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The map label for this gene is cueR [H]

Identifier: 157369394

GI number: 157369394

Start: 1268075

End: 1268476

Strand: Direct

Name: cueR [H]

Synonym: Spro_1151

Alternate gene names: 157369394

Gene position: 1268075-1268476 (Clockwise)

Preceding gene: 157369390

Following gene: 157369397

Centisome position: 23.27

GC content: 55.72

Gene sequence:

>402_bases
ATGAATATTAGCGACGTAGCGAAAAAAACCGGTTTAACCAGCAAGGCCATTCGCTTTTATGAAGAGAAAGGGCTGGTGAC
TGCGCCGATCCGTACCGACAACGGCTATCGCAGCTACAGCCCGAAGCACATCGAAGAACTGACGCTGCTGCGCCAGGCAC
GGCAGGTGGGATTTAATCTGGATGAATGCCGCGAGCTGGTGGCGCTGTTTAACGATCCGGCCCGCCACAGCGCCGATGTG
AAAGCGCGCACGCTGCAAAAAGTGGCGGATATTGAAAAGCACATCGCCGAACTCGGTGAGATGCGCCAGCGTTTGGTGGC
GCTGGCAGATCAATGCCCGGGTGATGACGGAGCCGAGTGCCCAATCATTAACAACCTGGCGGGCTGTTGCCATAAGCATT
AA

Upstream 100 bases:

>100_bases
GATTCCTCTCAAGAATGGTGTTTAAAGGTTGACCGCTTTACCTGTTTTCACTAAGAATGAAGGATAAACCTTCCAGCAAG
GGGAAGGTCAAGGAGTGAAA

Downstream 100 bases:

>100_bases
CGGGCAATGGCACGGATCACCAAAGTTATGCCTTCGACGGCAATGACTTCTACTTCGGTGCCCACCGCCAGGTCTTCACT
GGCCTGCGCGCGCCAGCTGC

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 133; Mature: 133

Protein sequence:

>133_residues
MNISDVAKKTGLTSKAIRFYEEKGLVTAPIRTDNGYRSYSPKHIEELTLLRQARQVGFNLDECRELVALFNDPARHSADV
KARTLQKVADIEKHIAELGEMRQRLVALADQCPGDDGAECPIINNLAGCCHKH

Sequences:

>Translated_133_residues
MNISDVAKKTGLTSKAIRFYEEKGLVTAPIRTDNGYRSYSPKHIEELTLLRQARQVGFNLDECRELVALFNDPARHSADV
KARTLQKVADIEKHIAELGEMRQRLVALADQCPGDDGAECPIINNLAGCCHKH
>Mature_133_residues
MNISDVAKKTGLTSKAIRFYEEKGLVTAPIRTDNGYRSYSPKHIEELTLLRQARQVGFNLDECRELVALFNDPARHSADV
KARTLQKVADIEKHIAELGEMRQRLVALADQCPGDDGAECPIINNLAGCCHKH

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=131, Percent_Identity=75.5725190839695, Blast_Score=213, Evalue=5e-57,
Organism=Escherichia coli, GI1789687, Length=127, Percent_Identity=33.0708661417323, Blast_Score=81, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 14830; Mature: 14830

Theoretical pI: Translated: 7.46; Mature: 7.46

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
3.8 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISDVAKKTGLTSKAIRFYEEKGLVTAPIRTDNGYRSYSPKHIEELTLLRQARQVGFNL
CCHHHHHHHHCCHHHHHHHHHHCCCEECCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCH
DECRELVALFNDPARHSADVKARTLQKVADIEKHIAELGEMRQRLVALADQCPGDDGAEC
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PIINNLAGCCHKH
CHHHHHHHHHCCC
>Mature Secondary Structure
MNISDVAKKTGLTSKAIRFYEEKGLVTAPIRTDNGYRSYSPKHIEELTLLRQARQVGFNL
CCHHHHHHHHCCHHHHHHHHHHCCCEECCEECCCCCCCCCHHHHHHHHHHHHHHHHCCCH
DECRELVALFNDPARHSADVKARTLQKVADIEKHIAELGEMRQRLVALADQCPGDDGAEC
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
PIINNLAGCCHKH
CHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11586360; 12142430 [H]