BacMap

Definition	Serratia proteamaculans 568 chromosome, complete genome.
Accession	NC_009832
Length	5,448,853

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The map label for this gene is fabG [C]

Identifier: 157368951

GI number: 157368951

Start: 779240

End: 780022

Strand: Reverse

Name: fabG [C]

Synonym: Spro_0706

Alternate gene names: 157368951

Gene position: 780022-779240 (Counterclockwise)

Preceding gene: 157368952

Following gene: 157368947

Centisome position: 14.32

GC content: 54.92

Gene sequence:

>783_bases
ATGCTTATCGACAAATCCGGACGAGTGGTGATCGTCACCGGTGCCAGCCAGGGCATAGGTCTGGCTATTACCAAGGCCTT
TCTCGCTAACGGCGATAGCGTTATGGGTTGCGCCGAACCAGCCCTGGAGAAAGCCCCCCATGCCCAGCAATTGCGGCGCG
AGTACCCGCAACATTTTTTCTACGACTCGGTGGATGTCACGCAGACCACCGAGATAAAACGTTTTGTCGCCAATGCTGAG
CAACGGTTCCATCGTATCGATATTGTGGTTTCCAACGCCGGTAAAAACGTTTTCAAAGGCATTGATTGCGAAGAAGAAGA
CTGGACACATAACTTCAATCTCAATCTGCGCTCACATTGGTATCTGGCCAAATGTGCCCGTGCGGCCCTGACCCAAAGCC
GTGGCGTGATCCTGGTGATCACCTCCAACCACGCATTCTCCACCCTGCCGGGCTGTGCGCCGTATAACATCAGCAAGCGG
GCACTACTCTCCCTGGTACAAAGCCTGACTATCGAGTGGGGTCCGGCGATCCGCACTCTGGGGATTGCTCCTGGTTTTAT
CGATACCGAAGGCAACCAAACCTGGTTCGATAGCCACCCAGATGCCAAACTGGCGCGGGAAAGAACCGTAAACAAGCACC
CGGTCGGCCGCCTGGGAGCACCTGAAGAAGTCGGTGATTTGTGTTTGTTTCTCGCCAGTGAACACGCGGGATTTATCGCA
GGCACCACGATTGTGATGGACGGAGGACGCAGTGCCATCATGCAGGATGAAGACCCCGACTAA

Upstream 100 bases:

>100_bases
CGTCACCCCGGCTGGCAACTCACCGCAGACGATCACCTGATGATCGACCGGTTTTTAGGCCAGTTTTCTCTTTAGCAAAA
CAGCCCTTGCCGAGGTTTAT

Downstream 100 bases:

>100_bases
CTGAAAGAAAAACGGGGAGCCAAAGCCCCCCGTTCGACAGACCATTCAACCGGCTAGGTTAACACTGCCACCTCGTCGGC
GATTGCCGTCAGTGCATCAT

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MLIDKSGRVVIVTGASQGIGLAITKAFLANGDSVMGCAEPALEKAPHAQQLRREYPQHFFYDSVDVTQTTEIKRFVANAE
QRFHRIDIVVSNAGKNVFKGIDCEEEDWTHNFNLNLRSHWYLAKCARAALTQSRGVILVITSNHAFSTLPGCAPYNISKR
ALLSLVQSLTIEWGPAIRTLGIAPGFIDTEGNQTWFDSHPDAKLARERTVNKHPVGRLGAPEEVGDLCLFLASEHAGFIA
GTTIVMDGGRSAIMQDEDPD

Sequences:

>Translated_260_residues
MLIDKSGRVVIVTGASQGIGLAITKAFLANGDSVMGCAEPALEKAPHAQQLRREYPQHFFYDSVDVTQTTEIKRFVANAE
QRFHRIDIVVSNAGKNVFKGIDCEEEDWTHNFNLNLRSHWYLAKCARAALTQSRGVILVITSNHAFSTLPGCAPYNISKR
ALLSLVQSLTIEWGPAIRTLGIAPGFIDTEGNQTWFDSHPDAKLARERTVNKHPVGRLGAPEEVGDLCLFLASEHAGFIA
GTTIVMDGGRSAIMQDEDPD
>Mature_260_residues
MLIDKSGRVVIVTGASQGIGLAITKAFLANGDSVMGCAEPALEKAPHAQQLRREYPQHFFYDSVDVTQTTEIKRFVANAE
QRFHRIDIVVSNAGKNVFKGIDCEEEDWTHNFNLNLRSHWYLAKCARAALTQSRGVILVITSNHAFSTLPGCAPYNISKR
ALLSLVQSLTIEWGPAIRTLGIAPGFIDTEGNQTWFDSHPDAKLARERTVNKHPVGRLGAPEEVGDLCLFLASEHAGFIA
GTTIVMDGGRSAIMQDEDPD

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=254, Percent_Identity=31.496062992126, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI66933014, Length=252, Percent_Identity=30.5555555555556, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI126723750, Length=252, Percent_Identity=26.984126984127, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI19923817, Length=268, Percent_Identity=26.865671641791, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI59889578, Length=228, Percent_Identity=29.3859649122807, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI15277342, Length=257, Percent_Identity=29.5719844357977, Blast_Score=83, Evalue=3e-16,
Organism=Homo sapiens, GI5031737, Length=253, Percent_Identity=26.0869565217391, Blast_Score=81, Evalue=9e-16,
Organism=Homo sapiens, GI126723191, Length=180, Percent_Identity=30, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI7705925, Length=250, Percent_Identity=26.8, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI33667109, Length=195, Percent_Identity=27.1794871794872, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI10190704, Length=260, Percent_Identity=27.3076923076923, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI1787335, Length=248, Percent_Identity=30.6451612903226, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1786812, Length=259, Percent_Identity=31.2741312741313, Blast_Score=95, Evalue=5e-21,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=27.843137254902, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=28.9795918367347, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1789208, Length=249, Percent_Identity=27.710843373494, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI2367365, Length=245, Percent_Identity=26.1224489795918, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI87082160, Length=249, Percent_Identity=27.3092369477912, Blast_Score=74, Evalue=9e-15,
Organism=Escherichia coli, GI1788459, Length=176, Percent_Identity=32.3863636363636, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790717, Length=251, Percent_Identity=24.3027888446215, Blast_Score=70, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17561402, Length=251, Percent_Identity=28.6852589641434, Blast_Score=106, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17560676, Length=249, Percent_Identity=29.3172690763052, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17563726, Length=265, Percent_Identity=27.1698113207547, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=29.3233082706767, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI72000259, Length=260, Percent_Identity=28.4615384615385, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=248, Percent_Identity=27.4193548387097, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17560150, Length=264, Percent_Identity=28.4090909090909, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=268, Percent_Identity=28.3582089552239, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI17560332, Length=269, Percent_Identity=28.2527881040892, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71994600, Length=256, Percent_Identity=25.390625, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=260, Percent_Identity=28.4615384615385, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=272, Percent_Identity=26.8382352941176, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=27.2388059701493, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17562906, Length=266, Percent_Identity=27.4436090225564, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17538480, Length=263, Percent_Identity=26.9961977186312, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17560220, Length=262, Percent_Identity=26.7175572519084, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=249, Percent_Identity=24.8995983935743, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17562910, Length=277, Percent_Identity=25.9927797833935, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17536025, Length=253, Percent_Identity=26.8774703557312, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17561272, Length=197, Percent_Identity=28.9340101522843, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=271, Percent_Identity=26.9372693726937, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=272, Percent_Identity=26.1029411764706, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17544670, Length=273, Percent_Identity=24.9084249084249, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17565030, Length=264, Percent_Identity=27.2727272727273, Blast_Score=66, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=253, Percent_Identity=26.4822134387352, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6323882, Length=252, Percent_Identity=28.1746031746032, Blast_Score=72, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6322226, Length=191, Percent_Identity=29.8429319371728, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322227, Length=196, Percent_Identity=29.0816326530612, Blast_Score=68, Evalue=1e-12,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=30.2788844621514, Blast_Score=113, Evalue=1e-25,
Organism=Drosophila melanogaster, GI23397609, Length=250, Percent_Identity=30.4, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357041, Length=250, Percent_Identity=29.6, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28571526, Length=252, Percent_Identity=30.5555555555556, Blast_Score=94, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24644339, Length=253, Percent_Identity=27.6679841897233, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24639444, Length=250, Percent_Identity=27.2, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24644337, Length=193, Percent_Identity=30.5699481865285, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24643142, Length=256, Percent_Identity=28.125, Blast_Score=83, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 28489; Mature: 28489

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIDKSGRVVIVTGASQGIGLAITKAFLANGDSVMGCAEPALEKAPHAQQLRREYPQHFF
CEECCCCCEEEEECCCCCCHHHHHHHHHCCCCCEECCCCHHHHHCCCHHHHHHHCCHHHC
YDSVDVTQTTEIKRFVANAEQRFHRIDIVVSNAGKNVFKGIDCEEEDWTHNFNLNLRSHW
CCCCCCCHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHCCCCCCCCCCCEEEEEEECCCH
YLAKCARAALTQSRGVILVITSNHAFSTLPGCAPYNISKRALLSLVQSLTIEWGPAIRTL
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEE
GIAPGFIDTEGNQTWFDSHPDAKLARERTVNKHPVGRLGAPEEVGDLCLFLASEHAGFIA
CCCCCEEECCCCCEECCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE
GTTIVMDGGRSAIMQDEDPD
EEEEEEECCCCCCCCCCCCC
>Mature Secondary Structure
MLIDKSGRVVIVTGASQGIGLAITKAFLANGDSVMGCAEPALEKAPHAQQLRREYPQHFF
CEECCCCCEEEEECCCCCCHHHHHHHHHCCCCCEECCCCHHHHHCCCHHHHHHHCCHHHC
YDSVDVTQTTEIKRFVANAEQRFHRIDIVVSNAGKNVFKGIDCEEEDWTHNFNLNLRSHW
CCCCCCCHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHCCCCCCCCCCCEEEEEEECCCH
YLAKCARAALTQSRGVILVITSNHAFSTLPGCAPYNISKRALLSLVQSLTIEWGPAIRTL
HHHHHHHHHHHCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEE
GIAPGFIDTEGNQTWFDSHPDAKLARERTVNKHPVGRLGAPEEVGDLCLFLASEHAGFIA
CCCCCEEECCCCCEECCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEE
GTTIVMDGGRSAIMQDEDPD
EEEEEEECCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8550425; 10360571 [H]