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The map label for this gene is ilvD [H]

Identifier: 157368953

GI number: 157368953

Start: 780950

End: 782662

Strand: Reverse

Name: ilvD [H]

Synonym: Spro_0708

Alternate gene names: 157368953

Gene position: 782662-780950 (Counterclockwise)

Preceding gene: 157368954

Following gene: 157368952

Centisome position: 14.36

GC content: 59.89

Gene sequence:

>1713_bases
ATGAGCGGATGTGGAACCTGTGGCGGCGGCAGTTGCGGCGCGCATTTTAACCCAATCCTCGAGGGTGATGACGGTGCGCT
GAAACGTGCGCTGTATAAATCGATGGGCCACAGCGACGAACAACTGCGACGCCCGGTGATCGCCGTGGTCAACAGTTATA
CCAACGCCACCGCCGGCCACGTCAACCTCAATGAACTGACGGCCAGGGTATTGCAGGGTATTGAAGAAGCCGGTGGTGTC
GGCATGGTGTTCGGTACTATCGCCCCCTGCGATGGCATTGCCGAAGGGCATCTTGGCATGCGCTACATCCTGGCCGCCCG
CGAGGTGATCACCGCCTCAATTGAAGTGATGATGCGCGCCCATCGTTTCGACGGCATGGTACTGCTGGGATCCTGCGACA
AAATTGTGCCTGCCATGCTGATGGCGGCGGCACGGCTGGACGTTCCGGCGATCATGGTCAACGGTGGCCCGATGTATCCG
GCGGAATATAAAGGCAAGCACTGGGACGGCAACATCGTCACCGAAGCCATCGGCTGGAAAAAACGCGGCGAAATCGATGA
GGCGGAATTCGCTCATATCGAAAATATCGCCGAGCCCGGCCCCGGTTCCTGCACCATGTACGGTACGGCTAACACCATGT
GCTGTATCGGCGAAGTTTTGGGTATGAGCCTGCCGGGTAGCAGCACACTGCCGGCGGTATCCGCCGAGCGGCGCGAATGC
GCTATCGAAACCGGCCGCCAGGCGGTGGCGCTGGTGCTCAACGGTATCAACGCGCGACAGATCATCACCGCGGCGTCGAT
CCGCAATGCGATGATTTATCTACTGGCCACCGGCGGTTCCACCAATGCCATTCTGCATCTGCAAGCCATTCACTACGAAG
CGGAATTGGGGCATCTGCCGCTGTCCGCCTTCGATGAGCTGAGCCATCAGGTGCCGCTGGTCGCATCGCTGTACCCGGCC
TCCGAGCATGACATGATTGATTTCTGGGAGGCGGGCGGCGTACCGGCGGTCGAAGTTGAGATTGCCAAACTGCTCGACCT
TAACGCCTTGACCGTCACCGGCAAAACCAAGGCTGAGCTACTGGCGAAGACCCCGCCAAGCCGACGTCCTGAGGTCATCC
ACACCCTGGCCATTCCGGTGCGCAATGAAGCCGGCGTTGCCGTGCTGCACGGCAACCTGTCGCCGCTCGGCTGCGTGGTG
AAACCGGCCGCAGTGCCCGATCACCTGATGCGTTTTAGTGGCCCCGCCGTGGTGTTCAACAGCGAGCAGGAATCGGTCGA
GGCGATTATGTCCGGCCAGATTAAACCGGGCAGTGCTCTGGTGTTGCGTTACGAAGGGCCTAAAGGCGGCCCCGGCATGC
CGGAAATGTATAAACCGATGAAATCACTGGAAGGTATGGGCCTGTCCGACAGTTGCGCCTTGATCACCGATGGCCGTTTT
TCCGGTTCCAACCGCGGGCTGTTTGTCGGCCACATTTCACCTGAGGCGGTAGAGGGCGGCGAACTGGCACTGGTGCAGAA
CGGAGACCCGATCTCCATCGATATTCCAGCTCGTACTCTAACGCTGCATGTCAGCGAGAGCGAACTGATCCTGCGACGTA
AAACCTGGCAACCGCTGGATAAAGAAGTGCCACGCGGTTTCCTGCGACTTTATCGCCGCTGGGCAATGCCGGCCGCGCAG
GGTGCCGTACTGGCTGACCGGGAGGAAGAATAA

Upstream 100 bases:

>100_bases
TCATGCTTCCGGCCAGATTGATAAACCCAAAGATCAAACCGCATCAGGCGACTCAGCCTGATACCGAAGGCCCTTTAAAT
ATCACTGAGAGATTTTAATT

Downstream 100 bases:

>100_bases
TGAGCCGTTATCAAGCCGCAGATATTTGCGGCGTCAATCCTATTGTCGCTATGCCGTTTAGGGCTGACGGCGAGATAGAT
GAAGCAAGCTTTGTGCGATT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD [H]

Number of amino acids: Translated: 570; Mature: 569

Protein sequence:

>570_residues
MSGCGTCGGGSCGAHFNPILEGDDGALKRALYKSMGHSDEQLRRPVIAVVNSYTNATAGHVNLNELTARVLQGIEEAGGV
GMVFGTIAPCDGIAEGHLGMRYILAAREVITASIEVMMRAHRFDGMVLLGSCDKIVPAMLMAAARLDVPAIMVNGGPMYP
AEYKGKHWDGNIVTEAIGWKKRGEIDEAEFAHIENIAEPGPGSCTMYGTANTMCCIGEVLGMSLPGSSTLPAVSAERREC
AIETGRQAVALVLNGINARQIITAASIRNAMIYLLATGGSTNAILHLQAIHYEAELGHLPLSAFDELSHQVPLVASLYPA
SEHDMIDFWEAGGVPAVEVEIAKLLDLNALTVTGKTKAELLAKTPPSRRPEVIHTLAIPVRNEAGVAVLHGNLSPLGCVV
KPAAVPDHLMRFSGPAVVFNSEQESVEAIMSGQIKPGSALVLRYEGPKGGPGMPEMYKPMKSLEGMGLSDSCALITDGRF
SGSNRGLFVGHISPEAVEGGELALVQNGDPISIDIPARTLTLHVSESELILRRKTWQPLDKEVPRGFLRLYRRWAMPAAQ
GAVLADREEE

Sequences:

>Translated_570_residues
MSGCGTCGGGSCGAHFNPILEGDDGALKRALYKSMGHSDEQLRRPVIAVVNSYTNATAGHVNLNELTARVLQGIEEAGGV
GMVFGTIAPCDGIAEGHLGMRYILAAREVITASIEVMMRAHRFDGMVLLGSCDKIVPAMLMAAARLDVPAIMVNGGPMYP
AEYKGKHWDGNIVTEAIGWKKRGEIDEAEFAHIENIAEPGPGSCTMYGTANTMCCIGEVLGMSLPGSSTLPAVSAERREC
AIETGRQAVALVLNGINARQIITAASIRNAMIYLLATGGSTNAILHLQAIHYEAELGHLPLSAFDELSHQVPLVASLYPA
SEHDMIDFWEAGGVPAVEVEIAKLLDLNALTVTGKTKAELLAKTPPSRRPEVIHTLAIPVRNEAGVAVLHGNLSPLGCVV
KPAAVPDHLMRFSGPAVVFNSEQESVEAIMSGQIKPGSALVLRYEGPKGGPGMPEMYKPMKSLEGMGLSDSCALITDGRF
SGSNRGLFVGHISPEAVEGGELALVQNGDPISIDIPARTLTLHVSESELILRRKTWQPLDKEVPRGFLRLYRRWAMPAAQ
GAVLADREEE
>Mature_569_residues
SGCGTCGGGSCGAHFNPILEGDDGALKRALYKSMGHSDEQLRRPVIAVVNSYTNATAGHVNLNELTARVLQGIEEAGGVG
MVFGTIAPCDGIAEGHLGMRYILAAREVITASIEVMMRAHRFDGMVLLGSCDKIVPAMLMAAARLDVPAIMVNGGPMYPA
EYKGKHWDGNIVTEAIGWKKRGEIDEAEFAHIENIAEPGPGSCTMYGTANTMCCIGEVLGMSLPGSSTLPAVSAERRECA
IETGRQAVALVLNGINARQIITAASIRNAMIYLLATGGSTNAILHLQAIHYEAELGHLPLSAFDELSHQVPLVASLYPAS
EHDMIDFWEAGGVPAVEVEIAKLLDLNALTVTGKTKAELLAKTPPSRRPEVIHTLAIPVRNEAGVAVLHGNLSPLGCVVK
PAAVPDHLMRFSGPAVVFNSEQESVEAIMSGQIKPGSALVLRYEGPKGGPGMPEMYKPMKSLEGMGLSDSCALITDGRFS
GSNRGLFVGHISPEAVEGGELALVQNGDPISIDIPARTLTLHVSESELILRRKTWQPLDKEVPRGFLRLYRRWAMPAAQG
AVLADREEE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family [H]

Homologues:

Organism=Escherichia coli, GI48994964, Length=593, Percent_Identity=39.7976391231029, Blast_Score=391, Evalue=1e-110,
Organism=Escherichia coli, GI1788157, Length=520, Percent_Identity=35.5769230769231, Blast_Score=233, Evalue=3e-62,
Organism=Escherichia coli, GI2367371, Length=467, Percent_Identity=32.3340471092077, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1786464, Length=503, Percent_Identity=31.013916500994, Blast_Score=174, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6322476, Length=551, Percent_Identity=37.5680580762251, Blast_Score=333, Evalue=6e-92,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558 [H]

Pfam domain/function: PF00920 ILVD_EDD [H]

EC number: =4.2.1.9 [H]

Molecular weight: Translated: 60644; Mature: 60512

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS00886 ILVD_EDD_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGCGTCGGGSCGAHFNPILEGDDGALKRALYKSMGHSDEQLRRPVIAVVNSYTNATAGH
CCCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCCHHHHHCHHHHHHHCCCCCCCCC
VNLNELTARVLQGIEEAGGVGMVFGTIAPCDGIAEGHLGMRYILAAREVITASIEVMMRA
CCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HRFDGMVLLGSCDKIVPAMLMAAARLDVPAIMVNGGPMYPAEYKGKHWDGNIVTEAIGWK
HHCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCEEEHHHCCC
KRGEIDEAEFAHIENIAEPGPGSCTMYGTANTMCCIGEVLGMSLPGSSTLPAVSAERREC
CCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHH
AIETGRQAVALVLNGINARQIITAASIRNAMIYLLATGGSTNAILHLQAIHYEAELGHLP
HHHCCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCCCCEEEEEEEEEEEHHCCCCC
LSAFDELSHQVPLVASLYPASEHDMIDFWEAGGVPAVEVEIAKLLDLNALTVTGKTKAEL
HHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCEEEEEHHHHHCCCEEEECCCHHHHH
LAKTPPSRRPEVIHTLAIPVRNEAGVAVLHGNLSPLGCVVKPAAVPDHLMRFSGPAVVFN
HCCCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCEEEECCCCHHHHHHCCCCEEEEC
SEQESVEAIMSGQIKPGSALVLRYEGPKGGPGMPEMYKPMKSLEGMGLSDSCALITDGRF
CCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCC
SGSNRGLFVGHISPEAVEGGELALVQNGDPISIDIPARTLTLHVSESELILRRKTWQPLD
CCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEEECCEEEEEEECCCCEEEECCCCCCHH
KEVPRGFLRLYRRWAMPAAQGAVLADREEE
HHHHHHHHHHHHHHCCCCCCCCEECCCCCC
>Mature Secondary Structure 
SGCGTCGGGSCGAHFNPILEGDDGALKRALYKSMGHSDEQLRRPVIAVVNSYTNATAGH
CCCCCCCCCCCCCCCCCEEECCCHHHHHHHHHHHCCCHHHHHCHHHHHHHCCCCCCCCC
VNLNELTARVLQGIEEAGGVGMVFGTIAPCDGIAEGHLGMRYILAAREVITASIEVMMRA
CCHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
HRFDGMVLLGSCDKIVPAMLMAAARLDVPAIMVNGGPMYPAEYKGKHWDGNIVTEAIGWK
HHCCCEEEECCCHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCEEEHHHCCC
KRGEIDEAEFAHIENIAEPGPGSCTMYGTANTMCCIGEVLGMSLPGSSTLPAVSAERREC
CCCCCCHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHH
AIETGRQAVALVLNGINARQIITAASIRNAMIYLLATGGSTNAILHLQAIHYEAELGHLP
HHHCCCCEEEEECCCCCHHHHHHHHHHCCEEEEEEECCCCCCEEEEEEEEEEEHHCCCCC
LSAFDELSHQVPLVASLYPASEHDMIDFWEAGGVPAVEVEIAKLLDLNALTVTGKTKAEL
HHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCCEEEEEHHHHHCCCEEEECCCHHHHH
LAKTPPSRRPEVIHTLAIPVRNEAGVAVLHGNLSPLGCVVKPAAVPDHLMRFSGPAVVFN
HCCCCCCCCCCEEEEEEEEECCCCCEEEEECCCCCCCEEEECCCCHHHHHHCCCCEEEEC
SEQESVEAIMSGQIKPGSALVLRYEGPKGGPGMPEMYKPMKSLEGMGLSDSCALITDGRF
CCHHHHHHHHCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHCCCCCCCCEEEEECCCC
SGSNRGLFVGHISPEAVEGGELALVQNGDPISIDIPARTLTLHVSESELILRRKTWQPLD
CCCCCCEEEECCCCCCCCCCCEEEEECCCEEEEEECCEEEEEEECCCCEEEECCCCCCHH
KEVPRGFLRLYRRWAMPAAQGAVLADREEE
HHHHHHHHHHHHHHCCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA