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The map label for this gene is bioA [C]

Identifier: 157368852

GI number: 157368852

Start: 673317

End: 674657

Strand: Reverse

Name: bioA [C]

Synonym: Spro_0607

Alternate gene names: 157368852

Gene position: 674657-673317 (Counterclockwise)

Preceding gene: 157368856

Following gene: 157368851

Centisome position: 12.38

GC content: 57.64

Gene sequence:

>1341_bases
ATGGCTGATTTAAATCACCCTGAAAATAAACCCGAACCTGAATGGTTAGAAGCCCATTGGATGCCGTTTACCGGTAACCG
TAATTTTAAAGCCAACCCGCGAATGATAAGCCATGCTGAAGGCGTTTATTATACCAGCCAGGACGGCCGCAAAATTTTTG
ACGGTTTATCCGGGTTATGGTGCTGCGGATTAGGTCACGGCCGTCAGGAAATTGCCGAGGCGGCCTACCGACAACTCTCT
CGGCTGGATTATTCTCCGGCGTTTCAGTTTGGCCATGCATTATCTTTCGAACTGGCCAACAAGATTAAGACCATGACGCC
TGCCGGGCTGGACTATGTGTTTTTCACCGGCTCCGGCTCCGAAGCCGCAGACACCTCGTTAAAAATGGCCCGTGCCTACT
GGCGCGCCAAGGGGCAGGCGGGCAAGACCTGCTTTATCGGCCGCGAAAAGGGTTACCACGGCGTTAACTTCGGTGGTATT
GCGGTGGGCGGCATCGCCGGCAACCGAAAAGCCTTTGGTGCCAGCGCCGAAGCGGATCATCTGCCGCATACCCTGCTGGC
AGGTAACGCCTTTTCACGCGGTATGCCCGAACAGGGCGCAGAACTGGCGGAAGAGCTGAACCGCATCATTACGCTACGTG
ACGCCTCAACCATCGCCGCGGTGATTATTGAGCCGTTCTCCGGCTCCGCCGGGGTGATTGTGCCACCGGTCGGTTATCTG
CAACGCATCCGCGAGATCTGCACTCAACACAATATCCTGCTGATTTTTGACGAAGTGATCACCGCCTTCGGTCGCTGCGG
TGCCCTGACCGGGGCCGAAGCCTTCGGCGTCACTCCGGACATCATGAATATCGCCAAACAGGTGACCAACGGCGCCCAGC
CGATGGGCGCGGTGGTAGTTCGGCCAGAGATTTACCAGGCCTTTATGACCACCGATGAACCCGAGTATTTGCTTGAGTTC
CCGCACGGCTACACCTATTCCGCCCACCCGGTCAGCTGTGCGGTAGGGCTGGCGACGCTGGATATCATTGAGCGCGAGCA
GATGATTGAACGGGTGCAGGCACTTGCACCCTATTTCGAGCAGGCGGTGCACGGTTTACAGGGTTGCCGTCACGTCACCG
ACATTCGCAACTTTGGTCTGGCAGCCGGCATCACGCTGGCGGCACGACCGGGGGAAGCGGCACGCAGGCCGTATGAGGTG
GCGATGCGCTGCTGGGAAAAAGGCTTTTATGTTCGCTACGGCGGCGACACCCTGCAGCTGGCACCGCCGTTTATCAGCAG
CGAGGCGCAGATCGATTCGTTGATCAACGCCCTGGGCGACGCCATCAACGCAACAGAATAA

Upstream 100 bases:

>100_bases
ATTCACATTAGTGAAGAAGCGGAACATAGTCAATTTGAAGCAACAATTCATTAACACGTCAGATTATTAACCCTACCTAT
TCTCCCGCCCGGAGGGAAAC

Downstream 100 bases:

>100_bases
TCAGGAGCGAATGCCATGCCTATTGCACATTGGATCAACGGCCAGTCCGCCACCGGCGGCAGCCGCAGCCAGCCGGTATT
CGATCCGGCGACCGGGCAGT

Product: beta alanine--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MADLNHPENKPEPEWLEAHWMPFTGNRNFKANPRMISHAEGVYYTSQDGRKIFDGLSGLWCCGLGHGRQEIAEAAYRQLS
RLDYSPAFQFGHALSFELANKIKTMTPAGLDYVFFTGSGSEAADTSLKMARAYWRAKGQAGKTCFIGREKGYHGVNFGGI
AVGGIAGNRKAFGASAEADHLPHTLLAGNAFSRGMPEQGAELAEELNRIITLRDASTIAAVIIEPFSGSAGVIVPPVGYL
QRIREICTQHNILLIFDEVITAFGRCGALTGAEAFGVTPDIMNIAKQVTNGAQPMGAVVVRPEIYQAFMTTDEPEYLLEF
PHGYTYSAHPVSCAVGLATLDIIEREQMIERVQALAPYFEQAVHGLQGCRHVTDIRNFGLAAGITLAARPGEAARRPYEV
AMRCWEKGFYVRYGGDTLQLAPPFISSEAQIDSLINALGDAINATE

Sequences:

>Translated_446_residues
MADLNHPENKPEPEWLEAHWMPFTGNRNFKANPRMISHAEGVYYTSQDGRKIFDGLSGLWCCGLGHGRQEIAEAAYRQLS
RLDYSPAFQFGHALSFELANKIKTMTPAGLDYVFFTGSGSEAADTSLKMARAYWRAKGQAGKTCFIGREKGYHGVNFGGI
AVGGIAGNRKAFGASAEADHLPHTLLAGNAFSRGMPEQGAELAEELNRIITLRDASTIAAVIIEPFSGSAGVIVPPVGYL
QRIREICTQHNILLIFDEVITAFGRCGALTGAEAFGVTPDIMNIAKQVTNGAQPMGAVVVRPEIYQAFMTTDEPEYLLEF
PHGYTYSAHPVSCAVGLATLDIIEREQMIERVQALAPYFEQAVHGLQGCRHVTDIRNFGLAAGITLAARPGEAARRPYEV
AMRCWEKGFYVRYGGDTLQLAPPFISSEAQIDSLINALGDAINATE
>Mature_445_residues
ADLNHPENKPEPEWLEAHWMPFTGNRNFKANPRMISHAEGVYYTSQDGRKIFDGLSGLWCCGLGHGRQEIAEAAYRQLSR
LDYSPAFQFGHALSFELANKIKTMTPAGLDYVFFTGSGSEAADTSLKMARAYWRAKGQAGKTCFIGREKGYHGVNFGGIA
VGGIAGNRKAFGASAEADHLPHTLLAGNAFSRGMPEQGAELAEELNRIITLRDASTIAAVIIEPFSGSAGVIVPPVGYLQ
RIREICTQHNILLIFDEVITAFGRCGALTGAEAFGVTPDIMNIAKQVTNGAQPMGAVVVRPEIYQAFMTTDEPEYLLEFP
HGYTYSAHPVSCAVGLATLDIIEREQMIERVQALAPYFEQAVHGLQGCRHVTDIRNFGLAAGITLAARPGEAARRPYEVA
MRCWEKGFYVRYGGDTLQLAPPFISSEAQIDSLINALGDAINATE

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=424, Percent_Identity=26.6509433962264, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI37574042, Length=435, Percent_Identity=28.0459770114943, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI226442705, Length=435, Percent_Identity=28.0459770114943, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI13994255, Length=439, Percent_Identity=24.8291571753986, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI226442709, Length=400, Percent_Identity=28.75, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI24119277, Length=446, Percent_Identity=25.5605381165919, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI284507298, Length=329, Percent_Identity=27.355623100304, Blast_Score=114, Evalue=2e-25,
Organism=Escherichia coli, GI1786991, Length=427, Percent_Identity=29.7423887587822, Blast_Score=161, Evalue=7e-41,
Organism=Escherichia coli, GI145693181, Length=301, Percent_Identity=31.5614617940199, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789759, Length=406, Percent_Identity=29.3103448275862, Blast_Score=138, Evalue=7e-34,
Organism=Escherichia coli, GI1788044, Length=407, Percent_Identity=28.5012285012285, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789016, Length=410, Percent_Identity=26.3414634146341, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1787560, Length=436, Percent_Identity=25.6880733944954, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1786349, Length=350, Percent_Identity=27.4285714285714, Blast_Score=86, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI32564660, Length=447, Percent_Identity=26.1744966442953, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI25144271, Length=425, Percent_Identity=24.9411764705882, Blast_Score=129, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI71992977, Length=440, Percent_Identity=25.6818181818182, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI25144274, Length=242, Percent_Identity=27.6859504132231, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6323470, Length=436, Percent_Identity=24.7706422018349, Blast_Score=145, Evalue=9e-36,
Organism=Saccharomyces cerevisiae, GI6324432, Length=412, Percent_Identity=25.9708737864078, Blast_Score=123, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6324386, Length=433, Percent_Identity=24.4803695150115, Blast_Score=121, Evalue=2e-28,
Organism=Drosophila melanogaster, GI21357415, Length=424, Percent_Identity=26.6509433962264, Blast_Score=140, Evalue=1e-33,
Organism=Drosophila melanogaster, GI21356575, Length=369, Percent_Identity=29.5392953929539, Blast_Score=129, Evalue=3e-30,
Organism=Drosophila melanogaster, GI28574759, Length=446, Percent_Identity=26.6816143497758, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI161085790, Length=444, Percent_Identity=26.1261261261261, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 48526; Mature: 48394

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADLNHPENKPEPEWLEAHWMPFTGNRNFKANPRMISHAEGVYYTSQDGRKIFDGLSGLW
CCCCCCCCCCCCCCHHHEECEEECCCCCCCCCCCEEECCCCEEEECCCCHHHHHCCCCEE
CCGLGHGRQEIAEAAYRQLSRLDYSPAFQFGHALSFELANKIKTMTPAGLDYVFFTGSGS
EECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCC
EAADTSLKMARAYWRAKGQAGKTCFIGREKGYHGVNFGGIAVGGIAGNRKAFGASAEADH
CHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCC
LPHTLLAGNAFSRGMPEQGAELAEELNRIITLRDASTIAAVIIEPFSGSAGVIVPPVGYL
CCCHHHCCCHHHCCCCHHHHHHHHHHHHEEEECCCCEEEEEEEECCCCCCCEEECCHHHH
QRIREICTQHNILLIFDEVITAFGRCGALTGAEAFGVTPDIMNIAKQVTNGAQPMGAVVV
HHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHCCCCCCCEEEE
RPEIYQAFMTTDEPEYLLEFPHGYTYSAHPVSCAVGLATLDIIEREQMIERVQALAPYFE
CHHHHHHHHCCCCCHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVHGLQGCRHVTDIRNFGLAAGITLAARPGEAARRPYEVAMRCWEKGFYVRYGGDTLQL
HHHHHHHHHHHHHHHHHCCHHHCEEEEECCCHHHCCHHHHHHHHHHCCCEEEECCCEEEE
APPFISSEAQIDSLINALGDAINATE
CCCCCCCHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
ADLNHPENKPEPEWLEAHWMPFTGNRNFKANPRMISHAEGVYYTSQDGRKIFDGLSGLW
CCCCCCCCCCCCCHHHEECEEECCCCCCCCCCCEEECCCCEEEECCCCHHHHHCCCCEE
CCGLGHGRQEIAEAAYRQLSRLDYSPAFQFGHALSFELANKIKTMTPAGLDYVFFTGSGS
EECCCCCHHHHHHHHHHHHHHCCCCHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCC
EAADTSLKMARAYWRAKGQAGKTCFIGREKGYHGVNFGGIAVGGIAGNRKAFGASAEADH
CHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCC
LPHTLLAGNAFSRGMPEQGAELAEELNRIITLRDASTIAAVIIEPFSGSAGVIVPPVGYL
CCCHHHCCCHHHCCCCHHHHHHHHHHHHEEEECCCCEEEEEEEECCCCCCCEEECCHHHH
QRIREICTQHNILLIFDEVITAFGRCGALTGAEAFGVTPDIMNIAKQVTNGAQPMGAVVV
HHHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCHHCCCCHHHHHHHHHHHCCCCCCCEEEE
RPEIYQAFMTTDEPEYLLEFPHGYTYSAHPVSCAVGLATLDIIEREQMIERVQALAPYFE
CHHHHHHHHCCCCCHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVHGLQGCRHVTDIRNFGLAAGITLAARPGEAARRPYEVAMRCWEKGFYVRYGGDTLQL
HHHHHHHHHHHHHHHHHCCHHHCEEEEECCCHHHCCHHHHHHHHHHCCCEEEECCCEEEE
APPFISSEAQIDSLINALGDAINATE
CCCCCCCHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]