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The map label for this gene is kdsC [H]

Identifier: 157372596

GI number: 157372596

Start: 4833607

End: 4834176

Strand: Direct

Name: kdsC [H]

Synonym: Spro_4363

Alternate gene names: 157372596

Gene position: 4833607-4834176 (Clockwise)

Preceding gene: 157372595

Following gene: 157372597

Centisome position: 88.71

GC content: 54.91

Gene sequence:

>570_bases
ATGGAAGAGAACTCAATGAGTCTGGTTGAAACCTGCTACGGGCCTGTAGAACAAGACGTCATGGCGCGCGCCGGTAAAAT
CCGCCTGCTGATTTGTGATGTCGATGGCGTGCTGTCAGACGGCCTGATTTTCATGGGCAACAACGGTGAAGAACTAAAAG
CGTTTAACGTGCGCGACGGTTACGGCATTCGCTGCCTGAAAACCTCGGATATTGAAGTGGCAATTATTACCGGCCGCTCC
GCCAAGCTGCTGGAGGACCGCGCAAATACCCTCGGTATTACCCACCTTTATCAGGGGCAATCCGATAAGCTTTTGGCCTT
CCGCGAACTGTTGGATACACTGTCGCTAACGGCAGATCAGGTAGCCTATATCGGCGACGATCTGATCGACTGGCCGGTGA
TGGCCCAGGTTGGCCTGGCAGTCGCGGTAGCAGATGCACATCCTCTGTTGTTGCCACGAGCCCACTATATTACCCGCATT
GCCGGCGGCCGCGGTGCGGTGCGCGAGCTGTGTGACATTATTCTTTTGGCTCAGAACAAGCTGGAGGACGCCAAAGGGCT
GTCGATATGA

Upstream 100 bases:

>100_bases
TGCAGCAACGTCATATCACCTCAGTGCTGGTTGCCGATGGCGACCAGTTGCTGGGTGTGGTACATATGCATGACATGCTG
CGCGCCGGCGTCGTTTAATT

Downstream 100 bases:

>100_bases
GTAAAACCAAACTTTGGATCACCATCCTGCTGGCGGTGATCGCATTGGCGCTGATTGGCTGGAACATGACTGATGTCAAT
GATGATGCCATGCCGGGACC

Product: 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase

Products: NA

Alternate protein names: KDO 8-P phosphatase [H]

Number of amino acids: Translated: 189; Mature: 189

Protein sequence:

>189_residues
MEENSMSLVETCYGPVEQDVMARAGKIRLLICDVDGVLSDGLIFMGNNGEELKAFNVRDGYGIRCLKTSDIEVAIITGRS
AKLLEDRANTLGITHLYQGQSDKLLAFRELLDTLSLTADQVAYIGDDLIDWPVMAQVGLAVAVADAHPLLLPRAHYITRI
AGGRGAVRELCDIILLAQNKLEDAKGLSI

Sequences:

>Translated_189_residues
MEENSMSLVETCYGPVEQDVMARAGKIRLLICDVDGVLSDGLIFMGNNGEELKAFNVRDGYGIRCLKTSDIEVAIITGRS
AKLLEDRANTLGITHLYQGQSDKLLAFRELLDTLSLTADQVAYIGDDLIDWPVMAQVGLAVAVADAHPLLLPRAHYITRI
AGGRGAVRELCDIILLAQNKLEDAKGLSI
>Mature_189_residues
MEENSMSLVETCYGPVEQDVMARAGKIRLLICDVDGVLSDGLIFMGNNGEELKAFNVRDGYGIRCLKTSDIEVAIITGRS
AKLLEDRANTLGITHLYQGQSDKLLAFRELLDTLSLTADQVAYIGDDLIDWPVMAQVGLAVAVADAHPLLLPRAHYITRI
AGGRGAVRELCDIILLAQNKLEDAKGLSI

Specific function: Catalyzes the hydrolysis of KDO 8-P to KDO and inorganic phosphate [H]

COG id: COG1778

COG function: function code R; Low specificity phosphatase (HAD superfamily)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kdsC family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=160, Percent_Identity=33.125, Blast_Score=89, Evalue=2e-18,
Organism=Escherichia coli, GI2367202, Length=179, Percent_Identity=77.6536312849162, Blast_Score=291, Evalue=2e-80,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR013200
- InterPro:   IPR006549
- InterPro:   IPR010023 [H]

Pfam domain/function: PF08282 Hydrolase_3 [H]

EC number: =3.1.3.45 [H]

Molecular weight: Translated: 20528; Mature: 20528

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEENSMSLVETCYGPVEQDVMARAGKIRLLICDVDGVLSDGLIFMGNNGEELKAFNVRDG
CCCCHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCHHHCCEEEECCCCCEEEEEECCCC
YGIRCLKTSDIEVAIITGRSAKLLEDRANTLGITHLYQGQSDKLLAFRELLDTLSLTADQ
CCEEEEEECCEEEEEEECCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCHHH
VAYIGDDLIDWPVMAQVGLAVAVADAHPLLLPRAHYITRIAGGRGAVRELCDIILLAQNK
HHHHCCCCCCCHHHHHHCEEEEEECCCCCCCCCHHHHHEECCCCHHHHHHHHHHHHHHCC
LEDAKGLSI
CCCCCCCCC
>Mature Secondary Structure
MEENSMSLVETCYGPVEQDVMARAGKIRLLICDVDGVLSDGLIFMGNNGEELKAFNVRDG
CCCCHHHHHHHHCCCHHHHHHHCCCCEEEEEECCCCHHHCCEEEECCCCCEEEEEECCCC
YGIRCLKTSDIEVAIITGRSAKLLEDRANTLGITHLYQGQSDKLLAFRELLDTLSLTADQ
CCEEEEEECCEEEEEEECCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHHCCHHH
VAYIGDDLIDWPVMAQVGLAVAVADAHPLLLPRAHYITRIAGGRGAVRELCDIILLAQNK
HHHHCCCCCCCHHHHHHCEEEEEECCCCCCCCCHHHHHEECCCCHHHHHHHHHHHHHHCC
LEDAKGLSI
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]