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The map label for this gene is cysM [H]

Identifier: 157371690

GI number: 157371690

Start: 3824041

End: 3824922

Strand: Reverse

Name: cysM [H]

Synonym: Spro_3453

Alternate gene names: 157371690

Gene position: 3824922-3824041 (Counterclockwise)

Preceding gene: 157371691

Following gene: 157371689

Centisome position: 70.2

GC content: 59.75

Gene sequence:

>882_bases
GTGACAACGCTTGAACAATGCATCGGTAATACCCCGCTGGTAAAATTACAACGACTGGCTGCAGGCTTGGGCAGCGAGGT
TTGGCTCAAACTGGAAGGCAATAACCCGGCGGGTTCGGTAAAGGATCGCGCCGCGCTGGCGATGATCCAGCAGGCGGAGC
TGCGCGGTGAGATAAAGCCCGGCGATCGGTTGATTGAGGCCACCAGCGGCAACACCGGCATTGCACTGGCGATGATAGCG
GCGCTCAAGGGCTATTCGATGACCCTGCTGATGCCGGAGAACATGAGCCTGGAACGTCAGGCGGCGATGCGTGCCTATGG
CGCAGAGTTGATCCTGGTCAGCCGCGAAGTGGGAATGGAAGGCGCGCGCGATCTGGCGCTGGAAATGCAGAATCAGGGAC
AGGGCAAGGTGCTGGATCAGTTCAATAATCTGGACAACCCTTACGCCCACTTCACCACCACCGGTCCGGAAATCTGGCAG
CAGAGCCATCAACGGGTGACCCATTTCGTTTCAAGTATGGGCACCACCGGCACCATTACCGGCGTGGGGGGCTACCTGAA
GAGCCAAAACCCGCAGGTGCAGATTATCGGCCTGCAGCCGGCAGAAGGCAGCAGTATTCCCGGCATTCGCCGCTGGGCAC
CGGCTTATATGCCGGGGATCTTCCGGCCGGACCTGGTGGATCAGGTGCTGGACATTGAGCAAACCGACGCTGAACAGACC
ATGCGTCAGTTGGCGCAGCGCGAAGGTATATTCTGCGGCGTCAGCTCCGGCGGGGCAGTAGCCGGTGCGCTACAGATTGC
GGCGGCCAATCCGGGCAGCGTGATCGTGGCTATCATCTGCGATCGCGGCGATCGTTATCTCTCCACCGGTGTTTTTGCTT
AA

Upstream 100 bases:

>100_bases
CCTTCGGCACGCTCTCCCTAATAACGGGCTTTGTCAGTAGTCTGAAAGGTAACCCCGGGGTTGCCTTTTTACTTTTCGCA
CTTCAACACAGGCAAAGATC

Downstream 100 bases:

>100_bases
GGGTTATCCCCTTTCCAACGCCTGTATCAGATCCATCCCGGCGGCGCGTTTCGCCGGGAAGAAATCATCCCCCCAATATC
TCTTCTTTAACGCGCCGTCG

Product: cysteine synthase B

Products: NA

Alternate protein names: CSase B; O-acetylserine (thiol)-lyase B; OAS-TL B; O-acetylserine sulfhydrylase B [H]

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MTTLEQCIGNTPLVKLQRLAAGLGSEVWLKLEGNNPAGSVKDRAALAMIQQAELRGEIKPGDRLIEATSGNTGIALAMIA
ALKGYSMTLLMPENMSLERQAAMRAYGAELILVSREVGMEGARDLALEMQNQGQGKVLDQFNNLDNPYAHFTTTGPEIWQ
QSHQRVTHFVSSMGTTGTITGVGGYLKSQNPQVQIIGLQPAEGSSIPGIRRWAPAYMPGIFRPDLVDQVLDIEQTDAEQT
MRQLAQREGIFCGVSSGGAVAGALQIAAANPGSVIVAIICDRGDRYLSTGVFA

Sequences:

>Translated_293_residues
MTTLEQCIGNTPLVKLQRLAAGLGSEVWLKLEGNNPAGSVKDRAALAMIQQAELRGEIKPGDRLIEATSGNTGIALAMIA
ALKGYSMTLLMPENMSLERQAAMRAYGAELILVSREVGMEGARDLALEMQNQGQGKVLDQFNNLDNPYAHFTTTGPEIWQ
QSHQRVTHFVSSMGTTGTITGVGGYLKSQNPQVQIIGLQPAEGSSIPGIRRWAPAYMPGIFRPDLVDQVLDIEQTDAEQT
MRQLAQREGIFCGVSSGGAVAGALQIAAANPGSVIVAIICDRGDRYLSTGVFA
>Mature_292_residues
TTLEQCIGNTPLVKLQRLAAGLGSEVWLKLEGNNPAGSVKDRAALAMIQQAELRGEIKPGDRLIEATSGNTGIALAMIAA
LKGYSMTLLMPENMSLERQAAMRAYGAELILVSREVGMEGARDLALEMQNQGQGKVLDQFNNLDNPYAHFTTTGPEIWQQ
SHQRVTHFVSSMGTTGTITGVGGYLKSQNPQVQIIGLQPAEGSSIPGIRRWAPAYMPGIFRPDLVDQVLDIEQTDAEQTM
RQLAQREGIFCGVSSGGAVAGALQIAAANPGSVIVAIICDRGDRYLSTGVFA

Specific function: Two cysteine synthase enzymes are found. Both catalyze the same reaction. Cysteine synthase B can also use thiosulfate in place of sulfide to give cysteine thiosulfonate as a product [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=304, Percent_Identity=37.171052631579, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI295821200, Length=304, Percent_Identity=37.171052631579, Blast_Score=174, Evalue=7e-44,
Organism=Homo sapiens, GI4557415, Length=304, Percent_Identity=37.171052631579, Blast_Score=174, Evalue=7e-44,
Organism=Escherichia coli, GI2367138, Length=292, Percent_Identity=79.1095890410959, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1788754, Length=306, Percent_Identity=41.5032679738562, Blast_Score=189, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17535051, Length=299, Percent_Identity=42.4749163879599, Blast_Score=223, Evalue=9e-59,
Organism=Caenorhabditis elegans, GI17562970, Length=297, Percent_Identity=41.0774410774411, Blast_Score=222, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI32566674, Length=291, Percent_Identity=41.9243986254296, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI115535073, Length=297, Percent_Identity=43.4343434343434, Blast_Score=200, Evalue=6e-52,
Organism=Caenorhabditis elegans, GI17561720, Length=297, Percent_Identity=39.0572390572391, Blast_Score=186, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI32566672, Length=213, Percent_Identity=37.5586854460094, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI25147552, Length=285, Percent_Identity=34.3859649122807, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI17534315, Length=281, Percent_Identity=35.5871886120996, Blast_Score=130, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6321594, Length=314, Percent_Identity=35.3503184713376, Blast_Score=170, Evalue=2e-43,
Organism=Saccharomyces cerevisiae, GI6321449, Length=324, Percent_Identity=33.0246913580247, Blast_Score=133, Evalue=3e-32,
Organism=Drosophila melanogaster, GI24643623, Length=308, Percent_Identity=38.961038961039, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI20129101, Length=308, Percent_Identity=38.961038961039, Blast_Score=159, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR005856
- InterPro:   IPR005858
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 31314; Mature: 31183

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00901 CYS_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLEQCIGNTPLVKLQRLAAGLGSEVWLKLEGNNPAGSVKDRAALAMIQQAELRGEIKP
CCCHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
GDRLIEATSGNTGIALAMIAALKGYSMTLLMPENMSLERQAAMRAYGAELILVSREVGME
CCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEHHCCCC
GARDLALEMQNQGQGKVLDQFNNLDNPYAHFTTTGPEIWQQSHQRVTHFVSSMGTTGTIT
CHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEE
GVGGYLKSQNPQVQIIGLQPAEGSSIPGIRRWAPAYMPGIFRPDLVDQVLDIEQTDAEQT
ECCCHHCCCCCCEEEEEECCCCCCCCCCHHHHCHHHCCCCCCHHHHHHHHCCCCCCHHHH
MRQLAQREGIFCGVSSGGAVAGALQIAAANPGSVIVAIICDRGDRYLSTGVFA
HHHHHHHCCEEEEECCCCCEEEEEEEEECCCCCEEEEEEECCCCCCHHCCCCC
>Mature Secondary Structure 
TTLEQCIGNTPLVKLQRLAAGLGSEVWLKLEGNNPAGSVKDRAALAMIQQAELRGEIKP
CCHHHHHCCCCHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCCCC
GDRLIEATSGNTGIALAMIAALKGYSMTLLMPENMSLERQAAMRAYGAELILVSREVGME
CCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHCCCEEEEEEHHCCCC
GARDLALEMQNQGQGKVLDQFNNLDNPYAHFTTTGPEIWQQSHQRVTHFVSSMGTTGTIT
CHHHHHHHHCCCCCCCHHHHHCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEE
GVGGYLKSQNPQVQIIGLQPAEGSSIPGIRRWAPAYMPGIFRPDLVDQVLDIEQTDAEQT
ECCCHHCCCCCCEEEEEECCCCCCCCCCHHHHCHHHCCCCCCHHHHHHHHCCCCCCHHHH
MRQLAQREGIFCGVSSGGAVAGALQIAAANPGSVIVAIICDRGDRYLSTGVFA
HHHHHHHCCEEEEECCCCCEEEEEEEEECCCCCEEEEEEECCCCCCHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2188958; 9205837; 9278503 [H]