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The map label for this gene is dsbD [H]

Identifier: 157371587

GI number: 157371587

Start: 3705919

End: 3707955

Strand: Reverse

Name: dsbD [H]

Synonym: Spro_3350

Alternate gene names: 157371587

Gene position: 3707955-3705919 (Counterclockwise)

Preceding gene: 157371588

Following gene: 157371586

Centisome position: 68.05

GC content: 61.36

Gene sequence:

>2037_bases
ATGTTAAATATCATCAGGTCGGCATTAGCCTGCCTGTTACTGCTGTGGCTACCTGCTTTGCAGGCGGCGGACAGCGGCTG
GCTACAAAGCCCGACTAACGATCACGCCAAGGTGCGGCTGCGCGCCGATACCTCGCACAGCGGGGAAACCCGTTTGCTGC
TGGGCATAGAGCTGCAAAAAGGCTGGAAAACCTACTGGCGTTCGCCGGGGGAAGGCGGAATTGCGCCGACCATCGCCTGG
CAGGGTAATCCACCGCCGGCAACCTGGTTCTGGCCAACGCCGCAGCGTTTTGACGTTGCCGGCATCTCCACCCAGGGTTA
TCACGATCGGGTTGAGCTGCCGATGGTGATGAAAGGCGCGGTGCCACGTCAGTTGGCGGGCACCTTGACGCTGTCTACCT
GCAGCAACGTCTGCATTTTGACCGACTATCCGTTCAGTCTGGATCTGGACGCGCCGTCCGACGCGCAGTTTACCCATGAC
TTTGCCCAGGCAATGGGGCAGGTACCTATTGCCGATGGGTTGGTGGAGAGCATTAAAGCCGGTTATCAGAACGGGGAACT
GCAGATCAGCGCCGAGCGAGCCGCCGGTTGGCAGCAGCCTGAGCTGTTCTTCGATACGCTGGAGGATGCCGATCTCGGCA
AGCCGAAGGTCAGCAGCGACGGAACCCGGATGTTCGCGCGGGTGCCGGTGAGTGATGGCTGGGGCGATAGCGCACCGGAT
CTGCGTGGCAAAACCCTGACGTTGGTGATCGGTGACGGCGGCGTGGCGCAGCAGGTGAAGCTACCTATTGAAGGGCCACT
GGCCTCTCCCGTTGCGGCAAGCTTCTCACTGTGGCAGGCGGTGCTGATGGCGCTGGCCGGTGGCCTGATCCTCAACCTGA
TGCCGTGCGTGCTGCCGGTATTGGGCATCAAGCTGGGCTCTATTTTGCAGGTCGAACAGCGTGATCGGCACAGTATTCGG
CTGCAGTTCCTGGCCTCGTCGTTCGGCATTGTGGCGTCATTTATGGCGCTGGCGTTGCTGATGACGCTGCTGCGACTGAG
CAACCAGGCGCTTGGCTGGGGCATTCAGTTCCAAAACCCGTGGTTTATCGGTTTTATGGTGCTGGTGACGCTGTTATTCA
GCGCTAACCTGTTCGGCCTGTTCCATCTGCAACTTTCCTCTTCGCTGAACACCAAACTGGCGACCCATAACGGCCGTGGC
CTGAGTGGGCATTTCTGGCAGGGCGCTTTCGCTACCTTACTGGCGACGCCATGTTCCGCGCCTTTCCTGGGTACCGCGGT
GGCCTTTGCTCTGGCAGCACCGCTGCCGGTGCTGTGGGGCATGTTTGTCGCGCTGGGCATCGGGATGAGCCTGCCCTGGC
TGTTGATTGCCGCCTGGCCGGCGCTGGCACTGCGTTTACCTCGTCCGGGGCGTTGGATGAACAGCCTGCGGCTGGTGATG
GGGTTGCTGATGCTGGCTTCTTCGTTGTGGCTGCTAAGCCTGATGGCCAACCATATCGGTGGCGTCCCAACGCTGGTGGT
GGGTGTTATCGCGCTGCTGGCCCTGTTGCTGGCGGTCGGTTGGCAACACGGGGTTCGCCTGGCGGCCAAGCTGGCAGCCG
CTACCCTGGTGCTGGTTGGGGTGGTGCTATTGGCCGGTTCGCTGACCGCCGGGCTGTGGCGTCAGCCGCTGCACGACAAT
GTGGCCTGGCAACCGCTGAGCGAGGAGGCGATCACCCAGGCGCTGGCCCAGAACAAACGGGTGTTTGTCGACGTCACCGC
TGACTGGTGCGTGACCTGTAAAGCCAACAAATTCAACGTACTGCTGCGCGATGACGTGCAAAAAGCGCTGAGCGCCGAGG
ACGTTGTCGCCCTGCGGGGGGACTGGAGCCGTCCATCGGCCGAAATTAGCGCCTTCCTGCAACAACGCGGCAGCGTCGCC
GTGCCTTTTAATCAAATTTATGGCCCCGGCAGGCGCGACGGCGTGGTGTTGTCCCCACTGTTGACCCGCGATGCCGTATT
GCAAACCCTGTCCGCCGCCAAAGGAAATTCACAATGA

Upstream 100 bases:

>100_bases
TCCCCCACCACCCTCAGGGTACATCTGCGATTATGCGTATTCCGTGAATGAGTTCATCGCCCGTCTGTTTTGGTGATTGA
TTCATTTATGGAGAAAAAAC

Downstream 100 bases:

>100_bases
AAAAATTAATGATTTTACTGATGTTGATCGCCACCCCTGTCTGGGCCGCTGCCCCATTTACTCCAGAACAGGAAGTCCGC
ATTAAAGAGCTGATCCGCGA

Product: cytochrome C biogenesis transmembrane protein

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 678; Mature: 678

Protein sequence:

>678_residues
MLNIIRSALACLLLLWLPALQAADSGWLQSPTNDHAKVRLRADTSHSGETRLLLGIELQKGWKTYWRSPGEGGIAPTIAW
QGNPPPATWFWPTPQRFDVAGISTQGYHDRVELPMVMKGAVPRQLAGTLTLSTCSNVCILTDYPFSLDLDAPSDAQFTHD
FAQAMGQVPIADGLVESIKAGYQNGELQISAERAAGWQQPELFFDTLEDADLGKPKVSSDGTRMFARVPVSDGWGDSAPD
LRGKTLTLVIGDGGVAQQVKLPIEGPLASPVAASFSLWQAVLMALAGGLILNLMPCVLPVLGIKLGSILQVEQRDRHSIR
LQFLASSFGIVASFMALALLMTLLRLSNQALGWGIQFQNPWFIGFMVLVTLLFSANLFGLFHLQLSSSLNTKLATHNGRG
LSGHFWQGAFATLLATPCSAPFLGTAVAFALAAPLPVLWGMFVALGIGMSLPWLLIAAWPALALRLPRPGRWMNSLRLVM
GLLMLASSLWLLSLMANHIGGVPTLVVGVIALLALLLAVGWQHGVRLAAKLAAATLVLVGVVLLAGSLTAGLWRQPLHDN
VAWQPLSEEAITQALAQNKRVFVDVTADWCVTCKANKFNVLLRDDVQKALSAEDVVALRGDWSRPSAEISAFLQQRGSVA
VPFNQIYGPGRRDGVVLSPLLTRDAVLQTLSAAKGNSQ

Sequences:

>Translated_678_residues
MLNIIRSALACLLLLWLPALQAADSGWLQSPTNDHAKVRLRADTSHSGETRLLLGIELQKGWKTYWRSPGEGGIAPTIAW
QGNPPPATWFWPTPQRFDVAGISTQGYHDRVELPMVMKGAVPRQLAGTLTLSTCSNVCILTDYPFSLDLDAPSDAQFTHD
FAQAMGQVPIADGLVESIKAGYQNGELQISAERAAGWQQPELFFDTLEDADLGKPKVSSDGTRMFARVPVSDGWGDSAPD
LRGKTLTLVIGDGGVAQQVKLPIEGPLASPVAASFSLWQAVLMALAGGLILNLMPCVLPVLGIKLGSILQVEQRDRHSIR
LQFLASSFGIVASFMALALLMTLLRLSNQALGWGIQFQNPWFIGFMVLVTLLFSANLFGLFHLQLSSSLNTKLATHNGRG
LSGHFWQGAFATLLATPCSAPFLGTAVAFALAAPLPVLWGMFVALGIGMSLPWLLIAAWPALALRLPRPGRWMNSLRLVM
GLLMLASSLWLLSLMANHIGGVPTLVVGVIALLALLLAVGWQHGVRLAAKLAAATLVLVGVVLLAGSLTAGLWRQPLHDN
VAWQPLSEEAITQALAQNKRVFVDVTADWCVTCKANKFNVLLRDDVQKALSAEDVVALRGDWSRPSAEISAFLQQRGSVA
VPFNQIYGPGRRDGVVLSPLLTRDAVLQTLSAAKGNSQ
>Mature_678_residues
MLNIIRSALACLLLLWLPALQAADSGWLQSPTNDHAKVRLRADTSHSGETRLLLGIELQKGWKTYWRSPGEGGIAPTIAW
QGNPPPATWFWPTPQRFDVAGISTQGYHDRVELPMVMKGAVPRQLAGTLTLSTCSNVCILTDYPFSLDLDAPSDAQFTHD
FAQAMGQVPIADGLVESIKAGYQNGELQISAERAAGWQQPELFFDTLEDADLGKPKVSSDGTRMFARVPVSDGWGDSAPD
LRGKTLTLVIGDGGVAQQVKLPIEGPLASPVAASFSLWQAVLMALAGGLILNLMPCVLPVLGIKLGSILQVEQRDRHSIR
LQFLASSFGIVASFMALALLMTLLRLSNQALGWGIQFQNPWFIGFMVLVTLLFSANLFGLFHLQLSSSLNTKLATHNGRG
LSGHFWQGAFATLLATPCSAPFLGTAVAFALAAPLPVLWGMFVALGIGMSLPWLLIAAWPALALRLPRPGRWMNSLRLVM
GLLMLASSLWLLSLMANHIGGVPTLVVGVIALLALLLAVGWQHGVRLAAKLAAATLVLVGVVLLAGSLTAGLWRQPLHDN
VAWQPLSEEAITQALAQNKRVFVDVTADWCVTCKANKFNVLLRDDVQKALSAEDVVALRGDWSRPSAEISAFLQQRGSVA
VPFNQIYGPGRRDGVVLSPLLTRDAVLQTLSAAKGNSQ

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm, thereby maintaining the

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=563, Percent_Identity=27.708703374778, Blast_Score=114, Evalue=3e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 72898; Mature: 72898

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNIIRSALACLLLLWLPALQAADSGWLQSPTNDHAKVRLRADTSHSGETRLLLGIELQK
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEEEHH
GWKTYWRSPGEGGIAPTIAWQGNPPPATWFWPTPQRFDVAGISTQGYHDRVELPMVMKGA
HHHHHCCCCCCCCCCCEEEECCCCCCCCEECCCCCCEEEECCCCCCCCCCCCCCHHHCCC
VPRQLAGTLTLSTCSNVCILTDYPFSLDLDAPSDAQFTHDFAQAMGQVPIADGLVESIKA
CCHHHHCCEEECCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHC
GYQNGELQISAERAAGWQQPELFFDTLEDADLGKPKVSSDGTRMFARVPVSDGWGDSAPD
CCCCCCEEEEEHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
LRGKTLTLVIGDGGVAQQVKLPIEGPLASPVAASFSLWQAVLMALAGGLILNLMPCVLPV
CCCCEEEEEECCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGIKLGSILQVEQRDRHSIRLQFLASSFGIVASFMALALLMTLLRLSNQALGWGIQFQNP
HHHHHCCHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCC
WFIGFMVLVTLLFSANLFGLFHLQLSSSLNTKLATHNGRGLSGHFWQGAFATLLATPCSA
HHHHHHHHHHHHHHCCHHHEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCC
PFLGTAVAFALAAPLPVLWGMFVALGIGMSLPWLLIAAWPALALRLPRPGRWMNSLRLVM
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHH
GLLMLASSLWLLSLMANHIGGVPTLVVGVIALLALLLAVGWQHGVRLAAKLAAATLVLVG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVLLAGSLTAGLWRQPLHDNVAWQPLSEEAITQALAQNKRVFVDVTADWCVTCKANKFNV
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCEEEEEECCCEEE
LLRDDVQKALSAEDVVALRGDWSRPSAEISAFLQQRGSVAVPFNQIYGPGRRDGVVLSPL
EEHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCEECCHHHHCCCCCCCCEEECHH
LTRDAVLQTLSAAKGNSQ
HHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MLNIIRSALACLLLLWLPALQAADSGWLQSPTNDHAKVRLRADTSHSGETRLLLGIELQK
CHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEEEEHH
GWKTYWRSPGEGGIAPTIAWQGNPPPATWFWPTPQRFDVAGISTQGYHDRVELPMVMKGA
HHHHHCCCCCCCCCCCEEEECCCCCCCCEECCCCCCEEEECCCCCCCCCCCCCCHHHCCC
VPRQLAGTLTLSTCSNVCILTDYPFSLDLDAPSDAQFTHDFAQAMGQVPIADGLVESIKA
CCHHHHCCEEECCCCCEEEEECCCCEEECCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHC
GYQNGELQISAERAAGWQQPELFFDTLEDADLGKPKVSSDGTRMFARVPVSDGWGDSAPD
CCCCCCEEEEEHHHCCCCCCHHHHHHHCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCC
LRGKTLTLVIGDGGVAQQVKLPIEGPLASPVAASFSLWQAVLMALAGGLILNLMPCVLPV
CCCCEEEEEECCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGIKLGSILQVEQRDRHSIRLQFLASSFGIVASFMALALLMTLLRLSNQALGWGIQFQNP
HHHHHCCHHHHHHCCCHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCC
WFIGFMVLVTLLFSANLFGLFHLQLSSSLNTKLATHNGRGLSGHFWQGAFATLLATPCSA
HHHHHHHHHHHHHHCCHHHEEEEEECCCCCCEEEECCCCCCCCCHHHHHHHHHHHCCCCC
PFLGTAVAFALAAPLPVLWGMFVALGIGMSLPWLLIAAWPALALRLPRPGRWMNSLRLVM
CHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHEECCCCCHHHHHHHHHH
GLLMLASSLWLLSLMANHIGGVPTLVVGVIALLALLLAVGWQHGVRLAAKLAAATLVLVG
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VVLLAGSLTAGLWRQPLHDNVAWQPLSEEAITQALAQNKRVFVDVTADWCVTCKANKFNV
HHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEECCEEEEEECCCEEE
LLRDDVQKALSAEDVVALRGDWSRPSAEISAFLQQRGSVAVPFNQIYGPGRRDGVVLSPL
EEHHHHHHHHCCCCEEEECCCCCCCHHHHHHHHHHCCCEECCHHHHCCCCCCCCEEECHH
LTRDAVLQTLSAAKGNSQ
HHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]