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The map label for this gene is folM [H]

Identifier: 157370829

GI number: 157370829

Start: 2847148

End: 2847870

Strand: Direct

Name: folM [H]

Synonym: Spro_2589

Alternate gene names: 157370829

Gene position: 2847148-2847870 (Clockwise)

Preceding gene: 157370827

Following gene: 157370830

Centisome position: 52.25

GC content: 57.68

Gene sequence:

>723_bases
ATGGAACTTCACAACTCAGCCCCGGTGCTGATTACGGGCGGCGCACGCCGGATTGGACTGGCATTGGCCAGGTCATTCTT
GCAACGTGATATTCCCGTGATCATTGCCTATCGCAGCGACTACCCGGCGCTGGGCGAACTGAAAAGACTGGGGGCAACCT
GCATTCAGGGCGATTTCTCAACGCACGACGGTATCTATCGTTTCGCCGAGCAGGTTCGCCAGGCAGCGCCCAAACTGCGC
GCGGTGATCCACAACGCCAGCGCCTGGCAGGCCGAATCACCGGAAGTACCACCGGAGCAAGTGATGGCGGCCATGTTGCA
AATTCACGTTTATACGCCTTATCTGCTCAATCAACTGCTGGAATCTTGTCTGTTGGGCCAGGGGCAAGCCGGTGCGGATA
TCATCCATCTTACCGACTATGTGGTGGAGAAAGGCAGCGACAAGCACATTGCCTATGCCGCCAGTAAGGCCGCGCTGGAC
AATATGACCCGCTCTTTTGCCCGCAAGCTGGCACCCGAAGTTAAAGTCAACGCCATCGCCCCGGCGCTGATTATTTTCAA
TCCGGGCGACGACGAGCATTATCGGCAACAGGCGCTGGCAAAATCACTGATGAAAATCGCCCCAGGCGAGAGCGAAGTGG
TCAATCTGGTGAACTATCTGCTGGACAGTCGCTATGTCACCGGCCGTACCCACGGTGTCGACGGCGGACGCCCGCTGCGC
TAA

Upstream 100 bases:

>100_bases
CATCCTGAAATGGATAATCGATGCGAAGCTTTAACGAATTTCCGCCGTATAATGGCATAATTCCCCTATTGTTTGCCAGT
CTGTCCAGGAGCTTTAATCA

Downstream 100 bases:

>100_bases
CGCATGATCTGCATGGCGTATCGCGGAGCCCCGCGTTATGCTGAATTTCGTTATTCTGATAAAACCGCTGAATATGCATA
AAATTGTTTTTGTGGAAGAC

Product: short chain dehydrogenase

Products: NA

Alternate protein names: DHFR [H]

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MELHNSAPVLITGGARRIGLALARSFLQRDIPVIIAYRSDYPALGELKRLGATCIQGDFSTHDGIYRFAEQVRQAAPKLR
AVIHNASAWQAESPEVPPEQVMAAMLQIHVYTPYLLNQLLESCLLGQGQAGADIIHLTDYVVEKGSDKHIAYAASKAALD
NMTRSFARKLAPEVKVNAIAPALIIFNPGDDEHYRQQALAKSLMKIAPGESEVVNLVNYLLDSRYVTGRTHGVDGGRPLR

Sequences:

>Translated_240_residues
MELHNSAPVLITGGARRIGLALARSFLQRDIPVIIAYRSDYPALGELKRLGATCIQGDFSTHDGIYRFAEQVRQAAPKLR
AVIHNASAWQAESPEVPPEQVMAAMLQIHVYTPYLLNQLLESCLLGQGQAGADIIHLTDYVVEKGSDKHIAYAASKAALD
NMTRSFARKLAPEVKVNAIAPALIIFNPGDDEHYRQQALAKSLMKIAPGESEVVNLVNYLLDSRYVTGRTHGVDGGRPLR
>Mature_240_residues
MELHNSAPVLITGGARRIGLALARSFLQRDIPVIIAYRSDYPALGELKRLGATCIQGDFSTHDGIYRFAEQVRQAAPKLR
AVIHNASAWQAESPEVPPEQVMAAMLQIHVYTPYLLNQLLESCLLGQGQAGADIIHLTDYVVEKGSDKHIAYAASKAALD
NMTRSFARKLAPEVKVNAIAPALIIFNPGDDEHYRQQALAKSLMKIAPGESEVVNLVNYLLDSRYVTGRTHGVDGGRPLR

Specific function: Catalyzes the reduction of dihydrofolate to tetrahydrofolate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. FolM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787891, Length=233, Percent_Identity=66.5236051502146, Blast_Score=319, Evalue=1e-88,
Organism=Caenorhabditis elegans, GI115534694, Length=242, Percent_Identity=25.6198347107438, Blast_Score=64, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.5.1.3 [H]

Molecular weight: Translated: 26281; Mature: 26281

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELHNSAPVLITGGARRIGLALARSFLQRDIPVIIAYRSDYPALGELKRLGATCIQGDFS
CCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCC
THDGIYRFAEQVRQAAPKLRAVIHNASAWQAESPEVPPEQVMAAMLQIHVYTPYLLNQLL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
ESCLLGQGQAGADIIHLTDYVVEKGSDKHIAYAASKAALDNMTRSFARKLAPEVKVNAIA
HHHHCCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PALIIFNPGDDEHYRQQALAKSLMKIAPGESEVVNLVNYLLDSRYVTGRTHGVDGGRPLR
CEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCC
>Mature Secondary Structure
MELHNSAPVLITGGARRIGLALARSFLQRDIPVIIAYRSDYPALGELKRLGATCIQGDFS
CCCCCCCCEEEECCCHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHCCCCC
THDGIYRFAEQVRQAAPKLRAVIHNASAWQAESPEVPPEQVMAAMLQIHVYTPYLLNQLL
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHH
ESCLLGQGQAGADIIHLTDYVVEKGSDKHIAYAASKAALDNMTRSFARKLAPEVKVNAIA
HHHHCCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHCCCCEEEEEC
PALIIFNPGDDEHYRQQALAKSLMKIAPGESEVVNLVNYLLDSRYVTGRTHGVDGGRPLR
CEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA