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The map label for this gene is licC [H]

Identifier: 157372456

GI number: 157372456

Start: 4682168

End: 4683487

Strand: Reverse

Name: licC [H]

Synonym: Spro_4223

Alternate gene names: 157372456

Gene position: 4683487-4682168 (Counterclockwise)

Preceding gene: 157372457

Following gene: 157372455

Centisome position: 85.95

GC content: 56.14

Gene sequence:

>1320_bases
ATGAGTATCAGCCAGGCCGCATTCAATTTTATTGAAAACCGTATCAGCCCCATTGCCGGTAAACTATCGACCCAGCGACA
TATTATGGCGATCCGCGACGGTTTTATTTCCGCGATGCCCTTTATGATCGTCGGCTCATTCTTATTGGTATTTGCCTACC
CGCCTTTTTCGGCCGACAGCAGTTGGGGAATAGCTCAATGGTGGCTGGGTGCTGCGGAGAAACATCAGGTCGCTATTCTC
ACCCCGTTTAATATGACCATGGGGATTATGTCGATTTATATTACTGCCGCCATCGCTTATAACCTGGCGCAGAGTTATAA
GCTCGATCCCTTTATGGCGGCCATGCTGGCGCTGATGTCATTTTTGCTGGTCGCCGCGCCGCAGACCGAAAAGATGCTGC
CGACCGCTGCGTTGGGCGGCGTGGGGATCTTCACCGCCATTTTGGTGGCGGTCTATACCACCGAACTGATCCGCTTTCTC
AAGCAGCACAATATCGGTATCTCACTGCCGGAACAGGTGCCGGCCAAGATCAAACAGTCGTTTGATCTGCTGATCCCGAT
CCTGGCGGTGGTGATCACCCTGTATCCGCTTAGCCTGCTGGTGCAGCATCAGTTCAACTTACTGTTGCCACAGGCGATCA
TGGCGCTGTTCCAGCCGCTGATTTCCGCTGCGGATTCGCTGCCGGCGATCCTGCTCGCGGTGCTGATCGGCCATTTATTG
TGGTTCGCCGGTATTCACGGCGCGGTGATCGTCTCCGGCATGCTGCAGGCATTCTGGCTGACCAATCTGGGCATCAATCA
GGATGCGTTGGCCGCCGGCCACCCGATGCCGCACATCTTTATGGAAGCTTTCTGGACCTTCTTTATCGTCATCGGCGGAT
CCGGCGCCACCTTTGGGCTGGTGCTGCTTTATCTGCGCAGCCGTTCGGCGCACCTGCGTTCGATCGGCAAGCTGAGCCTG
GTGCCGAGCTGCTTCAACATCAATGAACCGGTGATCTTCGGCACGCCGATCGTCATGAACCCGACCTTCTTTATCCCGTT
TATTACCGCGCCGATCGTCAATTCGATCATTGCCTATGCGGCCGTGAAGCTGGATCTGATTGGCCGCGTGATCTCGGTAG
TGCCCTGGACGGCACCGGCACCGATTGGCGCTGCCTGGGCCACCGGTTGGGATCTCCGTGCCGCACTGCTGGTGCTGCTG
CTGGCGGCGGTATCGGCACTGATTTACTACCCGTTCTTCAAGGTCTATGAGCAGCAGTTGCTGGATCAGGAAGTGAGTGA
GGCGGAGCAGATCGAACAGACACAAGGAGTCACCGAATGA

Upstream 100 bases:

>100_bases
ATCGCACAACACTAATTCCGCCGGGGCCACCTGCCGCCGCGCGTGGCGTCGGTTTGTTCGCCCCGTGACCATTGACTCAG
AACGTCCCGAGGGTTGAACC

Downstream 100 bases:

>100_bases
TCGACATGGAAACGGCGGTAATGGAATTGATCATCAACGCCGGTGAGGCTCGCAGTTGTGCCATGCAGGCGTTGTACGCA
GCGCGGAAATACCAGTGGGA

Product: PTS system lactose/cellobiose family transporter subunit IIC

Products: pyruvate; diacetylchitobiose-6-phosphate [Cytoplasm]; cellobiose-6-phosphate [Cytoplasm] [C]

Alternate protein names: EIIC-Lic; PTS system lichenan-specific EIIC component [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MSISQAAFNFIENRISPIAGKLSTQRHIMAIRDGFISAMPFMIVGSFLLVFAYPPFSADSSWGIAQWWLGAAEKHQVAIL
TPFNMTMGIMSIYITAAIAYNLAQSYKLDPFMAAMLALMSFLLVAAPQTEKMLPTAALGGVGIFTAILVAVYTTELIRFL
KQHNIGISLPEQVPAKIKQSFDLLIPILAVVITLYPLSLLVQHQFNLLLPQAIMALFQPLISAADSLPAILLAVLIGHLL
WFAGIHGAVIVSGMLQAFWLTNLGINQDALAAGHPMPHIFMEAFWTFFIVIGGSGATFGLVLLYLRSRSAHLRSIGKLSL
VPSCFNINEPVIFGTPIVMNPTFFIPFITAPIVNSIIAYAAVKLDLIGRVISVVPWTAPAPIGAAWATGWDLRAALLVLL
LAAVSALIYYPFFKVYEQQLLDQEVSEAEQIEQTQGVTE

Sequences:

>Translated_439_residues
MSISQAAFNFIENRISPIAGKLSTQRHIMAIRDGFISAMPFMIVGSFLLVFAYPPFSADSSWGIAQWWLGAAEKHQVAIL
TPFNMTMGIMSIYITAAIAYNLAQSYKLDPFMAAMLALMSFLLVAAPQTEKMLPTAALGGVGIFTAILVAVYTTELIRFL
KQHNIGISLPEQVPAKIKQSFDLLIPILAVVITLYPLSLLVQHQFNLLLPQAIMALFQPLISAADSLPAILLAVLIGHLL
WFAGIHGAVIVSGMLQAFWLTNLGINQDALAAGHPMPHIFMEAFWTFFIVIGGSGATFGLVLLYLRSRSAHLRSIGKLSL
VPSCFNINEPVIFGTPIVMNPTFFIPFITAPIVNSIIAYAAVKLDLIGRVISVVPWTAPAPIGAAWATGWDLRAALLVLL
LAAVSALIYYPFFKVYEQQLLDQEVSEAEQIEQTQGVTE
>Mature_438_residues
SISQAAFNFIENRISPIAGKLSTQRHIMAIRDGFISAMPFMIVGSFLLVFAYPPFSADSSWGIAQWWLGAAEKHQVAILT
PFNMTMGIMSIYITAAIAYNLAQSYKLDPFMAAMLALMSFLLVAAPQTEKMLPTAALGGVGIFTAILVAVYTTELIRFLK
QHNIGISLPEQVPAKIKQSFDLLIPILAVVITLYPLSLLVQHQFNLLLPQAIMALFQPLISAADSLPAILLAVLIGHLLW
FAGIHGAVIVSGMLQAFWLTNLGINQDALAAGHPMPHIFMEAFWTFFIVIGGSGATFGLVLLYLRSRSAHLRSIGKLSLV
PSCFNINEPVIFGTPIVMNPTFFIPFITAPIVNSIIAYAAVKLDLIGRVISVVPWTAPAPIGAAWATGWDLRAALLVLLL
AAVSALIYYPFFKVYEQQLLDQEVSEAEQIEQTQGVTE

Specific function: The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. This system i

COG id: COG1455

COG function: function code G; Phosphotransferase system cellobiose-specific component IIC

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PTS EIIC type-3 domain [H]

Homologues:

Organism=Escherichia coli, GI1788032, Length=444, Percent_Identity=31.7567567567568, Blast_Score=182, Evalue=3e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003352
- InterPro:   IPR004796
- InterPro:   IPR004501 [H]

Pfam domain/function: PF02378 PTS_EIIC [H]

EC number: NA

Molecular weight: Translated: 47845; Mature: 47714

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS51105 PTS_EIIC_TYPE_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSISQAAFNFIENRISPIAGKLSTQRHIMAIRDGFISAMPFMIVGSFLLVFAYPPFSADS
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SWGIAQWWLGAAEKHQVAILTPFNMTMGIMSIYITAAIAYNLAQSYKLDPFMAAMLALMS
CCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
FLLVAAPQTEKMLPTAALGGVGIFTAILVAVYTTELIRFLKQHNIGISLPEQVPAKIKQS
HHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
FDLLIPILAVVITLYPLSLLVQHQFNLLLPQAIMALFQPLISAADSLPAILLAVLIGHLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WFAGIHGAVIVSGMLQAFWLTNLGINQDALAAGHPMPHIFMEAFWTFFIVIGGSGATFGL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHH
VLLYLRSRSAHLRSIGKLSLVPSCFNINEPVIFGTPIVMNPTFFIPFITAPIVNSIIAYA
HHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEECCCEEECCCHHHHHHHHHHHHHHHHHH
AVKLDLIGRVISVVPWTAPAPIGAAWATGWDLRAALLVLLLAAVSALIYYPFFKVYEQQL
HHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDQEVSEAEQIEQTQGVTE
HHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SISQAAFNFIENRISPIAGKLSTQRHIMAIRDGFISAMPFMIVGSFLLVFAYPPFSADS
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
SWGIAQWWLGAAEKHQVAILTPFNMTMGIMSIYITAAIAYNLAQSYKLDPFMAAMLALMS
CCCHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
FLLVAAPQTEKMLPTAALGGVGIFTAILVAVYTTELIRFLKQHNIGISLPEQVPAKIKQS
HHHHCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHH
FDLLIPILAVVITLYPLSLLVQHQFNLLLPQAIMALFQPLISAADSLPAILLAVLIGHLL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WFAGIHGAVIVSGMLQAFWLTNLGINQDALAAGHPMPHIFMEAFWTFFIVIGGSGATFGL
HHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCCCHHHHH
VLLYLRSRSAHLRSIGKLSLVPSCFNINEPVIFGTPIVMNPTFFIPFITAPIVNSIIAYA
HHHHHHCCHHHHHHHHHHHCCCCCCCCCCCEEECCCEEECCCHHHHHHHHHHHHHHHHHH
AVKLDLIGRVISVVPWTAPAPIGAAWATGWDLRAALLVLLLAAVSALIYYPFFKVYEQQL
HHHHHHHHHHHHHCCCCCCCCCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LDQEVSEAEQIEQTQGVTE
HHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: diacetylchitobiose [Periplasm]; phosphoenolpyruvate; cellobiose [Periplasm] [C]

Specific reaction: phosphoenolpyruvate + diacetylchitobiose [Periplasm] = pyruvate + diacetylchitobiose-6-phosphate [Cytoplasm] phosphoenolpyruvate + cellobiose [Periplasm] = cellobiose-6-phosphate [Cytoplasm] + pyruvate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8990303; 8969509; 9384377 [H]