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The map label for this gene is cpxA [H]

Identifier: 157371688

GI number: 157371688

Start: 3821823

End: 3823151

Strand: Reverse

Name: cpxA [H]

Synonym: Spro_3451

Alternate gene names: 157371688

Gene position: 3823151-3821823 (Counterclockwise)

Preceding gene: 157371689

Following gene: 157371682

Centisome position: 70.16

GC content: 59.22

Gene sequence:

>1329_bases
ATGCCTATGCGTGGAAGACTGTTCTGGAAAATCCTGCTCGGCTTCTGGCTGACCTTTATCATCATGACCCAGGCGTTGTG
GGTCGCTTTTTCCTTGTATGGCGATCGCTACGAGCCACCTGAAAGTTCGATGGCCCGACGGGTGATTGGGTTGCAGCTGA
CGTCGGCCGCCACGCAGCTGCGCAGCGGAGGGATGCCGGCGTTGGACGCGATGCTGAAAGACTGGTCGGATGATGACCGG
CGCTTGCTTTCCGTGACCCCGCTGGCTCAGCCACCGGCACCGGTAACTGAGGAGCCGGTGTTTGAAGGCCGTCGGATGCC
GAAAGCAATTACCACATGGGTGGCAGGTGAGGGCGGCAAGGGCTATTTGCTGAGTTATGACATGCGCAGCCTGCGGGACG
AGTATCGCCCCAAAAAACGCTCGCATTTTTTCAATATTCCCGAGCCAATGATTTGGGTGGGTGGGTTAGCCGGGCTGTTG
TTCAGTGCGGTACTGGCCTGGAACCTGACCCGGCCGATGCGCAAACTGCGTGATGGTTTTGATCGTGTGGCACAGGGCGA
CTTGTCGGTGCGCCTGTTCCCGGCGATGCGTCGGCGGCATGACGAGCTTTCTGAGGTGGCACGTGACTTTGACAGCATGG
CGGAAAGGCTGGAGCTGTTAGTCAGCGCCCGCGAGCAGTTGCTGCATGACGTTTCGCACGAACTGCGTTCGCCGCTGGCC
CGCTTGCAATTGGCGATTGGCCTGGCGCGGCAGAATGCGGGTAACGTAGAGAATTCGCTGCAGCGCATTGAGCACGAAGC
GGGGCGGCTGGATAAAATGATCGGCGAACTGTTGGCGCTGTCGCGTGCCGAGAGCAACAGCCTGCCGGATGAAGAGTATT
TCGACCTGTACGGGCTGGTGGATGCGGTGGTGAGCGATGCGCGCTACGAAGCACAGATACCCGGCGTAGACATCGTGCTG
CAGGCCAGCTCGGACGTGGATTACACCGTCAAGGGCAATGCCGAACTGATGCGGCGTGCGGTGGATAATATCGTGCGTAA
TGCGTTGCGTTTCTCCAGCCACGGGCAGCGGGTGACGGTGGTGCTAACGCGTATCGAGCAGTTGTTCCAGATTGAGGTCA
GCGATCAGGGGCCGGGTGTGGAAGAGTCAAAAATTTCCAGCATTTTTGATCCGTTCGTCAGGGTGAAATCGGCAATGTCA
GGCAAGGGCTACGGGCTGGGCCTGGCGATCACCCGCAAGGTGGTCCTGGCGCACGGTGGCCAGGTTGAGGCGCGTAACGG
CGAAAGGGAAGGGTTGGTGATTACCCTGCGAATTCCACGTTGGAGTTAA

Upstream 100 bases:

>100_bases
TCGACGTGCATATCAGCAATATCCGCCAGAAGCTGGGGGCGTTGACGGACAACGCGCTCAGCATTGAGACGGTGCGCAGC
ATCGGCTATCGCATCCGATA

Downstream 100 bases:

>100_bases
TTGCTGTTGCGATTGGCTTGAATGACAGACATAAAAAAACGGCGCCGAGGGCGCCGTTCTTGCGTTCATCCGCTATTACT
TCTTGATGCGGATGATCGGG

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MPMRGRLFWKILLGFWLTFIIMTQALWVAFSLYGDRYEPPESSMARRVIGLQLTSAATQLRSGGMPALDAMLKDWSDDDR
RLLSVTPLAQPPAPVTEEPVFEGRRMPKAITTWVAGEGGKGYLLSYDMRSLRDEYRPKKRSHFFNIPEPMIWVGGLAGLL
FSAVLAWNLTRPMRKLRDGFDRVAQGDLSVRLFPAMRRRHDELSEVARDFDSMAERLELLVSAREQLLHDVSHELRSPLA
RLQLAIGLARQNAGNVENSLQRIEHEAGRLDKMIGELLALSRAESNSLPDEEYFDLYGLVDAVVSDARYEAQIPGVDIVL
QASSDVDYTVKGNAELMRRAVDNIVRNALRFSSHGQRVTVVLTRIEQLFQIEVSDQGPGVEESKISSIFDPFVRVKSAMS
GKGYGLGLAITRKVVLAHGGQVEARNGEREGLVITLRIPRWS

Sequences:

>Translated_442_residues
MPMRGRLFWKILLGFWLTFIIMTQALWVAFSLYGDRYEPPESSMARRVIGLQLTSAATQLRSGGMPALDAMLKDWSDDDR
RLLSVTPLAQPPAPVTEEPVFEGRRMPKAITTWVAGEGGKGYLLSYDMRSLRDEYRPKKRSHFFNIPEPMIWVGGLAGLL
FSAVLAWNLTRPMRKLRDGFDRVAQGDLSVRLFPAMRRRHDELSEVARDFDSMAERLELLVSAREQLLHDVSHELRSPLA
RLQLAIGLARQNAGNVENSLQRIEHEAGRLDKMIGELLALSRAESNSLPDEEYFDLYGLVDAVVSDARYEAQIPGVDIVL
QASSDVDYTVKGNAELMRRAVDNIVRNALRFSSHGQRVTVVLTRIEQLFQIEVSDQGPGVEESKISSIFDPFVRVKSAMS
GKGYGLGLAITRKVVLAHGGQVEARNGEREGLVITLRIPRWS
>Mature_441_residues
PMRGRLFWKILLGFWLTFIIMTQALWVAFSLYGDRYEPPESSMARRVIGLQLTSAATQLRSGGMPALDAMLKDWSDDDRR
LLSVTPLAQPPAPVTEEPVFEGRRMPKAITTWVAGEGGKGYLLSYDMRSLRDEYRPKKRSHFFNIPEPMIWVGGLAGLLF
SAVLAWNLTRPMRKLRDGFDRVAQGDLSVRLFPAMRRRHDELSEVARDFDSMAERLELLVSAREQLLHDVSHELRSPLAR
LQLAIGLARQNAGNVENSLQRIEHEAGRLDKMIGELLALSRAESNSLPDEEYFDLYGLVDAVVSDARYEAQIPGVDIVLQ
ASSDVDYTVKGNAELMRRAVDNIVRNALRFSSHGQRVTVVLTRIEQLFQIEVSDQGPGVEESKISSIFDPFVRVKSAMSG
KGYGLGLAITRKVVLAHGGQVEARNGEREGLVITLRIPRWS

Specific function: This protein is involved in several diverse cellular processes, such as the functioning of acetohydroxyacid synthetase I, in the biosynthesis of isoleucine and valine, the TraJ protein activation activity for tra gene expression in F plasmid, and the synt

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=35.4243542435424, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788393, Length=275, Percent_Identity=27.6363636363636, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786783, Length=306, Percent_Identity=27.4509803921569, Blast_Score=111, Evalue=9e-26,
Organism=Escherichia coli, GI1789808, Length=296, Percent_Identity=29.3918918918919, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1787894, Length=276, Percent_Identity=28.9855072463768, Blast_Score=95, Evalue=9e-21,
Organism=Escherichia coli, GI1786600, Length=259, Percent_Identity=29.3436293436293, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789149, Length=362, Percent_Identity=25.6906077348066, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790551, Length=268, Percent_Identity=29.8507462686567, Blast_Score=83, Evalue=4e-17,
Organism=Escherichia coli, GI87081816, Length=256, Percent_Identity=28.125, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1787374, Length=284, Percent_Identity=26.7605633802817, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790861, Length=296, Percent_Identity=25.3378378378378, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI48994928, Length=251, Percent_Identity=23.5059760956175, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=26.4069264069264, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1789403, Length=237, Percent_Identity=27.4261603375527, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI1786912, Length=232, Percent_Identity=25.8620689655172, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI145693157, Length=234, Percent_Identity=25.2136752136752, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI87082128, Length=247, Percent_Identity=25.5060728744939, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1788549, Length=234, Percent_Identity=26.9230769230769, Blast_Score=69, Evalue=9e-13,
Organism=Escherichia coli, GI1788713, Length=230, Percent_Identity=24.7826086956522, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49661; Mature: 49530

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMRGRLFWKILLGFWLTFIIMTQALWVAFSLYGDRYEPPESSMARRVIGLQLTSAATQL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
RSGGMPALDAMLKDWSDDDRRLLSVTPLAQPPAPVTEEPVFEGRRMPKAITTWVAGEGGK
HCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHCCCCCCHHHHHHCCCCCCC
GYLLSYDMRSLRDEYRPKKRSHFFNIPEPMIWVGGLAGLLFSAVLAWNLTRPMRKLRDGF
CEEEEHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRVAQGDLSVRLFPAMRRRHDELSEVARDFDSMAERLELLVSAREQLLHDVSHELRSPLA
HHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLQLAIGLARQNAGNVENSLQRIEHEAGRLDKMIGELLALSRAESNSLPDEEYFDLYGLV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
DAVVSDARYEAQIPGVDIVLQASSDVDYTVKGNAELMRRAVDNIVRNALRFSSHGQRVTV
HHHHHCCHHEECCCCEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEHH
VLTRIEQLFQIEVSDQGPGVEESKISSIFDPFVRVKSAMSGKGYGLGLAITRKVVLAHGG
HHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
QVEARNGEREGLVITLRIPRWS
EEEECCCCCCCEEEEEECCCCC
>Mature Secondary Structure 
PMRGRLFWKILLGFWLTFIIMTQALWVAFSLYGDRYEPPESSMARRVIGLQLTSAATQL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHH
RSGGMPALDAMLKDWSDDDRRLLSVTPLAQPPAPVTEEPVFEGRRMPKAITTWVAGEGGK
HCCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCCCHHCCCCCCHHHHHHCCCCCCC
GYLLSYDMRSLRDEYRPKKRSHFFNIPEPMIWVGGLAGLLFSAVLAWNLTRPMRKLRDGF
CEEEEHHHHHHHHHHCCCHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DRVAQGDLSVRLFPAMRRRHDELSEVARDFDSMAERLELLVSAREQLLHDVSHELRSPLA
HHHHCCCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLQLAIGLARQNAGNVENSLQRIEHEAGRLDKMIGELLALSRAESNSLPDEEYFDLYGLV
HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
DAVVSDARYEAQIPGVDIVLQASSDVDYTVKGNAELMRRAVDNIVRNALRFSSHGQRVTV
HHHHHCCHHEECCCCEEEEEEECCCCCEEECCCHHHHHHHHHHHHHHHHHHCCCCCEEHH
VLTRIEQLFQIEVSDQGPGVEESKISSIFDPFVRVKSAMSGKGYGLGLAITRKVVLAHGG
HHHHHHHHHEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCC
QVEARNGEREGLVITLRIPRWS
EEEECCCCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]