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The map label for this gene is malP [H]

Identifier: 157372868

GI number: 157372868

Start: 5113957

End: 5116362

Strand: Reverse

Name: malP [H]

Synonym: Spro_4636

Alternate gene names: 157372868

Gene position: 5116362-5113957 (Counterclockwise)

Preceding gene: 157372873

Following gene: 157372867

Centisome position: 93.9

GC content: 57.15

Gene sequence:

>2406_bases
ATGTCACAGCCTATGCTTAAAAAGGATGCTTTTCTGGCGGCACTGACCCGTCAGTGGCAACAGTTTGGCCTCAGTTCTGC
ACAACAGATGACCCAGCACCAATGGTGGGAAGCAGTCAGCCGCGCACTGGCCGAGCAGCTTGCTGCACAACCGGCTCCGC
GTAAAAGCAGTAAGCCGCTGCGCCATGTGAACTACATTTCGATGGAGTTTCTGATTGGCCGCCTGACGGCCAACAACCTG
ATTAACCTGGGCTGGTACGACACCGTCGAACAGGCATTGGCGGAACAGGATATCAAGCTGGCGGACCTGCTGGAGCAGGA
AACCGATCCGGCGTTGGGCAATGGCGGGCTGGGGCGTCTGGCGGCCTGTTTCCTGGATTCGATGGCGACGGTGGAGCAAC
CGGCCACCGGCTACGGGCTAAATTACCAGTATGGGTTGTTCCGTCAGTCGTTTAGTGGCGGCCAGCAGCAAGAAGCCCCG
GACAACTGGCAGCGCGAAAGCTACCCGTGGTTCCGTCACAATGCGGCGCTGTCGGTGGATGTCGGCATCGGCGGCAAACT
GGAGAAACTGGCCGATGGCCGCGAGCTGTGGCGCCCTGAGTTTACCCTGCGCGGTGAAGCCTGGGATCTGCCGGTGTTGG
GCTTCCGTAATGGCGTGACCCAACCGCTACGCCTGTGGCAGGCCACCCATCAGCATCCGTTTGATCTGAGTGATTTCAAC
GATGGCAAATTCCTGCAGGCGGAGAAGCAGGGCGTGGAAGCGGCCAAGCTGACCAAGGTGCTGTATCCGAATGATAACCA
CCAGGCGGGCAAGCGCCTGCGCCTGATGCAGCAATACTTCCAGTGTGCCTGTTCGGTGGCGGATATTCTGCGTAAGCACC
ATCTGGCGGGCCGCAAGATTGAAGACCTGCCGAAGTACGAAGTGATCCAGCTCAATGATACCCACCCGACCATCGCCATT
CCGGAAATGCTGCGCATTCTGCTCGATGAGCACCAGTTGGACTGGGATGCCGCCTGGGCTATTACCAGCAAAACCTTCGC
CTACACCAACCATACCCTGATGCCGGAAGCGCTGGAGTGCTGGGATGAGAAGCTGGTGCGCAGCCTGCTGCCGCGTCATT
TCTCCATCATCAAGCAGATCAACGCCAACTTCAAAAAGCTGGTGGATAAACACTGGCCGGGCGACGACGCGGTGTGGGCC
AAGCTGGCAGTGCATCATGATAAACAGGTGCGGATGGCAAACCTGTGCGTGGTCAGCGGCTTCGCGGTCAACGGCGTGGC
ACAGTTGCACTCCGATCTGGTGGTGAAGGATCTGTTCCCGGAATACCACCAATTGTGGCCCAACAAATTCCATAACGTCA
CCAACGGCATTACACCACGCCGCTGGCTGAAACAGTGCAACCCGGCGCTGTCAGGGCTGATTGATGAAACGCTGAAGGTG
GAGTGGGCCAACGATCTCGACGCCCTGAAAGGGCTGGAGAAATACGCCGATGATGCGGCGTTCCGTCAGCGTTATCAGCA
AATCAAACGCGATAACAAAGTCGTGTTGGCAAACTATGTGCACGACGTGATGGGGCTGACGCTCAATCCGGACGCGATTT
TCGACTTGCAAATCAAACGCCTGCACGAATACAAACGCCAGCATTTGAACCTGCTGCACATTCTGTCGCTGTATCGCCAA
CTGCGCGATAACCCGCAGCTGGATATCGTGCCACGGGTGTTCCTGTTCGGCGCCAAAGCGGCACCGGGTTACTACCTGGC
CAAGAACATCATTTACGCGATCAACCAAGCAGCGGAAAAGATCAACAACGATCCGCTGGTGAAGGATCGATTGAAAGTGG
CGTTTATTCCTGACTACCGCGTGTCTGTCGCTGAACTGATGATCCCGGCGGCGGATATTTCCGAGCAGATCTCCACCGCC
GGCAAAGAAGCCTCCGGCACCGGCAATATGAAGCTGGCGTTGAACGGCGCGCTGACCGTCGGCACCCTGGACGGCGCCAA
CGTGGAAATCGCCGAGCAGGTGGGTGAAGACAATATCTTTATCTTCGGTAACACCGTGGATCAGGTGAAGGCGCTGCTGG
CGAAAGGCTATGACCCGCTCAGCTATCGCAAGAAAGACAAGCACCTGAAGGCGATCCTGGACGAACTGGCGAGCGGCGCA
TTCAGCCACGGCGACAAGCATGCTTTCGACATGATGCTGCACAGCCTGCTGGAAGGTGGCGACCCTTATTTGGTGCTGGC
GGACTTTGCTTCTTATTGCAAAGCTCAACAGCAGGTAGATGAACTCTATCGTGACCGTGATGAGTGGACGCGCCGTACTA
TTCTTAACACCGCGCGGGTCGGTATGTTCAGTTCGGATCGCTCGATCCGCGACTACCAACAGCGTATCTGGCAAGCCAAA
CGTTAA

Upstream 100 bases:

>100_bases
CTCCTCCCCAGCTAATCCCCAGGCGGGATGATGCCTTCACTCTTTCTCCCCGGCACGATAACGGTAATTTGACCCACTTA
CTGGATAGAGAGTTTTCCTT

Downstream 100 bases:

>100_bases
GGAGAGCGAATGGATCGCAAGGTCATCGATCAGGCGGCAGCTCAGGCGGGTATCGCTGCCGATTATATTAATGCCCACGG
TCAACAGCAGGCGATCGCTG

Product: glycogen/starch/alpha-glucan phosphorylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 801; Mature: 800

Protein sequence:

>801_residues
MSQPMLKKDAFLAALTRQWQQFGLSSAQQMTQHQWWEAVSRALAEQLAAQPAPRKSSKPLRHVNYISMEFLIGRLTANNL
INLGWYDTVEQALAEQDIKLADLLEQETDPALGNGGLGRLAACFLDSMATVEQPATGYGLNYQYGLFRQSFSGGQQQEAP
DNWQRESYPWFRHNAALSVDVGIGGKLEKLADGRELWRPEFTLRGEAWDLPVLGFRNGVTQPLRLWQATHQHPFDLSDFN
DGKFLQAEKQGVEAAKLTKVLYPNDNHQAGKRLRLMQQYFQCACSVADILRKHHLAGRKIEDLPKYEVIQLNDTHPTIAI
PEMLRILLDEHQLDWDAAWAITSKTFAYTNHTLMPEALECWDEKLVRSLLPRHFSIIKQINANFKKLVDKHWPGDDAVWA
KLAVHHDKQVRMANLCVVSGFAVNGVAQLHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWLKQCNPALSGLIDETLKV
EWANDLDALKGLEKYADDAAFRQRYQQIKRDNKVVLANYVHDVMGLTLNPDAIFDLQIKRLHEYKRQHLNLLHILSLYRQ
LRDNPQLDIVPRVFLFGAKAAPGYYLAKNIIYAINQAAEKINNDPLVKDRLKVAFIPDYRVSVAELMIPAADISEQISTA
GKEASGTGNMKLALNGALTVGTLDGANVEIAEQVGEDNIFIFGNTVDQVKALLAKGYDPLSYRKKDKHLKAILDELASGA
FSHGDKHAFDMMLHSLLEGGDPYLVLADFASYCKAQQQVDELYRDRDEWTRRTILNTARVGMFSSDRSIRDYQQRIWQAK
R

Sequences:

>Translated_801_residues
MSQPMLKKDAFLAALTRQWQQFGLSSAQQMTQHQWWEAVSRALAEQLAAQPAPRKSSKPLRHVNYISMEFLIGRLTANNL
INLGWYDTVEQALAEQDIKLADLLEQETDPALGNGGLGRLAACFLDSMATVEQPATGYGLNYQYGLFRQSFSGGQQQEAP
DNWQRESYPWFRHNAALSVDVGIGGKLEKLADGRELWRPEFTLRGEAWDLPVLGFRNGVTQPLRLWQATHQHPFDLSDFN
DGKFLQAEKQGVEAAKLTKVLYPNDNHQAGKRLRLMQQYFQCACSVADILRKHHLAGRKIEDLPKYEVIQLNDTHPTIAI
PEMLRILLDEHQLDWDAAWAITSKTFAYTNHTLMPEALECWDEKLVRSLLPRHFSIIKQINANFKKLVDKHWPGDDAVWA
KLAVHHDKQVRMANLCVVSGFAVNGVAQLHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWLKQCNPALSGLIDETLKV
EWANDLDALKGLEKYADDAAFRQRYQQIKRDNKVVLANYVHDVMGLTLNPDAIFDLQIKRLHEYKRQHLNLLHILSLYRQ
LRDNPQLDIVPRVFLFGAKAAPGYYLAKNIIYAINQAAEKINNDPLVKDRLKVAFIPDYRVSVAELMIPAADISEQISTA
GKEASGTGNMKLALNGALTVGTLDGANVEIAEQVGEDNIFIFGNTVDQVKALLAKGYDPLSYRKKDKHLKAILDELASGA
FSHGDKHAFDMMLHSLLEGGDPYLVLADFASYCKAQQQVDELYRDRDEWTRRTILNTARVGMFSSDRSIRDYQQRIWQAK
R
>Mature_800_residues
SQPMLKKDAFLAALTRQWQQFGLSSAQQMTQHQWWEAVSRALAEQLAAQPAPRKSSKPLRHVNYISMEFLIGRLTANNLI
NLGWYDTVEQALAEQDIKLADLLEQETDPALGNGGLGRLAACFLDSMATVEQPATGYGLNYQYGLFRQSFSGGQQQEAPD
NWQRESYPWFRHNAALSVDVGIGGKLEKLADGRELWRPEFTLRGEAWDLPVLGFRNGVTQPLRLWQATHQHPFDLSDFND
GKFLQAEKQGVEAAKLTKVLYPNDNHQAGKRLRLMQQYFQCACSVADILRKHHLAGRKIEDLPKYEVIQLNDTHPTIAIP
EMLRILLDEHQLDWDAAWAITSKTFAYTNHTLMPEALECWDEKLVRSLLPRHFSIIKQINANFKKLVDKHWPGDDAVWAK
LAVHHDKQVRMANLCVVSGFAVNGVAQLHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWLKQCNPALSGLIDETLKVE
WANDLDALKGLEKYADDAAFRQRYQQIKRDNKVVLANYVHDVMGLTLNPDAIFDLQIKRLHEYKRQHLNLLHILSLYRQL
RDNPQLDIVPRVFLFGAKAAPGYYLAKNIIYAINQAAEKINNDPLVKDRLKVAFIPDYRVSVAELMIPAADISEQISTAG
KEASGTGNMKLALNGALTVGTLDGANVEIAEQVGEDNIFIFGNTVDQVKALLAKGYDPLSYRKKDKHLKAILDELASGAF
SHGDKHAFDMMLHSLLEGGDPYLVLADFASYCKAQQQVDELYRDRDEWTRRTILNTARVGMFSSDRSIRDYQQRIWQAKR

Specific function: Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties [

COG id: COG0058

COG function: function code G; Glucan phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycogen phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI5032009, Length=748, Percent_Identity=44.3850267379679, Blast_Score=638, Evalue=0.0,
Organism=Homo sapiens, GI21361370, Length=748, Percent_Identity=44.1176470588235, Blast_Score=622, Evalue=1e-178,
Organism=Homo sapiens, GI71037379, Length=751, Percent_Identity=43.8082556591212, Blast_Score=620, Evalue=1e-177,
Organism=Homo sapiens, GI255653002, Length=691, Percent_Identity=43.849493487699, Blast_Score=602, Evalue=1e-172,
Organism=Homo sapiens, GI257900462, Length=660, Percent_Identity=44.0909090909091, Blast_Score=579, Evalue=1e-165,
Organism=Escherichia coli, GI48994936, Length=802, Percent_Identity=75.6857855361596, Blast_Score=1268, Evalue=0.0,
Organism=Escherichia coli, GI2367228, Length=776, Percent_Identity=45.1030927835052, Blast_Score=684, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17564550, Length=754, Percent_Identity=46.0212201591512, Blast_Score=678, Evalue=0.0,
Organism=Caenorhabditis elegans, GI32566204, Length=754, Percent_Identity=46.0212201591512, Blast_Score=678, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6325418, Length=812, Percent_Identity=42.7339901477833, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI78706832, Length=748, Percent_Identity=45.855614973262, Blast_Score=653, Evalue=0.0,
Organism=Drosophila melanogaster, GI24581010, Length=748, Percent_Identity=45.855614973262, Blast_Score=653, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011833
- InterPro:   IPR000811 [H]

Pfam domain/function: PF00343 Phosphorylase [H]

EC number: =2.4.1.1 [H]

Molecular weight: Translated: 91067; Mature: 90936

Theoretical pI: Translated: 7.31; Mature: 7.31

Prosite motif: PS00102 PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQPMLKKDAFLAALTRQWQQFGLSSAQQMTQHQWWEAVSRALAEQLAAQPAPRKSSKPL
CCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
RHVNYISMEFLIGRLTANNLINLGWYDTVEQALAEQDIKLADLLEQETDPALGNGGLGRL
HHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHH
AACFLDSMATVEQPATGYGLNYQYGLFRQSFSGGQQQEAPDNWQRESYPWFRHNAALSVD
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCEEEEE
VGIGGKLEKLADGRELWRPEFTLRGEAWDLPVLGFRNGVTQPLRLWQATHQHPFDLSDFN
ECCCCCHHHHHCCHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
DGKFLQAEKQGVEAAKLTKVLYPNDNHQAGKRLRLMQQYFQCACSVADILRKHHLAGRKI
CCCEEEHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EDLPKYEVIQLNDTHPTIAIPEMLRILLDEHQLDWDAAWAITSKTFAYTNHTLMPEALEC
HCCCCEEEEEECCCCCCEEHHHHHHHHHHHHCCCCHHHHEEECCEEEECCCCCCHHHHHH
WDEKLVRSLLPRHFSIIKQINANFKKLVDKHWPGDDAVWAKLAVHHDKQVRMANLCVVSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHEECC
FAVNGVAQLHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWLKQCNPALSGLIDETLKV
HHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHEE
EWANDLDALKGLEKYADDAAFRQRYQQIKRDNKVVLANYVHDVMGLTLNPDAIFDLQIKR
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCEECCCCEEHHHHHH
LHEYKRQHLNLLHILSLYRQLRDNPQLDIVPRVFLFGAKAAPGYYLAKNIIYAINQAAEK
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
INNDPLVKDRLKVAFIPDYRVSVAELMIPAADISEQISTAGKEASGTGNMKLALNGALTV
CCCCCCCHHCEEEEECCCCHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCEEEEEECEEEE
GTLDGANVEIAEQVGEDNIFIFGNTVDQVKALLAKGYDPLSYRKKDKHLKAILDELASGA
EECCCCCCHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
FSHGDKHAFDMMLHSLLEGGDPYLVLADFASYCKAQQQVDELYRDRDEWTRRTILNTARV
CCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMFSSDRSIRDYQQRIWQAKR
CCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
SQPMLKKDAFLAALTRQWQQFGLSSAQQMTQHQWWEAVSRALAEQLAAQPAPRKSSKPL
CCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
RHVNYISMEFLIGRLTANNLINLGWYDTVEQALAEQDIKLADLLEQETDPALGNGGLGRL
HHHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCHHHH
AACFLDSMATVEQPATGYGLNYQYGLFRQSFSGGQQQEAPDNWQRESYPWFRHNAALSVD
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCEECCCEEEEE
VGIGGKLEKLADGRELWRPEFTLRGEAWDLPVLGFRNGVTQPLRLWQATHQHPFDLSDFN
ECCCCCHHHHHCCHHHCCCCEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCC
DGKFLQAEKQGVEAAKLTKVLYPNDNHQAGKRLRLMQQYFQCACSVADILRKHHLAGRKI
CCCEEEHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
EDLPKYEVIQLNDTHPTIAIPEMLRILLDEHQLDWDAAWAITSKTFAYTNHTLMPEALEC
HCCCCEEEEEECCCCCCEEHHHHHHHHHHHHCCCCHHHHEEECCEEEECCCCCCHHHHHH
WDEKLVRSLLPRHFSIIKQINANFKKLVDKHWPGDDAVWAKLAVHHDKQVRMANLCVVSG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHEECC
FAVNGVAQLHSDLVVKDLFPEYHQLWPNKFHNVTNGITPRRWLKQCNPALSGLIDETLKV
HHHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHCCCCHHHHHHHHCHHHHHHHHHHHEE
EWANDLDALKGLEKYADDAAFRQRYQQIKRDNKVVLANYVHDVMGLTLNPDAIFDLQIKR
ECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHCCEECCCCEEHHHHHH
LHEYKRQHLNLLHILSLYRQLRDNPQLDIVPRVFLFGAKAAPGYYLAKNIIYAINQAAEK
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
INNDPLVKDRLKVAFIPDYRVSVAELMIPAADISEQISTAGKEASGTGNMKLALNGALTV
CCCCCCCHHCEEEEECCCCHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCEEEEEECEEEE
GTLDGANVEIAEQVGEDNIFIFGNTVDQVKALLAKGYDPLSYRKKDKHLKAILDELASGA
EECCCCCCHHHHHCCCCCEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCC
FSHGDKHAFDMMLHSLLEGGDPYLVLADFASYCKAQQQVDELYRDRDEWTRRTILNTARV
CCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMFSSDRSIRDYQQRIWQAKR
CCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3037809; 9278503; 3155826; 2845225; 6283313; 6339728; 6986282; 9009262; 10220320; 10469642 [H]