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The map label for this gene is uxaA [H]

Identifier: 157372553

GI number: 157372553

Start: 4790002

End: 4791492

Strand: Reverse

Name: uxaA [H]

Synonym: Spro_4320

Alternate gene names: 157372553

Gene position: 4791492-4790002 (Counterclockwise)

Preceding gene: 157372554

Following gene: 157372545

Centisome position: 87.94

GC content: 58.48

Gene sequence:

>1491_bases
ATGCAAAGCATGGTAAAAATTCATTCGCTGGATAATGTCGCGGTAGCGCTGAGCGATCTGGCCGCCGGCGAAACCTTGGC
GTTGGACGCACTGACGATTCGGCTGGCGCAACCGGTGACGCGTGGGCACAAGTTTGCGCTGCAGCCGATCGCTGCCGGTG
AGGCCATCATCAAATACGGCTTGCCGATTGGTCATGCGTTGGAAGCCATAGCGCCGGGTGAACATATTCACTCGCAAAAT
GCCAAAACCAACCTGAGCGATCTCGACAGCTATCAGTATCAACCCGCTTTCCCGACGCTGCCACCACAGGCTGCGGATCG
TGAGGTGCAGCTTTACCGCCGTATCAGTGGGGAGGTGGGGATCCGCAACGAACTGTGGATCGTGCCGACCGTTGGCTGCG
TCAACGGCATTGCCCGGCAGATCCAGCAGCGTTTTCTGAAGGAAACTCAGGATGCGCAGGGGATTGACGGTGTGCATCTG
TTCAGTCATCCGTTTGGTTGTTCGCAACTGGGTCAGGATCACGAGAACACCCGCACCATGCTGCAAAATATGGTTCGCCA
TCCGAATGCCGGGGCGGTGCTGGTGATTGGACTCGGGTGCGAGAACAATCAGGTGGATGTGTTCCGCAGTACGCTGGGCG
CGACCGATGAGCAACGGGTGCGCTTTATGGTGTGCCAGCAGCAGGACGATGAGGTTGAAGCCGGGCTGGAGCAGTTGCAT
GCGCTGTATCAGGTGATGCGCGACGATCGCCGTCAGCCGGGTAAGCTGAGCGAGTTGAAGTTCGGACTGGAGTGTGGTGG
ATCGGACGGTCTGTCCGGGATTACCGCCAATCCATTGCTGGGGCGTTTTTCTGATTACCTGATCGCCAACGGCGGCACCA
CGGTGCTGACCGAGGTACCGGAGATGTTTGGTGCCGAACGGATCCTGATGAGCCGTTGTCGCGATCGGGCAACCTTCGAG
AAGACCGTCAGCATGGTCAACGACTTCAAACAGTACTTCATCGCCCATAATCAGCCGATTTATGAAAACCCTTCACCGGG
CAACAAGGCCGGCGGGATTACCACCCTGGAGGAGAAATCCCTCGGCTGCACGCAGAAAGCCGGGCAGAGTCAGGTGGTGG
ACGTGCTCAAGTATGGCGAACGCCTGCGCCAGCCCGGCTTAAACCTGCTCAGCGCGCCTGGCAATGATGCGGTAGCGACC
AGCGCGCTGGCCGGTGCCGGCTGTCATATGGTGCTGTTCAGCACCGGACGCGGCACGCCTTATGGCGGCTTCGTGCCGAC
GGTGAAACTGGCCACCAACAGCGAACTGGCGGCGAAGAAACCCCACTGGATTGATTTTGACGCCGGTCGGCTGATCCACG
GCACCTCGATGGAGAGTCTGCTGGAGCAGTTTGTCGACCTGATCGTGGCGATCGCCAATGGTCAGGCGGCGCGTAATGAA
GTGAATGATTTCCGTGAGTTGGCGATTTTTAAAAGCGGGGTAACCTTGTAG

Upstream 100 bases:

>100_bases
ATATCACGTTACTGGGTGAGATGGTGAAAAACATCTGTTTCGACAATGCCAAAAACTATTTCGCCATTGAACTGGCCTAG
CCGTTGCCCGAGGTGGGTTT

Downstream 100 bases:

>100_bases
GACTGTGATATTGAGGTAAAAAAAGGCGCCCGATAATGAGCGCCTTGTTGAATAAGCTCGGAAATTAACGCACCTTCAGC
GGATCTTCATCTGCCAAACG

Product: Altronate dehydratase

Products: NA

Alternate protein names: Altronic acid hydratase [H]

Number of amino acids: Translated: 496; Mature: 496

Protein sequence:

>496_residues
MQSMVKIHSLDNVAVALSDLAAGETLALDALTIRLAQPVTRGHKFALQPIAAGEAIIKYGLPIGHALEAIAPGEHIHSQN
AKTNLSDLDSYQYQPAFPTLPPQAADREVQLYRRISGEVGIRNELWIVPTVGCVNGIARQIQQRFLKETQDAQGIDGVHL
FSHPFGCSQLGQDHENTRTMLQNMVRHPNAGAVLVIGLGCENNQVDVFRSTLGATDEQRVRFMVCQQQDDEVEAGLEQLH
ALYQVMRDDRRQPGKLSELKFGLECGGSDGLSGITANPLLGRFSDYLIANGGTTVLTEVPEMFGAERILMSRCRDRATFE
KTVSMVNDFKQYFIAHNQPIYENPSPGNKAGGITTLEEKSLGCTQKAGQSQVVDVLKYGERLRQPGLNLLSAPGNDAVAT
SALAGAGCHMVLFSTGRGTPYGGFVPTVKLATNSELAAKKPHWIDFDAGRLIHGTSMESLLEQFVDLIVAIANGQAARNE
VNDFRELAIFKSGVTL

Sequences:

>Translated_496_residues
MQSMVKIHSLDNVAVALSDLAAGETLALDALTIRLAQPVTRGHKFALQPIAAGEAIIKYGLPIGHALEAIAPGEHIHSQN
AKTNLSDLDSYQYQPAFPTLPPQAADREVQLYRRISGEVGIRNELWIVPTVGCVNGIARQIQQRFLKETQDAQGIDGVHL
FSHPFGCSQLGQDHENTRTMLQNMVRHPNAGAVLVIGLGCENNQVDVFRSTLGATDEQRVRFMVCQQQDDEVEAGLEQLH
ALYQVMRDDRRQPGKLSELKFGLECGGSDGLSGITANPLLGRFSDYLIANGGTTVLTEVPEMFGAERILMSRCRDRATFE
KTVSMVNDFKQYFIAHNQPIYENPSPGNKAGGITTLEEKSLGCTQKAGQSQVVDVLKYGERLRQPGLNLLSAPGNDAVAT
SALAGAGCHMVLFSTGRGTPYGGFVPTVKLATNSELAAKKPHWIDFDAGRLIHGTSMESLLEQFVDLIVAIANGQAARNE
VNDFRELAIFKSGVTL
>Mature_496_residues
MQSMVKIHSLDNVAVALSDLAAGETLALDALTIRLAQPVTRGHKFALQPIAAGEAIIKYGLPIGHALEAIAPGEHIHSQN
AKTNLSDLDSYQYQPAFPTLPPQAADREVQLYRRISGEVGIRNELWIVPTVGCVNGIARQIQQRFLKETQDAQGIDGVHL
FSHPFGCSQLGQDHENTRTMLQNMVRHPNAGAVLVIGLGCENNQVDVFRSTLGATDEQRVRFMVCQQQDDEVEAGLEQLH
ALYQVMRDDRRQPGKLSELKFGLECGGSDGLSGITANPLLGRFSDYLIANGGTTVLTEVPEMFGAERILMSRCRDRATFE
KTVSMVNDFKQYFIAHNQPIYENPSPGNKAGGITTLEEKSLGCTQKAGQSQVVDVLKYGERLRQPGLNLLSAPGNDAVAT
SALAGAGCHMVLFSTGRGTPYGGFVPTVKLATNSELAAKKPHWIDFDAGRLIHGTSMESLLEQFVDLIVAIANGQAARNE
VNDFRELAIFKSGVTL

Specific function: Hexuronate conversion to KDG. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789475, Length=492, Percent_Identity=78.8617886178862, Blast_Score=825, Evalue=0.0,
Organism=Escherichia coli, GI1789516, Length=493, Percent_Identity=32.2515212981744, Blast_Score=209, Evalue=3e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.7 [H]

Molecular weight: Translated: 53872; Mature: 53872

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSMVKIHSLDNVAVALSDLAAGETLALDALTIRLAQPVTRGHKFALQPIAAGEAIIKYG
CCCCEEHHCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCEEECCHHCCHHHHHHC
LPIGHALEAIAPGEHIHSQNAKTNLSDLDSYQYQPAFPTLPPQAADREVQLYRRISGEVG
CCHHHHHHHCCCCHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
IRNELWIVPTVGCVNGIARQIQQRFLKETQDAQGIDGVHLFSHPFGCSQLGQDHENTRTM
CCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHCCCCHHHHHH
LQNMVRHPNAGAVLVIGLGCENNQVDVFRSTLGATDEQRVRFMVCQQQDDEVEAGLEQLH
HHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCHHHEEEEEECCCCCHHHHHHHHHH
ALYQVMRDDRRQPGKLSELKFGLECGGSDGLSGITANPLLGRFSDYLIANGGTTVLTEVP
HHHHHHHHHCCCCCCHHHHEECCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCHHHHHHH
EMFGAERILMSRCRDRATFEKTVSMVNDFKQYFIAHNQPIYENPSPGNKAGGITTLEEKS
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHCC
LGCTQKAGQSQVVDVLKYGERLRQPGLNLLSAPGNDAVATSALAGAGCHMVLFSTGRGTP
CCCHHHCCHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHCCCCEEEEEECCCCCC
YGGFVPTVKLATNSELAAKKPHWIDFDAGRLIHGTSMESLLEQFVDLIVAIANGQAARNE
CCCCCCEEEEECCCCCCCCCCCEEECCCCCEEECCCHHHHHHHHHHHHHHHCCCCHHHHH
VNDFRELAIFKSGVTL
HHHHHHHHHHHCCCCC
>Mature Secondary Structure
MQSMVKIHSLDNVAVALSDLAAGETLALDALTIRLAQPVTRGHKFALQPIAAGEAIIKYG
CCCCEEHHCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCEEECCHHCCHHHHHHC
LPIGHALEAIAPGEHIHSQNAKTNLSDLDSYQYQPAFPTLPPQAADREVQLYRRISGEVG
CCHHHHHHHCCCCHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCC
IRNELWIVPTVGCVNGIARQIQQRFLKETQDAQGIDGVHLFSHPFGCSQLGQDHENTRTM
CCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCHHHHCCCCHHHHHH
LQNMVRHPNAGAVLVIGLGCENNQVDVFRSTLGATDEQRVRFMVCQQQDDEVEAGLEQLH
HHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCHHHEEEEEECCCCCHHHHHHHHHH
ALYQVMRDDRRQPGKLSELKFGLECGGSDGLSGITANPLLGRFSDYLIANGGTTVLTEVP
HHHHHHHHHCCCCCCHHHHEECCCCCCCCCCCCCCCCCHHHHCCCEEEECCCCHHHHHHH
EMFGAERILMSRCRDRATFEKTVSMVNDFKQYFIAHNQPIYENPSPGNKAGGITTLEEKS
HHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEHHCC
LGCTQKAGQSQVVDVLKYGERLRQPGLNLLSAPGNDAVATSALAGAGCHMVLFSTGRGTP
CCCHHHCCHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHHCCCCEEEEEECCCCCC
YGGFVPTVKLATNSELAAKKPHWIDFDAGRLIHGTSMESLLEQFVDLIVAIANGQAARNE
CCCCCCEEEEECCCCCCCCCCCEEECCCCCEEECCCHHHHHHHHHHHHHHHCCCCHHHHH
VNDFRELAIFKSGVTL
HHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 3038546 [H]