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The map label for this gene is tyrP [H]

Identifier: 157372537

GI number: 157372537

Start: 4771748

End: 4772992

Strand: Reverse

Name: tyrP [H]

Synonym: Spro_4304

Alternate gene names: 157372537

Gene position: 4772992-4771748 (Counterclockwise)

Preceding gene: 157372538

Following gene: 157372535

Centisome position: 87.6

GC content: 57.91

Gene sequence:

>1245_bases
ATGTCTTCTGATAATACCTATATTCCTCCGGCGCTTAGCGCCGGGGTGCGAAAGCCTGCACCCACCAAATCACTGAGTTT
TCTCGAAGGGGTGGCGATGATTGTCGGCACCAACATTGGCGCCGGCGTGCTGTCTATCGCTTACGCTTCCAGCAAGGCCG
GTTTTTTACCGCTGTTGTTCTGGCTGGTGCTGGTGGGCAGCCTGATCACTATCACCATGCTTTACGTCGCCGAATCCACT
CTGCGCACCCGTTCTCACCTGCAATTAAGCGGGCTGGCGAAACGTTATGTCGGCGGTATCGGTGCCTGGCTGATGTTTGC
TTCGGTCTGCGTCAACAGTGTCGGGGCGCTGACCGCCTATATGACCGGCAGCGGTAAACTGCTGCAATCCCTGTTTGGTA
TCTCACCGGCGATCGGCAGCCTGCTGTTTTTCGTGCCGGCGGCGGGGGTGTTGTACCTGGGGCTGAAGGCGATTGGCCGT
GGCGAAAAGTTTATCAGCATTGGCATGGTGGTGATGCTGACCGCGCTGGTGGCCGCCACGCTGCTCAAAGACACCACTCA
GATGCGCAACCTGCTGGACGGCGACTGGCGCTTTATGGTGCCGGTCTTCAACGTGGTGGTGTTCTGCTTCTCGGCGCAGT
ATATCGTGCCGGAAATGGCGCGCGGTTTCTCGGACAAACCAGAGCAACTGCCCAAGGCGATTATGGTCGGTATGGCGGTG
ACCTTTGTGTTGCTGGCGGCGGTGCCGATGTCGGTCATTGCTCTCAGTGGATTGGATGGCATCACTGATGTGGCGACCAT
TTCATGGGGCCAGGCGTTGGGGCAATGGGCGTTCTTCTCCGCCAACATCTTTGCTCTGTGCGCGATGTTGACTTCTTACT
GGGGGCTGGGCGGCAGCTTCCTGACCAATATTTTCGACCAGTTCAGACTGGGTAATGACGAACAGCCGCTGCGTCGTTTC
GGCGTGCTGATGCTGGTGGTATTGCCGCCGTTCGCGCTGGCTTACAGCGGGCTGGTGTCATTCGTTAACGCACTGTATTT
CGCCGGGGTATTCAGCGGGGTGATCCTATCGATTATGCCGATGCTAATCCTGCGCGGGGCGCGCAAGCACGGTGACCAGA
CGCCACGTTGGCAGTGCAGCTGGATCACCCATCCGTTGTTGCAGGTAAGCATCGTATTGCTGTACTTGGGCAGTGCGGTG
TATGCCATTGCGTCGCTGTTCGGCTATCTGCCCTCTGGATGGTGA

Upstream 100 bases:

>100_bases
TATCTGGAGTTGAAATACCTGTGTATCGATGTGAGCTGTTAACCACTGGGAAATTAACCTCTCCCGGTGGCTCGCACCGC
CGGGAGACAAAGGATGCTGC

Downstream 100 bases:

>100_bases
ATTGCCTTCCCTCAAGAAGTGATGTTGTTTCTCGATAATTGAGAACGGCGGCGTCGTGGCCGCCGGTTTTTTTAGCCGCG
CATTTTCTCCGGCAGTGCCA

Product: aromatic amino acid permease

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease [H]

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MSSDNTYIPPALSAGVRKPAPTKSLSFLEGVAMIVGTNIGAGVLSIAYASSKAGFLPLLFWLVLVGSLITITMLYVAEST
LRTRSHLQLSGLAKRYVGGIGAWLMFASVCVNSVGALTAYMTGSGKLLQSLFGISPAIGSLLFFVPAAGVLYLGLKAIGR
GEKFISIGMVVMLTALVAATLLKDTTQMRNLLDGDWRFMVPVFNVVVFCFSAQYIVPEMARGFSDKPEQLPKAIMVGMAV
TFVLLAAVPMSVIALSGLDGITDVATISWGQALGQWAFFSANIFALCAMLTSYWGLGGSFLTNIFDQFRLGNDEQPLRRF
GVLMLVVLPPFALAYSGLVSFVNALYFAGVFSGVILSIMPMLILRGARKHGDQTPRWQCSWITHPLLQVSIVLLYLGSAV
YAIASLFGYLPSGW

Sequences:

>Translated_414_residues
MSSDNTYIPPALSAGVRKPAPTKSLSFLEGVAMIVGTNIGAGVLSIAYASSKAGFLPLLFWLVLVGSLITITMLYVAEST
LRTRSHLQLSGLAKRYVGGIGAWLMFASVCVNSVGALTAYMTGSGKLLQSLFGISPAIGSLLFFVPAAGVLYLGLKAIGR
GEKFISIGMVVMLTALVAATLLKDTTQMRNLLDGDWRFMVPVFNVVVFCFSAQYIVPEMARGFSDKPEQLPKAIMVGMAV
TFVLLAAVPMSVIALSGLDGITDVATISWGQALGQWAFFSANIFALCAMLTSYWGLGGSFLTNIFDQFRLGNDEQPLRRF
GVLMLVVLPPFALAYSGLVSFVNALYFAGVFSGVILSIMPMLILRGARKHGDQTPRWQCSWITHPLLQVSIVLLYLGSAV
YAIASLFGYLPSGW
>Mature_413_residues
SSDNTYIPPALSAGVRKPAPTKSLSFLEGVAMIVGTNIGAGVLSIAYASSKAGFLPLLFWLVLVGSLITITMLYVAESTL
RTRSHLQLSGLAKRYVGGIGAWLMFASVCVNSVGALTAYMTGSGKLLQSLFGISPAIGSLLFFVPAAGVLYLGLKAIGRG
EKFISIGMVVMLTALVAATLLKDTTQMRNLLDGDWRFMVPVFNVVVFCFSAQYIVPEMARGFSDKPEQLPKAIMVGMAVT
FVLLAAVPMSVIALSGLDGITDVATISWGQALGQWAFFSANIFALCAMLTSYWGLGGSFLTNIFDQFRLGNDEQPLRRFG
VLMLVVLPPFALAYSGLVSFVNALYFAGVFSGVILSIMPMLILRGARKHGDQTPRWQCSWITHPLLQVSIVLLYLGSAVY
AIASLFGYLPSGW

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788218, Length=366, Percent_Identity=26.2295081967213, Blast_Score=67, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 44382; Mature: 44251

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SSDNTYIPPALSAGVRKPAPTKSLSFLEGVAMIVGTNIGAGVLSIAYASSKAGFLPLLF
CCCCCCCCCHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHH
WLVLVGSLITITMLYVAESTLRTRSHLQLSGLAKRYVGGIGAWLMFASVCVNSVGALTAY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MTGSGKLLQSLFGISPAIGSLLFFVPAAGVLYLGLKAIGRGEKFISIGMVVMLTALVAAT
CCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LLKDTTQMRNLLDGDWRFMVPVFNVVVFCFSAQYIVPEMARGFSDKPEQLPKAIMVGMAV
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
TFVLLAAVPMSVIALSGLDGITDVATISWGQALGQWAFFSANIFALCAMLTSYWGLGGSF
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
LTNIFDQFRLGNDEQPLRRFGVLMLVVLPPFALAYSGLVSFVNALYFAGVFSGVILSIMP
HHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLILRGARKHGDQTPRWQCSWITHPLLQVSIVLLYLGSAVYAIASLFGYLPSGW
HHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3049553; 9097040; 9278503 [H]