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The map label for this gene is cpxR [H]

Identifier: 157371689

GI number: 157371689

Start: 3823151

End: 3823831

Strand: Reverse

Name: cpxR [H]

Synonym: Spro_3452

Alternate gene names: 157371689

Gene position: 3823831-3823151 (Counterclockwise)

Preceding gene: 157371690

Following gene: 157371688

Centisome position: 70.18

GC content: 58.88

Gene sequence:

>681_bases
ATGAAAATTTTATTGGTCGATGATGACCTCGAACTCGGCACCATGCTGAGCGAATACCTGACCGGCGAAGGCTTTAACGC
CACGCTGGTGCTGACCGGCAAGGCCGGGGTGGAAGGCGCGCTGTCAGGTGATTACACCGCAATGATCCTCGACATCATGC
TGCCGGACATGAGCGGCATCGACGTACTGCGCGACGTGCGCAAGAAGAGCCGCATGCCGATCATCATGCTGACGGCCAAG
GGCGATAACATCGATCGGGTCATCGGCCTGGAAATGGGCGCCGACGACTATATGCCCAAGCCGTGCTATCCCCGCGAACT
GGTGGCGCGCCTGCGTGCGGTACTGCGCCGCTTCGACGAGCGTCCGGATGAGGTGGACGATGAGATTGCGATTAATTTCG
GCGAACTGACCCTTAACCCATCGACCCGCAGCAGCGAATGGCGCGGCAAGGCGTTTGATCTGACCGCTTCCGAATTCAAC
CTGTTGGAGTTACTGCTGCGCGCGCCGGAGCGGGTGGTATCAAAAGACGAGCTGTCAGAAAAAGGTTTAGGCCGCCCACG
AGAAGCCTATGACCGCAGCGTCGACGTGCATATCAGCAATATCCGCCAGAAGCTGGGGGCGTTGACGGACAACGCGCTCA
GCATTGAGACGGTGCGCAGCATCGGCTATCGCATCCGATAA

Upstream 100 bases:

>100_bases
TGGTTAACTGGCGTTCAGGAATATGTAAGGATTGAGTAAAACCGGCTGCGAAGCAGACAAATAGGCGTGAAAATGACGAA
AATCCGCGAAGGAGCAAGGC

Downstream 100 bases:

>100_bases
TGCCTATGCGTGGAAGACTGTTCTGGAAAATCCTGCTCGGCTTCTGGCTGACCTTTATCATCATGACCCAGGCGTTGTGG
GTCGCTTTTTCCTTGTATGG

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MKILLVDDDLELGTMLSEYLTGEGFNATLVLTGKAGVEGALSGDYTAMILDIMLPDMSGIDVLRDVRKKSRMPIIMLTAK
GDNIDRVIGLEMGADDYMPKPCYPRELVARLRAVLRRFDERPDEVDDEIAINFGELTLNPSTRSSEWRGKAFDLTASEFN
LLELLLRAPERVVSKDELSEKGLGRPREAYDRSVDVHISNIRQKLGALTDNALSIETVRSIGYRIR

Sequences:

>Translated_226_residues
MKILLVDDDLELGTMLSEYLTGEGFNATLVLTGKAGVEGALSGDYTAMILDIMLPDMSGIDVLRDVRKKSRMPIIMLTAK
GDNIDRVIGLEMGADDYMPKPCYPRELVARLRAVLRRFDERPDEVDDEIAINFGELTLNPSTRSSEWRGKAFDLTASEFN
LLELLLRAPERVVSKDELSEKGLGRPREAYDRSVDVHISNIRQKLGALTDNALSIETVRSIGYRIR
>Mature_226_residues
MKILLVDDDLELGTMLSEYLTGEGFNATLVLTGKAGVEGALSGDYTAMILDIMLPDMSGIDVLRDVRKKSRMPIIMLTAK
GDNIDRVIGLEMGADDYMPKPCYPRELVARLRAVLRRFDERPDEVDDEIAINFGELTLNPSTRSSEWRGKAFDLTASEFN
LLELLLRAPERVVSKDELSEKGLGRPREAYDRSVDVHISNIRQKLGALTDNALSIETVRSIGYRIR

Specific function: Member of the two-component regulatory system CpxA/CpxR. This system combats a variety of extracytoplasmic protein-mediated toxicities. It performs this function by increasing the synthesis of the periplasmic protease, DegP as well as that of CpxP protein

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=42.6666666666667, Blast_Score=168, Evalue=2e-43,
Organism=Escherichia coli, GI1789809, Length=225, Percent_Identity=42.2222222222222, Blast_Score=160, Evalue=5e-41,
Organism=Escherichia coli, GI1788394, Length=223, Percent_Identity=37.6681614349776, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1790860, Length=227, Percent_Identity=36.1233480176211, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=37.5, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=37.8854625550661, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786599, Length=227, Percent_Identity=34.8017621145374, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787229, Length=211, Percent_Identity=34.5971563981043, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=34.8214285714286, Blast_Score=111, Evalue=4e-26,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=30.7017543859649, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI87082012, Length=223, Percent_Identity=32.7354260089686, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693140, Length=236, Percent_Identity=31.7796610169492, Blast_Score=101, Evalue=5e-23,
Organism=Escherichia coli, GI1786911, Length=226, Percent_Identity=30.5309734513274, Blast_Score=99, Evalue=2e-22,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=29.4372294372294, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790299, Length=120, Percent_Identity=30, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25291; Mature: 25291

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILLVDDDLELGTMLSEYLTGEGFNATLVLTGKAGVEGALSGDYTAMILDIMLPDMSGI
CEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCH
DVLRDVRKKSRMPIIMLTAKGDNIDRVIGLEMGADDYMPKPCYPRELVARLRAVLRRFDE
HHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
RPDEVDDEIAINFGELTLNPSTRSSEWRGKAFDLTASEFNLLELLLRAPERVVSKDELSE
CCCCCCCCEEEEECEEEECCCCCCCCCCCCEEECCHHHHHHHHHHHHCHHHHHHHHHHHH
KGLGRPREAYDRSVDVHISNIRQKLGALTDNALSIETVRSIGYRIR
HCCCCCHHHHCCCEEEEHHHHHHHHHHCCCCCHHHHHHHHCCCCCC
>Mature Secondary Structure
MKILLVDDDLELGTMLSEYLTGEGFNATLVLTGKAGVEGALSGDYTAMILDIMLPDMSGI
CEEEEECCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHHHHHHHCCCCCCH
DVLRDVRKKSRMPIIMLTAKGDNIDRVIGLEMGADDYMPKPCYPRELVARLRAVLRRFDE
HHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHC
RPDEVDDEIAINFGELTLNPSTRSSEWRGKAFDLTASEFNLLELLLRAPERVVSKDELSE
CCCCCCCCEEEEECEEEECCCCCCCCCCCCEEECCHHHHHHHHHHHHCHHHHHHHHHHHH
KGLGRPREAYDRSVDVHISNIRQKLGALTDNALSIETVRSIGYRIR
HCCCCCHHHHCCCEEEEHHHHHHHHHHCCCCCHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]