, GI1788024, Length=417, Percent_Identity=26.1390887290168, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1789473, Length=274, Percent_Identity=25.9124087591241, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71983106, Length=406, Percent_Identity=32.0197044334975, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71983099, Length=406, Percent_Identity=32.0197044334975, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI71996953, Length=442, Percent_Identity=30.0904977375566, Blast_Score=175, Evalue=4e-44,
Organism=Caenorhabditis elegans, GI17537407, Length=419, Percent_Identity=29.1169451073986, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI193206505, Length=389, Percent_Identity=28.5347043701799, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI193206654, Length=401, Percent_Identity=27.6807980049875, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI17541374, Length=392, Percent_Identity=28.0612244897959, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24583025, Length=416, Percent_Identity=29.3269230769231, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI17137668, Length=416, Percent_Identity=29.3269230769231, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24583023, Length=416, Percent_Identity=29.3269230769231, Blast_Score=157, Evalue=2e-38,
Organism=Drosophila melanogaster, GI281360481, Length=444, Percent_Identity=27.9279279279279, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI281360483, Length=444, Percent_Identity=27.9279279279279, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17137666, Length=444, Percent_Identity=27.9279279279279, Blast_Score=123, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 43009; Mature: 43009

Theoretical pI: Translated: 8.92; Mature: 8.92

Prosite motif: PS00713 NA_DICARBOXYL_SYMP_1 ; PS00308 LECTIN_LEGUME_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLWQKVTLGLSLGIIFGIYLPQYVSYIKPIGDIFLRLIKMIITPLIFFSLVSGITSMND
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TSALGRVGMKAVAAFLGTTFFATVFGLTVALVLKPGVGIHIDFTYSGMTNRTAFNIVDFF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHHH
VNIVPENAVGAFANGDVLQVVFFAIFVGITLNKMKSIGGPVTDLIHVMSKLILKMISFVI
HHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHH
QLSPYGAFALTGWIVGMQGIEVMISLSKLVVAVVVAMTFQYLVFGLLIYVFCRVSPIPFY
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCH
KKSFEYQILAFSTSSSKATLATTMQVCRAKLGISESSTSFVLPIGASINMDGFAINLSLT
HCCCCEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEEEECCEECCCCEEEEEHHH
TIFFAQMMGVTLAPHDYLVIILTSTLGSIGGAGIPGASLIMLPMVLSSVHLPIEGVAIIA
HHHHHHHHCCEECCCCEEEEEEEHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHH
GIDRILDMLRTTINITGDATITMIIDNSENTLDKEVYLS
HHHHHHHHHHHHEEECCCEEEEEEEECCCCCCCCCEECC
>Mature Secondary Structure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HHHHHHHHHHHHEEECCCEEEEEEEECCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA