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The map label for this gene is cadA [H]

Identifier: 157372002

GI number: 157372002

Start: 4161684

End: 4163825

Strand: Reverse

Name: cadA [H]

Synonym: Spro_3767

Alternate gene names: 157372002

Gene position: 4163825-4161684 (Counterclockwise)

Preceding gene: 157372003

Following gene: 157372001

Centisome position: 76.42

GC content: 51.21

Gene sequence:

>2142_bases
ATGAACGTTATTGCTATCATGAACCACATGGGTGTCTACTTCAAAGAAGAGCCCATCCGCGAACTGCACAACGCGTTGGA
AAAACTGAACTTCCGCATTGTTTACCCGAACGACCGCGAAGACCTGCTCAAATTGATCGAGAATAATGCCCGTCTGTGCG
GCGTGATCTTCGACTGGGATAAATACAACCTTGAGCTGTGCCAGGAAATCAGCGAGTTGAATGAGTACATGCCGCTGTAT
GCCTTTGCCAATACCTATTCAACCCTGGACGTTAGCCTCAACGATCTGCGTATGCAGGTGCGTTTCTTTGAATATGCGCT
CGGTGCGGCCAACGACATTGCCGACAAGATCAAACAGAACACCGATGAGTACGTAGACACCATCCTGCCACCGCTGACCA
AAGCGCTGTTCAAATATGTACGTGAAGGCAAATACACCTTCTGTACTCCTGGCCACATGGGCGGTACTGCCTTCCAGAAA
AGCCCGGTCGGTAGCCTGTTCTACGATTTCTTTGGCCCTAATGCGATGAAATCCGACGTGTCAATTTCGGTCTCTGAGCT
GGGTTCACTGCTGGATCACTCCGGCCCGCACAAAGAAGCTGAAGAATACATTGCCCGCGTGTTCAACGCTGAACGCAGCT
ATATGGTGACTAACGGCACTTCTACCGCCAACAAAATTGTCGGTATGTACTCTGCACCTGCCGGCAGCACGGTGCTGATT
GACCGTAACTGCCATAAATCGCTGACCCATCTGATGATGATGAGCGACATTACGCCAATTTATTTCCGCCCGACTCGTAA
TGCTTACGGCATCCTCGGTGGTATTCCACAGAGCGAGTTTGCCCGCGCCACCATCGCCAAACGCGTGAAAGAGACGCCGA
ACGCCACCTGGCCGGTACACGCGGTGATCACCAACTCGACCTACGACGGTCTGCTGTATAACACCGATTTCATCAAGAGC
ACGCTGGATGTGAAATCCATCCACTTTGACTCTGCCTGGGTGCCTTACACCAATTTCCACCCGATCTACAAAGGCAAGTG
CGGCATGAGCGGCGGCCGCGTGGAAGGGAAAGTGATCTATGAAACCCAATCCACCCATAAACTGCTGGCGGCGTTCTCAC
AGGCTTCGATGATCCACGTGAAAGGCGACATCAATGAAGAAACCTTCAGTGAAGCCTACATGATGCACACCACCACTTCA
CCGCACTACGGTATCGTGGCATCTACCGAAACCGCAGCGGCGATGATGAAAGGCAATGCCGGTAAGCGTCTGATTAACGG
TTCAATTGAGCGAGCTATCAAGTTCCGTAAAGAAATCAAACGTCTGAATGTCGAATCTGAAGGTTGGTTCTTTGACGTTT
GGCAGCCGGAACATATTGATGAAGCAGAATGTTGGCCGCTGCGTTCCGACAGTGCATGGCATGGTTTCAAAGGTATTGAT
AACGAACATATGTACCTTGACCCAATCAAGGTCACCATGTTGACACCGGGGATGAGCAAAGATGGCGAAATGGAGTCGTT
TGGTATCCCGGCCAGCCTGGTTGCCAAATACCTTGATGAGCACGGCATCATCGTTGAGAAAACCGGCCCGTATAACCTGC
TGTTCCTGTTCAGCATCGGTATCGATAAAACCAAGGCTCTCAGCCTGTTGCGCGGTCTGACTGACTTTAAACGCTCGTTC
GATCTGAACCTGCGGGTGAAAAACATGCTGCCTTCGCTGTATAAAGAGGCACCAGAGTTTTATGAAGACATGCGGATCCA
GGAGCTGGCTCAGAATATCCACAACCTGGTGAAACACCATAATCTGCCTGACCTGATGTACCGCGCCTTTGAAGTGCTGC
CGGCGATGGTAATGAACCCGTTCCAGGCCTTCCAGAAAGAACTGCACGGTGAAGTGGAAGAGGTTTATTTGGAAGACATG
GTGGGCAAAGTGAATGCCAACATGATCCTGCCATATCCTCCGGGTGTTCCGCTGGTCATGCCGGGTGAAATGCTCACCGA
GGAAAGCCGTCCGGTTCTGGAGTTCCTGCAAATGCTGTGCGAGATCGGCGCGCATTATCCAGGCTTCGAAACTGATATCC
ATGGCGCTTATCGCCAGGCGGATGGACGTTACACCGTGAAGGTGTTGAAAAACGATAAATAA

Upstream 100 bases:

>100_bases
GCGCACTAAGCACGTACTGACCCACTTCTTAATTCAGCCCCTTGCAACAACGATTGTCATCCGTGATGGCAAGGGGCTCG
CATTACCTGGAGAAATGATT

Downstream 100 bases:

>100_bases
GTGAACTAACAAGGGGAGGCGCTTGCGCTTCCCCTTTTGTCGTTCCCCGACTGATGGGAGAAAACCATGAAAACACCCTC
ACAGCCGCGCGCAATCTACT

Product: lysine decarboxylase

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MNVIAIMNHMGVYFKEEPIRELHNALEKLNFRIVYPNDREDLLKLIENNARLCGVIFDWDKYNLELCQEISELNEYMPLY
AFANTYSTLDVSLNDLRMQVRFFEYALGAANDIADKIKQNTDEYVDTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQK
SPVGSLFYDFFGPNAMKSDVSISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTVLI
DRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFARATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKS
TLDVKSIHFDSAWVPYTNFHPIYKGKCGMSGGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDINEETFSEAYMMHTTTS
PHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLNVESEGWFFDVWQPEHIDEAECWPLRSDSAWHGFKGID
NEHMYLDPIKVTMLTPGMSKDGEMESFGIPASLVAKYLDEHGIIVEKTGPYNLLFLFSIGIDKTKALSLLRGLTDFKRSF
DLNLRVKNMLPSLYKEAPEFYEDMRIQELAQNIHNLVKHHNLPDLMYRAFEVLPAMVMNPFQAFQKELHGEVEEVYLEDM
VGKVNANMILPYPPGVPLVMPGEMLTEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKNDK

Sequences:

>Translated_713_residues
MNVIAIMNHMGVYFKEEPIRELHNALEKLNFRIVYPNDREDLLKLIENNARLCGVIFDWDKYNLELCQEISELNEYMPLY
AFANTYSTLDVSLNDLRMQVRFFEYALGAANDIADKIKQNTDEYVDTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQK
SPVGSLFYDFFGPNAMKSDVSISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTVLI
DRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFARATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKS
TLDVKSIHFDSAWVPYTNFHPIYKGKCGMSGGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDINEETFSEAYMMHTTTS
PHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLNVESEGWFFDVWQPEHIDEAECWPLRSDSAWHGFKGID
NEHMYLDPIKVTMLTPGMSKDGEMESFGIPASLVAKYLDEHGIIVEKTGPYNLLFLFSIGIDKTKALSLLRGLTDFKRSF
DLNLRVKNMLPSLYKEAPEFYEDMRIQELAQNIHNLVKHHNLPDLMYRAFEVLPAMVMNPFQAFQKELHGEVEEVYLEDM
VGKVNANMILPYPPGVPLVMPGEMLTEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKNDK
>Mature_713_residues
MNVIAIMNHMGVYFKEEPIRELHNALEKLNFRIVYPNDREDLLKLIENNARLCGVIFDWDKYNLELCQEISELNEYMPLY
AFANTYSTLDVSLNDLRMQVRFFEYALGAANDIADKIKQNTDEYVDTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQK
SPVGSLFYDFFGPNAMKSDVSISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTVLI
DRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFARATIAKRVKETPNATWPVHAVITNSTYDGLLYNTDFIKS
TLDVKSIHFDSAWVPYTNFHPIYKGKCGMSGGRVEGKVIYETQSTHKLLAAFSQASMIHVKGDINEETFSEAYMMHTTTS
PHYGIVASTETAAAMMKGNAGKRLINGSIERAIKFRKEIKRLNVESEGWFFDVWQPEHIDEAECWPLRSDSAWHGFKGID
NEHMYLDPIKVTMLTPGMSKDGEMESFGIPASLVAKYLDEHGIIVEKTGPYNLLFLFSIGIDKTKALSLLRGLTDFKRSF
DLNLRVKNMLPSLYKEAPEFYEDMRIQELAQNIHNLVKHHNLPDLMYRAFEVLPAMVMNPFQAFQKELHGEVEEVYLEDM
VGKVNANMILPYPPGVPLVMPGEMLTEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKNDK

Specific function: Appears To Play A Role In pH Homeostasis By Consuming Protons And Neutralizing The Acidic By-Products Of Carbohydrate Fermentation. [C]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1790573, Length=712, Percent_Identity=90.5898876404494, Blast_Score=1382, Evalue=0.0,
Organism=Escherichia coli, GI1786384, Length=710, Percent_Identity=70.1408450704225, Blast_Score=1095, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=735, Percent_Identity=34.9659863945578, Blast_Score=470, Evalue=1e-133,
Organism=Escherichia coli, GI87082193, Length=615, Percent_Identity=34.1463414634146, Blast_Score=330, Evalue=2e-91,
Organism=Escherichia coli, GI1786909, Length=626, Percent_Identity=33.2268370607029, Blast_Score=313, Evalue=2e-86,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 80880; Mature: 80880

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVIAIMNHMGVYFKEEPIRELHNALEKLNFRIVYPNDREDLLKLIENNARLCGVIFDWD
CCEEEEEHHCCCEECHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCEEEEEEEECC
KYNLELCQEISELNEYMPLYAFANTYSTLDVSLNDLRMQVRFFEYALGAANDIADKIKQN
CCCHHHHHHHHHHHHCCCHHEECCCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHCC
TDEYVDTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNAMKSDV
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
SISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTVLI
EEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHEEEEEECCCCCEEEE
DRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFARATIAKRVKETPNATWPVH
ECCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCEE
AVITNSTYDGLLYNTDFIKSTLDVKSIHFDSAWVPYTNFHPIYKGKCGMSGGRVEGKVIY
EEEECCCCCCEEEEHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ETQSTHKLLAAFSQASMIHVKGDINEETFSEAYMMHTTTSPHYGIVASTETAAAMMKGNA
ECCHHHHHHHHHHCCCEEEEECCCCHHHHHHEEEEEECCCCCCEEEECCHHHHHHHCCCC
GKRLINGSIERAIKFRKEIKRLNVESEGWFFDVWQPEHIDEAECWPLRSDSAWHGFKGID
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NEHMYLDPIKVTMLTPGMSKDGEMESFGIPASLVAKYLDEHGIIVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHCCEEEECCCCCEEEEEEEEC
IDKTKALSLLRGLTDFKRSFDLNLRVKNMLPSLYKEAPEFYEDMRIQELAQNIHNLVKHH
CCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NLPDLMYRAFEVLPAMVMNPFQAFQKELHGEVEEVYLEDMVGKVNANMILPYPPGVPLVM
CCHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCCCCCEEE
PGEMLTEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKNDK
CCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEEECCC
>Mature Secondary Structure
MNVIAIMNHMGVYFKEEPIRELHNALEKLNFRIVYPNDREDLLKLIENNARLCGVIFDWD
CCEEEEEHHCCCEECHHHHHHHHHHHHHCCEEEECCCCHHHHHHHHHCCCEEEEEEEECC
KYNLELCQEISELNEYMPLYAFANTYSTLDVSLNDLRMQVRFFEYALGAANDIADKIKQN
CCCHHHHHHHHHHHHCCCHHEECCCCEEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHCC
TDEYVDTILPPLTKALFKYVREGKYTFCTPGHMGGTAFQKSPVGSLFYDFFGPNAMKSDV
HHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCC
SISVSELGSLLDHSGPHKEAEEYIARVFNAERSYMVTNGTSTANKIVGMYSAPAGSTVLI
EEEHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCEEEECCCCCHHHEEEEEECCCCCEEEE
DRNCHKSLTHLMMMSDITPIYFRPTRNAYGILGGIPQSEFARATIAKRVKETPNATWPVH
ECCHHHHHHHHHHHHCCCCEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHCCCCCCCEE
AVITNSTYDGLLYNTDFIKSTLDVKSIHFDSAWVPYTNFHPIYKGKCGMSGGRVEGKVIY
EEEECCCCCCEEEEHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
ETQSTHKLLAAFSQASMIHVKGDINEETFSEAYMMHTTTSPHYGIVASTETAAAMMKGNA
ECCHHHHHHHHHHCCCEEEEECCCCHHHHHHEEEEEECCCCCCEEEECCHHHHHHHCCCC
GKRLINGSIERAIKFRKEIKRLNVESEGWFFDVWQPEHIDEAECWPLRSDSAWHGFKGID
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCC
NEHMYLDPIKVTMLTPGMSKDGEMESFGIPASLVAKYLDEHGIIVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCHHCCCCHHHHHHHHHHCCEEEECCCCCEEEEEEEEC
IDKTKALSLLRGLTDFKRSFDLNLRVKNMLPSLYKEAPEFYEDMRIQELAQNIHNLVKHH
CCHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
NLPDLMYRAFEVLPAMVMNPFQAFQKELHGEVEEVYLEDMVGKVNANMILPYPPGVPLVM
CCHHHHHHHHHHHHHHHHCHHHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCCCCCEEE
PGEMLTEESRPVLEFLQMLCEIGAHYPGFETDIHGAYRQADGRYTVKVLKNDK
CCHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]