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The map label for this gene is maeB [H]

Identifier: 157371709

GI number: 157371709

Start: 3844221

End: 3846500

Strand: Reverse

Name: maeB [H]

Synonym: Spro_3472

Alternate gene names: 157371709

Gene position: 3846500-3844221 (Counterclockwise)

Preceding gene: 157371710

Following gene: 157371706

Centisome position: 70.59

GC content: 58.29

Gene sequence:

>2280_bases
ATGGACGAACAGCTCAAACAGAGTGCGCTTGATTTTCACCAGTATCCGACCCCAGGGAAGATCCAGGTATCTCCAACCAA
ACCGCTGGCAACGCAACGCGATCTGGCGCTGGCCTACTCGCCGGGCGTCGCAGCCCCTTGTCTGGAAATTGCTGCCGATC
CTCTCGCGGCCTACAAATACACCGCACGCGGCAACCTGGTGGCGGTGATTTCCAACGGTACGGCGGTGCTGGGGCTGGGT
AATATCGGTGCCTTGGCCGGTAAGCCGGTAATGGAAGGGAAAGGCGTCCTGTTCAAGAAATTTTCCGGTATCGACGTGTT
TGATATCGAAGTGGATGAGCTAAACCCTGACAAGCTGATCGACATCATCGCCGCGCTGGAGCCCACCTTTGGCGGTATCA
ACCTGGAAGACATCAAAGCGCCGGAGTGTTTCTACATCGAGCAGAAACTGCGTGAGCGCATGAAGATCCCGGTGTTCCAC
GACGATCAGCACGGCACCGCCATTATTACCACCGCCGCCGTGCTGAACGGCCTGCGGGTAGTGAAAAAGAATATTTCCGA
CGTGCGACTGGTGGTTTCCGGTGCCGGCGCGGCGTCGATCGCCTGTTTGAACCTGCTGGTGGCGCTGGGGTTGCGCCAGC
AGAACATTACCGTCTGCGACTCCAAGGGGGTTATCTACAAAGGTCGCGACGCCAACATGGAACAGACCAAAGCGGCCTAC
GCCATCGAAGACAACGGCCAGCGGACGCTGGGGGATGCTATCCCGGATGCCGATATCTTCCTCGGCTGTTCCGGTCCGGG
CGTGTTGACCCAGGATATGGTGAAAACCATGGCCAGGGATCCGTTGATCATGGCGCTGGCCAACCCGGAACCGGAGATCT
TGCCGCCGCTGGCGAAAGCCGTGCGTCCGGATGCCATTATCTGTACCGGCCGTTCCGACTACCCGAACCAGGTCAACAAC
GTCTTGTGCTTCCCGTTCATCTTCCGCGGTGCGCTGGACGTGGGCGCGACCACCATCAACGAAGAAATGAAGCTGGCCTG
CGTGCATGCGATTGCCGATCTGGCACTGGCAGAACAGAGCGACGTGGTGGCTTCGGCCTATGGCGATCAGGACCTGTCAT
TTGGCCCCGAATACATCATTCCCAAGCCTTTCGATCCGCGCCTGATTGTTAAAATCGCCCCGGCGGTTGCCAAGGCGGCG
ATGGAGTCCGGCGTGGCGACACGTCCGATCGAAGACTTTGACGCCTACGTCGAAAAACTGTCCGAGTTCGTCTACAAAAC
CAACCTGTTCATGAAGCCGATCTTCTCCCAGGCGAAGAAAGAAATGAAGCGCGTGGTGATGGCGGAAGGGGAAGAGGAAA
GGGTACTGCATGCGACTCAGGAACTGGTGTCGCAGGGGCTGGCCTATCCAATCCTGGTCGGTCGTCCGAGCGTGATTGAA
ATGCGGCTGCAAAAACTCGGCCTGCAACTGACGCCGGGTAAAGACTTTGAAGTGGTGAACAACGAGTCCGACCCACGCTT
TAACGAATACTGGGGCGAGTATTACCAGATCATGAAGCGTCGTGGCGTATCTCAGGAACAGGCGCGTCGTGCGGTAATTG
GTAACCCAACGCTGATCGCTGCCATCATGCTGCATCGCGGCGAGGCGGATGCGATGATCTGCGGCACCATCGGCAGCTAT
CACGAGCATTACGACGTGGTCGAGAAAGTGTTTGGTTTCCGCGAAGGGGCGCACGTTGCCGGGGCGATGAATGCGCTGCT
GCTGCCAAGCGGCAACACTTTTATTGCCGACACCTATGTCAATGACGATCCGACGCCGGAGCAACTGGCAGAAATCACCC
TGATGGCGGCGGAAACCGTGCGCCGTTTCGGGATTGAACCCAAGGTGGCGCTGCTGTCTCATTCCAGCTTTGGCTCTTCC
GATAACCCGGCGGCCTGCAAGATGCGTAAAACGCTGGAGCTGGTGAACAAGATGGCACCGGAGCTGGAGATTGACGGTGA
GATGCACGGTGACGCCGCGCTGGTGGAAAGCATCCGTAACGATCTGATGCCGGATAGCCCGCTGAAAGGGGCGGCCAACG
TGCTGATCATGCCGAATATGGAAGCGGCGCGTATCAGCTACAACCTGCTGCGCGTATCTTCTTCCGAAGGCGTTACCGTG
GGGCCGGTGCTGATGGGGGTATCGAAACCGGTACACATCCTGACGCCAATCGCCTCGGTACGCCGCATCGTCAATATGGT
CGCGCTGGCCGTGGTGGAAGCGCAGACCACGCCGTTATAA

Upstream 100 bases:

>100_bases
CCGCTTCAAAGTTTGTGACGTTTCTCTCACTATACTGGTCTAGCCTTAAAGGTTTACAAGTCTTACCTCAACATAAAAGC
AAAAAGCATAGGAACCCATA

Downstream 100 bases:

>100_bases
GCCTTAAGTGACTACAAGCCTCCAGCGTTTCGGCGCCGGAGGCTTTTTTTATTTTATGCCCTGCAGCGTGTGGCGATCTG
GTGGATATCCTGCGGTGTCG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 759; Mature: 759

Protein sequence:

>759_residues
MDEQLKQSALDFHQYPTPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIAADPLAAYKYTARGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFSGIDVFDIEVDELNPDKLIDIIAALEPTFGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIITTAAVLNGLRVVKKNISDVRLVVSGAGAASIACLNLLVALGLRQQNITVCDSKGVIYKGRDANMEQTKAAY
AIEDNGQRTLGDAIPDADIFLGCSGPGVLTQDMVKTMARDPLIMALANPEPEILPPLAKAVRPDAIICTGRSDYPNQVNN
VLCFPFIFRGALDVGATTINEEMKLACVHAIADLALAEQSDVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAA
MESGVATRPIEDFDAYVEKLSEFVYKTNLFMKPIFSQAKKEMKRVVMAEGEEERVLHATQELVSQGLAYPILVGRPSVIE
MRLQKLGLQLTPGKDFEVVNNESDPRFNEYWGEYYQIMKRRGVSQEQARRAVIGNPTLIAAIMLHRGEADAMICGTIGSY
HEHYDVVEKVFGFREGAHVAGAMNALLLPSGNTFIADTYVNDDPTPEQLAEITLMAAETVRRFGIEPKVALLSHSSFGSS
DNPAACKMRKTLELVNKMAPELEIDGEMHGDAALVESIRNDLMPDSPLKGAANVLIMPNMEAARISYNLLRVSSSEGVTV
GPVLMGVSKPVHILTPIASVRRIVNMVALAVVEAQTTPL

Sequences:

>Translated_759_residues
MDEQLKQSALDFHQYPTPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIAADPLAAYKYTARGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFSGIDVFDIEVDELNPDKLIDIIAALEPTFGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIITTAAVLNGLRVVKKNISDVRLVVSGAGAASIACLNLLVALGLRQQNITVCDSKGVIYKGRDANMEQTKAAY
AIEDNGQRTLGDAIPDADIFLGCSGPGVLTQDMVKTMARDPLIMALANPEPEILPPLAKAVRPDAIICTGRSDYPNQVNN
VLCFPFIFRGALDVGATTINEEMKLACVHAIADLALAEQSDVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAA
MESGVATRPIEDFDAYVEKLSEFVYKTNLFMKPIFSQAKKEMKRVVMAEGEEERVLHATQELVSQGLAYPILVGRPSVIE
MRLQKLGLQLTPGKDFEVVNNESDPRFNEYWGEYYQIMKRRGVSQEQARRAVIGNPTLIAAIMLHRGEADAMICGTIGSY
HEHYDVVEKVFGFREGAHVAGAMNALLLPSGNTFIADTYVNDDPTPEQLAEITLMAAETVRRFGIEPKVALLSHSSFGSS
DNPAACKMRKTLELVNKMAPELEIDGEMHGDAALVESIRNDLMPDSPLKGAANVLIMPNMEAARISYNLLRVSSSEGVTV
GPVLMGVSKPVHILTPIASVRRIVNMVALAVVEAQTTPL
>Mature_759_residues
MDEQLKQSALDFHQYPTPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIAADPLAAYKYTARGNLVAVISNGTAVLGLG
NIGALAGKPVMEGKGVLFKKFSGIDVFDIEVDELNPDKLIDIIAALEPTFGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIITTAAVLNGLRVVKKNISDVRLVVSGAGAASIACLNLLVALGLRQQNITVCDSKGVIYKGRDANMEQTKAAY
AIEDNGQRTLGDAIPDADIFLGCSGPGVLTQDMVKTMARDPLIMALANPEPEILPPLAKAVRPDAIICTGRSDYPNQVNN
VLCFPFIFRGALDVGATTINEEMKLACVHAIADLALAEQSDVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAA
MESGVATRPIEDFDAYVEKLSEFVYKTNLFMKPIFSQAKKEMKRVVMAEGEEERVLHATQELVSQGLAYPILVGRPSVIE
MRLQKLGLQLTPGKDFEVVNNESDPRFNEYWGEYYQIMKRRGVSQEQARRAVIGNPTLIAAIMLHRGEADAMICGTIGSY
HEHYDVVEKVFGFREGAHVAGAMNALLLPSGNTFIADTYVNDDPTPEQLAEITLMAAETVRRFGIEPKVALLSHSSFGSS
DNPAACKMRKTLELVNKMAPELEIDGEMHGDAALVESIRNDLMPDSPLKGAANVLIMPNMEAARISYNLLRVSSSEGVTV
GPVLMGVSKPVHILTPIASVRRIVNMVALAVVEAQTTPL

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=399, Percent_Identity=27.3182957393484, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI62420882, Length=345, Percent_Identity=26.9565217391304, Blast_Score=78, Evalue=4e-14,
Organism=Homo sapiens, GI62420880, Length=345, Percent_Identity=26.9565217391304, Blast_Score=78, Evalue=4e-14,
Organism=Homo sapiens, GI239049447, Length=345, Percent_Identity=26.9565217391304, Blast_Score=78, Evalue=4e-14,
Organism=Homo sapiens, GI4505145, Length=378, Percent_Identity=25.9259259259259, Blast_Score=73, Evalue=1e-12,
Organism=Homo sapiens, GI270265879, Length=325, Percent_Identity=27.3846153846154, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1788806, Length=759, Percent_Identity=84.4532279314888, Blast_Score=1338, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=346, Percent_Identity=29.1907514450867, Blast_Score=154, Evalue=3e-38,
Organism=Escherichia coli, GI1788800, Length=319, Percent_Identity=33.8557993730408, Blast_Score=149, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17537199, Length=405, Percent_Identity=26.1728395061728, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322823, Length=274, Percent_Identity=27.7372262773723, Blast_Score=89, Evalue=4e-18,
Organism=Drosophila melanogaster, GI78707242, Length=450, Percent_Identity=25.5555555555556, Blast_Score=89, Evalue=2e-17,
Organism=Drosophila melanogaster, GI78707238, Length=450, Percent_Identity=25.5555555555556, Blast_Score=89, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281362674, Length=474, Percent_Identity=24.6835443037975, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281362672, Length=474, Percent_Identity=24.6835443037975, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI21356279, Length=474, Percent_Identity=24.6835443037975, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24646388, Length=345, Percent_Identity=27.2463768115942, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI78707240, Length=355, Percent_Identity=25.0704225352113, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24646386, Length=345, Percent_Identity=27.2463768115942, Blast_Score=77, Evalue=4e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 82149; Mature: 82149

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQLKQSALDFHQYPTPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIAADPLAAYKY
CCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHCCCHHHEEE
TARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFSGIDVFDIEVDELNPDKLI
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCHHHHH
DIIAALEPTFGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIITTAAVLNGLRV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHH
VKKNISDVRLVVSGAGAASIACLNLLVALGLRQQNITVCDSKGVIYKGRDANMEQTKAAY
HHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCHHHHHEEE
AIEDNGQRTLGDAIPDADIFLGCSGPGVLTQDMVKTMARDPLIMALANPEPEILPPLAKA
EEECCCCEEHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
VRPDAIICTGRSDYPNQVNNVLCFPFIFRGALDVGATTINEEMKLACVHAIADLALAEQS
CCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHHHHCCC
DVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAAMESGVATRPIEDFDAYVEKL
CHHEECCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHH
SEFVYKTNLFMKPIFSQAKKEMKRVVMAEGEEERVLHATQELVSQGLAYPILVGRPSVIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHH
MRLQKLGLQLTPGKDFEVVNNESDPRFNEYWGEYYQIMKRRGVSQEQARRAVIGNPTLIA
HHHHHCCCEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHH
AIMLHRGEADAMICGTIGSYHEHYDVVEKVFGFREGAHVAGAMNALLLPSGNTFIADTYV
HHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCEEEEEECC
NDDPTPEQLAEITLMAAETVRRFGIEPKVALLSHSSFGSSDNPAACKMRKTLELVNKMAP
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
ELEIDGEMHGDAALVESIRNDLMPDSPLKGAANVLIMPNMEAARISYNLLRVSSSEGVTV
CEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHEEEEEEEEECCCCCEE
GPVLMGVSKPVHILTPIASVRRIVNMVALAVVEAQTTPL
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MDEQLKQSALDFHQYPTPGKIQVSPTKPLATQRDLALAYSPGVAAPCLEIAADPLAAYKY
CCHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCEEEEECCCCCHHHHHHHCCCHHHEEE
TARGNLVAVISNGTAVLGLGNIGALAGKPVMEGKGVLFKKFSGIDVFDIEVDELNPDKLI
ECCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCHHHHH
DIIAALEPTFGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIITTAAVLNGLRV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCEEEEHHHHHHHHHH
VKKNISDVRLVVSGAGAASIACLNLLVALGLRQQNITVCDSKGVIYKGRDANMEQTKAAY
HHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCCCCHHHHHEEE
AIEDNGQRTLGDAIPDADIFLGCSGPGVLTQDMVKTMARDPLIMALANPEPEILPPLAKA
EEECCCCEEHHCCCCCCCEEEECCCCCCHHHHHHHHHCCCCEEEEECCCCCCCCCHHHHH
VRPDAIICTGRSDYPNQVNNVLCFPFIFRGALDVGATTINEEMKLACVHAIADLALAEQS
CCCCEEEEECCCCCCHHHCCEEEHHHHHHHHHHCCCHHHCHHHHHHHHHHHHHHHHHCCC
DVVASAYGDQDLSFGPEYIIPKPFDPRLIVKIAPAVAKAAMESGVATRPIEDFDAYVEKL
CHHEECCCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHH
SEFVYKTNLFMKPIFSQAKKEMKRVVMAEGEEERVLHATQELVSQGLAYPILVGRPSVIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCEEEECCCHHHH
MRLQKLGLQLTPGKDFEVVNNESDPRFNEYWGEYYQIMKRRGVSQEQARRAVIGNPTLIA
HHHHHCCCEECCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCHHHH
AIMLHRGEADAMICGTIGSYHEHYDVVEKVFGFREGAHVAGAMNALLLPSGNTFIADTYV
HHHHHCCCCCEEEEECHHHHHHHHHHHHHHHCCCCCCHHHHHCCEEEECCCCEEEEEECC
NDDPTPEQLAEITLMAAETVRRFGIEPKVALLSHSSFGSSDNPAACKMRKTLELVNKMAP
CCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCC
ELEIDGEMHGDAALVESIRNDLMPDSPLKGAANVLIMPNMEAARISYNLLRVSSSEGVTV
CEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHEEEEEEEEECCCCCEE
GPVLMGVSKPVHILTPIASVRRIVNMVALAVVEAQTTPL
CHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]