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The map label for this gene is hutH [H]

Identifier: 157369044

GI number: 157369044

Start: 892579

End: 894102

Strand: Reverse

Name: hutH [H]

Synonym: Spro_0799

Alternate gene names: 157369044

Gene position: 894102-892579 (Counterclockwise)

Preceding gene: 157369045

Following gene: 157369035

Centisome position: 16.41

GC content: 61.09

Gene sequence:

>1524_bases
ATGCACTACCCTATTTCGGTCACCCTCGACAACCTGCCGTTGCGCTGGCAAGACGTGGTGGCGGTAGCCAGATATCAGGC
ACCGCTCAACCTGTCTGACGCTGCCTGGGCGCGTATCGACAATGCGCAGGCCATCGTTCAGAAAATTGTCGCCAGTGAAC
AACGTGCCTATGGCGTCAATACCGGCCTGGGGGCGCTATGCAATCAGGCGCTGCACGGCGAACAATTGGCGCAACTGTCC
CGCAACACGCTGATGAGTCACGCCTGCGGCGTAGGGGAACCGCTGAGCGATGAGCAGACCCGCGCCATTATCTGCTGCGC
CATCGTCAACTATTGCCAGGGTAAGTCCGGCATTCAACGCCCGGTCGTAGAAGCGCTGCTGGCACTGCTTAACCGGGGGA
TAACCCCGCGGGTGCCGTCGCAAGGGTCGGTCGGCTATCTGACCCATATGGCACACGTCGGCGTCGCGCTGCTCGGTCTG
GGCGAAGTCAGCTACCGTGGCCAACTCGTCACCGCAGCCCAGGCTTTGGCGGAGGAAGGCATTGTGCCGCCACAGTTGGG
CGCCAAAGATGGCCTGTGCCTGGTCAACGGCACGCCGTGCATGACGGGATTGAGCTGCCTGGCGCTGGCCGATGCCTGGC
GGTTGGCCCGCTGGGCGGACGTGCTCGCGGCGATGAGCTTTGAAGCGCTGGGTGGACAGATCGCCGCCTTCGACAGCGAA
ATCCTGGCACTGAAACCGCACCCGGGTATGCAACGGGTTGGCAGTAATTTGCGGATGTTATTGAACGGCAGCGAGATGAT
TGCCGCCAGCAAGGGCATTCGTACCCAGGATGCGCTGAGCATCCGTTCAATCCCGCAGGTGCACGGTGCCTGCCGCGATC
AAATTGCTCATGCAGAACGGCAGATTGAAATCGAGCTGAACGGCAATAGCGATAATCCCCTGCTGCTCGGTACGCCAGAC
AACTATAGAGTGATGTCACAGGCCAACCCACACGGCGAGTCTGTGGCTATGGCCGCCGATCTGCTGGCGATTGCCATCGC
CGAACTGGGTGGTATCGCAGAACGGCGCATTGATCGGCTGATTAACCCACTGGTCAGTGGCTTACCGGCATTTCTGGTCA
GCGAGCCTGGGGTGAACTCAGGCATGATGATCGCTCAATACGTGGCGGCATCGCTGTGCGCGGAGAACCGCCAACTGGCA
CAGCCTTGCGTGGTGGATAATTATGTGACCTCGGCGCTGCAGGAAGATCACCTCAGCCTGGGCACCGGGGCGGCGCTAAG
GCTGCATAAGGCGCTGGGCAACATTAACCAGATCCTGGCGATTGAATACCTGCTGGCGGCACAGGCCTTTGAGTTCCTGC
AGCAGCACCGTTTCGGTGACGGCACCCAACGTGCCTGGCAACGGCTGCGGCAAACAGTGGCCCCTTATCATCAGGATCGC
TGGCTGGCACCGGATATCGCCAGCAGCGCCGCACTGCTGCAGGATGAACAGGCGCTGGCGGAGATTGCCCCGACGCTGCT
GTAA

Upstream 100 bases:

>100_bases
GATGAGTATGTTAACCGCTTCGTGCAACGCCGTCTGGCGCTGGATGAGAACGTACAGAAACCGCGCCCGATGATCGCGGC
CCGTGCCTGAGGAGAGCAAT

Downstream 100 bases:

>100_bases
TCCCCGCCCCTGCCCCCGTTCTGTACACCCACAGGGCGGGGGCATCGTGCTTAGCGCTGGGCCAAGGCCTGACGGATATC
CGCCTGCAGATCGTCAGGAT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MHYPISVTLDNLPLRWQDVVAVARYQAPLNLSDAAWARIDNAQAIVQKIVASEQRAYGVNTGLGALCNQALHGEQLAQLS
RNTLMSHACGVGEPLSDEQTRAIICCAIVNYCQGKSGIQRPVVEALLALLNRGITPRVPSQGSVGYLTHMAHVGVALLGL
GEVSYRGQLVTAAQALAEEGIVPPQLGAKDGLCLVNGTPCMTGLSCLALADAWRLARWADVLAAMSFEALGGQIAAFDSE
ILALKPHPGMQRVGSNLRMLLNGSEMIAASKGIRTQDALSIRSIPQVHGACRDQIAHAERQIEIELNGNSDNPLLLGTPD
NYRVMSQANPHGESVAMAADLLAIAIAELGGIAERRIDRLINPLVSGLPAFLVSEPGVNSGMMIAQYVAASLCAENRQLA
QPCVVDNYVTSALQEDHLSLGTGAALRLHKALGNINQILAIEYLLAAQAFEFLQQHRFGDGTQRAWQRLRQTVAPYHQDR
WLAPDIASSAALLQDEQALAEIAPTLL

Sequences:

>Translated_507_residues
MHYPISVTLDNLPLRWQDVVAVARYQAPLNLSDAAWARIDNAQAIVQKIVASEQRAYGVNTGLGALCNQALHGEQLAQLS
RNTLMSHACGVGEPLSDEQTRAIICCAIVNYCQGKSGIQRPVVEALLALLNRGITPRVPSQGSVGYLTHMAHVGVALLGL
GEVSYRGQLVTAAQALAEEGIVPPQLGAKDGLCLVNGTPCMTGLSCLALADAWRLARWADVLAAMSFEALGGQIAAFDSE
ILALKPHPGMQRVGSNLRMLLNGSEMIAASKGIRTQDALSIRSIPQVHGACRDQIAHAERQIEIELNGNSDNPLLLGTPD
NYRVMSQANPHGESVAMAADLLAIAIAELGGIAERRIDRLINPLVSGLPAFLVSEPGVNSGMMIAQYVAASLCAENRQLA
QPCVVDNYVTSALQEDHLSLGTGAALRLHKALGNINQILAIEYLLAAQAFEFLQQHRFGDGTQRAWQRLRQTVAPYHQDR
WLAPDIASSAALLQDEQALAEIAPTLL
>Mature_507_residues
MHYPISVTLDNLPLRWQDVVAVARYQAPLNLSDAAWARIDNAQAIVQKIVASEQRAYGVNTGLGALCNQALHGEQLAQLS
RNTLMSHACGVGEPLSDEQTRAIICCAIVNYCQGKSGIQRPVVEALLALLNRGITPRVPSQGSVGYLTHMAHVGVALLGL
GEVSYRGQLVTAAQALAEEGIVPPQLGAKDGLCLVNGTPCMTGLSCLALADAWRLARWADVLAAMSFEALGGQIAAFDSE
ILALKPHPGMQRVGSNLRMLLNGSEMIAASKGIRTQDALSIRSIPQVHGACRDQIAHAERQIEIELNGNSDNPLLLGTPD
NYRVMSQANPHGESVAMAADLLAIAIAELGGIAERRIDRLINPLVSGLPAFLVSEPGVNSGMMIAQYVAASLCAENRQLA
QPCVVDNYVTSALQEDHLSLGTGAALRLHKALGNINQILAIEYLLAAQAFEFLQQHRFGDGTQRAWQRLRQTVAPYHQDR
WLAPDIASSAALLQDEQALAEIAPTLL

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=509, Percent_Identity=36.9351669941061, Blast_Score=322, Evalue=5e-88,
Organism=Caenorhabditis elegans, GI17567831, Length=508, Percent_Identity=35.8267716535433, Blast_Score=279, Evalue=3e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 54239; Mature: 54239

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYPISVTLDNLPLRWQDVVAVARYQAPLNLSDAAWARIDNAQAIVQKIVASEQRAYGVN
CCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCC
TGLGALCNQALHGEQLAQLSRNTLMSHACGVGEPLSDEQTRAIICCAIVNYCQGKSGIQR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHH
PVVEALLALLNRGITPRVPSQGSVGYLTHMAHVGVALLGLGEVSYRGQLVTAAQALAEEG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCC
IVPPQLGAKDGLCLVNGTPCMTGLSCLALADAWRLARWADVLAAMSFEALGGQIAAFDSE
CCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
ILALKPHPGMQRVGSNLRMLLNGSEMIAASKGIRTQDALSIRSIPQVHGACRDQIAHAER
EEEECCCCCHHHHCCCCEEEECCCHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCE
QIEIELNGNSDNPLLLGTPDNYRVMSQANPHGESVAMAADLLAIAIAELGGIAERRIDRL
EEEEEEECCCCCCEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
INPLVSGLPAFLVSEPGVNSGMMIAQYVAASLCAENRQLAQPCVVDNYVTSALQEDHLSL
HHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHCC
GTGAALRLHKALGNINQILAIEYLLAAQAFEFLQQHRFGDGTQRAWQRLRQTVAPYHQDR
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHCCC
WLAPDIASSAALLQDEQALAEIAPTLL
CCCCHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHYPISVTLDNLPLRWQDVVAVARYQAPLNLSDAAWARIDNAQAIVQKIVASEQRAYGVN
CCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHCCCC
TGLGALCNQALHGEQLAQLSRNTLMSHACGVGEPLSDEQTRAIICCAIVNYCQGKSGIQR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCHH
PVVEALLALLNRGITPRVPSQGSVGYLTHMAHVGVALLGLGEVSYRGQLVTAAQALAEEG
HHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCC
IVPPQLGAKDGLCLVNGTPCMTGLSCLALADAWRLARWADVLAAMSFEALGGQIAAFDSE
CCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCC
ILALKPHPGMQRVGSNLRMLLNGSEMIAASKGIRTQDALSIRSIPQVHGACRDQIAHAER
EEEECCCCCHHHHCCCCEEEECCCHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHHHHCCE
QIEIELNGNSDNPLLLGTPDNYRVMSQANPHGESVAMAADLLAIAIAELGGIAERRIDRL
EEEEEEECCCCCCEEEECCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHH
INPLVSGLPAFLVSEPGVNSGMMIAQYVAASLCAENRQLAQPCVVDNYVTSALQEDHLSL
HHHHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHCC
GTGAALRLHKALGNINQILAIEYLLAAQAFEFLQQHRFGDGTQRAWQRLRQTVAPYHQDR
CCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCHHCCC
WLAPDIASSAALLQDEQALAEIAPTLL
CCCCHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA