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The map label for this gene is maeA

Identifier: 157369810

GI number: 157369810

Start: 1708018

End: 1709715

Strand: Reverse

Name: maeA

Synonym: Spro_1567

Alternate gene names: 157369810

Gene position: 1709715-1708018 (Counterclockwise)

Preceding gene: 157369811

Following gene: 157369809

Centisome position: 31.38

GC content: 56.65

Gene sequence:

>1698_bases
ATGGAACTTGAATACGAAAGCAAACGCCCTCTCTACATCCCTTATGCCGGCCCGATCCTGTTGGAATTCCCACTGCTGAA
TAAAGGCAGTGCTTTCACCGAAGAAGAGCGCAACCATTTCAACCTGCAAGGCTTGTTGCCCGACGCGGTGGAAACCATTG
AAGAACAGGCTGAGCGCGCCTATCGCCAATATCAGGATTTCAAAAACGACAGCGATAAGCACATTTACCTGCGCAACATT
CAGGACACCAACGAAACCCTGTTCTACCGCCTGCTGGACTCCCACCTGAGCGAAATGATGCCGATCATCTACACGCCAAC
GGTGGGTGAAGCCTGCGAGCACTTCTCCGATATTTACCGCCGGGCACGCGGGTTGTTTATCTCCTACCCGAACCGCGATC
GCATTGACGACATGCTGCAAAACGCCACCAAACAAAACGTCAAAGTGATTGTCGTCACCGACGGCGAACGTATTCTCGGC
CTGGGCGACCAGGGCATTGGCGGCATGGGCATTCCTATCGGCAAGCTTTCGCTGTATACCGCCTGCGGTGGTATCAGCCC
GGCCTATACCCTGCCGGTAGTGCTGGACGTGGGTACCAACAACCCACAGCGCCTGAACGATCCGCTGTATATGGGCTGGC
GTCATCCGCGCATTTCCGGTGATGAATACCACGCTTTCGTTGAAGAGTTTATTCAGGCGGTGAAACGCCGCTGGCCGAAC
GTGCTGTTGCAGTTCGAGGATTTCGCTCAGAACAACGCGACTCCGCTGCTGAACCGCTATCGTGACGAAATCTGCTGCTT
TAACGACGATATTCAGGGTACCGCAGCGGTTACGCTGGGTAGCCTGATTGCCGCCAGCCGCGCTGCGGGCAGCCAATTGC
GTGACCAAACCGTGACCTTCCTGGGTGCCGGTTCCGCCGGCTGCGGCATTGCCGAGCAAATTATCGCCCAGATGAAATCC
GAAGGTCTGAGCGAAGACGAAGCGCGCGCCCGCGTGTTCATGGTTGACCGTTTTGGTCTGCTGACCGACAAACTGCCTAA
CCTGCTCGATTTCCAAAGCAAGCTGGTGCAAAAAAGCGAAAACCTGACCGCATGGCAAACCCAAAGCGATGCCATCTCGC
TGTTGGACGTAGTACGTAACGCCAAGCCCACCATTTTGATCGGCGTTTCCGGCCAGCCGGGTCTGTTCACCGAAGAACTG
ATCCGCGAAATGCACAAGCATTGCCCGCGGCCGATCGTAATGCCGCTGTCCAACCCGACTTCACGCGTGGAAGCCCGTCC
GGAAGACATCATCAACTGGACCGAAGGCGCTGCGCTGGTCGCCACCGGCAGCCCGTTCGCACCGGTACACTATAAAGAGC
AACAGATCCCGATTGCCCAATGCAACAACTCCTATATCTTCCCGGGGATTGGTCTGGGTGTGTTGGCCTCTGGCGCGACC
CGTGTAACGGACGCGATGCTGATGGCCGCCAGCCGGGCACTGGCCGAGTGTTCGCCGCTGGCCACCGACGGACATGGCGC
ACTGTTACCGGATATTGACGATATTCAGGGCGTGTCAAAATGCATCGCGATGGAAGTGGGTAAAGCGGCTCAACTGCAGG
GAATGGCGGTAGTCACTTCTGAAGAAGCGCTGTCGAAAGCCATCGAACACAACTTCTGGCGACCGCAATACCGCAGCTAC
AAGCGCACCTCTTTCTGA

Upstream 100 bases:

>100_bases
CCAATTTACCTCATGATCCGATAACAATTGCTGTACATATTTCGCCGATCTTTTAGGATCACCCTTATAAAGTTATCCGA
TACGTTGAAGAGCAAAAGTC

Downstream 100 bases:

>100_bases
TTTGCACAAGCAAGATGATAAAGTCCGGCTCGCCGGACTTTTTTTATGGCCGAAAACGCCTAAAAATGCGGCGCAATGCG
TGCCAGAAGGGGGACAAGCT

Product: malate dehydrogenase

Products: NA

Alternate protein names: NAD-ME

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MELEYESKRPLYIPYAGPILLEFPLLNKGSAFTEEERNHFNLQGLLPDAVETIEEQAERAYRQYQDFKNDSDKHIYLRNI
QDTNETLFYRLLDSHLSEMMPIIYTPTVGEACEHFSDIYRRARGLFISYPNRDRIDDMLQNATKQNVKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRISGDEYHAFVEEFIQAVKRRWPN
VLLQFEDFAQNNATPLLNRYRDEICCFNDDIQGTAAVTLGSLIAASRAAGSQLRDQTVTFLGAGSAGCGIAEQIIAQMKS
EGLSEDEARARVFMVDRFGLLTDKLPNLLDFQSKLVQKSENLTAWQTQSDAISLLDVVRNAKPTILIGVSGQPGLFTEEL
IREMHKHCPRPIVMPLSNPTSRVEARPEDIINWTEGAALVATGSPFAPVHYKEQQIPIAQCNNSYIFPGIGLGVLASGAT
RVTDAMLMAASRALAECSPLATDGHGALLPDIDDIQGVSKCIAMEVGKAAQLQGMAVVTSEEALSKAIEHNFWRPQYRSY
KRTSF

Sequences:

>Translated_565_residues
MELEYESKRPLYIPYAGPILLEFPLLNKGSAFTEEERNHFNLQGLLPDAVETIEEQAERAYRQYQDFKNDSDKHIYLRNI
QDTNETLFYRLLDSHLSEMMPIIYTPTVGEACEHFSDIYRRARGLFISYPNRDRIDDMLQNATKQNVKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRISGDEYHAFVEEFIQAVKRRWPN
VLLQFEDFAQNNATPLLNRYRDEICCFNDDIQGTAAVTLGSLIAASRAAGSQLRDQTVTFLGAGSAGCGIAEQIIAQMKS
EGLSEDEARARVFMVDRFGLLTDKLPNLLDFQSKLVQKSENLTAWQTQSDAISLLDVVRNAKPTILIGVSGQPGLFTEEL
IREMHKHCPRPIVMPLSNPTSRVEARPEDIINWTEGAALVATGSPFAPVHYKEQQIPIAQCNNSYIFPGIGLGVLASGAT
RVTDAMLMAASRALAECSPLATDGHGALLPDIDDIQGVSKCIAMEVGKAAQLQGMAVVTSEEALSKAIEHNFWRPQYRSY
KRTSF
>Mature_565_residues
MELEYESKRPLYIPYAGPILLEFPLLNKGSAFTEEERNHFNLQGLLPDAVETIEEQAERAYRQYQDFKNDSDKHIYLRNI
QDTNETLFYRLLDSHLSEMMPIIYTPTVGEACEHFSDIYRRARGLFISYPNRDRIDDMLQNATKQNVKVIVVTDGERILG
LGDQGIGGMGIPIGKLSLYTACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRISGDEYHAFVEEFIQAVKRRWPN
VLLQFEDFAQNNATPLLNRYRDEICCFNDDIQGTAAVTLGSLIAASRAAGSQLRDQTVTFLGAGSAGCGIAEQIIAQMKS
EGLSEDEARARVFMVDRFGLLTDKLPNLLDFQSKLVQKSENLTAWQTQSDAISLLDVVRNAKPTILIGVSGQPGLFTEEL
IREMHKHCPRPIVMPLSNPTSRVEARPEDIINWTEGAALVATGSPFAPVHYKEQQIPIAQCNNSYIFPGIGLGVLASGAT
RVTDAMLMAASRALAECSPLATDGHGALLPDIDDIQGVSKCIAMEVGKAAQLQGMAVVTSEEALSKAIEHNFWRPQYRSY
KRTSF

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the malic enzymes family

Homologues:

Organism=Homo sapiens, GI4505143, Length=544, Percent_Identity=43.0147058823529, Blast_Score=441, Evalue=1e-123,
Organism=Homo sapiens, GI62420882, Length=560, Percent_Identity=41.7857142857143, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI62420880, Length=560, Percent_Identity=41.7857142857143, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI239049447, Length=560, Percent_Identity=41.7857142857143, Blast_Score=427, Evalue=1e-119,
Organism=Homo sapiens, GI4505145, Length=554, Percent_Identity=41.8772563176895, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI270265879, Length=463, Percent_Identity=44.7084233261339, Blast_Score=380, Evalue=1e-105,
Organism=Escherichia coli, GI87081919, Length=565, Percent_Identity=75.5752212389381, Blast_Score=878, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17537199, Length=543, Percent_Identity=43.0939226519337, Blast_Score=419, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6322823, Length=560, Percent_Identity=44.8214285714286, Blast_Score=450, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24646388, Length=518, Percent_Identity=44.2084942084942, Blast_Score=439, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24646386, Length=518, Percent_Identity=44.2084942084942, Blast_Score=438, Evalue=1e-123,
Organism=Drosophila melanogaster, GI21356279, Length=538, Percent_Identity=42.5650557620818, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI281362674, Length=538, Percent_Identity=42.5650557620818, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI281362672, Length=538, Percent_Identity=42.5650557620818, Blast_Score=432, Evalue=1e-121,
Organism=Drosophila melanogaster, GI78707242, Length=539, Percent_Identity=38.0333951762523, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI78707238, Length=539, Percent_Identity=38.0333951762523, Blast_Score=365, Evalue=1e-101,
Organism=Drosophila melanogaster, GI78707240, Length=507, Percent_Identity=38.6587771203156, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI78707232, Length=494, Percent_Identity=37.8542510121458, Blast_Score=360, Evalue=2e-99,
Organism=Drosophila melanogaster, GI281363505, Length=494, Percent_Identity=37.8542510121458, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI78707236, Length=494, Percent_Identity=37.8542510121458, Blast_Score=358, Evalue=4e-99,
Organism=Drosophila melanogaster, GI281363503, Length=492, Percent_Identity=37.6016260162602, Blast_Score=355, Evalue=5e-98,
Organism=Drosophila melanogaster, GI19922384, Length=536, Percent_Identity=31.7164179104478, Blast_Score=266, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MAO1_SERP5 (A8GC31)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477799.1
- ProteinModelPortal:   A8GC31
- SMR:   A8GC31
- STRING:   A8GC31
- GeneID:   5602866
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1567
- eggNOG:   COG0281
- HOGENOM:   HBG289821
- OMA:   IQDNNET
- ProtClustDB:   PRK13529
- BioCyc:   SPRO399741:SPRO_1567-MONOMER
- HAMAP:   MF_01619
- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR001891
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000106
- PRINTS:   PR00072
- SMART:   SM00919

Pfam domain/function: PF00390 malic; PF03949 Malic_M

EC number: =1.1.1.38

Molecular weight: Translated: 62751; Mature: 62751

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: ACT_SITE 104-104 ACT_SITE 175-175 BINDING 157-157 BINDING 270-270 BINDING 418-418

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELEYESKRPLYIPYAGPILLEFPLLNKGSAFTEEERNHFNLQGLLPDAVETIEEQAERA
CCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCHHHCCCEEEECCCHHHHHHHHHHHHHH
YRQYQDFKNDSDKHIYLRNIQDTNETLFYRLLDSHLSEMMPIIYTPTVGEACEHFSDIYR
HHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
RARGLFISYPNRDRIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYT
HHCCEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHH
ACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRISGDEYHAFVEEFIQAVKRRWPN
HHCCCCCCEEEEEEEECCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCC
VLLQFEDFAQNNATPLLNRYRDEICCFNDDIQGTAAVTLGSLIAASRAAGSQLRDQTVTF
EEEEEHHHCCCCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEE
LGAGSAGCGIAEQIIAQMKSEGLSEDEARARVFMVDRFGLLTDKLPNLLDFQSKLVQKSE
EECCCCCCCHHHHHHHHHHHCCCCCCHHHEEEEEEHHHHHHHHHCCHHHHHHHHHHHCCC
NLTAWQTQSDAISLLDVVRNAKPTILIGVSGQPGLFTEELIREMHKHCPRPIVMPLSNPT
CCEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCH
SRVEARPEDIINWTEGAALVATGSPFAPVHYKEQQIPIAQCNNSYIFPGIGLGVLASGAT
HHHCCCHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCHHHCCCCEECCCCCHHHHHCCHH
RVTDAMLMAASRALAECSPLATDGHGALLPDIDDIQGVSKCIAMEVGKAAQLQGMAVVTS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCEEEEEC
EEALSKAIEHNFWRPQYRSYKRTSF
HHHHHHHHHHCCCCCHHHCCCCCCC
>Mature Secondary Structure
MELEYESKRPLYIPYAGPILLEFPLLNKGSAFTEEERNHFNLQGLLPDAVETIEEQAERA
CCCCCCCCCCEEEECCCCEEEEECCCCCCCCCCHHHCCCEEEECCCHHHHHHHHHHHHHH
YRQYQDFKNDSDKHIYLRNIQDTNETLFYRLLDSHLSEMMPIIYTPTVGEACEHFSDIYR
HHHHHHHCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
RARGLFISYPNRDRIDDMLQNATKQNVKVIVVTDGERILGLGDQGIGGMGIPIGKLSLYT
HHCCEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCEEEECCCCCCCCCCCCHHHHHHHH
ACGGISPAYTLPVVLDVGTNNPQRLNDPLYMGWRHPRISGDEYHAFVEEFIQAVKRRWPN
HHCCCCCCEEEEEEEECCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCC
VLLQFEDFAQNNATPLLNRYRDEICCFNDDIQGTAAVTLGSLIAASRAAGSQLRDQTVTF
EEEEEHHHCCCCCCHHHHHHHHHHEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHCEEEE
LGAGSAGCGIAEQIIAQMKSEGLSEDEARARVFMVDRFGLLTDKLPNLLDFQSKLVQKSE
EECCCCCCCHHHHHHHHHHHCCCCCCHHHEEEEEEHHHHHHHHHCCHHHHHHHHHHHCCC
NLTAWQTQSDAISLLDVVRNAKPTILIGVSGQPGLFTEELIREMHKHCPRPIVMPLSNPT
CCEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEECCCCH
SRVEARPEDIINWTEGAALVATGSPFAPVHYKEQQIPIAQCNNSYIFPGIGLGVLASGAT
HHHCCCHHHHCCCCCCCEEEECCCCCCCCCCCCCCCCHHHCCCCEECCCCCHHHHHCCHH
RVTDAMLMAASRALAECSPLATDGHGALLPDIDDIQGVSKCIAMEVGKAAQLQGMAVVTS
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCEEEEEC
EEALSKAIEHNFWRPQYRSYKRTSF
HHHHHHHHHHCCCCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA