Click here to switch to the map view.

The map label for this gene is fklB [H]

Identifier: 157368699

GI number: 157368699

Start: 500372

End: 500992

Strand: Direct

Name: fklB [H]

Synonym: Spro_0452

Alternate gene names: 157368699

Gene position: 500372-500992 (Clockwise)

Preceding gene: 157368697

Following gene: 157368701

Centisome position: 9.18

GC content: 59.58

Gene sequence:

>621_bases
ATGACAACCCCTTCTTTTGACAGCGTTGAAGCTCAAGCGAGTTACGGGATTGGTTTACAGGTCGGCCAGCAGTTGCAAGA
GTCCGGTCTGGAAGGTTTACAACCGGAAGCTCTGCTGGCAGGTTTGCGTGACGCGCTGGAAGGGAATGCCCCGGCGGTTC
CGGTAGACGTGGTTCACCGTGCGCTGCGTGAAATTCACGAACGTGCGGATGCCGTGCGTCGCGATCGTCAGCAGGCGATG
GCCGTTGAAGGTCAGAAATTCCTGGAAGACAACGCCAAGCGTGACGAAGTGACGCTGACCGAATCCGGTCTGCAGTTCTC
CGTGCTGGAGCAGGGCGATGGCCCAATCCCGTCCCGTCAGGATCGCGTGCGTGTGCATTACACCGGTCGTCTGATTAACG
GCGACGTGTTCGACAGCTCTGTAGAGCGCGGCCAGCCGGCAGAATTCCCGGTCAGCGGCGTGATCCCAGGCTGGATCGAA
GCGCTGACTCTGATGCCGGTCGGCTCCAAATGGCAGTTGTACATCCCACACGACCTGGCCTACGGCGAGCGTGGTGCAGG
CGCATCCATCCCGCCATTCAGCGCGCTGGTGTTTGACGTCGAGCTGTTGGAAATTCTGTAA

Upstream 100 bases:

>100_bases
TTCTACGACAAAAGTCATCATTCTCCACACAAGATTTTACCCGGCTTTACGGCGCTGTTATGCTGCGCTTTCGACTTTTT
AAAGACTAAAGGAAAACCCC

Downstream 100 bases:

>100_bases
GTCACCGCAGAGTTTTTCAAGGGCGCCTTAACGGCGCCCTTATTGTTTATTTCTTCTGCAAATCAATCTGATAAACCGCA
AAGCCGATGCTGTCTGTCCC

Product: peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: FKBP22; PPIase; Rotamase [H]

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MTTPSFDSVEAQASYGIGLQVGQQLQESGLEGLQPEALLAGLRDALEGNAPAVPVDVVHRALREIHERADAVRRDRQQAM
AVEGQKFLEDNAKRDEVTLTESGLQFSVLEQGDGPIPSRQDRVRVHYTGRLINGDVFDSSVERGQPAEFPVSGVIPGWIE
ALTLMPVGSKWQLYIPHDLAYGERGAGASIPPFSALVFDVELLEIL

Sequences:

>Translated_206_residues
MTTPSFDSVEAQASYGIGLQVGQQLQESGLEGLQPEALLAGLRDALEGNAPAVPVDVVHRALREIHERADAVRRDRQQAM
AVEGQKFLEDNAKRDEVTLTESGLQFSVLEQGDGPIPSRQDRVRVHYTGRLINGDVFDSSVERGQPAEFPVSGVIPGWIE
ALTLMPVGSKWQLYIPHDLAYGERGAGASIPPFSALVFDVELLEIL
>Mature_205_residues
TTPSFDSVEAQASYGIGLQVGQQLQESGLEGLQPEALLAGLRDALEGNAPAVPVDVVHRALREIHERADAVRRDRQQAMA
VEGQKFLEDNAKRDEVTLTESGLQFSVLEQGDGPIPSRQDRVRVHYTGRLINGDVFDSSVERGQPAEFPVSGVIPGWIEA
LTLMPVGSKWQLYIPHDLAYGERGAGASIPPFSALVFDVELLEIL

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0545

COG function: function code O; FKBP-type peptidyl-prolyl cis-trans isomerases 1

Gene ontology:

Cell location: Cytoplasm. Periplasm. Note=According to PubMed:7610040 it is periplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase FKBP-type domain [H]

Homologues:

Organism=Homo sapiens, GI17149836, Length=106, Percent_Identity=44.3396226415094, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI4503725, Length=106, Percent_Identity=44.3396226415094, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI206725530, Length=106, Percent_Identity=47.1698113207547, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI17149844, Length=106, Percent_Identity=47.1698113207547, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI17149842, Length=106, Percent_Identity=47.1698113207547, Blast_Score=80, Evalue=9e-16,
Organism=Homo sapiens, GI4758380, Length=106, Percent_Identity=39.622641509434, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI4503727, Length=139, Percent_Identity=38.8489208633094, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI4503729, Length=92, Percent_Identity=41.304347826087, Blast_Score=70, Evalue=1e-12,
Organism=Escherichia coli, GI87082390, Length=206, Percent_Identity=80.5825242718447, Blast_Score=341, Evalue=2e-95,
Organism=Escherichia coli, GI1789745, Length=211, Percent_Identity=34.1232227488152, Blast_Score=113, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI17540882, Length=106, Percent_Identity=43.3962264150943, Blast_Score=76, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71993519, Length=106, Percent_Identity=40.5660377358491, Blast_Score=71, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17561782, Length=100, Percent_Identity=37, Blast_Score=64, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6320727, Length=88, Percent_Identity=53.4090909090909, Blast_Score=86, Evalue=4e-18,
Organism=Saccharomyces cerevisiae, GI6324194, Length=110, Percent_Identity=45.4545454545455, Blast_Score=84, Evalue=1e-17,
Organism=Drosophila melanogaster, GI281363946, Length=88, Percent_Identity=48.8636363636364, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17352457, Length=88, Percent_Identity=48.8636363636364, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24655568, Length=106, Percent_Identity=43.3962264150943, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24583150, Length=104, Percent_Identity=35.5769230769231, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24647110, Length=114, Percent_Identity=40.3508771929825, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001179
- InterPro:   IPR000774 [H]

Pfam domain/function: PF00254 FKBP_C; PF01346 FKBP_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 22427; Mature: 22296

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS50059 FKBP_PPIASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPSFDSVEAQASYGIGLQVGQQLQESGLEGLQPEALLAGLRDALEGNAPAVPVDVVHR
CCCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHH
ALREIHERADAVRRDRQQAMAVEGQKFLEDNAKRDEVTLTESGLQFSVLEQGDGPIPSRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCCCCCC
DRVRVHYTGRLINGDVFDSSVERGQPAEFPVSGVIPGWIEALTLMPVGSKWQLYIPHDLA
CEEEEEEEEEEECCCHHCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCC
YGERGAGASIPPFSALVFDVELLEIL
CCCCCCCCCCCCHHHHHHHHHHHHHC
>Mature Secondary Structure 
TTPSFDSVEAQASYGIGLQVGQQLQESGLEGLQPEALLAGLRDALEGNAPAVPVDVVHR
CCCCCCCCHHHHHCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHH
ALREIHERADAVRRDRQQAMAVEGQKFLEDNAKRDEVTLTESGLQFSVLEQGDGPIPSRQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEECCCCCCCCCC
DRVRVHYTGRLINGDVFDSSVERGQPAEFPVSGVIPGWIEALTLMPVGSKWQLYIPHDLA
CEEEEEEEEEEECCCHHCCHHHCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEECCCCC
YGERGAGASIPPFSALVFDVELLEIL
CCCCCCCCCCCCHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 8703024; 9298646 [H]