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The map label for this gene is hisM [H]

Identifier: 157371561

GI number: 157371561

Start: 3679879

End: 3680583

Strand: Reverse

Name: hisM [H]

Synonym: Spro_3324

Alternate gene names: 157371561

Gene position: 3680583-3679879 (Counterclockwise)

Preceding gene: 157371562

Following gene: 157371560

Centisome position: 67.55

GC content: 55.89

Gene sequence:

>705_bases
ATGATCGAGATTTTACAACAGTACTGGCAATCGCTGCTGTGGAGCGACGGTTACCGTTTCACCGGGGTCGCCGTTACCCT
GTGGCTGCTGATTTCCTCGGTAGTGATGGGCGGTTTGCTGGCGATCCCGATGGCGGTGGCACGCGTTTCCTCCATCACCT
GGGTGCGTTTCCCGGTTTGGCTCTACACCTATATATTCCGTGGTACGCCGCTGTACGTGCAGCTGCTGGTGTTTTACTCC
GGTATGTACAGCCTGGAAATCGTGCGTGGGACGGACTTCCTCAACGCTTTCTTCCGCAGCGGGCTCAATTGCACCATTTT
GGCGCTAACGCTGAACACCTGTGCTTACACCACCGAGATCTTCGCCGGGGCGATACGCTCGGTATCGCACGGTGAAATCG
AAGCGGCCAATGCTTACGGTTTCTCACGTTTCAAAATGTACCGCTGTATCATTTTGCCTTCAGCACTGCGCACCGCGCTG
CCGGCCTACAGCAATGAAGTGATCCTGATGCTGCACTCGACCGCGCTGGCGTTCACCGCCACCGTGCCGGACCTGCTGAA
GATAGCGCGAGATATCAATGCGGCGACCTACCAGCCGTTCTATGCCTTTGGCATTGCAGCGGTGCTGTATCTGATCATCT
CTTACGGATTAATCAGCCTGTTCCGCAAGGCGGAAAAGCGCTGGATGGCACACGTTAATCACTGA

Upstream 100 bases:

>100_bases
TCGTGGCCGGTGTGGTTTATCTGGTTTTCACAACCGTTTCCAATGGTGTGCTGCTGTGGCTTGAACGGCGTTATTCCCTG
GGCGTCCGGAGGGCTGAGCT

Downstream 100 bases:

>100_bases
TAATGACGGGAACCTACTATGTCTGAGAATAAATTAGCCGTCACCGAACTGCATAAACGCTATGGCGAACACGAAGTGCT
GAAAGGCGTCTCGCTGGCGG

Product: polar amino acid ABC transporter inner membrane subunit

Products: ADP; phosphate; L-histidine [Cytoplasm]; ADP; L-ornithine [Cytoplasm]; L-arginine [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 234; Mature: 234

Protein sequence:

>234_residues
MIEILQQYWQSLLWSDGYRFTGVAVTLWLLISSVVMGGLLAIPMAVARVSSITWVRFPVWLYTYIFRGTPLYVQLLVFYS
GMYSLEIVRGTDFLNAFFRSGLNCTILALTLNTCAYTTEIFAGAIRSVSHGEIEAANAYGFSRFKMYRCIILPSALRTAL
PAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFYAFGIAAVLYLIISYGLISLFRKAEKRWMAHVNH

Sequences:

>Translated_234_residues
MIEILQQYWQSLLWSDGYRFTGVAVTLWLLISSVVMGGLLAIPMAVARVSSITWVRFPVWLYTYIFRGTPLYVQLLVFYS
GMYSLEIVRGTDFLNAFFRSGLNCTILALTLNTCAYTTEIFAGAIRSVSHGEIEAANAYGFSRFKMYRCIILPSALRTAL
PAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFYAFGIAAVLYLIISYGLISLFRKAEKRWMAHVNH
>Mature_234_residues
MIEILQQYWQSLLWSDGYRFTGVAVTLWLLISSVVMGGLLAIPMAVARVSSITWVRFPVWLYTYIFRGTPLYVQLLVFYS
GMYSLEIVRGTDFLNAFFRSGLNCTILALTLNTCAYTTEIFAGAIRSVSHGEIEAANAYGFSRFKMYRCIILPSALRTAL
PAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFYAFGIAAVLYLIISYGLISLFRKAEKRWMAHVNH

Specific function: Part of the binding-protein-dependent transport system for histidine; probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG4160

COG function: function code E; ABC-type arginine/histidine transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1788645, Length=233, Percent_Identity=84.9785407725322, Blast_Score=410, Evalue=1e-116,
Organism=Escherichia coli, GI1788226, Length=225, Percent_Identity=32.8888888888889, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787086, Length=214, Percent_Identity=32.2429906542056, Blast_Score=101, Evalue=4e-23,
Organism=Escherichia coli, GI1788646, Length=226, Percent_Identity=32.7433628318584, Blast_Score=94, Evalue=8e-21,
Organism=Escherichia coli, GI1787030, Length=207, Percent_Identity=29.4685990338164, Blast_Score=85, Evalue=4e-18,
Organism=Escherichia coli, GI1786873, Length=207, Percent_Identity=29.4685990338164, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787087, Length=164, Percent_Identity=28.6585365853659, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082239, Length=212, Percent_Identity=26.8867924528302, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010065
- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 26378; Mature: 26378

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEILQQYWQSLLWSDGYRFTGVAVTLWLLISSVVMGGLLAIPMAVARVSSITWVRFPVW
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYTYIFRGTPLYVQLLVFYSGMYSLEIVRGTDFLNAFFRSGLNCTILALTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHCCHHEEEEEECHHHHHHHHHCCCCEEEEEEEHHHHHHHHHH
FAGAIRSVSHGEIEAANAYGFSRFKMYRCIILPSALRTALPAYSNEVILMLHSTALAFTA
HHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHH
TVPDLLKIARDINAATYQPFYAFGIAAVLYLIISYGLISLFRKAEKRWMAHVNH
HHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIEILQQYWQSLLWSDGYRFTGVAVTLWLLISSVVMGGLLAIPMAVARVSSITWVRFPVW
CHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LYTYIFRGTPLYVQLLVFYSGMYSLEIVRGTDFLNAFFRSGLNCTILALTLNTCAYTTEI
HHHHHHCCCHHHHHHHHHHCCHHEEEEEECHHHHHHHHHCCCCEEEEEEEHHHHHHHHHH
FAGAIRSVSHGEIEAANAYGFSRFKMYRCIILPSALRTALPAYSNEVILMLHSTALAFTA
HHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHHHH
TVPDLLKIARDINAATYQPFYAFGIAAVLYLIISYGLISLFRKAEKRWMAHVNH
HHHHHHHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-histidine [Periplasm]; H2O; ATP; L-ornithine [Periplasm]; L-arginine [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: ATP + L-histidine [Periplasm] + H2O = ADP + phosphate + L-histidine [Cytoplasm] ATP + L-ornithine [Periplasm] + H2O = ADP + phosphate + L-ornithine [Cytoplasm] ATP + L-arginine [Periplasm] + H2O = ADP + phosphate + L-arginine [Cytoplasm] ATP + L-lysine [P

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]