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The map label for this gene is rppH

Identifier: 157372059

GI number: 157372059

Start: 4232143

End: 4232670

Strand: Reverse

Name: rppH

Synonym: Spro_3824

Alternate gene names: 157372059

Gene position: 4232670-4232143 (Counterclockwise)

Preceding gene: 157372064

Following gene: 157372058

Centisome position: 77.68

GC content: 53.79

Gene sequence:

>528_bases
GTGATCGATGATGATGGCTACCGCCCGAATGTTGGTATCGTAATCTGTAATCGTCAGGGGCAAGTCCTGTGGGCTCGCCG
TTACGGTCAACACTCCTGGCAGTTTCCCCAAGGTGGGATTAACCCTGGTGAAACCGCAGAACAGGCCATGTACCGTGAGC
TGTTCGAAGAAGTGGGGCTGAGTAAAAAGGATGTCCGTATCCTGGCCTCAACCCGCAACTGGTTGCGCTATAAATTGCCA
AAACGTTTGGTGCGTTGGGACACAAAGCCGGTTTGTATCGGCCAAAAGCAGAAATGGTTTCTGTTGCAGTTAATGTGCAA
TGACGCTGATATCAATATGCAACGCAGCAGCACGCCGGAGTTTGACGGTTGGCGCTGGGTAAGTTTTTGGTATCCGGTGC
GCCAGGTGGTGTCGTTCAAACGCGACGTTTACCGCCGGGTGATGAAAGAATTCGCCGTCACCGTGATGCCGATGCAGGAG
CAGGCAGCACAGCGGCAGACCCCCGCTTATCGCCGGAAGAGAGGTTAA

Upstream 100 bases:

>100_bases
TTATCCGGTTTGCAGCGCCGCAAAGCAGTGGTTTACCGCCTGTAGCTTGTGTGAAACAATCAGGGTATCTATGCGAATTT
AAGCTTATCGAGGTAGTCCG

Downstream 100 bases:

>100_bases
GTTAAGCCGACTATGCTCACGCGCTTGCGAGAAATTGTTGAGAAGGTGGCCGCGGCGGCCAGTCTGACAGATGCGCTGGA
TCTTTTGGTCAATGAAACCT

Product: dinucleoside polyphosphate hydrolase

Products: NA

Alternate protein names: (Di)nucleoside polyphosphate hydrolase

Number of amino acids: Translated: 175; Mature: 175

Protein sequence:

>175_residues
MIDDDGYRPNVGIVICNRQGQVLWARRYGQHSWQFPQGGINPGETAEQAMYRELFEEVGLSKKDVRILASTRNWLRYKLP
KRLVRWDTKPVCIGQKQKWFLLQLMCNDADINMQRSSTPEFDGWRWVSFWYPVRQVVSFKRDVYRRVMKEFAVTVMPMQE
QAAQRQTPAYRRKRG

Sequences:

>Translated_175_residues
MIDDDGYRPNVGIVICNRQGQVLWARRYGQHSWQFPQGGINPGETAEQAMYRELFEEVGLSKKDVRILASTRNWLRYKLP
KRLVRWDTKPVCIGQKQKWFLLQLMCNDADINMQRSSTPEFDGWRWVSFWYPVRQVVSFKRDVYRRVMKEFAVTVMPMQE
QAAQRQTPAYRRKRG
>Mature_175_residues
MIDDDGYRPNVGIVICNRQGQVLWARRYGQHSWQFPQGGINPGETAEQAMYRELFEEVGLSKKDVRILASTRNWLRYKLP
KRLVRWDTKPVCIGQKQKWFLLQLMCNDADINMQRSSTPEFDGWRWVSFWYPVRQVVSFKRDVYRRVMKEFAVTVMPMQE
QAAQRQTPAYRRKRG

Specific function: Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain

Homologues:

Organism=Escherichia coli, GI1789194, Length=176, Percent_Identity=87.5, Blast_Score=321, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RPPH_SERP5 (A8GII0)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001480048.1
- ProteinModelPortal:   A8GII0
- SMR:   A8GII0
- STRING:   A8GII0
- GeneID:   5606721
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_3824
- eggNOG:   COG0494
- HOGENOM:   HBG302451
- OMA:   GQKQIWY
- ProtClustDB:   PRK00714
- BioCyc:   SPRO399741:SPRO_3824-MONOMER
- HAMAP:   MF_00298
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797
- InterPro:   IPR022927
- Gene3D:   G3DSA:3.90.79.10
- PRINTS:   PR00502

Pfam domain/function: PF00293 NUDIX; SSF55811 NUDIX_hydrolase

EC number: 3.6.1.- [C]

Molecular weight: Translated: 20894; Mature: 20894

Theoretical pI: Translated: 10.56; Mature: 10.56

Prosite motif: PS51462 NUDIX; PS00893 NUDIX_BOX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDDDGYRPNVGIVICNRQGQVLWARRYGQHSWQFPQGGINPGETAEQAMYRELFEEVGL
CCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
SKKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQKWFLLQLMCNDADINMQRSSTPE
CHHHHEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEEECCCCCCCCCCCCCC
FDGWRWVSFWYPVRQVVSFKRDVYRRVMKEFAVTVMPMQEQAAQRQTPAYRRKRG
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHCCC
>Mature Secondary Structure
MIDDDGYRPNVGIVICNRQGQVLWARRYGQHSWQFPQGGINPGETAEQAMYRELFEEVGL
CCCCCCCCCCCEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCC
SKKDVRILASTRNWLRYKLPKRLVRWDTKPVCIGQKQKWFLLQLMCNDADINMQRSSTPE
CHHHHEEHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCEEEEEEEECCCCCCCCCCCCCC
FDGWRWVSFWYPVRQVVSFKRDVYRRVMKEFAVTVMPMQEQAAQRQTPAYRRKRG
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA