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The map label for this gene is aroL

Identifier: 157369261

GI number: 157369261

Start: 1119602

End: 1120126

Strand: Direct

Name: aroL

Synonym: Spro_1018

Alternate gene names: 157369261

Gene position: 1119602-1120126 (Clockwise)

Preceding gene: 157369260

Following gene: 157369263

Centisome position: 20.55

GC content: 58.67

Gene sequence:

>525_bases
ATGACACAAACCATTTTCATGGTAGGCGCGCGCGGAGCCGGTAAAACCACGGTGGGCAGCGCACTGGCGCTGGCGCTGGG
CTATCAATTCATCGATACCGATCTGTTTATGCAGCAGACCACGCAGATGAGCGTGGCGGAAATGGTCGAACAAGAAGGCT
GGCTGGGATTTCGTCGCCGTGAAAGCATTGCTCTGCAAACGGTCACTCAACCGTCAACTGTAGTTGCCACTGGTGGTGGT
GCGATCCTGGCGGAGGAGAACCGCCGCTTTATGCGTCAGCACGGCAAGGTCATCTACCTGCGTTCACCCGCCGAAGTATT
GGCACAGCGGCTGGAAGAGTACCCGCAAGATACACAGCGCCCTACGCTGACCGGCCGTCCGATTGCCGAAGAAATGCTGG
AGGTGCTGGCCGCGCGTGAAGCGCTGTATCAGGAGGCCGCTCACTACGTGATGGACGGCACCGGTGGCCCGCAACAGGTG
GTTGAGCAGATCCTCTCCGCCCTGCAGTTGGAAACGGTAAAATAA

Upstream 100 bases:

>100_bases
TGATGGCGGTATGATGCAGCAACCACGCCATCGCAGGATTTAGCACGCCGGGTTCTGGCGAGCAAATGCACTCAAGTCAC
CGTATAAGGGACAACCCGTA

Downstream 100 bases:

>100_bases
GCTCTCTCTTGGGGCACCGTCAATTGCGCCTGACGGCTGCCTCGTTTTTCTCCCGAATATGAGTCTCGCGCTGAACAAAA
TACAATCCCGGTGTGGTGCC

Product: shikimate kinase II

Products: NA

Alternate protein names: SK 2

Number of amino acids: Translated: 174; Mature: 173

Protein sequence:

>174_residues
MTQTIFMVGARGAGKTTVGSALALALGYQFIDTDLFMQQTTQMSVAEMVEQEGWLGFRRRESIALQTVTQPSTVVATGGG
AILAEENRRFMRQHGKVIYLRSPAEVLAQRLEEYPQDTQRPTLTGRPIAEEMLEVLAAREALYQEAAHYVMDGTGGPQQV
VEQILSALQLETVK

Sequences:

>Translated_174_residues
MTQTIFMVGARGAGKTTVGSALALALGYQFIDTDLFMQQTTQMSVAEMVEQEGWLGFRRRESIALQTVTQPSTVVATGGG
AILAEENRRFMRQHGKVIYLRSPAEVLAQRLEEYPQDTQRPTLTGRPIAEEMLEVLAAREALYQEAAHYVMDGTGGPQQV
VEQILSALQLETVK
>Mature_173_residues
TQTIFMVGARGAGKTTVGSALALALGYQFIDTDLFMQQTTQMSVAEMVEQEGWLGFRRRESIALQTVTQPSTVVATGGGA
ILAEENRRFMRQHGKVIYLRSPAEVLAQRLEEYPQDTQRPTLTGRPIAEEMLEVLAAREALYQEAAHYVMDGTGGPQQVV
EQILSALQLETVK

Specific function: Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate

COG id: COG0703

COG function: function code E; Shikimate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate kinase family. AroL subfamily

Homologues:

Organism=Escherichia coli, GI1786587, Length=168, Percent_Identity=55.3571428571429, Blast_Score=197, Evalue=2e-52,
Organism=Escherichia coli, GI87082255, Length=170, Percent_Identity=34.7058823529412, Blast_Score=85, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320332, Length=156, Percent_Identity=33.3333333333333, Blast_Score=76, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROL_SERP5 (A8GAI2)

Other databases:

- EMBL:   CP000826
- RefSeq:   YP_001477250.1
- ProteinModelPortal:   A8GAI2
- SMR:   A8GAI2
- STRING:   A8GAI2
- GeneID:   5603038
- GenomeReviews:   CP000826_GR
- KEGG:   spe:Spro_1018
- eggNOG:   COG0703
- HOGENOM:   HBG335815
- OMA:   VEKEGWE
- ProtClustDB:   PRK03731
- BioCyc:   SPRO399741:SPRO_1018-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01269
- InterPro:   IPR000623
- InterPro:   IPR023000
- PRINTS:   PR01100

Pfam domain/function: PF01202 SKI

EC number: =2.7.1.71

Molecular weight: Translated: 19190; Mature: 19059

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS01128 SHIKIMATE_KINASE

Important sites: BINDING 34-34 BINDING 58-58 BINDING 79-79 BINDING 120-120 BINDING 139-139

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTIFMVGARGAGKTTVGSALALALGYQFIDTDLFMQQTTQMSVAEMVEQEGWLGFRRR
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ESIALQTVTQPSTVVATGGGAILAEENRRFMRQHGKVIYLRSPAEVLAQRLEEYPQDTQR
HHHHEEEECCCCEEEEECCCEEEEHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCC
PTLTGRPIAEEMLEVLAAREALYQEAAHYVMDGTGGPQQVVEQILSALQLETVK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TQTIFMVGARGAGKTTVGSALALALGYQFIDTDLFMQQTTQMSVAEMVEQEGWLGFRRR
CCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHH
ESIALQTVTQPSTVVATGGGAILAEENRRFMRQHGKVIYLRSPAEVLAQRLEEYPQDTQR
HHHHEEEECCCCEEEEECCCEEEEHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCC
PTLTGRPIAEEMLEVLAAREALYQEAAHYVMDGTGGPQQVVEQILSALQLETVK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA