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The map label for this gene is hutH [H]

Identifier: 157369049

GI number: 157369049

Start: 898400

End: 899935

Strand: Reverse

Name: hutH [H]

Synonym: Spro_0804

Alternate gene names: 157369049

Gene position: 899935-898400 (Counterclockwise)

Preceding gene: 157369050

Following gene: 157369048

Centisome position: 16.52

GC content: 61.52

Gene sequence:

>1536_bases
ATGAAAGCGCTGACTATTCGCCCAGGCCAACTGACACTGGCGCAACTGCGTGAAATTTATCAACACCCGGTCACCCTGAC
TCTGGACGACAACGCCTACGCAGATATCCAGAAAAGCGTTGCCTGCGTTGAACGTATCGTTGAGGAAAACCGTACCACCT
ACGGCATTAACACCGGTTTCGGCCTGCTGGCATCCACCCGCATCGCTCGCGAAGATCTGGAAGATCTGCAGCGTTCTATC
GTGCTGTCGCATGCCGCCGGCGTCGGTGCGCCCACCGACGACAATCTGGTGCGCCTGATTATGGTGCTGAAAATCAATAG
CCTGTCGCGCGGCTTCTCCGGCATCCGTCTGGAAGTGATCGAGGCGCTGATGGCGCTGGTCAACGCCGAAGTCTATCCGC
ATATCCCGCTGAAAGGCTCCGTAGGCGCCTCCGGCGACCTGGCACCGCTGGCACACATGAGCCTGGTGCTGTTGGGTGAA
GGCAAGGCCCGTTATCAGGGCGAATGGCTGCCTGCCACCGAAGCGCTGGCCAAAGCGGGCCTGAAACCGCTGACGCTGGC
GGCCAAAGAAGGCCTGGCACTGCTGAACGGCACCCAAGTTTCCGCCGCCTTTGCCCTGCGCGGTTTGTTTGACGTGGAAG
ACCTGTACGCCGCGGCAACGGTCACCGGTAGCCTGACGGTGGAAGCCGCTCTGGGTTCACGCAGCCCGTTTGATGCGCGC
ATTCATGCCGTGCGCGGTCAGCGTGGTCAGATTGACGCCGCCGCCGCTTACCGCCATCTGCTGGGCGAGCGCAGCGAAGT
GTCCGATTCACACCGCAACTGTGAAAAAGTGCAGGATCCGTACTCCCTGCGCTGCCAGCCGCAGGTGATGGGCGCCTGCC
TGACGCAAATTCGCCAGGCCGCCGAAGTGCTGGAAATTGAAGCCAACGCGGTCTCCGACAACCCGTTGGTCTTTGCTGAC
CAAGGCGACGTACTGTCCGGCGGTAACTTCCACGCCGAACCGGTCGCCATGGCCGCCGACAATCTGGCGCTGGCGTTTGC
CGAAATAGGTTCACTGTCCGAGCGCCGCATCTCGCTGATGATGGATAAACACATGTCGCAGCTGCCACCTTTCCTGGTGG
ACAACGGCGGGGTGAACTCCGGCTTTATGATTGCCCAGGTGACCGCCGCGGCGCTAACCAGCGAAAACAAAGCGCTGGCG
CACCCGGCCAGCGTCGACAGCATTCCGACCTCGGCCAACCAGGAAGACCACGTTTCCATGGCACCGGCCGCCGGTCGTCG
CCTGTGGGAAATGGCGGATAACGTTCGCGGCATTCTGGCCGTCGAGTGGCTGGCAGCCTGTCAGGGGCTGGATCTGCGTA
AAGGGCTGAAAACCACCGAAAGCCTGGAGCAGGCCCGCCGCACACTGCGCGAGCAAGTCAGTTACTACGACAAGGATCGT
TTCTTCGCTCCCGACATTGAAGCCGCCAGCCTGCTGTTGGCGGCCGGTCACCTGACCTCGCTAATGCCTGCAGCACTGCT
GCCTAGCCAGGCATAA

Upstream 100 bases:

>100_bases
TAATGCGTCACGCCGATGCCGGTTACGACATCGCCATTGAATGCGCCCGCGAGCAAGGTCTGAACCTGCCGATGGTGGCT
GCGACTCAAGGAGACAAAGC

Downstream 100 bases:

>100_bases
ATAAAACCTACCACGCAGTTTGTTCTGTCCCACCGGGCGCTATCCGCCCGGTGCGGATAGCGCGTGCCTGTTCTGCCGTA
AAAACTCGACGGGAAGCAAC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 511; Mature: 511

Protein sequence:

>511_residues
MKALTIRPGQLTLAQLREIYQHPVTLTLDDNAYADIQKSVACVERIVEENRTTYGINTGFGLLASTRIAREDLEDLQRSI
VLSHAAGVGAPTDDNLVRLIMVLKINSLSRGFSGIRLEVIEALMALVNAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGE
GKARYQGEWLPATEALAKAGLKPLTLAAKEGLALLNGTQVSAAFALRGLFDVEDLYAAATVTGSLTVEAALGSRSPFDAR
IHAVRGQRGQIDAAAAYRHLLGERSEVSDSHRNCEKVQDPYSLRCQPQVMGACLTQIRQAAEVLEIEANAVSDNPLVFAD
QGDVLSGGNFHAEPVAMAADNLALAFAEIGSLSERRISLMMDKHMSQLPPFLVDNGGVNSGFMIAQVTAAALTSENKALA
HPASVDSIPTSANQEDHVSMAPAAGRRLWEMADNVRGILAVEWLAACQGLDLRKGLKTTESLEQARRTLREQVSYYDKDR
FFAPDIEAASLLLAAGHLTSLMPAALLPSQA

Sequences:

>Translated_511_residues
MKALTIRPGQLTLAQLREIYQHPVTLTLDDNAYADIQKSVACVERIVEENRTTYGINTGFGLLASTRIAREDLEDLQRSI
VLSHAAGVGAPTDDNLVRLIMVLKINSLSRGFSGIRLEVIEALMALVNAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGE
GKARYQGEWLPATEALAKAGLKPLTLAAKEGLALLNGTQVSAAFALRGLFDVEDLYAAATVTGSLTVEAALGSRSPFDAR
IHAVRGQRGQIDAAAAYRHLLGERSEVSDSHRNCEKVQDPYSLRCQPQVMGACLTQIRQAAEVLEIEANAVSDNPLVFAD
QGDVLSGGNFHAEPVAMAADNLALAFAEIGSLSERRISLMMDKHMSQLPPFLVDNGGVNSGFMIAQVTAAALTSENKALA
HPASVDSIPTSANQEDHVSMAPAAGRRLWEMADNVRGILAVEWLAACQGLDLRKGLKTTESLEQARRTLREQVSYYDKDR
FFAPDIEAASLLLAAGHLTSLMPAALLPSQA
>Mature_511_residues
MKALTIRPGQLTLAQLREIYQHPVTLTLDDNAYADIQKSVACVERIVEENRTTYGINTGFGLLASTRIAREDLEDLQRSI
VLSHAAGVGAPTDDNLVRLIMVLKINSLSRGFSGIRLEVIEALMALVNAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGE
GKARYQGEWLPATEALAKAGLKPLTLAAKEGLALLNGTQVSAAFALRGLFDVEDLYAAATVTGSLTVEAALGSRSPFDAR
IHAVRGQRGQIDAAAAYRHLLGERSEVSDSHRNCEKVQDPYSLRCQPQVMGACLTQIRQAAEVLEIEANAVSDNPLVFAD
QGDVLSGGNFHAEPVAMAADNLALAFAEIGSLSERRISLMMDKHMSQLPPFLVDNGGVNSGFMIAQVTAAALTSENKALA
HPASVDSIPTSANQEDHVSMAPAAGRRLWEMADNVRGILAVEWLAACQGLDLRKGLKTTESLEQARRTLREQVSYYDKDR
FFAPDIEAASLLLAAGHLTSLMPAALLPSQA

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=488, Percent_Identity=45.0819672131148, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17567831, Length=457, Percent_Identity=44.2013129102845, Blast_Score=372, Evalue=1e-103,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54715; Mature: 54715

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00488 PAL_HISTIDASE ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALTIRPGQLTLAQLREIYQHPVTLTLDDNAYADIQKSVACVERIVEENRTTYGINTGF
CCCEECCCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCCH
GLLASTRIAREDLEDLQRSIVLSHAAGVGAPTDDNLVRLIMVLKINSLSRGFSGIRLEVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
EALMALVNAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGEGKARYQGEWLPATEALAKAG
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCHHHHHHHCC
LKPLTLAAKEGLALLNGTQVSAAFALRGLFDVEDLYAAATVTGSLTVEAALGSRSPFDAR
CCCEEHHHHCCCEEECCCHHHHHHHHHHCCCHHHHHHHHEEECCEEEEEECCCCCCCHHH
IHAVRGQRGQIDAAAAYRHLLGERSEVSDSHRNCEKVQDPYSLRCQPQVMGACLTQIRQA
HHEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
AEVLEIEANAVSDNPLVFADQGDVLSGGNFHAEPVAMAADNLALAFAEIGSLSERRISLM
HHHHHHCCCCCCCCCEEEECCCCEECCCCCCCCCHHHHHCHHHHHHHHHCCHHHHHHHHH
MDKHMSQLPPFLVDNGGVNSGFMIAQVTAAALTSENKALAHPASVDSIPTSANQEDHVSM
HHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEE
APAAGRRLWEMADNVRGILAVEWLAACQGLDLRKGLKTTESLEQARRTLREQVSYYDKDR
CCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
FFAPDIEAASLLLAAGHLTSLMPAALLPSQA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKALTIRPGQLTLAQLREIYQHPVTLTLDDNAYADIQKSVACVERIVEENRTTYGINTGF
CCCEECCCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEECCCCH
GLLASTRIAREDLEDLQRSIVLSHAAGVGAPTDDNLVRLIMVLKINSLSRGFSGIRLEVI
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHH
EALMALVNAEVYPHIPLKGSVGASGDLAPLAHMSLVLLGEGKARYQGEWLPATEALAKAG
HHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHEEEEEEECCCCCCCCCCCCHHHHHHHCC
LKPLTLAAKEGLALLNGTQVSAAFALRGLFDVEDLYAAATVTGSLTVEAALGSRSPFDAR
CCCEEHHHHCCCEEECCCHHHHHHHHHHCCCHHHHHHHHEEECCEEEEEECCCCCCCHHH
IHAVRGQRGQIDAAAAYRHLLGERSEVSDSHRNCEKVQDPYSLRCQPQVMGACLTQIRQA
HHEECCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
AEVLEIEANAVSDNPLVFADQGDVLSGGNFHAEPVAMAADNLALAFAEIGSLSERRISLM
HHHHHHCCCCCCCCCEEEECCCCEECCCCCCCCCHHHHHCHHHHHHHHHCCHHHHHHHHH
MDKHMSQLPPFLVDNGGVNSGFMIAQVTAAALTSENKALAHPASVDSIPTSANQEDHVSM
HHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEEE
APAAGRRLWEMADNVRGILAVEWLAACQGLDLRKGLKTTESLEQARRTLREQVSYYDKDR
CCHHHHHHHHHHHCCCHHHHHHHHHHHCCCCHHHCCCHHHHHHHHHHHHHHHHHHHCCCC
FFAPDIEAASLLLAAGHLTSLMPAALLPSQA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12928499 [H]